Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells

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1999 • 21,494 citations

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1993 • 10,730 citations

Oxidants, antioxidants, and the degenerative diseases of aging.

1993 • 6,011 citations

eIF4 Initiation Factors: Effectors of mRNA Recruitment to Ribosomes and Regulators of Translation

1999 • 2,096 citations

Nuclear Factor Kb: An Oxidative Stress-Responsive Transcription Factor of Eukaryotic Cells (A Review)

1992 • 1,421 citations

The role of oxidized lipoproteins in atherogenesis

1996 • 1,382 citations

Translational control of gene expression

2001 • 1,192 citations

Oxygen radicals and signaling

1998 • 1,163 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Mitogen-activated protein kinases activate the serine/threonine kinases Mnk1 and Mnk2

1997 • 927 citations

Hierarchical phosphorylation of the translation inhibitor 4E-BP1

2001 • 849 citations

Hypertension and the Pathogenesis of Atherosclerosis

1995 • 760 citations

Cocrystal Structure of the Messenger RNA 5′ Cap-Binding Protein (eIF4E) Bound to 7-methyl-GDP

1997 • 660 citations

MNK1, a new MAP kinase-activated protein kinase, isolated by a novel expression screening method for identifying protein kinase substrates

1997 • 658 citations

Active oxygen species stimulate vascular smooth muscle cell growth and proto-oncogene expression.

1992 • 653 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

mRNAs containing extensive secondary structure in their 5′ non-coding region translate efficiently in cells overexpressing initiation factor eIF-4E.

1992 • 414 citations

The Role of Oxygen Radicals in Human Disease, with Particular Reference to the Vascular System

1993 • 371 citations

The Phosphorylation of Eukaryotic Initiation Factor eIF4E in Response to Phorbol Esters, Cell Stresses, and Cytokines Is Mediated by Distinct MAP Kinase Pathways

1998 • 302 citations

Transient Adaptation to Oxidative Stress in Mammalian Cells

1995 • 300 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-).

1994 • 280 citations

Elevated Levels of Cyclin D1 Protein in Response to Increased Expression of Eukaryotic Initiation Factor 4E

1993 • 270 citations

Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation

1988 • 266 citations

Phosphorylation of Eukaryotic Initiation Factor 4E Markedly Reduces Its Affinity for Capped mRNA

2002 • 252 citations

Negative Regulation of Protein Translation by Mitogen-Activated Protein Kinase-Interacting Kinases 1 and 2

2001 • 241 citations

eIF4G Dramatically Enhances the Binding of eIF4E to the mRNA 5′-Cap Structure

1997 • 235 citations

Overproduction of ornithine decarboxylase caused by relief of translational repression is associated with neoplastic transformation.

1994 • 202 citations

Regulation of translation initiation factors by signal transduction

1998 • 195 citations

Elevated levels of cyclin D1 protein in response to increased expression of eukaryotic initiation factor 4E.

1993 • 186 citations

The 5′ Untranslated Sequence of the c-sis/Platelet-Derived Growth Factor 2 Transcript Is a Potent Translational Inhibitor

1988 • 180 citations

Phosphorylation of Eukaryotic Translation Initiation Factor 4E Is Critical for Growth

2002 • 175 citations

The mRNA 5' cap-binding protein, eIF-4E, cooperates with v-myc or E1A in the transformation of primary rodent fibroblasts.

1992 • 172 citations

Expression of Antisense RNA against Initiation Factor eIF-4E mRNA in HeLa Cells Results in Lengthened Cell Division Times, Diminished Translation Rates, and Reduced Levels of Both eIF-4E and the p220 Component of eIF-4F

1991 • 151 citations

Serine 209, Not Serine 53, Is the Major Site of Phosphorylation in Initiation Factor eIF-4E in Serum-treated Chinese Hamster Ovary Cells

1995 • 149 citations

A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate

1996 • 139 citations

Translational enhancement of FGF-2 by eIF-4 factors, and alternate utilization of CUG and AUG codons for translation initiation.

1995 • 131 citations

Decreasing the level of translation initiation factor 4E with antisense rna causes reversal of ras‐mediated transformation and tumorigenesis of cloned rat embryo fibroblasts

1993 • 114 citations

Evaluation of isoelectric focusing running conditions during two-dimensional isoelectric focusing/sodium dodecyl sulfate-polyacrylamide gel electrophoresis: Variation of gel patterns with changing conditions and optimized isoelectric focusing conditions

1984 • 114 citations

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E.

1990 • 110 citations

Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.

1991 • 93 citations

Oxidants induce phosphorylation of ribosomal protein S6.

1988 • 91 citations

Phosphorylation of eukaryotic initiation factor 4E (eIF4E) at Ser209 is not required for protein synthesis in vitro and in vivo

2001 • 91 citations

cis-acting elements involved in the alternative translation initiation process of human basic fibroblast growth factor mRNA.

1992 • 81 citations

cis-acting translational effects of the 5' noncoding region of c-myc mRNA.

1988 • 75 citations

Preferential translation of heat shock mRNAs in HeLa cells deficient in protein synthesis initiation factors eIF-4E and eIF-4 gamma.

1992 • 74 citations

Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation

1993 • 71 citations

Inactivation of eIF2B and Phosphorylation of PHAS-I in Heat-shocked Rat Hepatoma Cells

1997 • 57 citations

Increased rate of phosphorylation-dephosphorylation of the translational initiation factor eIF-4E correlates with the induction of protein and glycoprotein biosynthesis in activated B lymphocytes.

1990 • 55 citations

Heat shock causes diverse changes in the phosphorylation of the ribosomal proteins of mammalian cells

1984 • 54 citations

Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts

1991 • 50 citations

Linoleic acid hydroperoxide-induced peroxidation of endothelial cell phospholipids and cytotoxicity

1994 • 47 citations

The mRNA 5' Cap-Binding Protein, eIF-4E, Cooperates with v-myc or E1A in the Transformation of Primary Rodent Fibroblasts

1992 • 47 citations

In vitro synthesis of human protein synthesis initiation factor 4 gamma and its localization on 43 and 48 S initiation complexes.

1994 • 45 citations

Oxidant Stress Stimulates Phosphorylation of eIF4E without an Effect on Global Protein Synthesis in Smooth Muscle Cells

2000 • 33 citations

Inhibition by linoleic acid hydroperoxide of alveolar macrophage superoxide production: Effects upon mitochondrial and plasma membrane potentials

1989 • 32 citations

Oxidative stress increases eukaryotic initiation factor 4E phosphorylation in vascular cells

2003 • 31 citations

Striking multiplicity of eIF4E‐BP1 phosphorylated isoforms identified by 2D gel electrophoresis

1999 • 24 citations

cis-Acting Elements Involved in the Alternative Translation Initiation Process of Human Basic Fibroblast Growth Factor mRNA

1992 • 24 citations

cis-Acting Translational Effects of the 5′ Noncoding Region of c-myc mRNA

1988 • 23 citations