GTPase mechanism of Gproteins from the 1.7-Å crystal structure of transducin α - GDP AIF−4

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

Why Nature Chose Phosphates

1987 • 1,583 citations

GTPase inhibiting mutations activate the α chain of Gs and stimulate adenylyl cyclase in human pituitary tumours

1989 • 1,405 citations

FUNCTION AND REGULATION OF RAS

1993 • 1,161 citations

Refined crystal structure of the triphosphate conformation of H-ras p21 at 1.35 A resolution: implications for the mechanism of GTP hydrolysis.

1990 • 1,077 citations

Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis

1994 • 823 citations

RIBBONS 2.0

1991 • 814 citations

The 2.2 Å crystal structure of transducin-α complexed with GTPγS

1993 • 788 citations

Structural determinants for activation of the α-subunit of a heterotrimeric G protein

1994 • 636 citations

Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride.

1982 • 618 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Fluoroaluminates activate transducin‐GDP by mimicking the γ‐phosphate of GTP in its binding site

1985 • 420 citations

Three-dimensional structures of H-ras p21 mutants: Molecular basis for their inability to function as signal switch molecules

1990 • 395 citations

Inhibition of GTPase Activating Protein Stimulation of Ras-p21 GTPase by the K rev -1 Gene Product

1990 • 254 citations

gsp mutations in human thyroid tumours.

1991 • 198 citations

Structural requirements for the interaction of p21ras with GAP, exchange factors, and its biological effector target

1993 • 189 citations

Concerted Displacement Reactions. VIII. Polyfunctional Catalysis¹

1952 • 174 citations

Role of Glutamine-61 in the Hydrolysis of GTP by p21H-ras: An Experimental and Theoretical Study

1994 • 141 citations

X-ray crystal structures of transforming p21 ras mutants suggest a transition-state stabilization mechanism for GTP hydrolysis.

1992 • 132 citations

Probing the Structure and Mechanism of Ras Protein with an Expanded Genetic Code

1993 • 130 citations

Why have mutagenesis studies not located the general base in ras p21

1994 • 122 citations

Hydrolysis of an amide in a carboxypeptidase model using cobalt(III) and bifunctional catalysts

1987 • 88 citations

19F and 31P NMR spectroscopy of G protein alpha subunits. Mechanism of activation by Al3+ and F-

1991 • 82 citations

Formation of the stable myosin-ADP-aluminum fluoride and myosin-ADP-beryllium fluoride complexes and their analysis using 19F NMR.

1993 • 74 citations

GTP hydrolysis mechanisms in ras p21 and in the ras-GAP complex studied by fluorescence measurements on tryptophan mutants

1991 • 45 citations

Studies on the structure and mechanism of H-ras p21

1992 • 40 citations

Direct identification of the fluoroaluminate and fluoroberyllate species responsible for inhibition of the mitochondrial F₁‐ATPase

1989 • 40 citations

[50] Transducin and the cyclic GMP phosphodiesterase of retinal rod outer segments

1983 • 33 citations

An X-ray and nuclear magnetic resonance study of structure and ion motions in (C(NH₂)₃)₃AlF₆

1992 • 14 citations