Oxidants induce phosphorylation of ribosomal protein S6.

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Prooxidant States and Tumor Promotion

1985 • 2,541 citations

Calmodulin Plays a Pivotal Role in Cellular Regulation

1980 • 2,441 citations

The metabolism of menadione (2-methyl-1,4-naphthoquinone) by isolated hepatocytes. A study of the implications of oxidative stress in intact cells.

1982 • 893 citations

Synergistic functions of protein phosphorylation and calcium mobilization in platelet activation.

1983 • 705 citations

Protein Phosphatases: Properties and Role in Cellular Regulation

1983 • 645 citations

Diamide, a new reagent for the intracellular oxidation of glutathione to the disulfide

1969 • 523 citations

The effect of serum, EGF, PGF2α and insulin on S6 phosphorylation and the initiation of protein and DNA synthesis

1982 • 362 citations

Carcinogenesis—A Comprehensive survey

1982 • 311 citations

Regulation of intracellular calcium compartmentation: studies with isolated hepatocytes and t-butyl hydroperoxide.

1982 • 303 citations

Cystamine induces toxicity in hepatocytes through the elevation of cytosolic Ca2+ and the stimulation of a nonlysosomal proteolytic system.

1986 • 249 citations

Differential formation of hydroxyl radicals by adriamycin in sensitive and resistant MCF-7 human breast tumor cells: implications for the mechanism of action

1987 • 214 citations

A protein kinase from Xenopus eggs specific for ribosomal protein S6.

1985 • 195 citations

Phosphatidylinositol turnover in platelet activation; Calcium mobilization and protein phosphorylation

1982 • 193 citations

An activated S6 kinase in extracts from serum- and epidermal growth factor-stimulated Swiss 3T3 cells.

1984 • 193 citations

Calmodulin is involved in regulation of cell proliferation.

1987 • 183 citations

Inhibition of ATP-dependent microsomal Ca2+ sequestration during oxidative stress and its prevention by glutathione.

1983 • 176 citations

Critical role of sulfhydryl group(s) in ATP‐dependent Ca²⁺ sequestration by the plasma membrane fraction from rat liver

1983 • 172 citations

Inhibition of hepatocyte plasma membrane Ca²⁺‐ATPase activity by menadione metabolism and its restoration by thiols

1985 • 168 citations

Purified rat brain calcium- and phospholipid-dependent protein kinase phosphorylates ribosomal protein S6.

1983 • 160 citations

The metabolism of menadione impairs the ability of rat liver mitochondria to take up and retain calcium.

1982 • 159 citations

Protein phosphatase 2A inactivates the mitogen-stimulated S6 kinase from Swiss mouse 3T3 cells.

1988 • 151 citations

Preferential Utilization of Phosphorylated 40‐S Ribosomal Subunits during Initiation Complex Formation

1982 • 139 citations

Increased phosphorylation of specific nuclear proteins in superior cervical ganglia and PC12 cells in response to nerve growth factor.

1980 • 132 citations

Role of reactive oxygen in tumor promotion: implication of superoxide anion in promotion of neoplastic transformation in JB-6 cells by TPA

1985 • 129 citations

Molecular properties of calcium-pumping ATPase from human erythrocytes

1982 • 123 citations

Intracellular calcium homeostasis during hydrogen peroxide injury to cultured P388D₁ cells

1986 • 120 citations

Active oxygen induced DNA strand breakage and poly ADP-ribosylation in promotable and non-promotable JB6 mouse epidermal cells

1988 • 119 citations

Inhibition of erythrocyte Ca2+-ATPase by activated oxygen through thiol- and lipid-dependent mechanisms

1986 • 113 citations

Changes in ribosome function by cAMP-dependent and cAMP-independent phosphorylation of ribosomal protein S6.

1983 • 106 citations

Pertussis toxin or phorbol 12-myristate 13-acetate can distinguish between epidermal growth factor- and angiotensin-stimulated signals in hepatocytes.

1986 • 101 citations

Identification of a ribosomal protein S6 kinase regulated by transformation and growth-promoting stimuli.

1987 • 99 citations

Insulin-treated 3T3-L1 adipocytes and cell-free extracts derived from them incorporate 32P into ribosomal protein S6.

1980 • 98 citations

Purification and mechanism of activation of a nerve growth factor-sensitive S6 kinase from PC12 cells.

1987 • 92 citations

The phosphorylation of eukaryotic ribosomal protein S6 by protein kinase C

1985 • 91 citations

Phosphorylation of hepatic ribosomal protein S6 on 80 and 40 S ribosomes. Primary structure of S6 in the region of the major phosphorylation sites for cAMP-dependent protein kinases.

1984 • 91 citations

Calcium calmodulin-dependent microtubule-associated protein 2 kinase: broad substrate specificity and multifunctional potential in diverse tissues

1985 • 73 citations

Immunochemical detection of proteins in the small subunit of rat liver ribosomes involved in binding of the ternary initiation complex

1980 • 64 citations

Interleukin 2 and diacylglycerol stimulate phosphorylation of 40 S ribosomal S6 protein. Correlation with increased protein synthesis and S6 kinase activation.

1987 • 53 citations

Evidence for the activation of the multifunctional Ca2+/calmodulin-dependent protein kinase in response to hormones that increase intracellular Ca2+.

1987 • 47 citations

Platelet‐derived growth factor stimulates the phosphorylation of ribosomal protein S6

1983 • 45 citations

Mobilization of mitochondrial Ca2+ by hydroperoxy-eicosatetraenoic acid

1987 • 43 citations

Oxygen radicals alter the cell membrane potential in a renal cell line (LLC-PK1) with differentiated characteristics of proximal tubular cells

1987 • 42 citations

[20] Purification of eukaryotic initiation factor 1 (EIF1) from Artemia saliva embryos

1974 • 38 citations

Comparison of phosphorylation of ribosomal proteins from HeLa and Krebs II ascites-tumour cells by cyclic AMP-dependent and cyclic GMP-dependent protein kinases

1980 • 37 citations

Ribosome conformational changes associated with protein S6 phosphorylation.

1984 • 34 citations

Activation of S6 kinase activity in astrocytes by insulin, somatomedin C and TPA

1986 • 34 citations

Identification of protein phosphatases 1 and 2B as ribosomal protein S6 phosphatases in vitro and in vivo.

1987 • 30 citations

Free radical-mediated membrane depolarization in renal and cardiac cells

1987 • 29 citations

Phosphopeptide patterns of the ribosomal protein S6 following stimulation of guineapig parotid glands by secretagogues involving either cAMP or calcium as second messenger

1983 • 19 citations