Reaction mechanism of alkaline phosphatase based on crystal structures

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

The interpretation of protein structures: Estimation of static accessibility

1971 • 5,771 citations

Crystallographic R Factor Refinement by Molecular Dynamics

1987 • 1,982 citations

A graphics model building and refinement system for macromolecules

1978 • 1,858 citations

Enzyme-Catalyzed Phosphoryl Transfer Reactions

1980 • 1,120 citations

Bone and Mineral Research

1990 • 1,070 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Computational crystallography

2012 • 705 citations

Slow-cooling protocols for crystallographic refinement by simulated annealing

1990 • 530 citations

High-resolution (1.5 Å) crystal structure of phospholipase C from Bacillus cereus

1989 • 451 citations

Structure of thermolysin refined at 1.6 Å resolution

1982 • 443 citations

A missense mutation in the human liver/bone/kidney alkaline phosphatase gene causing a lethal form of hypophosphatasia.

1988 • 326 citations

Cocrystal structure of an editing complex of Klenow fragment with DNA.

1988 • 324 citations

Phosphate metabolism and cellular regulation in microorganisms

1988 • 274 citations

Refined structure of alkaline phosphatase from Escherichia coli at 2.8 Å resolution

1985 • 233 citations

Alkaline Phosphatase of Escherichia coli: A Zinc Metalloenzyme^*

1962 • 230 citations

Incorporation of fast Fourier transforms to speed restrained least-squares refinement of protein structures

1987 • 221 citations

Structural aspects of metal ion carboxylate interactions

1988 • 220 citations

Determination of the tautomeric form of the imidazole ring of L-histidine in basic solution by carbon-13 magnetic resonance spectroscopy

1973 • 214 citations

RIBBON: a stereo cartoon drawing program for proteins

1988 • 190 citations

Some Properties of Alkaline Phosphatase from Escherichia coli

1964 • 183 citations

Phosphate Binding to Alkaline Phosphatase

1970 • 178 citations

Amino acid sequence of Escherichia coli alkaline phosphatase.

1981 • 176 citations

17 E. coli Alkaline Phosphatase

1971 • 175 citations

Structure of alkaline phosphatases

1990 • 174 citations

Manganese and calcium binding sites of concanavalin A

1982 • 174 citations

Nucleotide sequence of the alkaline phosphatase gene of Escherichia coli

1986 • 140 citations

Phosphorus-31 nuclear magnetic resonance study of alkaline phosphatase: the role of inorganic phosphate in limiting the enzyme turnover rate at alkaline pH

1976 • 137 citations

The effect of divalent metal ions on the rate and transition-state structure of phosphoryl-transfer reactions

1987 • 133 citations

Metal ion promoted phosphate ester hydrolysis. Intramolecular attack of coordinated hydroxide ion

1989 • 108 citations

Effect of magnesium on the properties of zinc alkaline phosphatase

1977 • 104 citations

Bacillus subtilis alkaline phosphatases III and IV. Cloning, sequencing, and comparisons of deduced amino acid sequence with Escherichia coli alkaline phosphatase three-dimensional structure.

1991 • 99 citations

Aspartic acid-484 of nascent placental alkaline phosphatase condenses with a phosphatidylinositol glycan to become the carboxyl terminus of the mature enzyme.

1988 • 97 citations

Function of arginine-166 in the active site of Escherichia coli alkaline phosphatase

1988 • 95 citations

Stereochemistry of phosphoryl group transfer using a chiral [16O, 17O, 18O] stereochemical course of alkaline phosphatase

1978 • 92 citations

The Phosphate Content of Escherichia coli Alkaline Phosphatase and Its Effect on Stopped Flow Kinetic Studies

1973 • 92 citations

Alkaline Phosphatase, Solution Structure, and Mechanism

1983 • 89 citations

Structural characteristics of the PHO8 gene encoding repressible alkaline phosphatase in Saccharomyces cerevisiae

1987 • 86 citations

Cobalt(III)-promoted hydrolysis of a phosphate ester

1977 • 78 citations

SPECIFIC INTERACTIONS INVOLVING GUANIDYL GROUP OBSERVED IN CRYSTAL STRUCTURES

1981 • 76 citations

31P NMR of phosphate and phosphonate complexes of metalloalkaline phosphatases.

1976 • 75 citations

Mechanisms of Hydrolysis of O-Phosphorothioates and Inorganic Thiophosphate by Escherichia coli Alkaline Phosphatase

1974 • 71 citations

Allosteric interactions between metal ion and phosphate at the active sites of alkaline phosphatase as determined by 31P NMR and 113Cd NMR.

1977 • 69 citations

31P nuclear magnetic resonance of phosphoenzyme intermediates of alkaline phosphatase.

1983 • 66 citations

18 Mammalian Alkaline Phosphatases

1971 • 66 citations

Structure of bis(methylguanidinium) monohydrogen orthophosphate. Model for the arginine-phosphate interactions at the active site of staphylococcal nuclease and other phosphohydrolytic enzymes

1974 • 64 citations

The phosphorylation of Tris by alkaline phosphatase

1964 • 61 citations

Determination by cadmium-113 nuclear magnetic resonance of the structural basis for metal ion dependent anticooperativity in alkaline phosphatase

1980 • 59 citations

113Cd nuclear magnetic resonance of Cd(II) alkaline phosphatases.

1983 • 52 citations

Alkaline phosphatase. 31P NMR probes of the mechanism.

1985 • 52 citations

The three Dimensional Structure of Alkaline Phosphatase from E. coli

1983 • 49 citations

Characterization of the properties of the multiple metal binding sites in alkaline phosphatase by carbon-13 nuclear magnetic resonance

1980 • 41 citations

Use of site-directed mutagenesis to elucidate the role of arginine-166 in the catalytic mechanism of alkaline phosphatase.

1988 • 41 citations

Nitrogen Ligands at the Active Site of Alkaline Phosphatase

1972 • 39 citations

Divalent metal ion catalysis in the hydrolysis of phosphomonoesters. Hydrolysis of 2-(1,10-phenanthrolyl) phosphate

1988 • 37 citations

Presteady State Kinetics of Phosphorothioate Hydrolysis by Alkaline Phosphatase

1972 • 33 citations

Characterization of the histidine residues in alkaline phosphatase by carbon-13 nuclear magnetic resonance

1980 • 33 citations

Oxygen Chiral Phosphate Esters

1983 • 33 citations

Crystal and molecular structure of the monoclinic form of aqua(5'-cytidine monophosphato)cadmium(II)-1.5-water

1978 • 33 citations

Metallophosphoryl and Apophosphoryl Alkaline Phosphatases.

1976 • 29 citations

Phosphate binding to Escherichia coli alkaline phosphatase. Evidence for site homogeneity.

1978 • 29 citations

Crystal structures of bis(urea)bis(dihydrogenphosphato)calcium-bis(urea) and its isomorphous magnesium analog, M[OC(NH2)2]2(H2PO4)2.2CO(NH2)2 (M = Ca, Mg)

1982 • 19 citations

Stereochemistry of phospho group transfer catalyzed by a mutant alkaline phosphatase

1988 • 15 citations

Crystal Structure of Propylguanidinium Diethyl Phosphate.

1972 • 13 citations

Binding of calcium to amino acids: the crystal structure of pentaaquobis(hydroxy-(L)-prolinato)calcium, Ca(C5H8O3N)2.5H2O

1985 • 11 citations

Crystal Structure Studies of Calcium Complexes and Implications for Biological Systems

2024 • 4 citations