Linear Free Energy Relationships in the Intrinsic and GTPase Activating Protein-Stimulated Guanosine 5‘-Triphosphate Hydrolysis of p21^ras

Chemical and Electrochemical Electron-Transfer Theory

1964 • 4,224 citations

Enzyme structure and mechanism

1978 • 2,897 citations

X-ray Structures of the Myosin Motor Domain of Dictyostelium discoideum Complexed with MgADP.cntdot.BeFx and MgADP.cntdot.AlF4-

1995 • 610 citations

GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

1994 • 564 citations

The crystal structure of elongation factor EF-Tu from Thermus aquaticus in the GTP conformation

1993 • 399 citations

Microscopic examination of free-energy relationships for electron transfer in polar solvents

1987 • 307 citations

Simulation of free energy relationships and dynamics of SN2 reactions in aqueous solution

1988 • 291 citations

Expression of p21 proteins in Escherichia coli and stereochemistry of the nucleotide-binding site.

1986 • 287 citations

Substrate-assisted catalysis as a mechanism for GTP hydrolysis of p21ras and other GTP-binding proteins

1995 • 273 citations

The Application of the Marcus Relation to Reactions in Solution

1980 • 232 citations

Formation of a Transition-State Analog of the Ras GTPase Reaction by Ras·GDP, Tetrafluoroaluminate, and GTPase-Activating Proteins

1996 • 201 citations

Acetylcholinesterase: Enthalpies and Entropies of Activation¹

1956 • 177 citations

Role of solvent reorganization energies in the catalytic activity of enzymes

1991 • 127 citations

C-terminal Truncation of p21H Preserves Crucial Kinetic and Structural Properties

1989 • 112 citations

p21 with a phenylalanine 28—-leucine mutation reacts normally with the GTPase activating protein GAP but nevertheless has transforming properties.

1991 • 102 citations

The Mechanism of Guanosine Nucleotide Hydrolysis by p21 c-Ha-ras

1989 • 91 citations

Equilibrium deuterium isotope effects on the ionization of thiol acids

1971 • 85 citations

Interaction of GTPase activating proteins (GAPs) with p21ras measured by a novel fluorescence anisotropy method. Essential role of Arg-903 of GAP in activation of GTP hydrolysis on p21ras

1993 • 78 citations

Experimental designs for estimating the parameters of the Michaelis-Menten equation from progress curves of enzyme-catalyzed reactions

1991 • 61 citations

Dynamics of hydride transfer between NAD+ analogs

1990 • 48 citations

Linear Free Energy Relationships in Enzymes. Theoretical Analysis of the Reaction of Tyrosyl-tRNA Synthetase

1994 • 38 citations

Linear free-energy relationship

2006 • 37 citations