Rapid Kinetics of Regulator of G-protein Signaling (RGS)-mediated Gαi and Gαo Deactivation

Mice Deficient in Cellular Glutathione Peroxidase Show Increased Vulnerability to Malonate, 3-Nitropropionic Acid, and 1-Methyl-4-Phenyl-1,2,5,6-Tetrahydropyridine

2000 • 1,112 citations

G PROTEIN MECHANISMS: Insights from Structural Analysis

1997 • 1,061 citations

G PROTEIN βγ SUBUNITS

1997 • 834 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

1996 • 729 citations

The Regulator of G Protein Signaling Family

2000 • 586 citations

EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins

1996 • 573 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding.

1982 • 542 citations

RGS Proteins and Signaling by Heterotrimeric G Proteins

1997 • 522 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

1996 • 470 citations

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

1997 • 355 citations

The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis

1996 • 354 citations

RGS10 is a selective activator of Gαi GTPase activity

1996 • 354 citations

RGS proteins reconstitute the rapid gating kinetics of Gβγ-activated inwardly rectifying K⁺ channels

1997 • 336 citations

Sst2, a Negative Regulator of Pheromone Signaling in the Yeast Saccharomyces cerevisiae: Expression, Localization, and Genetic Interaction and Physical Association with Gpa1 (the G-Protein α Subunit)

1996 • 331 citations

Emerging roles for RGS proteins in cell signalling

1999 • 255 citations

The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go.

1987 • 231 citations

Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 216 citations

A new family of G-protein regulators — the RGS proteins

1997 • 201 citations

RGS proteins: more than just GAPs for heterotrimeric G proteins

1999 • 200 citations

Inhibition of G-Protein Signaling by Dominant Gain-of-Function Mutations in Sst2p, a Pheromone Desensitization Factor in Saccharomyces cerevisiae

1995 • 198 citations

The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins.

1987 • 190 citations

Rapid GTP binding and hydrolysis by G _q promoted by receptor and GTPase-activating proteins

1999 • 175 citations

A Point Mutation in Gαo and Gαi1Blocks Interaction with Regulator of G Protein Signaling Proteins

1998 • 172 citations

The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro

1997 • 167 citations

Regulators of G Protein Signaling 6 and 7

1999 • 136 citations

Identification of the Gβ5-RGS7 Protein Complex in the Retina

1998 • 120 citations

[20] Myristoylation of G-protein α subunits

1994 • 113 citations

Tryptophan W207 in transducin T alpha is the fluorescence sensor of the G protein activation switch and is involved in the effector binding.

1993 • 103 citations

Gβ5 prevents the RGS7-Gαo interaction through binding to a distinct Gγ-like domain found in RGS7 and other RGS proteins

1999 • 95 citations

The intrinsic fluorescence of the alpha subunit of transducin. Measurement of receptor-dependent guanine nucleotide exchange.

1988 • 92 citations

RGS7 and RGS8 Differentially Accelerate G Protein-mediated Modulation of K+ Currents

1999 • 88 citations

G-protein signaling: Fine-tuning signaling kinetics

1998 • 77 citations

Endogenous Regulator of G-Protein Signaling Proteins Modify N-Type Calcium Channel Modulation in Rat Sympathetic Neurons

2000 • 74 citations

Regulators of G-protein signalling: a novel protein family involved in timely deactivation and desensitization of signalling via heterotrimeric G proteins

1999 • 68 citations

Fluorescent guanine nucleotide analogs and G protein activation.

1994 • 65 citations

RGS7 Attenuates Signal Transduction Through the G_αq Family of Heterotrimeric G Proteins in Mammalian Cells

1998 • 59 citations

Mutational Analysis of the Asn Residue Essential for RGS Protein Binding to G-proteins

1998 • 43 citations

Rhodopsin-stimulated activation-deactivation cycle of transducin: kinetics of the intrinsic fluorescence response of the .alpha.-subunit

1990 • 38 citations

Substitution of Transducin Ser202 by Asp Abolishes G-protein/RGS Interaction

1998 • 28 citations

Roles of G_oα Tryptophans in GTP Hydrolysis, GDP Release, and Fluorescence Signals

1998 • 22 citations

Interaction of human retinal RGS with G‐protein α‐subunits

1997 • 16 citations

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