Ras-catalyzed hydrolysis of GTP: a new perspective from model studies.

ras GENES

1987 • 3,818 citations

The GTPase superfamily: a conserved switch for diverse cell functions

1990 • 2,330 citations

Proteins regulating Ras and its relatives

1993 • 1,930 citations

Hydrogen bonding in globular proteins

1984 • 1,760 citations

Mechanism and theory in Organic chemistry

1977 • 1,434 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

A Cytoplasmic Protein Stimulates Normal N- ras p21 GTPase, But Does Not Affect Oncogenic Mutants

1987 • 1,197 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1980 • 1,120 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Molecular Switch for Signal Transduction: Structural Differences Between Active and Inactive Forms of Protooncogenic ras Proteins

1990 • 1,037 citations

Binding Energy, Specificity, and Enzymic Catalysis: The Circe Effect

1975 • 844 citations

Mechanism and Theory in Organic Chemistry

1976 • 844 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

X-ray Structures of the Myosin Motor Domain of Dictyostelium discoideum Complexed with MgADP.cntdot.BeFx and MgADP.cntdot.AlF4-

1995 • 610 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

The ras protein family: evolutionary tree and role of conserved amino acids

1991 • 573 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Enzymatic Catalysis and Transition-State Theory

1973 • 501 citations

Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis

1990 • 489 citations

Transition States of Biochemical Processes

1978 • 418 citations

Kinetics of interaction of nucleotides with nucleotide-free H-ras p21

1990 • 410 citations

The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation

1993 • 399 citations

Structural details of the binding of guanosine diphosphate to elongation factor Tu from E. coli as studied by X-ray crystallography.

1985 • 396 citations

Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules

1990 • 395 citations

The structure of Ras protein: a model for a universal molecular switch

1991 • 310 citations

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

1995 • 273 citations

Mutational and kinetic analyses of the GTPase-activating protein (GAP)-p21 interaction: the C-terminal domain of GAP is not sufficient for full activity.

1992 • 268 citations

Crystal structures at 2.2 Å resolution of the catalytic domains of normal ras protein and an oncogenic mutant complexed with GDP

1991 • 261 citations

The Energetics of Hydrogen Bonds in Model Systems: Implications for Enzymatic Catalysis

1996 • 251 citations

Metal Ions in Biological Systems

1976 • 225 citations

Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli.

1990 • 208 citations

Biochemical properties of Ha-ras encoded p21 mutants and mechanism of the autophosphorylation reaction.

1988 • 196 citations

Mapping the transition state for ATP hydrolysis: implications for enzymatic catalysis

1995 • 196 citations

Mutations of Gs α Designed to Alter the Reactivity of the Protein with Bacterial Toxins

1989 • 177 citations

Role of Glutamine-61 in the Hydrolysis of GTP by p21H-ras: An Experimental and Theoretical Study

1994 • 141 citations

The nature of the transition state for enzyme-catalyzed phosphoryl transfer. Hydrolysis of O-aryl phosphorothioates by alkaline phosphatase

1995 • 136 citations

Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction

1995 • 134 citations

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.

1992 • 132 citations

Kinetic analysis of the hydrolysis of GTP by p21N-ras. The basal GTPase mechanism.

1988 • 130 citations

Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code

1993 • 130 citations

On the mechanism of guanosine triphosphate hydrolysis in ras p21 proteins

1992 • 124 citations

ANTIGEN SPECIFIC SUPPRESSOR CELL FUNCTION IN AUTOIMMUNE CHRONIC ACTIVE HEPATITIS

1984 • 123 citations

Why have mutagenesis studies not located the general base in ras p21

1994 • 122 citations

C-terminal Truncation of p21H Preserves Crucial Kinetic and Structural Properties

1989 • 112 citations

The importance of being ribose at the cleavage site in the Tetrahymena ribozyme reaction

1993 • 105 citations

Three-dimensional structures and properties of a transforming and a nontransforming glycine-12 mutant of p21H-ras

1993 • 96 citations

Catalysis of the hydrolysis of phosphorylated pyridines by Mg(OH)+: a possible model for enzymic phosphoryl transfer

1990 • 94 citations

Acyl-transfer reactions of amides and esters with alcohols and thiols. Reference system for the serine and cysteine proteinases. Nitrogen protonation of amides and amide-imidate equilibriums

1971 • 90 citations

19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-

1991 • 82 citations

Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras

1993 • 78 citations

The world according to GAP.

1990 • 72 citations

Use of binding energy by an RNA enzyme for catalysis by positioning and substrate destabilization.

1995 • 60 citations

Use of the Glu-Glu-Phe C-terminal epitope for rapid purification of the catalytic domain of normal and mutant ras GTPase-activating proteins

1991 • 56 citations

NMR study of the phosphoryl binding loop in purine nucleotide proteins: evidence for strong hydrogen bonding in human N-ras p21

1990 • 49 citations

Pyruvate kinase: is the mechanism of phospho transfer associative or dissociative?

1982 • 49 citations

Studies on the structure and mechanism of H-ras p21

1992 • 40 citations

NMR Studies of the Mechanism of Enzyme Action

1987 • 35 citations

Nucleotide binding and GTP hydrolysis by elongation factor Tu from Thermus thermophilus as monitored by proton NMR

1992 • 34 citations

NMR studies of the conformational change in human N-p21ras produced by replacement of bound GDP with the GTP analog GTP.gamma.S

1992 • 31 citations

An NMR comparison of the changes produced by different guanosine 5'-triphosphate analogs in wild-type and oncogenic mutant p21ras

1993 • 31 citations

Identification of resonances from an oncogenic activating locus of human N-RAS-encoded p21 protein using isotope-edited NMR.

1989 • 30 citations

Gasp: not just another oncogene

1989 • 29 citations

Structural and dynamic differences between normal and transforming N-ras gene products: a phosphorus-31 and isotope-edited proton NMR study

1989 • 20 citations

The world according to GAP.

1990 • 6 citations