RGS3 Is a GTPase-Activating Protein for G_iαand G_qαand a Potent Inhibitor of Signaling by GTPase-Deficient Forms of G_qαand G_11α

The GTPase superfamily: conserved structure and molecular mechanism

1991 • 3,365 citations

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

G proteins

1992 • 871 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

1996 • 729 citations

EGL-10 Regulates G Protein Signaling in the C. elegans Nervous System and Shares a Conserved Domain with Many Mammalian Proteins

1996 • 573 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family

1996 • 470 citations

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

1997 • 355 citations

The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis

1996 • 354 citations

RGS10 is a selective activator of Gαi GTPase activity

1996 • 354 citations

RGS2/G0S8 is a selective inhibitor of Gqα function

1997 • 342 citations

Sst2, a Negative Regulator of Pheromone Signaling in the Yeast Saccharomyces cerevisiae: Expression, Localization, and Genetic Interaction and Physical Association with Gpa1 (the G-Protein α Subunit)

1996 • 331 citations

Crystal Structure of the Adenylyl Cyclase Activator G _{s α}

1997 • 310 citations

Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity

1998 • 296 citations

GAIP, a protein that specifically interacts with the trimeric G protein G alpha i3, is a member of a protein family with a highly conserved core domain.

1995 • 291 citations

Receptors induce chemotaxis by releasing the βγ subunit of G _i , not by activating G _q or G _s

1997 • 276 citations

RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

1999 • 256 citations

Receptors and G proteins as primary components of transmembrane signal transduction

1995 • 199 citations

A Colorimetric Assay for Measuring Activation of Gs- and Gq-Coupled Signaling Pathways

1995 • 187 citations

Mutations of Gs α Designed to Alter the Reactivity of the Protein with Bacterial Toxins

1989 • 177 citations

Attenuation of G _i - and G _q -mediated signaling by expression of RGS4 or GAIP in mammalian cells

1997 • 176 citations

The regulators of G protein signaling (RGS) domains of RGS4, RGS10, and GAIP retain GTPase activating protein activity in vitro

1997 • 167 citations

Chemotaxis in a lymphocyte cell line transfected with C-C chemokine receptor 2B: Evidence that directed migration is mediated by βγ dimers released by activation of G_αi-coupled receptors

1997 • 158 citations

Regulation of Chemotactic and Proadhesive Responses to Chemoattractant Receptors by RGS (Regulator of G-protein Signaling) Family Members

1998 • 125 citations

Receptors and G proteins as primary components of transmembrane signal transduction

1995 • 123 citations

Mechanism of RGS4, a GTPase-activating Protein for G Protein α Subunits

1998 • 122 citations

Regulator of G Protein Signaling 1 (RGS1) Markedly Impairs Giα Signaling Responses of B Lymphocytes

2000 • 118 citations

Mechanism of GTP hydrolysis by G-protein alpha subunits.

1994 • 117 citations

A Truncated Form of RGS3 Negatively Regulates G Protein-coupled Receptor Stimulation of Adenylyl Cyclase and Phosphoinositide Phospholipase C

1997 • 117 citations

RGS3 Inhibits G Protein-Mediated Signaling via Translocation to the Membrane and Binding to Gα₁₁

1999 • 107 citations

Phospholipase C-β1 Directly Accelerates GTP Hydrolysis by Gαq and Acceleration Is Inhibited by Gβγ Subunits

1999 • 98 citations

Potential Role for a Regulator of G Protein Signaling (RGS3) in Gonadotropin-Releasing Hormone (GnRH) Stimulated Desensitization

1997 • 92 citations

Role of Regulator of G Protein Signaling in Desensitization of the Glucose-Dependent Insulinotropic Peptide Receptor*1This work was supported by USPHS Grant DK-52186 (to C.-C.T.).

1998 • 79 citations

Inhibition of regulator of G protein signaling function by two mutant RGS4 proteins

1997 • 54 citations

Potential Role for a Regulator of G Protein Signaling (RGS3) in Gonadotropin-Releasing Hormone (GnRH) Stimulated Desensitization

1997 • 35 citations

Role of Regulator of G Protein Signaling in Desensitization of the Glucose-Dependent Insulinotropic Peptide Receptor

1998 • 33 citations

Genomic Organization, 5′-Flanking Region, and Chromosomal Localization of the HumanRGS3Gene

1997 • 17 citations