A Reevaluation of the Cap-binding Protein, eIF4E, as a Rate-limiting Factor for Initiation of Translation in Reticulocyte Lysate

The scanning model for translation: an update.

1989 • 3,525 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

TRANSLATIONAL CONTROL IN MAMMALIAN CELLS

1991 • 1,041 citations

Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5' cap

1990 • 949 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 • 662 citations

Bidirectional RNA helicase activity of eucaryotic translation initiation factors 4A and 4F.

1990 • 632 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

Mechanism and regulation of eukaryotic protein synthesis

1992 • 591 citations

[4] Preparation and use of nuclease-treated rabbit reticulocyte lysates for the translation of eukaryotic messenger RNA

1983 • 547 citations

Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

1995 • 541 citations

Regulated phosphorylation and low abundance of HeLa cell initiation factor eIF-4F suggest a role in translational control. Heat shock effects on eIF-4F.

1987 • 494 citations

New initiation factor activity required for globin mRNA translation.

1983 • 416 citations

ATP-dependent unwinding of messenger RNA structure by eukaryotic initiation factors.

1985 • 404 citations

Dominant negative mutants of mammalian translation initiation factor eIF-4A define a critical role for eIF-4F in cap-dependent and cap-independent initiation of translation.

1994 • 384 citations

Leader protein of foot-and-mouth disease virus is required for cleavage of the p220 component of the cap-binding protein complex

1988 • 319 citations

Regulation of eukaryotic protein synthesis by initiation factors.

1993 • 300 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

Overexpression of eukaryotic protein synthesis initiation factor 4E in HeLa cells results in aberrant growth and morphology.

1990 • 281 citations

Control of PHAS-I by Insulin in 3T3-L1 Adipocytes

1995 • 239 citations

Involvement of the 24-kDa cap-binding protein in regulation of protein synthesis in mitosis.

1987 • 220 citations

RNA-stimulated ATPase activity of eukaryotic initiation factors.

1984 • 211 citations

Phosphorylation of Eukaryotic Protein Synthesis Initiation Factor 4E at Ser-209

1995 • 210 citations

Immunological detection of the messenger RNA cap-binding protein.

1985 • 201 citations

Identification and quantitation of levels of protein synthesis initiation factors in crude HeLa cell lysates by two-dimensional polyacrylamide gel electrophoresis.

1983 • 193 citations

Foot-and-mouth disease virus leader proteinase: purification of the Lb form and determination of its cleavage site on eIF-4 gamma

1994 • 191 citations

Adenovirus inhibition of cellular protein synthesis involves inactivation of cap-binding protein

1991 • 177 citations

Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.

1994 • 165 citations

Serine 209, Not Serine 53, Is the Major Site of Phosphorylation in Initiation Factor eIF-4E in Serum-treated Chinese Hamster Ovary Cells

1995 • 149 citations

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

1994 • 138 citations

A Consideration of Alternative Models for the Initiation of Translation in Eukaryotes

1992 • 137 citations

Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.

1990 • 133 citations

mRNA Cap-Binding Protein: Cloning of the Gene Encoding Protein Synthesis Initiation Factor eIF-4E from Saccharomyces cerevisiae

1987 • 130 citations

Cloning and expression of eukaryotic initiation factor 4B cDNA: sequence determination identifies a common RNA recognition motif.

1990 • 125 citations

Regulation of translation and cell growth by eIF-4E

1994 • 121 citations

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E.

1990 • 110 citations

The Translation Initiation Factor eIF-4B Contains an RNA-Binding Region That Is Distinct and Independent from its Ribonucleoprotein Consensus Sequence

1994 • 108 citations

Modification of eukaryotic initiation factor 4F during infection by influenza virus

1993 • 94 citations

Proteolytic cleavage of initiation factor elF-4γ in the reticulocyte lysate inhibits translation of capped mRNAs but enhances that of uncapped mRNAs

1995 • 91 citations

Novel phosphorylation sites of eukaryotic initiation factor-4F and evidence that phosphorylation stabilizes interactions of the p25 and p220 subunits.

1993 • 90 citations

Purification of the messenger RNA cap-binding protein using a new affinity medium

1984 • 89 citations

Heat shock impairs the interaction of cap-binding protein complex with 5' mRNA cap.

1991 • 87 citations

Demonstration in vitro that eucaryotic initiation factor 3 is active but that a cap-binding protein complex is inactive in poliovirus-infected HeLa cells

1984 • 86 citations

Foot-and-mouth disease virus Lb proteinase can stimulate rhinovirus and enterovirus IRES-driven translation and cleave several proteins of cellular and viral origin

1995 • 82 citations

Increased phosphorylation of eukaryotic initiation factor 4α during early activation of T lymphocytes correlates with increased initiation factor 4F complex formation

1993 • 71 citations

In Vitro Synthesis, Phosphorylation, and Localization on 48 S Initiation Complexes of Human Protein Synthesis Initiation Factor 4E

1989 • 67 citations

The cap-binding protein complex in uninfected and poliovirus-infected HeLa cells.

1987 • 66 citations

Hormone-induced meiotic maturation in Xenopus oocytes occurs independently of p70s6k activation and is associated with enhanced initiation factor (eIF)-4F phosphorylation and complex formation

1995 • 62 citations

Signal transduction mechanisms in the regulation of protein synthesis

1994 • 50 citations

In vitro synthesis of human protein synthesis initiation factor 4 gamma and its localization on 43 and 48 S initiation complexes.

1994 • 45 citations

Eukaryotic protein synthesis: An in vitro analysis

1994 • 43 citations

Isolation and sequence of a cDNA encoding the cap binding protein of wheat eukaryotic protein synthesis initiation factor 4F

1992 • 41 citations

Protein phosphorylation in cell growth regulation

1996 • 36 citations

Cap binding complexes and cellular growth control

1995 • 34 citations

Fluorescence study of the binding of m7GpppG and rabbit globin mRNA to protein synthesis initiation factors 4A, 4E, and 4F

1990 • 33 citations

Translation initiation factor eIF-4E from Drosophila: cDNA sequence and expression of the gene

1995 • 28 citations

Variations in cap-binding complexes from uninfected and poliovirus-infected HeLa cells.

1990 • 24 citations

Mechanism of action of developmentally regulated sea urchin inhibitor of eIF‐4

1993 • 20 citations

A fractionated reticulocyte lysate retains high efficiency for protein synthesis

1990 • 20 citations

Localization of Cap-Binding Protein in Subcellular Fractions of HeLa Cells

1982 • 19 citations

Localization of Cap-Binding Protein in Subcellular Fractions of HeLa Cells

1982 • 8 citations