Use of site-directed mutagenesis to elucidate the role of arginine-166 in the catalytic mechanism of alkaline phosphatase.

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Experiments in molecular genetics

1972 • 28,260 citations

Culture Medium for Enterobacteria

1974 • 3,002 citations

Oligonucleotide-Directed Mutagenesis: A Simple Method Using Two Oligonucleotide Primers and a Single-Stranded DNA Template

1984 • 947 citations

Tinkering with Enzymes: What Are We Learning?

1987 • 304 citations

Refined structure of alkaline phosphatase from Escherichia coli at 2.8 Å resolution

1985 • 233 citations

Amino acid sequence of Escherichia coli alkaline phosphatase.

1981 • 176 citations

Interaction of Alkaline Phosphatase of E. coli with Metal Ions and Chelating Agents^*

1962 • 152 citations

Cloning and restriction mapping of the alkaline phosphatase structural gene (phoA) of Escherichia coli and generation of deletion mutants in vitro

1981 • 126 citations

Idealization of the hydrophobic segment of the alkaline phosphatase signal peptide

1986 • 98 citations

Modification of the Active Site of Alkaline Phosphatase by Site-Directed Mutagenesis

1986 • 61 citations

Etude cinetique du mecanisme d'action catalytique de la phosphatase alcaline d’Escherichia coli

1966 • 60 citations

Kinetics of the Escherichia coli alkaline phosphatase catalyzed hydrolysis of 2,4-dinitrophenyl phosphate

1967 • 54 citations

Leaving group dependence in the phosphorylation of Escherichia coli alkaline phosphatase by monophosphate esters

1986 • 45 citations