Inactivation of eIF2B and Phosphorylation of PHAS-I in Heat-shocked Rat Hepatoma Cells

Heat shock, from bacteria to man

1982 • 1,260 citations

Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5'-cap function

1994 • 1,222 citations

Rapamycin-FKBP specifically blocks growth-dependent activation of and signaling by the 70 kd S6 protein kinases

1992 • 1,146 citations

Initiation of Protein Synthesis in Eukaryotic Cells

1996 • 715 citations

PHAS-I as a Link Between Mitogen-Activated Protein Kinase and Translation Initiation

1994 • 672 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Rapamycin-Induced Inhibition of the 70-Kilodalton S6 Protein Kinase

1992 • 666 citations

The Translation Initiation Factor eIF-4E Binds to a Common Motif Shared by the Translation Factor eIF-4γ and the Translational Repressors 4E-Binding Proteins

1995 • 662 citations

Rapamycin selectively represses translation of the "polypyrimidine tract" mRNA family.

1994 • 634 citations

Repression of cap-dependent translation by 4E-binding protein 1: competition with p220 for binding to eukaryotic initiation factor-4E.

1995 • 606 citations

Mapping of Functional Domains in Eukaryotic Protein Synthesis Initiation Factor 4G (eIF4G) with Picornaviral Proteases

1995 • 541 citations

Translational control

1991 • 464 citations

Glycogen synthase kinase-3 is rapidly inactivated in response to insulin and phosphorylates eukaryotic initiation factor eIF-2B

1993 • 399 citations

Rapamycin selectively inhibits translation of mRNAs encoding elongation factors and ribosomal proteins.

1994 • 358 citations

Regulation of protein synthesis in HeLa cells: Translation at elevated temperatures

1969 • 302 citations

Chromatographic resolution of in vivo phosphorylated and nonphosphorylated eukaryotic translation initiation factor eIF-4E: increased cap affinity of the phosphorylated form.

1994 • 285 citations

Insulin stimulation of gene expression mediated by p21ras activation.

1991 • 284 citations

Heat shock-induced translational alterations in HeLa cells. Initiation factor modifications and the inhibition of translation.

1984 • 282 citations

4E-BP1 phosphorylation is mediated by the FRAP-p70s6k pathway and is independent of mitogen-activated protein kinase.

1996 • 238 citations

cAMP- and rapamycin-sensitive regulation of the association of eukaryotic initiation factor 4E and the translational regulator PHAS-I in aortic smooth muscle cells.

1995 • 225 citations

Stimulation of Protein Synthesis, Eukaryotic Translation Initiation Factor 4E Phosphorylation, and PHAS-I Phosphorylation by Insulin Requires Insulin Receptor Substrate 1 and Phosphatidylinositol 3-Kinase

1996 • 217 citations

Protein synthesis and protein phosphorylation during heat stress, recovery, and adaptation.

1989 • 203 citations

Heat-shock-induced alterations of ribosomal protein phosphorylation in plant cell cultures

1982 • 180 citations

Protein Phosphorylation in Translational Control

1992 • 180 citations

Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in vitro and in response to insulin in rat adipocytes.

1994 • 165 citations

Modulation of heat shock polypeptide synthesis in HeLa cells during hyperthermia and recovery

1982 • 162 citations

Regulation of Both Glycogen Synthase and PHAS-I by Insulin in Rat Skeletal Muscle Involves Mitogen-activated Protein Kinase-independent and Rapamycin-sensitive Pathways

1996 • 153 citations

Molecular cloning and tissue distribution of PHAS-I, an intracellular target for insulin and growth factors.

1994 • 138 citations

Alteration of the major phosphorylation site of eukaryotic protein synthesis initiation factor 4E prevents its association with the 48 S initiation complex.

1990 • 133 citations

Identification of Xenopus S6 protein kinase homologs (pp90rsk) in somatic cells: phosphorylation and activation during initiation of cell proliferation.

1990 • 126 citations

Cap binding protein complex that restores protein synthesis in heat-shocked Ehrlich cell lysates contains highly phosphorylated eIF-4E.

1990 • 110 citations

Molecular mechanisms in the control of translation by hormones and growth factors

1994 • 101 citations

Distinct mechanisms for the activation of the RSK kinases/MAP2 kinase/pp90rsk and pp70-S6 kinase signaling systems are indicated by inhibition of protein synthesis.

1991 • 100 citations

Phosphorylation of the guanine nucleotide exchange factor from rabbit reticulocytes regulates its activity in polypeptide chain initiation.

1988 • 98 citations

Heat shock impairs the interaction of cap-binding protein complex with 5' mRNA cap.

1991 • 87 citations

Activation of hemin-regulated initiation factor-2 kinase in heat-shocked HeLa cells.

1986 • 84 citations

Cap-Binding Protein (Eukaryotic Initiation Factor 4E) and 4E-Inactivating Protein BP-1 Independently Regulate Cap-Dependent Translation

1996 • 72 citations

Thermotolerance in Cultured Hepatoma Cells: Cell Viability, Cell Morphology, Protein Synthesis, and Heat-Shock Proteins

1984 • 70 citations

In Vitro Synthesis, Phosphorylation, and Localization on 48 S Initiation Complexes of Human Protein Synthesis Initiation Factor 4E

1989 • 67 citations

The effect of Mg2+ and guanine nucleotide exchange factor on the binding of guanine nucleotides to eukaryotic initiation factor 2.

1988 • 55 citations

Heat shock causes diverse changes in the phosphorylation of the ribosomal proteins of mammalian cells

1984 • 54 citations

Heat shock induces two distinct S6 protein kinase activities in quiescent mammalian fibroblasts

1991 • 50 citations

Cap-Independent Translation

1995 • 46 citations

Dephosphorylation of S6 and expression of the heat shock response in Drosophila melanogaster.

1983 • 43 citations

Heat Shock Effects on Phosphorylation of Protein Synthesis Initiation Factor Proteins eIF-4E and eIF-2.alpha. in Drosophila

1995 • 37 citations

Protein synthesis in brine shrimp embryos and rabbit reticulocytes. The effect of Mg2+ on binary (eukaryotic initiation factor 2 X GDP) and ternary (eukaryotic initiation factor 2 X GTP X met-tRNAf) complex formation.

1983 • 37 citations

Cap-Independent Translation of Heat Shock Messenger RNAs

1995 • 35 citations

Phosphorylation of the eIF4E‐binding protein PHAS‐I after exposure of PC12 cells to EGF and NGF

1996 • 24 citations

Characterization of the ribosomal proteins from mosquito (Aedes albopictus) cells

1985 • 23 citations

Phosphorylation of elF‐4E and initiation of protein synthesis in P19 embryonal carcinoma cells

1995 • 21 citations

Regulation of ribosomal protein S6 phosphorylation in heat-shocked HeLa cells

1987 • 20 citations

Inhibition of HeLa cell protein synthesis under heat shock conditions in the absence of initiation factor eIF-2α phosphorylation

1986 • 19 citations

Temperature-dependency of the expression of heat shock proteins in rat hepatoma cells with a different degree of heat sensitivity

1993 • 3 citations