Research advances in ethanol metabolism

High Blood Alcohol Levels in Women

1990 • 1,248 citations

3 Alcohol Dehydrogenases

1975 • 706 citations

Effects of Moderate Alcohol Consumption on the Central Nervous System*

1998 • 633 citations

Alcohol and aldehyde dehydrogenase genotypes and alcoholism in Chinese men.

1991 • 613 citations

Genotypes for aldehyde dehydrogenase deficiency and alcohol sensitivity. The inactive ALDH2(2) allele is dominant.

1989 • 579 citations

Human aldehyde dehydrogenase gene family

1998 • 473 citations

Interaction between the Functional Polymorphisms of the Alcohol-Metabolism Genes in Protection against Alcoholism

1999 • 471 citations

Microsomal Ethanol‐Oxidizing System (MEOS): The First 30 Years (1968‐1998)–A Review

1999 • 428 citations

Gender differences in moderate drinking effects.

1999 • 318 citations

Alcohol and aldehyde dehydrogenase polymorphisms and the risk for alcoholism

1995 • 314 citations

Clinical Pharmacokinetics of Ethanol

1987 • 273 citations

Recommended nomenclature for the vertebrate alcohol dehydrogenase gene family

1999 • 255 citations

Polymorphism of ADH and ALDH Genes among Four Ethnic Groups in China and Effects upon the Risk for Alcoholism

1997 • 241 citations

Ethanol Elimination in Males and Females: Relationship to Menstrual Cycle and Body Composition

1983 • 219 citations

Eukaryotic aldehyde dehydrogenase (ALDH) genes: human polymorphisms, and recommended nomenclature based on divergent evolution and chromosomal mapping.

1999 • 218 citations

Physiological Substrates for Rat Alcohol Dehydrogenase Classes: Aldehydes of Lipid Peroxidation, ω-Hydroxyfatty Acids, and Retinoids

1993 • 207 citations

Genetic Factors in Alcohol Metabolism and Alcoholism

1993 • 195 citations

Gender differences in alcohol metabolism: Relationship to liver volume and effect of adjusting for body mass

1998 • 193 citations

Human metabolism of alcohol

1989 • 189 citations

Human gastric alcohol dehydrogenase activity: effect of age, sex, and alcoholism.

1993 • 188 citations

Pharmacokinetics of ethanol after oral administration in the fasting state

1977 • 172 citations

Role of acetaldehyde in the actions of ethanol on the brain — A review

1996 • 170 citations

Alcohol-Metabolising Genes and Alcoholism Among Taiwanese Han Men: Independent Effect of ADH2, ADH3 and ALDH2

1996 • 164 citations

A Physiologically‐Based Pharmacokinetic (PBPK) Model for Alcohol Facilitates Rapid BrAC Clamping

1999 • 162 citations

Clamping Breath Alcohol Concentration Reduces Experimental Variance: Application to the Study of Acute Tolerance to Alcohol and Alcohol Elimination Rate

1998 • 159 citations

Alcohol dehydrogenase-2*3 allele protects against alcohol-related birth defects among African Americans.

1997 • 149 citations

Absorption, distribution and elimination of alcohol: highway safety aspects.

1985 • 148 citations

The kinetics of ethanol absorption and elimination in twins and supplementary repetitive experiments in singleton subjects

1977 • 145 citations

ADH2 Gene Polymorphisms Are Determinants of Alcohol Pharmacokinetics

1995 • 144 citations

A twin study of ethanol metabolism

1985 • 141 citations

Regulation of the mammalian alcohol dehydrogenase genes

2000 • 138 citations

First pass metabolism of ethanol is strikingly influenced by the speed of gastric emptying

1998 • 130 citations

Disposition and first-pass metabolism of ethanol in humans: Is it gastric or hepatic and does it depend on gender?*

1996 • 124 citations

Effect of Food and Food Composition on Alcohol Elimination Rates in Healthy Men and Women

2001 • 120 citations

Characteristics of Japanese Alcoholics with the Atypical Aldehyde Dehydrogenase 2*2.I. A Comparison of the Genotypes of ALDH2, ADH2, ADH3, and Cytochrome P‐4502E1 Between Alcoholics and Nonalcoholics

1996 • 119 citations

Development and utilization of physiologically based pharmacokinetic models for toxicological applications

1991 • 118 citations

Superior mesenteric artery blood flow and gastric emptying in humans and the differential effects of high fat and high carbohydrate meals.

1994 • 118 citations

Food effects on absorption and metabolism of alcohol.

1976 • 115 citations

Involvement of acetaldehyde for full protection against alcoholism by homozygosity of the variant allele of mitochondrial aldehyde dehydrogenase gene in Asians.

1999 • 114 citations

Alcohol and acetaldehyde metabolism in Caucasians, Chinese and Amerinds.

1976 • 109 citations

Distribution and Kinetics of Ethanol Metabolism in Rat Brain

1998 • 109 citations

Effect of high‐fat, high‐protein, and high‐carbohydrate meals on the pharmacokinetics of a small dose of ethanol

1997 • 101 citations

Ethanol ‘dose‐dependent’ elimination: Michaelis‐Menten v classical kinetic analysis.

1981 • 98 citations

Variation in Ethanol Pharmacokinetics and Perceived Gender and Ethnic Differences in Alcohol Elimination

2000 • 72 citations

Polymorphism of the human alcohol dehydrogenase 4 (ADH4) promoter affects gene expression

1999 • 69 citations

Variability in blood alcohol concentrations. Implications for estimating individual results.

1983 • 68 citations

A Novel Polymorphism (‐357 G/A) of the ALDH2 Gene: Linkage Disequilibrium and an Association With Alcoholism

1999 • 67 citations

An A/G Polymorphism in the Promoter of Mitochondrial Aldehyde Dehydrogenase (ALDH2): Effects of the Sequence Variant on Transcription Factor Binding and Promoter Strength

1999 • 57 citations

A Comparison of Physiologically Based Pharmacokinetic Model Predictions and Experimental Data for Inhaled Ethanol in Male and Female B6C3F1Mice, F344 Rats, and Humans

1997 • 55 citations

Ethanol Pharmacokinetics in White Women: Nonlinear Model Fitting Versus Zero‐Order Elimination Analyses

2000 • 52 citations

INFLUENCE OF SEVERAL FACTORS ON BLOOD ALCOHOL CONCENTRATIONS AFTER DRINKING ALCOHOL

1988 • 49 citations

Physiological Pharmacokinetic Models: Some Aspects of Theory, Practice and Potential

1988 • 45 citations

Effects of Food and Body Composition on Blood Alcohol Curves

2000 • 44 citations

Alcohol Elimination in Native American Mission Indians: An Investigation of Interindividual Variation

1996 • 42 citations

DIFFERING EFFECTS OF CARBOHYDRATE, FAT AND PROTEIN ON THE RATE OF ETHANOL METABOLISM

1987 • 41 citations

The Effect of Food on Alcohol Absorption and Elimination Patterns

1993 • 40 citations

Ethanol Metabolism in Male American Indians and Whites

1978 • 38 citations

DEVELOPMENT AND APPLICATION OF A PHYSIOLOGICALLY BASED PHARMACOKINETIC MODEL FOR ETHANOL IN THE MOUSE

1996 • 36 citations

GENETIC POLYMORPHISMS IN ETHANOL METABOLISM: ISSUES AND GOALS FOR PHYSIOLOGICALLY BASED PHARMACOKINETIC MODELING*

2000 • 35 citations

Enzymic Catalysis of the Accumulation of Acetaldehyde From Ethanol in Human Prenatal Cephalic Tissues: Evaluation of the Relative Contributions of CYP2E1, Alcohol Dehydrogenase, and Catalase/Peroxidases

2000 • 31 citations

EFFECT OF ALCOHOL ON GASTRIC EMPTYING IN VOLUNTEERS †

1993 • 31 citations

Genetic Polymorphism and Properties of Human Alcohol and Aldehyde Dehydrogenases: Implications for Ethanol Metabolism and Toxicity

1989 • 16 citations

The Relationship between Gut Hormone Secretion and Gastric Emptying in Different Phases of the Migrating Motor Complex

1996 • 15 citations

VARIABILITY IN BLOOD ALCOHOL CONCENTRATIONS

1983 • 12 citations

Ethanol metabolism and memory impairment in American Indian and white women social drinkers.

1978 • 11 citations

Experimental Model for the Investigation of Kinetic and/or Dynamic Interactions between Drugs and Ethanol in Humans

1988 • 10 citations

Pharmacokinetics of Intravenous Alcohol: Two Compartment, Dual Michaelis‐Menten Elimination

2000 • 8 citations

Molecular Mechanisms of Alcohol: Neurobiology and Metabolism

1990 • 6 citations

Decreased activity of gastric class III (χ) ADH can explain increased bioavailability of alcohol in women

1998 • 6 citations