Mechanisms of signaling and related enzymes

Structure at 2.8 Â resolution of F1-ATPase from bovine heart mitochondria

1994 • 2,954 citations

A general two-metal-ion mechanism for catalytic RNA.

1993 • 1,125 citations

The 2.0 Å crystal structure of a heterotrimeric G protein

1996 • 1,118 citations

Crystal structure of the tyrosine kinase domain of the human insulin receptor

1994 • 1,071 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Reaction mechanism of alkaline phosphatase based on crystal structures

1991 • 930 citations

A Proficient Enzyme

1995 • 859 citations

Role of multiple basic residues in determining the substrate specificity of cyclic AMP-dependent protein kinase.

1977 • 844 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Crystal Structure of Human Protein Tyrosine Phosphatase 1B

1994 • 747 citations

Two‐Metal Ion Catalysis in Enzymatic Acyl‐ and Phosphoryl‐Transfer Reactions

1996 • 605 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

X-ray Structure of the Magnesium(II)·ADP·Vanadate Complex of the Dictyostelium discoideum Myosin Motor Domain to 1.9 Å Resolution^,

1996 • 479 citations

The protein kinases of budding yeast: six score and more

1997 • 473 citations

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

1991 • 468 citations

Crystal Structure of the Catalytic Subunit of Human Protein Phosphatase 1 and its Complex with Tungstate

1995 • 418 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate

1994 • 392 citations

Molecular mechanisms of theprotein serine/threonine phosphatases

1996 • 365 citations

The GTPase-activating Protein RGS4 Stabilizes the Transition State for Nucleotide Hydrolysis

1996 • 354 citations

Structure and function of theprotein tyrosine phosphatases

1996 • 339 citations

Rational scanning mutagenesis of a protein kinase identifies functional regions involved in catalysis and substrate interactions

1991 • 334 citations

The Reactivity of Phosphate Esters. Monoester Hydrolysis

1967 • 324 citations

Kinetic Analysis of ATPase Mechanisms

1976 • 285 citations

cAMP‐dependent protein kinase: Crystallographic insights into substrate recognition and phosphotransfer

1994 • 279 citations

Active site labeling of the Yersinia protein tyrosine phosphatase: The determination of the pKa of the active site cysteine and the function of the conserved histidine 402

1993 • 276 citations

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

1996 • 271 citations

The GTP binding motif: variations on a theme

1996 • 262 citations

Dissecting the catalytic mechanism of protein-tyrosinephosphatases.

1994 • 255 citations

The crystal structure of a low-molecular-weight phosphotyrosine protein phosphatase

1994 • 208 citations

Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.

1990 • 208 citations

Ras-catalyzed hydrolysis of GTP: a new perspective from model studies.

1996 • 205 citations

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1996 • 201 citations

Mutational analysis of a Ser/Thr phosphatase. Identification of residues important in phosphoesterase substrate binding and catalysis

1994 • 181 citations

A catalytic mechanism for the dual-specific phosphatases.

1995 • 178 citations

Roles of Aspartic Acid-181 and Serine-222 in Intermediate Formation and Hydrolysis of the Mammalian Protein-Tyrosine-Phosphatase PTP1

1997 • 176 citations

Carboxypeptidase E Activity Is Deficient in Mice with the fat Mutation

1996 • 170 citations

Kinetic and magnetic resonance studies of active-site mutants of staphylococcal nuclease: factors contributing to catalysis

1987 • 168 citations

Quantitative interpretations of double mutations of enzymes

1992 • 145 citations

Role of Glutamine-61 in the Hydrolysis of GTP by p21H-ras: An Experimental and Theoretical Study

1994 • 141 citations

Metal−Substrate Interactions Facilitate the Catalytic Activity of the Bacterial Phosphotriesterase

1996 • 138 citations

Phosphorus-31 nuclear magnetic resonance study of alkaline phosphatase: the role of inorganic phosphate in limiting the enzyme turnover rate at alkaline pH

1976 • 137 citations

The nature of the transition state for enzyme-catalyzed phosphoryl transfer. Hydrolysis of O-aryl phosphorothioates by alkaline phosphatase

1995 • 136 citations

Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction

1995 • 134 citations

Regulation of transducin GTPase activity in bovine rod outer segments.

1994 • 131 citations

Mechanisms of phosphoryl and acyl transfer.

1995 • 122 citations

Mechanism of GTP hydrolysis by G-protein alpha subunits.

1994 • 117 citations

Purification and characterization of a bindable form of mitochondrial bound hexokinase from the highly glycolytic AS-30D rat hepatoma cell line.

1988 • 113 citations

The Catalytic Role of Aspartic Acid-92 in the Human Dual-Specific Protein-Tyrosine-Phosphatase Vaccinia H1-Related

1995 • 112 citations

Purple acid phosphatase: a diiron enzyme that catalyzes a direct phospho group transfer to water

1993 • 106 citations

Kinetics of interaction between normal and proline 12 Ras and the GTPase-activating proteins, p120-GAP and neurofibromin. The significance of the intrinsic GTPase rate in determining the transforming ability of ras.

1993 • 104 citations

Isolation and structural elucidation of a novel phosphocysteine intermediate in the LAR protein tyrosine phosphatase enzymic pathway

1992 • 103 citations

Pre-Steady-State Kinetic Analysis of cAMP-Dependent Protein Kinase Using Rapid Quench Flow Techniques

1996 • 98 citations

Vaccinia DNA topoisomerase I: Single-turnover and steady-state kinetic analysis of the DNA strand cleavage and ligation reactions

1994 • 96 citations

Function of arginine-166 in the active site of Escherichia coli alkaline phosphatase

1988 • 95 citations

Further examination of seventeen mutations in Escherichia coli F1-ATPase beta-subunit.

1992 • 94 citations

Structure and Properties of the Condensed Phosphates. VII. Hydrolytic Degradation of Pyro- and Tripolyphosphate

1955 • 94 citations

Mechanistic Analysis of the Observed Linear Free Energy Relationships in p21^ras and Related Systems

1996 • 80 citations

NMR docking of a substrate into the X‐ray structure of staphylococcal nuclease

1992 • 73 citations

Linear Free Energy Relationships in the Intrinsic and GTPase Activating Protein-Stimulated Guanosine 5‘-Triphosphate Hydrolysis of p21^ras

1996 • 72 citations

Effects of mutations of conserved Lys-155 and Thr-156 residues in the phosphate-binding glycine-rich sequence of the F1-ATPase beta subunit of Escherichia coli.

1992 • 71 citations

Reactivity of Alcohols Toward the Phosphoenzyme Intermediate in the Protein-Tyrosine Phosphatase-Catalyzed Reaction: Probing the Transition State of the Dephosphorylation Step

1996 • 58 citations

Nuclear magnetic resonance studies of the conformation of tetraamminecobalt(III)-ATP bound at the active site of bovine heart protein kinase

1979 • 57 citations

Use of the Glu-Glu-Phe C-terminal epitope for rapid purification of the catalytic domain of normal and mutant ras GTPase-activating proteins

1991 • 56 citations

Divalent Ion Effects and Insights into the Catalytic Mechanism of Protein Tyrosine Kinase Csk

1997 • 54 citations

Magnetic resonance measurements of intersubstrate distances at the active site of protein kinase using substitution-inert cobalt(III) and chromium(III) complexes of adenosine 5'-(.beta.,.gamma.-methylenetriphosphate)

1980 • 49 citations

Energetic measure for the ionic character of bonds

1990 • 48 citations

Conserved Glu-181 and Arg-182 Residues of Escherichia coli H+-ATPase (ATP Synthase) β Subunit Are Essential for Catalysis: Properties of 33 Mutants between βGlu-161 and βLys-201 Residues1

1994 • 47 citations

Electron spin echo modulation and nuclear relaxation studies of staphylococcal nuclease and its metal-coordinating mutants

1988 • 45 citations

The Role of Glu 57 in the Mechanism of the Escherichia coli MutT Enzyme by Mutagenesis and Heteronuclear NMR

1996 • 44 citations

Nuclear Overhauser effect studies of the conformations of tetraamminecobalt(III)-ATP free and bound to bovine heart protein kinase

1983 • 41 citations

Use of site-directed mutagenesis to elucidate the role of arginine-166 in the catalytic mechanism of alkaline phosphatase.

1988 • 41 citations

Kinetic mechanisms of the forward and reverse pp60c-src tyrosine kinase reactions

1995 • 40 citations

NMR studies of the backbone protons and secondary structure of pentapeptide and heptapeptide substrates bound to bovine heart protein kinase

1984 • 39 citations

NMR Studies of the Mechanism of Enzyme Action

1987 • 35 citations

Turnstile Rearrangement and Pseudorotation in the Permutational Isomerization of Pentavalent Phosphorus Compounds

1971 • 33 citations

Conformations and arrangement of subtrates at active sites of ATP - utilizing enzymes

1981 • 31 citations

Metaphosphate and tris(methylene)metaphosphate [P(CH2)3-] anions. Do they have three double bonds to phosphorus?

1987 • 30 citations

Specificity of bovine heart protein kinase for the Δ‐stereoisomer of the metal—ATP complex

1979 • 25 citations

Kinetic and conformational effects of lysine substitutions for arginines 35 and 87 in the active site of staphylococcal nuclease

1990 • 24 citations

Conformation of Leu-Arg-Arg-Ala-Ser-Leu-Gly bound in the active site of adenosine cyclic 3',5'-phosphate dependent protein kinase

1987 • 23 citations

Rate-Determining Steps for Tyrosine Phosphorylation by the Kinase Domain of v-fps

1996 • 14 citations

NMR docking of the competitive inhibitor thymidine 3′,5′‐diphosphate into the X‐ray structure of staphylococcal nuclease

1993 • 13 citations