RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

G PROTEINS: TRANSDUCERS OF RECEPTOR-GENERATED SIGNALS

1987 • 6,374 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins

1996 • 573 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

1996 • 470 citations

Lipid modifications of G proteins: alpha subunits are palmitoylated.

1993 • 336 citations

Sst2, a Negative Regulator of Pheromone Signaling in the Yeast Saccharomyces cerevisiae: Expression, Localization, and Genetic Interaction and Physical Association with Gpa1 (the G-Protein α Subunit)

1996 • 331 citations

Regulation of deactivation of photoreceptor G protein by its target enzyme and cGMP

1992 • 324 citations

Rapid β-Adrenergic Modulation of Cardiac Calcium Channel Currents by a Fast G Protein Pathway

1989 • 307 citations

GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

1995 • 291 citations

Lipid modifications of G protein subunits.

1991 • 274 citations

Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones.

1982 • 216 citations

Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.

1990 • 208 citations

Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues.

1988 • 205 citations

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1996 • 201 citations

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.

1993 • 146 citations

Mechanism of GTP hydrolysis by G-protein alpha subunits.

1994 • 117 citations

Second messenger signalling in olfaction

1992 • 109 citations

cGMP suppresses GTPase activity of a portion of transducin equimolar to phosphodiesterase in frog rod outer segments. Light-induced cGMP decreases as a putative feedback mechanism of the photoresponse.

1991 • 102 citations

Deactivation kinetics of the transduction cascade of vision.

1991 • 101 citations

Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.

1994 • 99 citations

Subsecond deactivation of transducin by endogenous GTP hydrolysis

1990 • 95 citations

Retinal rod GTPase turnover rate increases with concentration: A key to the control of visual excitation?

1987 • 93 citations

Isolation and characterization of a novel B cell activation gene.

1993 • 93 citations

Receptor kinase‐dependent desensitization of the muscarinic K+ current in rat atrial cells.

1995 • 43 citations

Influence of Mg2+ on the Structure and Function of Rab5

1996 • 27 citations