The Erythromycin Breath Test For the Prediction of Drug Clearance

A formula to estimate the approximate surface area if height and weight be known

1916 • 4,502 citations

CLINICAL CALORIMETRY

1916 • 4,077 citations

Prediction of in vivo drug metabolism in the human liver from in vitro metabolism data

1997 • 460 citations

Effect of age and gender on the activity of human hepatic CYP3A

1992 • 425 citations

Noninvasive tests of CYP3A enzymes

1994 • 414 citations

Erythromycin breath test as an assay of glucocorticoid-inducible liver cytochromes P-450. Studies in rats and patients.

1989 • 349 citations

Cytochrome P4503A (CYP3A) metabolism: Prediction ofIn Vivo activity in humans

1996 • 308 citations

The effect of an individual's cytochrome CYP3A4 activity on docetaxel clearance.

2000 • 199 citations

Clinical Pharmacokinetics of Verapamil, Nifedipine and Diltiazem

1986 • 184 citations

Whole body lipid and energy metabolism in the cancer patient

1987 • 138 citations

The erythromycin breath test predicts the clearance of midazolam*

1995 • 132 citations

Failure of erythromycin breath test to correlate with midazolam clearance as a probe of cytochrome P4503A*

1999 • 131 citations

Gender‐Specific Effects on Verapamil Pharmacokinetics and Pharmacodynamics in Humans

2000 • 115 citations

Intersubject and dose‐related variability after intravenous administration of erythromycin.

1980 • 112 citations

Hepatic cytochrome P-4503A (CYP3A) activity in the elderly

1992 • 91 citations

Mdr1 Limits CYP3A Metabolism in Vivo

2000 • 90 citations

METABOLISM OF [2-14C] PYRUVATE IN NORMAL, ACROMEGALIC AND HGH-TREATED HUMAN SUBJECTS

1970 • 87 citations

Body composition and resting metabolic rate: the myth of feminine metabolism

1982 • 80 citations

The aminopyrine breath test as a measure of liver function. A quantitative description of its metabolic basis in normal subjects.

1982 • 61 citations

Steady-state pharmacokinetics of delavirdine in HIV-positive patients: Effect on erythromycin breath test *

1997 • 59 citations

Metabolism of cytochrome P4503A substrates in vivo administered by the same route: Lack of correlation between alfentanil clearance and erythromycin breath test

1994 • 57 citations

Optimizing the erythromycin breath test for use in cancer patients.

2000 • 48 citations

A Physiologic Basis for the Provision of Fuel Mixtures in Normal and Stressed Patients

1990 • 45 citations

In vivo comparison of putative probes of CYP3A4/5 activity: Erythromycin, dextromethorphan, and verapamil

1999 • 45 citations

Demethylation of erythromycins by rabbit tissues in vitro

1965 • 42 citations

Pharmacokinetic Interaction between Ketoconazole and Amprenavir after Single Doses in Healthy Men

1999 • 42 citations

In vitro analysis of the activity of the major human hepatic CYP enzyme (CYP3A4) using [N-methyl-14C]-erythromycin

1997 • 42 citations

Effect of Multiple Doses of Rifampin on the [¹⁴C N‐methyl] Erythromycin Breath Test in Healthy Male Volunteers

1998 • 33 citations

Drug pharmacokinetics and the carbon dioxide breath test

1986 • 21 citations

Studies in primary hyperuricaemia. 3. The conversion of 14C to breath 14CO2 from glucose-1-14C and glucose-6-14C in hyperuricaemia and gout.

1968 • 3 citations