Selective Regulation of Gαq/11 by an RGS Domain in the G Protein-coupled Receptor Kinase, GRK2

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

The Mouse Locus Encodes Axin, an Inhibitor of the Wnt Signaling Pathway That Regulates Embryonic Axis Formation

1997 • 908 citations

G proteins

1992 • 871 citations

p115 RhoGEF, a GTPase Activating Protein for Gα ₁₂ and Gα ₁₃

1998 • 834 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

Structure of RGS4 Bound to AlF4−-Activated Giα1: Stabilization of the Transition State for GTP Hydrolysis

1997 • 770 citations

Direct Stimulation of the Guanine Nucleotide Exchange Activity of p115 RhoGEF by Gα ₁₃

1998 • 765 citations

GAIP and RGS4 Are GTPase-Activating Proteins for the Gi Subfamily of G Protein α Subunits

1996 • 729 citations

RGS family members: GTPase-activating proteins for heterotrimeric G-protein α-subunits

1996 • 547 citations

Mammalian RGS Proteins: Barbarians at the Gate

1998 • 487 citations

Activation of Phosphatidylinositol-3′ Kinase by Src-Family Kinase SH3 Binding to the p85 Subunit

1994 • 437 citations

Cellular expression of the carboxyl terminus of a G protein-coupled receptor kinase attenuates G beta gamma-mediated signaling.

1994 • 414 citations

RGS4 and GAIP are GTPase-activating proteins for G _qα and block activation of phospholipase Cβ by γ-thio-GTP-G _qα

1997 • 355 citations

The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis

1996 • 354 citations

RGS2/G0S8 is a selective inhibitor of Gqα function

1997 • 342 citations

Purification of Recombinant G Proteins from Sf9 Cells by Hexahistidine Tagging of Associated Subunits

1995 • 332 citations

Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin

1993 • 303 citations

Dynamic Regulation of RGS2 Suggests a Novel Mechanism in G-Protein Signaling and Neuronal Plasticity

1998 • 296 citations

G-protein-coupled receptors: turn-ons and turn-offs

1998 • 277 citations

Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits

1993 • 262 citations

RGS Proteins Determine Signaling Specificity of Gq-coupled Receptors

1999 • 256 citations

GAPs for rho-related GTPases

1994 • 248 citations

Phosphorylation of the Type 1A Angiotensin II Receptor by G Protein-coupled Receptor Kinases and Protein Kinase C

1996 • 246 citations

Regulation of Phospholipase C-β1 by Gq and m1 Muscarinic Cholinergic Receptor

1996 • 220 citations

D-AKAP2, a novel protein kinase A anchoring protein with a putative RGS domain

1997 • 220 citations

A new family of regulators of G-protein-coupled receptors?

1996 • 209 citations

RGS proteins: more than just GAPs for heterotrimeric G proteins

1999 • 200 citations

Phosphatidylinositol 4,5-Bisphosphate (PIP2)-enhanced G Protein-coupled Receptor Kinase (GRK) Activity: LOCATION, STRUCTURE, AND REGULATION OF THE PIP2 BINDING SITE DISTINGUISHES THE GRK SUBFAMILIES

1996 • 187 citations

Phosphorylation and Desensitization of Human Endothelin A and B Receptors

1997 • 185 citations

Effect of Different G Protein-coupled Receptor Kinases on Phosphorylation and Desensitization of the α1B-Adrenergic Receptor

1996 • 175 citations

Internalization of the TXA2 Receptor α and β Isoforms

1999 • 174 citations

Regulation of G Protein-coupled Receptor Kinases by Caveolin

1999 • 173 citations

Regulation of G Protein-coupled Receptor Kinases by Calmodulin and Localization of the Calmodulin Binding Domain

1997 • 165 citations

The G Protein-coupled Receptor Kinase 2 Is a Microtubule-associated Protein Kinase That Phosphorylates Tubulin

1998 • 153 citations

Identification of the N-terminal region in rhodopsin kinase involved in its interaction with rhodopsin.

1993 • 139 citations

Phosphorylation-independent inhibition of parathyroid hormone receptor signaling by G protein-coupled receptor kinases

1999 • 134 citations

Activation of the G Protein Gq/11 Through Tyrosine Phosphorylation of the α Subunit

1997 • 134 citations

Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation.

1993 • 127 citations

Binding and Phosphorylation of Tubulin by G Protein-coupled Receptor Kinases

1998 • 123 citations

Mechanism of RGS4, a GTPase-activating Protein for G Protein α Subunits

1998 • 122 citations

G²γ dimers stimulate vascular L‐type Ca²⁺channels via phosphoinositide 3‐kinase

1999 • 113 citations

Expression and characterization of two beta-adrenergic receptor kinase isoforms using the baculovirus expression system.

1993 • 88 citations

G-protein signaling: Fine-tuning signaling kinetics

1998 • 77 citations

High Affinity Binding of β-Adrenergic Receptor Kinase to Microsomal Membranes

1996 • 67 citations

Regulators of G Protein Signaling (RGS) Proteins Constitutively Activate Gβγ-gated Potassium Channels

1998 • 65 citations

Regulation of G protein-coupled Receptor Kinase 5 (GRK5) by Actin

1998 • 55 citations

Phosphorylation of phospholipase C-coupled receptors

1997 • 54 citations

Targeting G protein-coupled receptor kinases to their receptor substrates

1997 • 47 citations

Mutational Analysis of the Asn Residue Essential for RGS Protein Binding to G-proteins

1998 • 43 citations

Functional Regulation of Gα16 by Protein Kinase C

1999 • 25 citations

[16] Purification of recombinant Gqα, G11α, and G16α from Sf9 cells

1994 • 17 citations