Decreasing the level of translation initiation factor 4E with antisense rna causes reversal of ras‐mediated transformation and tumorigenesis of cloned rat embryo fibroblasts

A genetic model for colorectal tumorigenesis

1990 • 11,800 citations

An analysis of 5'-noncoding sequences from 699 vertebrate messenger RNAs

1987 • 5,139 citations

ras oncogenes in human cancer: a review.

1989 • 5,116 citations

Cooperation between oncogenes

1991 • 792 citations

Requirement for c-ras proteins during viral oncogene transformation

1986 • 680 citations

Ornithine decarboxylase activity is critical for cell transformation

1992 • 630 citations

New procedure for DNA transfection with polycation and dimethyl sulfoxide.

1984 • 481 citations

Model for the regulation of mRNA translation applied to haemoglobin synthesis

1974 • 416 citations

Immunology of spontaneous mammary carcinomas in mice. V. Acquired tumor resistance and enhancement in strain A mice infected with mammary tumor virus.

1966 • 314 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

ras oncogenes: their role in neoplasia

1990 • 244 citations

Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes.

1983 • 221 citations

Expression of Antisense RNA against Initiation Factor eIF-4E mRNA in HeLa Cells Results in Lengthened Cell Division Times, Diminished Translation Rates, and Reduced Levels of Both eIF-4E and the p220 Component of eIF-4F

1991 • 151 citations

Analysis of type 5 adenovirus transformation with a cloned rat embryo cell line (CREF).

1982 • 126 citations

Differential efficiencies of in vitro translation of mouse c-myc transcripts differing in the 5' untranslated region.

1985 • 104 citations

Expression of antisense RNA against initiation factor eIF-4E mRNA in HeLa cells results in lengthened cell division times, diminished translation rates, and reduced levels of both eIF-4E and the p220 component of eIF-4F.

1991 • 93 citations

Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation.

1992 • 86 citations

Protein synthesis, cell growth and oncogenesis

1991 • 82 citations

Ras transformation of cloned rat embryo fibroblasts results in increased rates of protein synthesis and phosphorylation of eukaryotic initiation factor 4E.

1992 • 81 citations

How does p21ras transform cells?

1991 • 75 citations

Preferential translation of heat shock mRNAs in HeLa cells deficient in protein synthesis initiation factors eIF-4E and eIF-4 gamma.

1992 • 74 citations

Role of the Ha-ras (RasH) oncogene in mediating progression of the tumor cell phenotype (review).

1990 • 24 citations