Crystal Structure of Human Protein Tyrosine Phosphatase 1B

Dictionary of protein secondary structure: Pattern recognition of hydrogen‐bonded and geometrical features

1983 • 14,802 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

1988 • 1,516 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

SIGNALLING BY RECEPTOR TYROSINE KINASES

1993 • 1,098 citations

Resolution of phase ambiguity in macromolecular crystallography

1985 • 1,040 citations

[3] Protein kinase phosphorylation site sequences and consensus specificity motifs: Tabulations

1991 • 1,036 citations

Structure of a Peptide Inhibitor Bound to the Catalytic Subunit of Cyclic Adenosine Monophosphate-Dependent Protein Kinase

1991 • 949 citations

Crystal structure of cyclin-dependent kinase 2

1993 • 946 citations

Reaction mechanism of alkaline phosphatase based on crystal structures

1991 • 930 citations

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

1993 • 758 citations

Mutations at the murine motheaten locus are within the hematopoietic cell protein-tyrosine phosphatase (Hcph) gene

1993 • 756 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

SH2-Containing Phosphotyrosine Phosphatase as a Target of Protein-Tyrosine Kinases

1993 • 666 citations

2 Evolutionary and Structural Relationships among Dehydrogenases

1975 • 607 citations

The nontransmembrane tyrosine phosphatase PTP-1B localizes to the endoplasmic reticulum via its 35 amino acid C-terminal sequence

1992 • 593 citations

Motheaten and viable motheaten mice have mutations in the haematopoietic cell phosphatase gene

1993 • 578 citations

Protein Tyrosine Phosphatase Activity of an Essential Virulence Determinant in Yersinia

1990 • 566 citations

Purification of the major protein-tyrosine-phosphatases of human placenta.

1988 • 564 citations

Characterization of the major protein-tyrosine-phosphatases of human placenta.

1988 • 554 citations

PROTEIN TYROSINE PHOSPHATASES

1993 • 532 citations

Evidence that the leukocyte-common antigen is required for antigen-induced T lymphocyte proliferation

1989 • 509 citations

Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck

1993 • 497 citations

Evidence for protein-tyrosine-phosphatase catalysis proceeding via a cysteine-phosphate intermediate.

1991 • 468 citations

Tyrosine phosphatase CD45 is essential for coupling T-cell antigen receptor to the phosphatidyl inositol pathway

1990 • 466 citations

A Tyr/Ser protein phosphatase encoded by vaccinia virus

1991 • 403 citations

A protein-tyrosine phosphatase with sequence similarity to the SH2 domain of the protein-tyrosine kinases

1991 • 401 citations

corkscrew encodes a putative protein tyrosine phosphatase that functions to transduce the terminal signal from the receptor tyrosine kinase torso

1992 • 400 citations

Phosphotransferase and substrate binding mechanism of the cAMP-dependent protein kinase catalytic subunit from porcine heart as deduced from the 2.0 A structure of the complex with Mn2+ adenylyl imidodiphosphate and inhibitor peptide PKI(5-24).

1993 • 399 citations

Crystal orientation and X-ray pattern prediction routines for area-detector diffractometer systems in macromolecular crystallography

1987 • 396 citations

Characterization of hematopoietic intracellular protein tyrosine phosphatases: description of a phosphatase containing an SH2 domain and another enriched in proline-, glutamic acid-, serine-, and threonine-rich sequences.

1992 • 367 citations

Distinct functional roles of the two intracellular phosphatase like domains of the receptor-linked protein tyrosine phosphatases LCA and LAR.

1990 • 365 citations

Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew.

1992 • 359 citations

Protein tyrosine phosphatase containing SH2 domains: characterization, preferential expression in hematopoietic cells, and localization to human chromosome 12p12-p13.

1992 • 349 citations

1002 Protein Phosphatases?

1992 • 330 citations

Calpain-catalyzed cleavage and subcellular relocation of protein phosphotyrosine phosphatase 1B (PTP-1B) in human platelets.

1993 • 309 citations

The human CL100 gene encodes a Tyr/Thr-protein phosphatase which potently and specifically inactivates MAP kinase and suppresses its activation by oncogenic ras in Xenopus oocyte extracts.

1993 • 305 citations

Human placenta protein-tyrosine-phosphatase: amino acid sequence and relationship to a family of receptor-like proteins.

1989 • 276 citations

Active site labeling of the Yersinia protein tyrosine phosphatase: The determination of the pKa of the active site cysteine and the function of the conserved histidine 402

1993 • 276 citations

Regulation of B Cell Antigen Receptor Signal Transduction and Phosphorylation by CD45

1991 • 269 citations

Homophilic binding of PTP mu, a receptor-type protein tyrosine phosphatase, can mediate cell-cell aggregation

1993 • 268 citations

The cdc25 M-phase inducer: An unconventional protein phosphatase

1992 • 266 citations

Cloning of a cDNA for a major human protein-tyrosine-phosphatase.

1990 • 223 citations

Cloning and expression of a protein-tyrosine-phosphatase.

1990 • 215 citations

Isolation of a cDNA clone encoding a human protein-tyrosine phosphatase with homology to the cytoskeletal-associated proteins band 4.1, ezrin, and talin.

1991 • 203 citations

Identification, cloning, and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to cytoskeletal protein 4.1.

1991 • 198 citations

Substrate specificity of the protein tyrosine phosphatases.

1993 • 189 citations

Refined crystal structure of dogfish M4 apo-lactate dehydrogenase

1987 • 182 citations

Expression of a protein tyrosine phosphatase in normal and v-src-transformed mouse 3T3 fibroblasts

1992 • 176 citations

Molecular cloning and chromosome mapping of the human gene encoding protein phosphotyrosyl phosphatase 1B.

1990 • 174 citations

Multi-site phosphorylation of the protein tyrosine phosphatase, PTP1B: identification of cell cycle regulated and phorbol ester stimulated sites of phosphorylation.

1993 • 156 citations

Algorithm for ribbon models of proteins

1986 • 143 citations

Effect of protein tyrosine phosphatase 1B expression on transformation by the human neu oncogene.

1992 • 143 citations

Cloning, bacterial expression, purification, and characterization of the cytoplasmic domain of rat LAR, a receptor-like protein tyrosine phosphatase.

1991 • 132 citations

Three-dimensional structure of rat acid phosphatase.

1993 • 110 citations

Isolation and structural elucidation of a novel phosphocysteine intermediate in the LAR protein tyrosine phosphatase enzymic pathway

1992 • 103 citations

Sequence specificity in recognition of the epidermal growth factor receptor by protein tyrosine phosphatase 1B.

1993 • 99 citations

Cloning and expression of a cytosolic megakaryocyte protein-tyrosine-phosphatase with sequence homology to retinaldehyde-binding protein and yeast SEC14p.

1992 • 91 citations

A protein-tyrosine/serine phosphatase encoded by the genome of the cyanobacterium Nostoc commune UTEX 584.

1993 • 86 citations

Analysis of a spatially regulated phosphotyrosine phosphatase identifies tyrosine phosphorylation as a key regulatory pathway in Dictyostelium

1992 • 81 citations

Regulation of protein tyrosine phosphatases by insulin and insulin-like growth factor I.

1993 • 78 citations

Substrate specificities of catalytic fragments of protein tyrosine phosphatases (HPTPβ, LAR, and CD45) toward phosphotyrosylpeptide substrates and thiophosphotyrosylated peptides as inhibitors

1993 • 72 citations

Isolation and characterization of temperature-sensitive and thermostable mutants of the human receptor-like protein tyrosine phosphatase LAR

1991 • 58 citations

Acidic residues are involved in substrate recognition by two soluble protein tyrosine phosphatases, PTP-5 and rrbPTP-1

1993 • 43 citations

A homozygous deletion within the carbonic anhydrase-like domain of the Ptprg gene in murine L-cells.

1993 • 31 citations

Introduction: Protein tyrosine phosphatases

1993 • 30 citations

Secondary structure prediction from multiple sequence data: blood clotting factor XIII and Yersinia protein‐tyrosine phosphatase

1994 • 19 citations

Cloning and functional expression of a Dictyostelium discoideum protein tyrosine phosphatase.

1993 • 17 citations

<title>Large-aperture CCD x-ray detector for protein crystallography using a fiber-optic taper</title>

1991 • 4 citations