Substrate specificity for rat cytochrome P450 (CYP) isoforms: screening with cDNA-expressed systems of the rat

Human cytochrome P-450PA (P-450IA2), the phenacetin O-deethylase, is primarily responsible for the hepatic 3-demethylation of caffeine and N-oxidation of carcinogenic arylamines.

1989 • 643 citations

Regulation of rat hepatic cytochrome P-450: age-dependent expression, hormonal imprinting, and xenobiotic inducibility of sex-specific isoenzymes

1985 • 593 citations

Cytochrome P450 specificities of alkoxyresorufin O-dealkylation in human and rat liver

1994 • 546 citations

Hydroxylation of chlorzoxazone as a specific probe for human liver cytochrome P-450IIE1

1990 • 535 citations

Phenobarbital induction of cytochrome P-450 gene expression

1992 • 530 citations

Oxidation of midazolam and triazolam by human liver cytochrome P450IIIA4.

1989 • 528 citations

p-Nitrophenol hydroxylation. A microsomal oxidation which is highly inducible by ethanol.

1985 • 412 citations

Evidence That CYP2C19 is the Major (S)-Mephenytoin 4'-Hydroxylase in Humans

1994 • 366 citations

Regio- and stereoselective metabolism of two C19 steroids by five highly purified and reconstituted rat hepatic cytochrome P-450 isozymes.

1983 • 339 citations

Purification and characterization of human liver microsomal cytochrome P-450 2A6.

1991 • 267 citations

Specificity of substrate and inhibitor probes for cytochrome P450s: evaluation ofin vitrometabolism using cDNA-expressed human P450s and human liver microsomes

1996 • 263 citations

Cytochrome P450TB (CYP2C): A major monooxygenase catalyzing diclofenac 4′-hydroxylation in human liver

1993 • 258 citations

Catalytic selectivity of human cytochrome P450 enzymes: relevance to drug metabolism and toxicity

1994 • 160 citations

P450 in the rat and man: methods of investigation, substrate specificities and relevance to cancer

1994 • 150 citations

Debrisoquine 4-Hydroxylase: Characterization of a New P450 Gene Subfamily, Regulation, Chromosomal Mapping, and Molecular Analysis of the DA Rat Polymorphism

1987 • 139 citations

Validation of 4-nitrophenol as an in vitro substrate probe for human liver CYP2E1 using cDNA expression and microsomal kinetic techniques

1993 • 134 citations

Immunochemical and catalytical studies on hepatic coumarin 7-hydroxylase in man, rat, and mouse

1988 • 131 citations

Testosterone metabolism by cytochrome P-450 isozymes RLM3 and RLM5 and by microsomes. Metabolite identification.

1983 • 126 citations

The role of CYP2D6 in primary and secondary oxidative metabolism of dextromethorphan: in vitro studies using human liver microsomes.

1994 • 101 citations

Biphasic O-deethylation of phenacetin and 7-ethoxycoumarin by human and rat liver microsomal fractions

1981 • 85 citations

Cytochrome P-450 catalysis: radical intermediates and dehydrogenation reactions

1989 • 85 citations

Distinction of CYP1A1 and CYP1A2 activity by selective inhibition using fluvoxamine and isosafrole

1997 • 77 citations

The rat P450 IID subfamily: Complete sequences of four closely linked genes and evidence that gene conversions maintained sequence homogeneity at the heme-binding region of the cytochrome P450 active site

1990 • 71 citations

Genetic polymorphism in drug oxidation: In vitro studies of human debrisoquine 4-hydroxylase and bufuralol 1′-hydroxylase activities

1985 • 65 citations

Biotransformation of coumarin by rodent and human cytochromes P-450: metabolic basis of tissue-selective toxicity in olfactory mucosa of rats and mice.

1999 • 64 citations

Highly sensitive high-performance liquid chromatographic assay for coumarin 7-hydroxylation and 7-ethoxycoumarin O-deethylation by human liver cytochrome P450 enzymes

1999 • 59 citations

Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate.

2000 • 58 citations

Mephenytoin hydroxylation polymorphism: Characterization of the enzymatic deficiency in liver microsomes of poor metabolizers phenotyped in vivo

1985 • 54 citations

Both Cytochromes P450 2E1 and 3A Are Involved in the O-Hydroxylation of p-Nitrophenol, a Catalytic Activity Known To Be Specific for P450 2E1

1997 • 53 citations

Molecular basis of the Dark Agouti rat drug oxidation polymorphism: importance of CYP2D1 and CYP2D2

1998 • 48 citations

Cytochrome P-450 2E1 is not the sole catalyst of chlorzoxazone hydroxylation in rat liver microsomes. off.

1995 • 46 citations

Developmental changes in the catalytic activity and expression of CYP2D isoforms in the rat liver.

1999 • 39 citations

cDNA Cloning of a Novel Rat Brain Cytochrome P450 Belonging to the CYP2D Subfamily

1995 • 38 citations

Species differences in stereoselective metabolism of mephenytoin by cytochrome P450 (CYP2C and CYP3A).

1993 • 37 citations

The importance of substrate concentration in determining cytochromes P450 therapeutically relevant in vivo

1994 • 35 citations

PhenacetinO-deethylase activity of the rat: strain differences and the effects of enzyme-inducing compounds

1987 • 11 citations

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