Interactions of Herbs with Cytochrome P450

Unconventional Medicine in the United States -- Prevalence, Costs, and Patterns of Use

1993 • 4,259 citations

Interindividual variations in human liver cytochrome P-450 enzymes involved in the oxidation of drugs, carcinogens and toxic chemicals: studies with liver microsomes of 30 Japanese and 30 Caucasians.

1994 • 2,716 citations

Influence of Piperine on the Pharmacokinetics of Curcumin in Animals and Human Volunteers

1998 • 1,721 citations

Human UDP-Glucuronosyltransferases: Metabolism, Expression, and Disease

2000 • 1,477 citations

Human Cytochrome P450 Enzymes: A Status Report Summarizing Their Reactions, Substrates, Inducers, and Inhibitors

1997 • 1,161 citations

Intake of Garlic and Its Bioactive Components

2001 • 996 citations

St. John's wort induces hepatic drug metabolism through activation of the pregnane X receptor

2000 • 929 citations

Herb–Drug Interactions

2006 • 896 citations

Pharmacokinetic-Pharmacodynamic Consequences and Clinical Relevance of Cytochrome P450 3A4 Inhibition

2000 • 877 citations

Utility of in vitro drug metabolism data in predicting in vivo metabolic clearance

1994 • 865 citations

Inhibition and Induction of Cytochrome P450 and the Clinical Implications

1998 • 821 citations

Herbal Medicinals

1998 • 820 citations

Human P450 metabolism of warfarin

1997 • 790 citations

Use of In Vitro and In Vivo Data to Estimate the Likelihood of Metabolic Pharmacokinetic Interactions

1997 • 755 citations

Grapefruit juice–drug interactions

1998 • 740 citations

Arzneimittelforschung

2015 • 736 citations

Interactions Between Herbal Medicines and Prescribed Drugs

2001 • 711 citations

Flavonoids and isoflavonoids – a gold mine for metabolic engineering

1999 • 693 citations

St John's wort (Hypericum perforatum L.): a review of its chemistry, pharmacology and clinical properties

2001 • 685 citations

Flavonoid Antioxidants

2001 • 680 citations

Antioxidant Health Effects of Aged Garlic Extract

2001 • 680 citations

Flavonoids-potent and versatile biologically active compounds interacting with cytochromes P450

2002 • 632 citations

Grapefruit juice increases felodipine oral availability in humans by decreasing intestinal CYP3A protein expression.

1997 • 620 citations

Pharmacokinetic interaction of digoxin with an herbal extract from St John's wort (Hypericum perforatum)*1

1999 • 602 citations

Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.

1995 • 601 citations

Study on the Inhibitory Effect of Tannins and Flavonoids against the 1,1-Diphenyl-2-picrylhydrazyl Radical

1998 • 601 citations

Interaction of citrus juices with felodipine and nifedipine

1991 • 595 citations

Absorption, metabolism and health effects of dietary flavonoids in man

1997 • 595 citations

St John's Wort induces intestinal P-glycoprotein/MDR1 and intestinal and hepatic CYP3A4

2000 • 587 citations

The Gut as a Barrier to Drug Absorption

2001 • 518 citations

A Drug over the Millennia : Pharmacognosy, Chemistry, and Pharmacology of Licorice

2000 • 515 citations

Screening for human ADME/Tox drug properties in drug discovery

2001 • 503 citations

Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

1998 • 497 citations

The Risk–Benefit Profile of Commonly Used Herbal Therapies: Ginkgo, St. John's Wort, Ginseng, Echinacea, Saw Palmetto, and Kava

2002 • 469 citations

Human hepatocyte culture systems for the in vitro evaluation of cytochrome P450 expression and regulation

2001 • 459 citations

The Effect of Garlic Supplements on the Pharmacokinetics of Saquinavir

2002 • 433 citations

Phenotyping of drug-metabolizing enzymes in adults: a review of in-vivo cytochrome P450 phenotyping probes

2000 • 429 citations

Inhibition of human cytochrome P450 enzymes by constituents of St. John's Wort, an herbal preparation used in the treatment of depression.

2000 • 400 citations

In vitro-in vivo scaling of CYP kinetic data not consistent with the classical Michaelis-Menten model.

2000 • 388 citations

Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4

1997 • 380 citations

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

2001 • 377 citations

Species similarities and differences in pharmacokinetics.

1995 • 364 citations

Cytochrome P450 isoform inhibitors as a tool for the investigation of metabolic reactions catalyzed by human liver microsomes.

1996 • 358 citations

Inhibition and induction of human cytochrome P450 (CYP) enzymes

1998 • 356 citations

An in vitro evaluation of human cytochrome P450 3A4 inhibition by selected commercial herbal extracts and tinctures

2000 • 355 citations

Regulation of the human CYP2B6 gene by the nuclear pregnane X receptor.

2001 • 355 citations

Herb–drug interactions: Review and assessment of report reliability

2001 • 354 citations

Potential interactions between alternative therapies and warfarin

2000 • 352 citations

Disposition of intravenous and oral cyclosporine after administration with grapefruit juice*

1995 • 349 citations

Drug Interactions with Grapefruit Juice

1997 • 343 citations

Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially

1999 • 339 citations

Probable interaction between warfarin and ginseng

1997 • 334 citations

St John's Wort: Effect on CYP3A4 activity

2000 • 318 citations

Human Drug Metabolism and the Cytochromes P450: Application and Relevance of In Vitro Models

2001 • 310 citations

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

1993 • 310 citations

Inactivation of Cytochrome P450 3A4 by Bergamottin, a Component of Grapefruit Juice

1998 • 309 citations

Should we be concerned about herbal remedies

2001 • 303 citations

Mechanisms of enhanced oral availability of CYP3A4 substrates by grapefruit constituents: Decreased enterocyte CYP3A4 concentration and mechanism-based inactivation by furanocoumarins

1997 • 303 citations

Genetic Polymorphisms of HumanN-Acetyltransferase, Cytochrome P450, Glutathione-S-Transferase, and Epoxide Hydrolase Enzymes: Relevance to Xenobiotic Metabolism and Toxicity

1999 • 303 citations

Metabolism of 20(S)- and 20(R)-Ginsenoside Rg3 by Human Intestinal Bacteria and Its Relation to in Vitro Biological Activities.

2002 • 301 citations

Drug–Grapefruit Juice Interactions

2000 • 301 citations

Intestinal secretion of drugs. The role of P-glycoprotein and related drug efflux systems in limiting oral drug absorption

1997 • 287 citations

Bioflavonoids: selective substrates and inhibitors for cytochrome P450 CYP1A and CYP1B1

2000 • 281 citations

Interindividual Variability in Inhibition and Induction of Cytochrome P450 Enzymes

2001 • 280 citations

QUANTITATIVE PREDICTION OF IN VIVO DRUG CLEARANCE AND DRUG INTERACTIONS FROM IN VITRO DATA ON METABOLISM, TOGETHER WITH BINDING AND TRANSPORT

1998 • 280 citations

St John's Wort increases expression of P‐glycoprotein: Implications for drug interactions

2002 • 280 citations

Effects of ginseng components on c-DNA-expressed cytochrome P450 enzyme catalytic activity

1999 • 278 citations

CRYOPRESERVED PRIMARY HEPATOCYTES AS A CONSTANTLY AVAILABLE IN VITRO MODEL FOR THE EVALUATION OF HUMAN AND ANIMAL DRUG METABOLISM AND ENZYME INDUCTION*

2000 • 277 citations

Constituents and pharmacological effects of Eucommia and Siberian ginseng.

2001 • 258 citations

STRUCTURE AND FUNCTION OF URIDINE DIPHOSPHATE GLUCURONOSYLTRANSFERASES

1997 • 252 citations

Growth inhibitory effects of diallyl disulfide on human breast cancer cell lines

2001 • 250 citations

A review of the biological and pharmacological activities of saponins

1996 • 244 citations

Validation of the five-drug “Pittsburgh cocktail” approach for assessment of selective regulation of drug-metabolizing enzymes*

1997 • 244 citations

Precision-cut tissue slices: Applications in pharmacology and toxicology

1995 • 242 citations

Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents.

1990 • 240 citations

St John's wort, a herbal antidepressant, activates the steroid X receptor

2000 • 236 citations

Effect of grapefruit juice on digoxin pharmacokinetics in humans.

2001 • 235 citations

Different effects of St John's Wort on the pharmacokinetics of simvastatin and pravastatin

2001 • 232 citations

A method for the simultaneous evaluation of the activities of seven major human drug-metabolizing cytochrome P450s using an in vitro cocktail of probe substrates and fast gradient liquid chromatography tandem mass spectrometry.

2001 • 232 citations

CYP2A6: a human coumarin 7-hydroxylase

2000 • 230 citations

Hyperforin, a major antidepressant constituent of St. John's Wort, inhibits serotonin uptake by elevating free intracellular Na+1.

1999 • 230 citations

Research advances in ethanol metabolism

2001 • 229 citations

Cancer Chemoprevention and Apoptosis Mechanisms Induced by Dietary Polyphenolics

2000 • 228 citations

Herbal Medicines Today and the Roots of Modern Pharmacology

2001 • 227 citations

Chemoprevention of colon carcinogenesis by organosulfur compounds.

1993 • 224 citations

Present and future in vitro approaches for drug metabolism

2000 • 222 citations

Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism.

1997 • 221 citations

In vitro inhibition of human P450 enzymes by prenylated flavonoids from hops, Humulus lupulus

2000 • 220 citations

Elucidation of Distinct Ligand Binding Sites for Cytochrome P450 3A4

2000 • 218 citations

Orphan Nuclear Receptors: The Exotics of Xenobiotics

2001 • 216 citations

Selective Inhibitors of Cytochromes P450

1994 • 215 citations

A flavonoid antioxidant, silymarin, affords exceptionally high protection against tumor promotion in the SENCAR mouse skin tumorigenesis model.

1999 • 215 citations

Neuroprotective Effects of Ginseng Total Saponin and Ginsenosides Rb1 and Rg1 on Spinal Cord Neurons in Vitro

2002 • 214 citations

Historical Perspective on Garlic and Cardiovascular Disease

2001 • 212 citations

Green tea polyphenol epigallocatechin-3 gallate inhibits Her-2/neu signaling, proliferation, and transformed phenotype of breast cancer cells.

2002 • 209 citations

Mechanisms of Inhibition of Chemical Toxicity and Carcinogenesis by Diallyl Sulfide (DAS) and Related Compounds from Garlic

2001 • 206 citations

Effect of piperine on bioavailability and pharmacokinetics of propranolol and theophylline in healthy volunteers

1991 • 205 citations

Effect of grapefruit juice on blood cyclosporin concentration

1995 • 205 citations

Effect of Purified Allicin, the Major Ingredient ofFreshly Crushed Garlic, on Cancer Cell Proliferation

2000 • 202 citations

Alteration of drug biotransformation and elimination during infection and inflammation

2001 • 201 citations

Efficacy, safety, and use of ginkgo biloba in clinical and preclinical applications.

2001 • 201 citations

Niaziminin, a Thiocarbamate from the Leaves ofMoringa oleifera, Holds a Strict Structural Requirement for Inhibition of Tumor-Promoter-Induced Epstein-Barr Virus Activation

1998 • 198 citations

Inhibition by green tea catechins of metabolic activation of procarcinogens by human cytochrome P450

2001 • 196 citations

In Vitro Approaches to Predicting Drug Interactions In Vivo

1998 • 196 citations

Potentiation of Warfarin by Dong Quai

1999 • 195 citations

In vitro antioxidant activity of piperine

2000 • 189 citations

An in vitro evaluation of human cytochrome P450 3A4 and P-glycoprotein inhibition by garlic.

2001 • 188 citations

Specific CYP3 A4 inhibitors in grapefruit juice: furocoumarin dimers as components of drug interaction

1997 • 187 citations

Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat

2002 • 187 citations

Inhibition of human CYP3A4 activity by grapefruit flavonoids, furanocoumarins and related compounds.

2001 • 185 citations

Decreased Plasma Levels of Amitriptyline and Its Metabolites on Comedication With an Extract From St. John’s Wort (Hypericum perforatum)

2002 • 178 citations

Drug interaction between St John's wort and nevirapine

2001 • 177 citations

Interactions of Warfarin with Garlic, Ginger, Ginkgo, or Ginseng: Nature of the Evidence

2000 • 175 citations

Saquinavir, an HIV protease inhibitor, is transported by P-glycoprotein.

1998 • 174 citations

Applications and limitations of interspecies scaling and in vitro extrapolation in pharmacokinetics.

1998 • 173 citations

Differential Effects of Garlic Oil and Its Three Major Organosulfur Components on the Hepatic Detoxification System in Rats

2001 • 173 citations

Inhibition of CYP3A, CYP1A and CYP2E1 activities by resveratrol and other non volatile red wine components

2001 • 169 citations

Constituents of Chinese Piper species and their inhibitory activity on prostaglandin and leukotriene biosynthesis in vitro

2001 • 166 citations

Herbals, Cancer Prevention and Health

2001 • 165 citations

Cyp3A regulation: from pharmacology to nuclear receptors.

2001 • 163 citations

Induction of apoptosis by diallyl disulfide through activation of caspase-3 in human leukemia HL-60 cells11Abbreviations: Ac-DEVD-CHO, N-acetyl-Asp-Glu-Val-Asp-CHO (aldehyde); Ac-DEVD-AFC, N-acetyl-Asp-Glu-Val-Asp-AFC (7-amino-4-trifluoromethyl-coumaine); Ac-YVAD-CHO, N-acetyl-Tyr-Val-Ala-Asp-CHO (aldehyde); CAD, caspase-activated deoxyribonuclease; CM-H2DCFDA, 5-(and -6)-chloromethyl-2′,7′-dichlorodihydrofluorescein diacetate; DADS, diallyl disulfide; FACS, fluorescence-activated cell sorter; …

2002 • 162 citations

Glucuronidation of Drugs

1992 • 162 citations

Grapefruit-felodipine interaction: Effect of unprocessed fruit and probable active ingredients

2000 • 162 citations

Concise review of the cytochrome P450s and their roles in toxicology

1999 • 161 citations

Heterotropic Cooperativity of Cytochrome P450 3A4 and Potential Drug-Drug Interactions

2001 • 161 citations

Herbal products: active constituents, modes of action and quality control

2000 • 160 citations

Inhibition of cytochrome P450 2E1 expression by oleanolic acid: hepatoprotective effects against carbon tetrachloride-induced hepatic injury

1999 • 153 citations

A Pharmacophore for Human Pregnane X Receptor Ligands

2002 • 152 citations

Effect of St. John's wort (Hypericum perforatum) on cytochrome P-450 2D6 and 3A4 activity in healthy volunteers

2000 • 150 citations

The Risk–Benefit Profile of Commonly Used Herbal Therapies

2002 • 150 citations

Three-Dimensional Quantitative Structure-Activity Relationships of Dioxins and Dioxin-like Compounds: Model Validation and Ah Receptor Characterization

1995 • 149 citations

Interaction between Warfarin and Danshen (Salvia Miltiorrhiza)

2001 • 149 citations

Present status of the application of cryopreserved hepatocytes in the evaluation of xenobiotics: consensus of an international expert panel

1999 • 148 citations

Milk thistle, a herbal supplement, decreases the activity of CYP3A4 and uridine diphosphoglucuronosyl transferase in human hepatocyte cultures.

2000 • 148 citations

Modulation of oral bioavailability of anticancer drugs: from mouse to man

2000 • 147 citations

The use of heterologously expressed drug metabolizing enzymes— state of the art and prospects for the future

1999 • 145 citations

The flavonoid galangin is an inhibitor of CYP1A1 activity and an agonist/antagonist of the aryl hydrocarbon receptor

1999 • 144 citations

Use of in vitro human metabolism studies in drug development

1994 • 142 citations

Carbamazepine is not a substrate for P‐glycoprotein

2001 • 142 citations

The Licorice Root Derived Isoflavan Glabridin Inhibits the Activities of Human Cytochrome P450S 3A4, 2B6, and 2C9

2002 • 142 citations

Chinese herbs and warfarin potentiation by ‘Danshen’

1997 • 141 citations

Influence of Dietary Components on the Gastrointestinal Metabolism and Transport of Drugs

2000 • 141 citations

The effects of St John's wort (Hypericum perforatum) on human cytochrome P450 activity

2001 • 140 citations

Assessment of Liver Metabolic Function

1994 • 138 citations

Potentiation of thioacetamide liver injury in diabetic rats is due to induced CYP2E1.

2000 • 138 citations

Medicinal uses of licorice through the millennia: The good and plenty of it

1991 • 135 citations

The Effect of Piperine on Pharmacokinetics of Phenytoin in Healthy Volunteers

1987 • 135 citations

Cancer chemopreventive and therapeutic activities of red ginseng

1998 • 133 citations

In Vivo 11β-HSD-2 Activity

2001 • 132 citations

The effects of dietary ellagic acid on rat hepatic and esophageal mucosal cytochromes P450 and phase II enzymes

1996 • 131 citations

Diosmin and diosmetin are agonists of the aryl hydrocarbon receptor that differentially affect cytochrome P450 1A1 activity.

1998 • 130 citations

Evaluation of Caffeine as an In Vivo Probe for CYP1A2 Using Measurements in Plasma, Saliva, and Urine

2000 • 128 citations

Use of cDNA-Expressed Human Cytochrome P450 Enzymes to Study Potential Drug-Drug Interactions

1997 • 125 citations

Cytotoxic Activities of Tanshinones Against Human Carcinoma Cell Lines

1991 • 123 citations

Lack of effect of St John's Wort on carbamazepine pharmacokinetics in healthy volunteers

2000 • 122 citations

In vitro assessment of human cytochrome P450

1998 • 120 citations

Comparative inhibition of human cytochromes P450 1A1 and 1A2 by flavonoids.

1998 • 120 citations

Cytochromes P450 and species differences in xenobiotic metabolism and activation of carcinogen.

1998 • 119 citations

Metabolism of the Chemoprotective Agent Diallyl Sulfide to Glutathione Conjugates in Rats

1997 • 118 citations

Impairment of UDP-glucose dehydrogenase and glucuronidation activities in liver and small intestine of rat and guinea pig in vitro by piperine

1993 • 114 citations

Isozyme- and species-specific susceptibility of cDNA-expressed CYP1A P-450s to different flavonoids

1994 • 112 citations

In Vitro High Throughput Screening of Compounds for Favorable Metabolic Properties in Drug Discovery.

2001 • 110 citations

Dietary flavonols quercetin and kaempferol are ligands of the aryl hydrocarbon receptor that affect CYP1A1 transcription differentially

1999 • 109 citations

Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats

2002 • 109 citations

Species variation in the response of the cytochrome P-450-dependent monooxygenase system to inducers and inhibitors

1990 • 109 citations

Interaction between cyclosporine and Hypericum perforatum (St. John's wort) after organ transplantation

2001 • 109 citations

Suppression of cell cycle progression by flavonoids: dependence on the aryl hydrocarbon receptor

1999 • 108 citations

Chlorzoxazone, a selective probe for phenotyping CYP2E1 in humans

1999 • 107 citations

Hyperforin, Possibly the Major Non-Nitrogenous Secondary Metabolite of Hypericum perforatum L.

1998 • 104 citations

Cytochrome P4502E1 induction increases thioacetamide liver injury in diet-restricted rats.

2001 • 102 citations

Antimutagenic activity of organosulfur compounds from Allium is associated with phase II enzyme induction

2001 • 101 citations

A taste of Chinese medicine!

1998 • 101 citations

Initial study on naturally occurring products from traditional Chinese herbs and vegetables for chemoprevention

1997 • 101 citations

Neuroprotective effects of Ginkgo biloba constituents

1995 • 99 citations

Inhibitory Effects of Naturally Occurring Compounds on Aflatoxin B₁ Biotransformation

2001 • 96 citations

COMPARATIVE ANTI-NOCICEPTIVE, ANTI-INFLAMMATORY AND TOXICITY PROFILE OF NIMESULIDE vs NIMESULIDE AND PIPERINE COMBINATION

2000 • 95 citations

Liver slices in in vitro pharmacotoxicology with special reference to the use of human liver tissue

1997 • 94 citations

Cytochrome P450 Pharmacogenetics in Drug Development: In Vitro Studies and Clinical Consequences

2002 • 94 citations

Biotransformation of the anthraquinones emodin and chrysophanol by cytochrome P450 enzymes. Bioactivation to genotoxic metabolites.

1998 • 94 citations

Glycyrrhizin Inhibits the Lytic Pathway of Complement — Possible Mechanism of Its Anti‐Inflammatory Effect on Liver Cells in Viral Hepatitis —

2000 • 93 citations

Differential Effects of Flavonoid Compounds on Tumor Promoter-Induced Activation of the Human CYP1A2 Enhancer

2000 • 92 citations

Past, Present, and Future Applications of Precision-Cut Liver Slices for in Vitro Xenobiotic Metabolism

1996 • 91 citations

Possible Influences of Ginseng on the Pharmacokinetics and Pharmacodynamics of Warfarin in Rats

1999 • 91 citations

The Structure and Function of the UDP-Glucuronosyltransferase Gene Family

1997 • 89 citations

Structure–activity relationship of piperine and its synthetic analogues for their inhibitory potentials of rat hepatic microsomal constitutive and inducible cytochrome P450 activities

2000 • 89 citations

Immunomodulating activity of CVT-E002, a proprietary extract from North American ginseng (Panax quinquefolium)

2001 • 89 citations

Effects of Garlic Oil and Its Organosulfur Compounds on the Activities of Hepatic Drug-Metabolizing and Antioxidant Enzymes in Rats Fed High- and Low-Fat Diets

1999 • 88 citations

Protective action of piperine against experimental gastric ulcer.

2000 • 88 citations

Mechanism-based inactivation of human cytochrome P450 3A4 by grapefruit juice and red wine

1998 • 87 citations

Kaempferol-induced nuclear DNA damage and lipid peroxidation

1994 • 86 citations

Abstracts

1994 • 86 citations

Oxidation of the Flavonoids Galangin and Kaempferide by Human Liver Microsomes and CYP1A1, CYP1A2, and CYP2C9

2002 • 85 citations

Protection by Naringin and Some Other Flavonoids of Hepatocytic Autophagy and Endocytosis against Inhibition by Okadaic Acid

1995 • 84 citations

Effect of oleanolic acid on hepatic toxicant-activating and detoxifying systems in mice.

1995 • 84 citations

Flavonoids inhibit genetic toxicity produced by carcinogens in cells expressing CYP1A2 and CYP1A1

2002 • 83 citations

In Vitro Effect of Standardized Ginseng Extracts and Individual Ginsenosides on the Catalytic Activity of Human CYP1A1, CYP1A2, and CYP1B1

2002 • 83 citations

Protection of Rat Liver Microsomes against Carbon Tetrachloride-Induced Lipid Peroxidation by Red Ginseng Saponin through Cytochrome P450 Inhibition

1997 • 82 citations

Advances in in vitro drug metabolism screening

1999 • 81 citations

Effect of vanilloid drugs on gastrointestinal transit in mice

2001 • 81 citations

Hypericum LI 160 inhibits uptake of serotonin and norepinephrine in astrocytes

1999 • 80 citations

Modification of hepatic drug-metabolizing enzymes in rats treated with alkyl sulfides

1997 • 79 citations

Quercetin Inhibits Benzo[a]Pyrene-Induced DNA Adducts in Human Hep G2 Cells by Altering Cytochrome P-450 1A1 Gene Expression

1999 • 79 citations

Modulation of rat hepatic cytochromeP‐450 activity by garlic organosulfur compounds

1996 • 78 citations

The use of a high-volume screening procedure to assess the effects of dietary flavonoids on human cyp1a1 expression.

2001 • 77 citations

Anticonvulsant activity of piperine on seizures induced by excitatory amino acid receptor agonists.

1996 • 77 citations

Simultaneous assessment of CYP3A4 and CYP1A2 activity in vivo with alprazolam and caffeine

1999 • 76 citations

Structure-Related Inhibition of Human Hepatic Caffeine N3-Demethylation by Naturally Occurring Flavonoids

1998 • 76 citations

Detoxication of vinca alkaloids by human P450 CYP3A4-mediated metabolism: implications for the development of drug resistance.

2000 • 76 citations

Tea consumption modulates hepatic drug metabolizing enzymes in Wistar rats

2001 • 74 citations

Biological activity of polyphenol extracts from different plant sources

2002 • 73 citations

Assessment of cytochrome P450 activity by a five‐drug cocktail approach

2001 • 73 citations

Effect of licorice and glycyrrhizin on murine liver CYP-dependent monooxygenases

1998 • 73 citations

The effects of Danshen (Salvia miltiorrhiza) on pharmacokinetics and pharmacodynamics of warfarin in rats

1992 • 72 citations

Application of in silico approaches to predicting drug–drug interactions

2001 • 72 citations

Inhibitory Effect of Coptidis Rhizoma and Scutellariae Radix on Azoxymethane-Induced Aberrant Crypt Foci Formation in Rat Colon.

1998 • 72 citations

The rational selection of drug interaction studies: implications of recent advances in drug metabolism.

1992 • 72 citations

The Erythromycin Breath Test For the Prediction of Drug Clearance

2001 • 70 citations

Coumaroyl flavonol glycosides from the leaves of Ginkgo biloba

2001 • 70 citations

Differential effects of dietary diallyl sulfide and diallyl disulfide on rat intestinal and hepatic drug‐metabolizing enzymes

1995 • 70 citations

Caffeine induces cytochrome P4501A2: induction of CYP1A2 by tea in rats.

1996 • 69 citations

Evaluation of Synaptosomal Uptake Inhibition of most Relevant Constituents of St. John's Wort

2001 • 69 citations

Involvement of rat cytochrome 1A1 in the biotransformation of kaempferol to quercetin: relevance to the genotoxicity of kaempferol

1997 • 69 citations

Lack of effect of grapefruit juice on the pharmacokinetics and pharmacodynamics of amlodipine

2000 • 68 citations

Modification of hepatic drug-metabolizing enzymes in rat fed naturally occurring allyl sulphides

1994 • 68 citations

Antiviral Activity of Plant Flavonoid, 5,7,4'-Trihydroxy-8-methoxyflavone, from the Roots of Scutellaria baicalensis against Influenza A (H3N2) and B Viruses.

1995 • 68 citations

An interaction between the cytochrome P450 probe substrates chlorzoxazone (CYP2E1) and midazolam (CYP3A)

2001 • 68 citations

Chloroquine modulation of specific metabolizing enzymes activities: investigation with selective five drug cocktail

1998 • 67 citations

Metabolism of diallyl disulfide by human liver microsomal cytochromes P-450 and flavin-containing monooxygenases.

1999 • 67 citations

The Alkaloid Rutaecarpine Is a Selective Inhibitor of Cytochrome P450 1A in Mouse and Human Liver Microsomes

2002 • 66 citations

Phenolic Constituents of Licorice. IV. Correlation of Phenolic Constituents and Licorice Specimens from Various Sources, and Inhibitory Effects of Licorice Extracts on Xanthine Oxidase and Monoamine Oxidase

1991 • 65 citations

Liver subcellular fractions from rats treated by organosulfur compounds from Allium modulate mutagen activation

2000 • 64 citations

St. John's Wort Extract Induces CYP3A and CYP2E1 in the Swiss Webster Mouse

2002 • 63 citations

Interaction of Drugs and Chinese Herbs: Pharmacokinetic Changes of Tolbutamide and Diazepam Caused by Extract of Angelica dahurica

2000 • 63 citations

Effect of liquorice and glycyrrhizin on rat liver carcinogen metabolizing enzymes

1999 • 62 citations

Carbamazepine: a 'blind' assessment of CYP-associated metabolism and interactions in human liver-derivedin vitrosystems

2001 • 61 citations

Inhibition of 11 beta-hydroxysteroid dehydrogenase activity enhances the antiproliferative effect of glucocorticosteroids on MCF-7 and ZR-75-1 breast cancer cells

1997 • 61 citations

Inhibitory Potential of Herbal Medicines on Human Cytochrome P450-Mediated Oxidation: Properties of Umbelliferous or Citrus Crude Drugs and Their Relative Prescriptions

2001 • 61 citations

Different Effects of Traditional Chinese Medicines Containing Similar Herbal Constituents on Prednisolone Pharmacokinetics

1995 • 61 citations

Effect of Oral Administration of Glycyrrhizin on the Pharmacokinetics of Prednisolone.

1991 • 60 citations

Piperine Impairs Cytochrome P4501A1 Activity by Direct Interaction with the Enzyme and Not by Down Regulation of CYP1A1 Gene Expression in the Rat Hepatoma 5L Cell Line

1996 • 58 citations

Metabolism of Genistein by Rat and Human Cytochrome P450s

1999 • 57 citations

Piperine inhibits aflatoxin B1-induced cytotoxicity and genotoxicity in V79 Chinese hamster cells genetically engineered to express rat cytochrome P4502B1

1997 • 56 citations

Primary Hepatocyte Cultures as an in Vitro Experimental Model for the Evaluation of Pharmacokinetic Drug–Drug Interactions

1997 • 56 citations

Carbamazepine induces multiple cytochrome P450 subfamilies in rats

1999 • 54 citations

Stimulation of Mouse Melanocyte Proliferation by Piper nigrum Fruit Extract and its Main Alkaloid, Piperine

1999 • 54 citations

Phenolic Constituents of Licorice. III. Structures of Glicoricone and Licofuranone, and Inhibitory Effects of Licorice Constituents on Monoamine Oxidase.

1991 • 53 citations

EFFECTS OF PANAX GINSENG ON BLOOD ALCOHOL CLEARANCE IN MAN

1987 • 52 citations

Effects of furanocoumarin derivatives in grapefruit juice on nifedipine pharmacokinetics in rats.

2001 • 52 citations

Alterations in hepatic Phase I and Phase II biotransformation enzymes by garlic oil in rats

1992 • 49 citations

Cytochrome P4501A1-Inhibitory Action of Antimutagenic Anthraquinones in Medicinal Plants and the Structure-activity Relationship

2000 • 49 citations

Lack of correlation between in vitro and in vivo studies on the effects of tangeretin and tangerine juice on midazolam hydroxylation

2000 • 48 citations

Assessment of cytochrome P450 activity by a five-drug cocktail approach

2001 • 45 citations

Induction of cytochromes P450 1A1 and 1B1 by emodin in human lung adenocarcinoma cell line CL5.

2001 • 44 citations

Overview: dietary approaches for reducing cardiovascular disease risks.

1995 • 44 citations

Dipiperamides A, B, and C: bisalkaloids from the white pepper Piper nigrum inhibiting CYP3A4 activity

2002 • 44 citations

The isoflavones equol and genistein do not induce xenobiotic-metabolizing enzymes in mouse and in human cells

1997 • 44 citations

Treatment with aged garlic extract protects against bromobenzene toxicity to precision cut rat liver slices

1999 • 44 citations

Metabolism of galangin by rat cytochromes P450: relevance to the genotoxicity of galangin

1997 • 43 citations

Differences in the Effects of Piperine and Piperonyl Butoxide on Hepatic Drug-Metabolizing Enzyme System in Rats

1991 • 42 citations

The effects of alcohol and diallyl sulphide on CYP2E1 activity in humans: a phenotyping study using chlorzoxazone

2001 • 42 citations

Differential Effects of Nonhydroxylated Flavonoids as Inducers of Cytochrome P450 1A and 2B Isozymes in Rat Liver

1996 • 41 citations

Suppressive effect of the herbal medicine Oren-gedoku-to on cyclooxygenase-2 activity and azoxymethane-induced aberrant crypt foci development in rats

2000 • 41 citations

COMPACT: a structural approach to the modelling of cytochromes P450 and their interactions with xenobiotics

2001 • 41 citations

Piperine, a major ingredient of black and long peppers, protects against AFB1-induced cytotoxicity and micronuclei formation in H4IIEC3 rat hepatoma cells

1994 • 41 citations

Olive Oil Phenols Inhibit Human Hepatic Microsomal Activity

2000 • 40 citations

Plasma pharmacokinetics and cerebrospinal fluid penetration of hypericin in nonhuman primates

2000 • 40 citations

A Novel 11β-Hydroxysteroid Dehydrogenase Inhibitor Contained in Saiboku-To, a Herbal Remedy for Steroid-dependent Bronchial Asthma

1994 • 39 citations

Lack of effect of grapefruit juice on diltiazem bioavailability in normal subjects.

1994 • 39 citations

α-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6

2001 • 39 citations

Metabolism of ezlopitant, a nonpeptidic substance P receptor antagonist, in liver microsomes: enzyme kinetics, cytochrome P450 isoform identity, and in vitro-in vivo correlation.

2000 • 37 citations

Screening of organosulfur compounds as inhibitors of human CYP2A6.

2001 • 36 citations

Effect of Ginseng on Plasma Levels of Ethanol in the Rat

1993 • 36 citations

Anticarcinogenic effect of black tea on pulmonary tumors in Swiss albino mice

2002 • 36 citations

Effect of Glycyrrhizin on the Pharmacokinetics of Prednisolone Following Low Dosage of Prednisolone Hemisuccinate.

1990 • 36 citations

Prevention of Acetaminophen-induced Cataract by a Combination of Diallyl Disulfide and N-acetylcysteine

1998 • 35 citations

Inhibition of CYP3A-mediated oxidation in human hepatic microsomes by the dietary derived complex phenol, gallic acid

2002 • 35 citations

Induction of cytochrome P450-dependent monooxygenase in mouse liver and kidney by rutaecarpine, an alkaloid of the herbal drug Evodia rutaecarpa

2001 • 35 citations

Antioxidant Activity and Protective Effect on DNA Cleavage of Resveratrol

2002 • 35 citations

Piperine effects on the expression of P4502E1, P4502B and P4501A in rat

1994 • 34 citations

Quercetin and the mutagenicity of wines

1993 • 34 citations

Salvia miltiorrhiza Extract Inhibits Alcohol Absorption, Preference, and Discrimination in sP Rats

1999 • 34 citations

Cancer Chemoprevention by Ginseng in Mouse Liver and Other Organs

2001 • 33 citations

The growing knowledge of St. John's wort (Hypericum perforatum L) drug interactions and their clinical significance

2000 • 33 citations

Effect of an Extract of the Root of Scutellaria baicalensis and its Flavonoids on Aflatoxin B1 Oxidizing Cytochrome P450 Enzymes

2001 • 32 citations

Diallyl Sulfide Inhibition of CYP2E1 Does Not Rescue Diabetic Rats from Thioacetamide-Induced Mortality

2001 • 32 citations

Efficacy of Garlic Supplementation in Lowering Serum Cholesterol Levels

2009 • 30 citations

Structure-activity relationships of anthraquinones as inhibitors of 7-ethoxycoumarin O-deethylase and mutagenicity of 2-amino-3-methylimidazo64,5-f9quinoline

1995 • 30 citations

Protective effects of baicalein and wogonin against benzo[a]pyrene- and aflatoxin B1-induced genotoxicities11Abbreviations: AF, aflatoxin; AFB1, aflatoxin B1; AHH, benzo[a]pyrene hydroxylation; CYP, cytochrome P450; and AFO, aflatoxin B1 oxidation.

2001 • 29 citations

Cell Cycle Arrest and Differential Gene Expression inHT-29 Cells Exposed to an Aqueous Garlic Extract

2000 • 29 citations

Physiological modeling of a proposed mechanism of enzyme induction by TCDD

2001 • 27 citations

COMPARISON OF THE EFFECTS OF PIPERINE ADMINISTERED INTRAGASTRICALLY AND INTRAPERITONEALLY ON THE LIVER AND LIVER MIXED-FUNCTION OXIDASES IN RATS

1991 • 27 citations

Inactivation of hepatic CYP2E1 by an epoxide of diallyl sulfone.

2000 • 25 citations

Determination of hypericin in plasma by high-performance liquid chromatography

1999 • 24 citations

Effect of Garlic Active Principle, Diallyl Disulfide, on Cell Viability, Lipid Peroxidation, Glutathione Concentration and its Related Enzyme Activities in Primary Rat Hepatocytes

1999 • 23 citations

Influence of piperine on nimesulide induced antinociception

1998 • 23 citations

The PXR crystal structure: the end of the beginning

2002 • 22 citations

Liver Slices as a Model in Drug Metabolism

1997 • 22 citations

Modulation of hepatic cytochrome P450 activity and carcinogen bioactivation by black and decaffeinated black tea

1999 • 22 citations

Interactions of herbal remedies with prescription cardiovascular medications

2001 • 22 citations

Combined Effects of Ethanol and Garlic on Hepatic Ethanol Metabolism in Mice.

1999 • 21 citations

Inhibitory Effects of Glycyrrhetic Acid Derivatives on 11.BETA.-and 3.ALPHA.-Hydroxysteroid Dehydrogenases of Rat Liver.

1992 • 21 citations

Panax vietnamensis Protects Mice Against Carbon Tetrachloride-Induced Hepatotoxicity without any Modification of CYP2E1 Gene Expression

2000 • 20 citations

Metabolism of Ipecac Alkaloids Cephaeline and Emetine by Human Hepatic Microsomal Cytochrome P450s, and Their Inhibitory Effects on P450 Enzyme Activities.

2001 • 19 citations

Induction of Hepatic Bilirubin and Drug Metabolizing Enzymes by Individual Herbs Present in the Traditional Chinese Medicine, Yin Zhi Huang

1993 • 19 citations

Effects of Sho-saiko-to on the Pharmacokinetics and Pharmacodynamics of Tolbutamide in Rats

1998 • 18 citations

Evaluation of analytical and clinical performance of a dual-probe phenotyping method for CYP2D6 polymorphism and CYP3A4 activity screening.

2000 • 18 citations

[Induction of arrhythmia by licorice abuse].

1991 • 17 citations

Modulation of Microsomal Cytochrome P450 by Scutellariae Radix and Gentianae Scabrae Radix in Rat Liver

1996 • 17 citations

The Inhibitory Effects of Glycyrrhizin and Glycyrrhetinic Acid on the Metabolism of Cortisol and Prednisolone

1990 • 15 citations

Inherited variations in drug-metabolizing enzymes: Significance in clinical oncology

1999 • 15 citations

Heterogenous effects of anthraquinones on drug-metabolizing enzymes in the liver and small intestine of rat

2000 • 14 citations

Triterpenoids

1997 • 14 citations

Effect of water extracts of aloe and some herbs in decreasing blood ethanol concentration in rats. II.

1989 • 14 citations

Effects of traditional Chinese medicines on pharmacokinetics of levofloxacin

1995 • 13 citations

Protection of N‐methyl‐N′‐nitro‐N‐nitrosoguanidine‐induced in vivo clastogenicity by aqueous garlic extract

2001 • 11 citations

Effects of Sho-saiko-to (Xiao Chai Hu Tang), a Chinese Traditional Medicine, on the Gastric Function and Absorption of Tolbutamide in Rats

2001 • 10 citations

[Licorice-induced pseudoaldosteronism in a patient with a non-functioning adrenal tumor].

2001 • 9 citations

Microsomal Enzyme Induction

2000 • 9 citations

Suppression of constitutive and inducible cytochrome P450 gene expression by α‐hederin in mice

1998 • 9 citations

Effects of Sino-Japanese herbs in the family Compositae on the hepatic drug metabolizing enzymes and lipid peroxidation in rats.

1992 • 8 citations

Studies on interactions between traditional herbal and western medicines. IV: Lack of pharmacokinetic interactions between Saiko-ka-ryukotsu-borei-to and carbamazepine in rats

2001 • 8 citations

FOREWORD

2001 • 8 citations

Suppressive effects of α-Hederin on 2,3,7,8-tetrachlorodibenzo-p-dioxin-mediated murine Cyp1a-1 expression in the mouse hepatoma Hepa-1c1c7 cells

1999 • 6 citations

Effects of Sino-Japanese herbs in the family Umbelliferae on the hepatic drug metabolizing enzymes and lipid peroxidation in rats.

1992 • 6 citations

Preventive Effect of the Extract of Du-Zhong (Tochu) Leaf and Ginseng Root on Acute Toxicity of Chlorpyrifos.

1997 • 5 citations

Effects of Sino-Japanese herbs in the family Labiatae on the hepatic drug metabolizing enzymes and lipid peroxidation in rats.

1993 • 3 citations

[Licorice-induced high blood pressure].

2001 • 3 citations

Modulation of Carcinogen-Metabolizing Enzymes by Gallic Acid and Its Synthetic Analogue Propylgallate in Mice.

1995 • 2 citations

[Recent progress in the study of anti-PAF (platelet activating factor) constituents of medicinal herbs].

1993 • 1 citations

Deleted Work

1955 • 0 citations