α-Naphthoflavone acts as activator and reversible or irreversible inhibitor of rabbit microsomal CYP3A6

The Carbon Monoxide-binding Pigment of Liver Microsomes

1964 • 11,832 citations

The colorimetric estimation of formaldehyde by means of the Hantzsch reaction

1953 • 4,357 citations

Enzyme kinetics; behavior and analysis of rapid equilibrium and steady state enzyme systems

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Ethoxy-, pentoxy- and benzyloxyphenoxazones and homologues: a series of substrates to distinguish between different induced cytochromes P-450

1985 • 1,272 citations

Spectral studies of drug interaction with hepatic microsomal cytochrome.

1967 • 1,126 citations

Investigation of the bicinchoninic acid protein assay: Identification of the groups responsible for color formation

1988 • 751 citations

Properties of electrophoretically homogeneous phenobarbital-inducible and beta-naphthoflavone-inducible forms of liver microsomal cytochrome P-450

1976 • 536 citations

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

1989 • 528 citations

Evaluation of Atypical Cytochrome P450 Kinetics with Two-Substrate Models: Evidence That Multiple Substrates Can Simultaneously Bind to Cytochrome P450 Active Sites

1998 • 508 citations

Cooperativity in Oxidations Catalyzed by Cytochrome P450 3A4

1997 • 380 citations

[27] Measurement of substrate and inhibitor binding to microsomal cytochrome P-450 by optical-difference spectroscopy

1978 • 354 citations

Activation of CYP3A4: Evidence for the Simultaneous Binding of Two Substrates in a Cytochrome P450 Active Site

1994 • 348 citations

Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s

1991 • 326 citations

Specificity of substrate and inhibitor probes for human cytochromes P450 1A1 and 1A2.

1993 • 310 citations

Evidence for cytochrome P-450NF, the nifedipine oxidase, being the principal enzyme involved in the bioactivation of aflatoxins in human liver.

1989 • 303 citations

Activation and inhibition of benzo(a)pyrene and aflatoxin B1 metabolism in human liver microsomes by naturally occurring flavonoids.

1981 • 290 citations

Selectivity in the inhibition of mammalian cytochromes P-450 by chemical agents.

1990 • 240 citations

Analysis of human cytochrome P450 3A4 cooperativity: Construction and characterization of a site-directed mutant that displays hyperbolic steroid hydroxylation kinetics

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Metabolism of nitrosamines by purified rabbit liver cytochrome P-450 isozymes.

1985 • 221 citations

Elucidation of Distinct Ligand Binding Sites for Cytochrome P450 3A4

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Oxidation of Aflatoxin B1 by Bacterial Recombinant Human Cytochrome P450 Enzymes

1995 • 208 citations

Selectivity of Polycyclic Inhibitors for Human Cytochrome P450s 1A1, 1A2, and 1B1

1998 • 208 citations

Demonstration in multiple species of inducible hepatic cytochromes P-450 and their mRNAs related to the glucocorticoid-inducible cytochrome P-450 of the rat.

1985 • 194 citations

Kinetics of suicide substrates

1980 • 188 citations

Kinetics of suicide substrates. Practical procedures for determining parameters

1985 • 155 citations

Aryl hydrocarbon (benzo[a]pyrene) hydroxylases in liver from rats of different age, sex and nutritional status

1975 • 146 citations

Modulation of rabbit and human hepatic cytochrome P-450-catalyzed steroid hydroxylations by alpha-naphthoflavone.

1988 • 143 citations

Differential Mechanisms of Cytochrome P450 Inhibition and Activation by α-Naphthoflavone

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Human cytochrome P450 3A4: enzymatic properties of a purified recombinant fusion protein containing NADPH-P450 reductase.

1993 • 120 citations

Human cytochrome P450 3A (CYP3A) mediated midazolam metabolism

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Specificity in the activation and inhibition by flavonoids of benzo[a]pyrene hydroxylation by cytochrome P-450 isozymes from rabbit liver microsomes.

1981 • 119 citations

Oxidation of aflatoxins and sterigmatocystin by human liver microsomes: significance of aflatoxin Q1 as a detoxication product of aflatoxin B1

1992 • 118 citations

Analysis of Four Residues within Substrate Recognition Site 4 of Human Cytochrome P450 3A4: Role in Steroid Hydroxylase Activity and α-Naphthoflavone Stimulation

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NADPH-cytochrome c (P-450) reductase. Spectrophotometric and stopped flow kinetic studies on the formation of reduced flavoprotein intermediates.

1979 • 110 citations

Dual role of human cytochrome P450 3A4 residue Phe-304 in substrate specificity and cooperativity.

2000 • 103 citations

Studies on the mechanism of activation of microsomal benzo[a]pyrene hydroxylation by flavonoids.

1981 • 81 citations

Identification of Three Key Residues in Substrate Recognition Site 5 of Human Cytochrome P450 3A4 by Cassette and Site-Directed Mutagenesis

1997 • 77 citations

Human cytochromes P450: evolution and cDNA-directed expression.

1992 • 69 citations

7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver

1978 • 68 citations

Activation of monooxygenases in human liver by 7,8‐benzoflavone

1977 • 66 citations

Carcinogenicity, mutagenicity and cancer preventing activities of flavonoids: A structure-system-activity relationship (SSAR) analysis

1994 • 63 citations

Positive effectors of the binding of an active site-directed amino steroid to rabbit cytochrome P-450 3c.

1988 • 61 citations

Benzenediazonium Ion Derived from Sudan I Forms an 8-(Phenylazo)guanine Adduct in DNA

1995 • 61 citations

Metabolism of alpha-naphthoflavone and beta-naphthoflavone by rat liver microsomes and highly purified reconstituted cytochrome P-450 systems.

1983 • 54 citations

[40] Induction of cytochromes P450IA1 and P450IA2 and measurement of catalytic activities

1991 • 44 citations

Mechanism of formation and ³²P-postlabeling of DNA adducts derived from peroxidative activation of carcinogenic non-aminoazo dye 1-phenylazo-2-hydroxynaphthalene (Sudan I)

1990 • 43 citations

Mechanism-Based Inactivation of Cytochromes P450 2B1 and P450 2B6 by n-Propylxanthate

1999 • 32 citations

Activation of phenacetinO-deethylase activity byα-naphthoflavone in human liver microsomes

1999 • 24 citations

Species-specific enhancement by 7,8-benzoflavone of hepatic microsomal metabolism of benzo[e]pyrene 9,10-dihydrodiol to bay-region diol epoxides.

1981 • 21 citations

Involvement of cytochrome P-450c in alpha-naphthoflavone metabolism by rat liver microsomes.

1990 • 18 citations

Enhanced rates of cytochrome P450 metabolic-intermediate complex formation from nonmacrolide amines in rifampicin-treated rabbit liver microsomes.

1995 • 17 citations

Escherichia coli expression and substrate specificities of canine cytochrome P450 3A12 and rabbit cytochrome P450 3A6.

1996 • 12 citations

Cytochromes P450 Involved in Cyclophosphamide, Paclitaxel and Docetaxel Metabolism in Rats

2000 • 3 citations