Amino-terminal Cysteine Residues of RGS16 Are Required for Palmitoylation and Modulation of Gi- and Gq-mediated Signaling

Functional rafts in cell membranes

1997 • 9,471 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

Acylation Targets Endothelial Nitric-oxide Synthase to Plasmalemmal Caveolae

1996 • 798 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

Interactions between saturated acyl chains confer detergent resistance on lipids and glycosylphosphatidylinositol (GPI)-anchored proteins: GPI-anchored proteins in liposomes and cells show similar behavior.

1994 • 688 citations

Role of Lipid Modifications in Targeting Proteins to Detergent-resistant Membrane Rafts

1999 • 626 citations

EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins

1996 • 573 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

1996 • 470 citations

Lipid Modifications of Trimeric G Proteins

1995 • 468 citations

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

1997 • 355 citations

The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis

1996 • 354 citations

Activation and depalmitoylation of Gsα

1994 • 336 citations

GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

1995 • 291 citations

RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

1999 • 256 citations

Reversible palmitoylation of signaling proteins

1997 • 256 citations

Signals determining protein tyrosine kinase and glycosyl-phosphatidylinositol-anchored protein targeting to a glycolipid-enriched membrane fraction.

1994 • 240 citations

The N-terminal Domain of RGS4 Confers Receptor-selective Inhibition of G Protein Signaling

1998 • 235 citations

Receptor regulation of G-protein palmitoylation.

1994 • 229 citations

Myristoylation of an inhibitory GTP-binding protein alpha subunit is essential for its membrane attachment.

1990 • 225 citations

A Colorimetric Assay for Measuring Activation of Gs- and Gq-Coupled Signaling Pathways

1995 • 187 citations

Cysteine String Proteins: a Potential Link Between Synaptic Vesicles and Presynaptic Ca ²⁺ Channels

1994 • 180 citations

Increased palmitoylation of the Gs protein alpha subunit after activation by the beta-adrenergic receptor or cholera toxin.

1993 • 180 citations

Attenuation of G _i - and G _q -mediated signaling by expression of RGS4 or GAIP in mammalian cells

1997 • 176 citations

The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro

1997 • 167 citations

GAIP is membrane-anchored by palmitoylation and interacts with the activated (GTP-bound) form of Gα _i subunits

1996 • 166 citations

Altered phosphorylation and desensitization patterns of a human beta 2-adrenergic receptor lacking the palmitoylated Cys341.

1993 • 158 citations

RGS4 Inhibits Gq-mediated Activation of Mitogen-activated Protein Kinase and Phosphoinositide Synthesis

1997 • 157 citations

Inhibition of Brain G _z GAP and Other RGS Proteins by Palmitoylation of G Protein α Subunits

1997 • 147 citations

Association of GAP-43 with Detergent-resistant Membranes Requires Two Palmitoylated Cysteine Residues

1998 • 144 citations

RGSZ1, a Gz-selective RGS Protein in Brain

1998 • 144 citations

Functional Importance of the Amino Terminus of Gqα

1996 • 143 citations

Plasma membrane localization is required for RGS4 function in Saccharomyces cerevisiae

1998 • 137 citations

RGS-r, a retinal specific RGS protein, binds an intermediate conformation of transducin and enhances recycling

1996 • 123 citations

RGSZ1, a Gz-selective Regulator of G Protein Signaling Whose Action Is Sensitive to the Phosphorylation State of Gzα

1998 • 122 citations

Mechanism of RGS4, a GTPase-activating Protein for G Protein α Subunits

1998 • 122 citations

Palmitoylated Cysteine 341 Modulates Phosphorylation of the β2-Adrenergic Receptor by the cAMP-dependent Protein Kinase

1996 • 116 citations

Extensive lipidation of a Torpedo cysteine string protein.

1994 • 109 citations

The G protein .alpha.s subunit incorporates [3H]palmitic acid and mutation of cysteine-3 prevents this modification

1993 • 97 citations

The p53 tumor suppressor targets a novel regulator of G protein signaling

1997 • 97 citations

Plasma Membrane Localization of Gα_zRequires Two Signals

1998 • 94 citations

RGS-GAIP, a GTPase-activating Protein for Gα_iHeterotrimeric G Proteins, Is Located on Clathrin-coated Vesicles

1998 • 94 citations

The core domain of a new retina specific RGS protein stimulates the GTPase activity of transducin in vitro

1997 • 90 citations

Enhanced phospholipase C stimulation and transformation in NIH-3T3 cells expressing Q209LGq-alpha-subunits.

1992 • 86 citations

Expression of GTPase-deficient Giα2 Results in Translocation of Cytoplasmic RGS4 to the Plasma Membrane

1998 • 78 citations

Posttranslational modification of tubulin by palmitoylation: I. In vivo and cell-free studies.

1997 • 74 citations

Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins

1997 • 54 citations

Cloning of a retinally abundant regulator of G-protein signaling (RGS-r/RGS16): genomic structure and chromosomal localization of the human gene

1998 • 50 citations

The core domain of RGS16 retains G‐protein binding and GAP activity in vitro, but is not functional in vivo

1998 • 39 citations

[25] Palmitoylation of G-protein α subunits

1995 • 39 citations

Interaction of human retinal RGS with G‐protein α‐subunits

1997 • 16 citations