Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

Current protocols in molecular biology

1988 • 4,543 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Inhibition of HeLa cell protein synthesis following poliovirus infection correlates with the proteolysis of a 220,000-dalton polypeptide associated with eucaryotic initiation factor 3 and a cap binding protein complex.

1982 • 580 citations

Inducible production of c-fos antisense RNA inhibits 3T3 cell proliferation.

1986 • 468 citations

Antisense RNA-Induced Reduction in Murine TIMP Levels Confers Oncogenicity on Swiss 3T3 Cells

1989 • 459 citations

The mechanism of action of protein synthesis initiation factors from rabbit reticulocytes.

1978 • 436 citations

New initiation factor activity required for globin mRNA translation.

1983 • 416 citations

Injected anti-sense RNAs specifically block messenger RNA translation in vivo.

1985 • 410 citations

A polypeptide in eukaryotic initiation factors that crosslinks specifically to the 5'-terminal cap in mRNA.

1978 • 365 citations

Constitutive and Conditional Suppression of Exogenous and Endogenous Genes by Anti-Sense RNA

1985 • 343 citations

Initiation of protein synthesis: Evidence for messenger RNA-independent binding of methionyl-transfer RNA to the 40 S ribosomal subunit

1973 • 296 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

Cap-Binding Proteins of Eukaryotic Messenger RNA: Functions in Initiation and Control of Translation

1988 • 266 citations

Two forms of purified m7G-cap binding protein with different effects on capped mRNA translation in extracts of uninfected and poliovirus-infected HeLa cells.

1981 • 224 citations

Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis.

1987 • 220 citations

Differential stimulation of phosphorylation of initiation factors eIF-4F, eIF-4B, eIF-3, and ribosomal protein S6 by insulin and phorbol esters.

1990 • 197 citations

Quantitation of mRNA by the polymerase chain reaction

1990 • 188 citations

Purification of a factor that restores translation of vesicular stomatitis virus mRNA in extracts from poliovirus-infected HeLa cells.

1980 • 164 citations

Control of cytochrome P1-450 gene expression: analysis of a dioxin-responsive enhancer system.

1986 • 146 citations

CDC33 encodes mRNA cap-binding protein eIF-4E of Saccharomyces cerevisiae.

1988 • 135 citations

Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.

1990 • 133 citations

Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.

1990 • 125 citations

Phorbol esters stimulate phosphorylation of eukaryotic initiation factors 3, 4B, and 4F

1989 • 121 citations

Simultaneous cytoplasmic redistribution of ribosomal protein L32 mRNA and phosphorylation of eukaryotic initiation factor 4E after mitogenic stimulation of Swiss 3T3 cells.

1990 • 120 citations

Amino acid sequence of the mRNA cap-binding protein from human tissues.

1987 • 112 citations

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E.

1990 • 110 citations

Inhibition of heat shock protein synthesis by heat-inducible antisense RNA.

1986 • 105 citations

Translation in Saccharomyces cerevisiae: initiation factor 4E-dependent cell-free system.

1989 • 103 citations

Antisense Myc sequences induce differentiation of F9 cells.

1988 • 90 citations

mRNA cap-binding protein: cloning of the gene encoding protein synthesis initiation factor eIF-4E from Saccharomyces cerevisiae.

1987 • 90 citations

Demonstration in vitro that eucaryotic initiation factor 3 is active but that a cap-binding protein complex is inactive in poliovirus-infected HeLa cells

1984 • 86 citations

Structural analysis of the messenger RNA cap-binding protein. Presence of phosphate, sulfhydryl, and disulfide groups.

1986 • 80 citations

Human rhinovirus 14 infection of HeLa cells results in the proteolytic cleavage of the p220 cap-binding complex subunit and inactivates globin mRNA translation in vitro

1985 • 77 citations

Translation in Saccharomyces cerevisiae: initiation factor 4A-dependent cell-free system.

1989 • 76 citations

2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible, Ah receptor-mediated bending of enhancer DNA.

1990 • 70 citations

In Vitro Synthesis, Phosphorylation, and Localization on 48 S Initiation Complexes of Human Protein Synthesis Initiation Factor 4E

1989 • 67 citations

The cap-binding protein complex in uninfected and poliovirus-infected HeLa cells.

1987 • 66 citations

Association of initiation factor eIF-4E in a cap binding protein complex (eIF-4F) is critical for and enhances phosphorylation by protein kinase C.

1990 • 63 citations

Epidermal growth factor or okadaic acid stimulates phosphorylation of eukaryotic initiation factor 4F.

1991 • 61 citations

Increased rate of phosphorylation-dephosphorylation of the translational initiation factor eIF-4E correlates with the induction of protein and glycoprotein biosynthesis in activated B lymphocytes.

1990 • 55 citations

Association of cap-binding protein with eucaryotic initiation factor 3 in initiation factor preparations from uninfected and poliovirus-infected HeLa cells

1982 • 50 citations

Identification of a 48 S preinitiation complex in reticulocyte lysate.

1978 • 49 citations

A polypeptide which reverses cap analogue inhibition of cell-free protein synthesis. Purification and binding to capped oligonucleotides.

1982 • 46 citations

Monoclonal antibody-aided characterization of cellular p220 in uninfected and poliovirus-infected HeLa cells: subcellular distribution and identification of conformers

1987 • 39 citations

Two-dimensional gel analyses of the 24-kDa cap binding protein from poliovirus-infected and uninfected HeLa cells

1986 • 29 citations

Separation of protein synthesis initiation factor eIF4A from a p220-associated cap binding complex activity

1987 • 26 citations

The Role of Antisense RNA in Gene Regulation

1986 • 26 citations

A novel BK virus-based episomal vector for expression of foreign genes in mammalian cells

1991 • 22 citations

A fractionated reticulocyte lysate retains high efficiency for protein synthesis

1990 • 20 citations

Translation in Eukaryotes

2006 • 3 citations