Brain iron metabolism: Neurobiology and neurochemistry

Hepcidin Regulates Cellular Iron Efflux by Binding to Ferroportin and Inducing Its Internalization

2004 • 4,503 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

The ferritins: molecular properties, iron storage function and cellular regulation

1996 • 2,572 citations

Hepcidin, a Urinary Antimicrobial Peptide Synthesized in the Liver

2001 • 2,140 citations

Disorders of Iron Metabolism

1999 • 2,062 citations

Iron, brain ageing and neurodegenerative disorders

2004 • 1,737 citations

Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter

2000 • 1,624 citations

A Novel Duodenal Iron-Regulated Transporter, IREG1, Implicated in the Basolateral Transfer of Iron to the Circulation

2000 • 1,413 citations

THE EFFECT OF AGE ON THE NON‐HAEMIN IRON IN THE HUMAN BRAIN

1958 • 1,401 citations

Microsomal Heme Oxygenase

1969 • 1,348 citations

LEAP‐1, a novel highly disulfide‐bonded human peptide, exhibits antimicrobial activity

2000 • 1,313 citations

Molecular control of vertebrate iron metabolism: mRNA-based regulatory circuits operated by iron, nitric oxide, and oxidative stress.

1996 • 1,311 citations

A Novel Mammalian Iron-regulated Protein Involved in Intracellular Iron Metabolism

2000 • 1,259 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 ( USF2 ) knockout mice

2001 • 1,212 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

Hephaestin, a ceruloplasmin homologue implicated in intestinal iron transport, is defective in the sla mouse

1999 • 1,068 citations

An Iron-Regulated Ferric Reductase Associated with the Absorption of Dietary Iron

2001 • 1,038 citations

A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study

1986 • 999 citations

Targeted Drug Delivery via the Transferrin Receptor-Mediated Endocytosis Pathway

2002 • 987 citations

Mutations in HFE2 cause iron overload in chromosome 1q–linked juvenile hemochromatosis

2003 • 979 citations

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

1998 • 946 citations

Age-related myelin breakdown: a developmental model of cognitive decline and Alzheimer’s disease

2003 • 923 citations

Carbon Monoxide: Endogenous Production, Physiological Functions, and Pharmacological Applications

2005 • 914 citations

C<scp>ERULOPLASMIN</scp> M<scp>ETABOLISM AND</scp> F<scp>UNCTION</scp>

2002 • 850 citations

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

2001 • 738 citations

Genetic, Clinical, and Radiographic Delineation of Hallervorden–Spatz Syndrome

2003 • 698 citations

The Possible Significance of the Ferrous Oxidase Activity of Ceruloplasmin in Normal Human Serum

1966 • 672 citations

The FET3 gene of S. cerevisiae encodes a multicopper oxidase required for ferrous iron uptake

1994 • 659 citations

I<scp>RON</scp> R<scp>EGULATORY</scp> P<scp>ROTEINS AND THE</scp> M<scp>OLECULAR</scp> C<scp>ONTROL OF</scp> M<scp>AMMALIAN</scp> I<scp>RON</scp> M<scp>ETABOLISM</scp>

2000 • 657 citations

Genetic or Pharmacological Iron Chelation Prevents MPTP-Induced Neurotoxicity In Vivo

2003 • 613 citations

Structure of human lactoferrin: Crystallographic structure analysis and refinement at 2·8 Å resolution

1989 • 588 citations

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

1999 • 572 citations

Aceruloplasminemia: molecular characterization of this disorder of iron metabolism.

1995 • 550 citations

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

2001 • 533 citations

Haem oxygenase-1 prevents cell death by regulating cellular iron

1999 • 519 citations

Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice

2001 • 479 citations

Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin

2005 • 471 citations

Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains

1990 • 457 citations

A mutation in the ceruloplasmin gene is associated with systemic hemosiderosis in humans

1995 • 456 citations

The role of iron and copper molecules in the neuronal vulnerability of locus coeruleus and substantia nigra during aging

2004 • 453 citations

Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron

1999 • 445 citations

Brain iron and ferritin in Parkinson's and Alzheimer's diseases

1990 • 440 citations

Plasma cysteine and sulphate levels in patients with motor neurone, Parkinson's and Alzheimer's disease

1990 • 431 citations

Previously uncharacterized isoforms of divalent metal transporter (DMT)-1: Implications for regulation and cellular function

2002 • 418 citations

Iron homeostasis: insights from genetics and animal models

2000 • 410 citations

Iron metabolism

1999 • 408 citations

Transferrin/transferrin receptor‐mediated drug delivery

2002 • 408 citations

Espinosa de los Monteros

1999 • 404 citations

Healthy Aging and Dementia: Findings from the Nun Study

2003 • 385 citations

Iron, neuromelanin and ferritin content in the substantia nigra of normal subjects at different ages: consequences for iron storage and neurodegenerative processes

2001 • 381 citations

The ferroportin disease

2003 • 376 citations

Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease

1992 • 367 citations

Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier

1999 • 365 citations

Ferritin as a source of iron for oxidative damage

1992 • 359 citations

Hepcidin, A New Iron Regulatory Peptide

2002 • 358 citations

Brain iron pathways and their relevance to Parkinson's disease

2001 • 356 citations

Glycosylphosphatidylinositol-anchored Ceruloplasmin Is Required for Iron Efflux from Cells in the Central Nervous System

2003 • 354 citations

Transferrin and transferrin receptor function in brain barrier systems.

2000 • 353 citations

Hepcidin expression inversely correlates with the expression of duodenal iron transporters and iron absorption in rats

2002 • 340 citations

Lactoferrin and transferrin: A comparative study

1972 • 335 citations

Iron misregulation in the brain: a primary cause of neurodegenerative disorders

2003 • 334 citations

Brain ferritin iron may influence age- and gender-related risks of neurodegeneration

2006 • 330 citations

Neuropathological spectrum of synucleinopathies

2003 • 324 citations

A Quantitative Analysis of Isoferritins in Select Regions of Aged, Parkinsonian, and Alzheimer's Diseased Brains

1995 • 320 citations

A Novel Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin Is Expressed by Mammalian Astrocytes

1997 • 318 citations

The Human Nramp2 Gene: Characterization of the Gene Structure, Alternative Splicing, Promoter Region and Polymorphisms

1998 • 314 citations

Neural roles for heme oxygenase: Contrasts to nitric oxide synthase

2001 • 298 citations

Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α₂‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

1995 • 297 citations

Identification and characterization of a second mouse Nramp gene

1995 • 289 citations

Familial apoceruloplasmin deficiency associated with blepharospasm and retinal degeneration

1987 • 289 citations

Iron regulatory proteins in pathobiology

2000 • 288 citations

Study of the localization of iron, ferritin, and hemosiderin in Alzheimer’s disease hippocampus by analytical microscopy at the subcellular level

2005 • 287 citations

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat

2001 • 287 citations

Brain iron uptake and homeostatic mechanisms: an overview.

2003 • 279 citations

Neurodegeneration with brain iron accumulation

2018 • 275 citations

Transport of Iron in the Blood‐Brain‐Cerebrospinal Fluid System

1997 • 272 citations

Hepcidin: A putative iron-regulatory hormone relevant to hereditary hemochromatosis and the anemia of chronic disease

2001 • 271 citations

Heme oxygenase-1: role in brain aging and neurodegeneration

2000 • 268 citations

Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein.

1991 • 267 citations

Brain Iron Metabolism

2006 • 266 citations

Early Embryonic Lethality of H Ferritin Gene Deletion in Mice

2000 • 266 citations

Nramp2 Expression Is Associated with pH-dependent Iron Uptake across the Apical Membrane of Human Intestinal Caco-2 Cells

2000 • 263 citations

Disruption of ceruloplasmin and hephaestin in mice causes retinal iron overload and retinal degeneration with features of age-related macular degeneration

2004 • 255 citations

Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis

1998 • 249 citations

Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation

2006 • 247 citations

Mammalian Tissue Oxygen Levels Modulate Iron-Regulatory Protein Activities in Vivo

2004 • 242 citations

Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

2003 • 241 citations

The Metabolism of Neuronal Iron and Its Pathogenic Role in Neurological Disease: Review

2004 • 236 citations

Iron and neurodegenerative disorders

2001 • 235 citations

Localisation of divalent metal transporter 1 (DMT1) to the microvillus membrane of rat duodenal enterocytes in iron deficiency, but to hepatocytes in iron overload

2000 • 234 citations

Heme oxygenase expression in human central nervous system disorders

2004 • 232 citations

Ironing Iron Out in Parkinson's Disease and Other Neurodegenerative Diseases with Iron Chelators: A Lesson from 6‐Hydroxydopamine and Iron Chelators, Desferal and VK‐28

2004 • 230 citations

Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2

2005 • 221 citations

The Role of Iron in Neurodegeneration

1999 • 220 citations

Genes that modify the hemochromatosis phenotype in mice

2000 • 219 citations

Expression of iron transport proteins and excessive iron accumulation in the brain in neurodegenerative disorders

1998 • 219 citations

Iron in the basal ganglia in Parkinson's disease

1999 • 216 citations

A Mutation, in the Iron-Responsive Element of H Ferritin mRNA, Causing Autosomal Dominant Iron Overload

2001 • 211 citations

Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease.

1995 • 209 citations

The correlation between phase shifts in gradient-echo MR images and regional brain iron concentration

1999 • 207 citations

In vivo detection of iron and neuromelanin by transcranial sonography: A new approach for early detection of substantia nigra damage

2005 • 203 citations

Expression of the iron transporter ferroportin in synaptic vesicles and the blood–brain barrier

2004 • 202 citations

Hallervorden-Spatz Syndrome and Brain Iron Metabolism

1991 • 197 citations

Role of Ceruloplasmin in Cellular Iron Uptake

1998 • 196 citations

Alternative RNA Splicing Generates a Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin in Mammalian Brain

2000 • 194 citations

Ceruloplasmin gene expression in the murine central nervous system.

1996 • 193 citations

Brain iron transport and neurodegeneration

2001 • 191 citations

Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases

2004 • 187 citations

Glial heme oxygenase-1 expression in Alzheimer disease and mild cognitive impairment

2005 • 187 citations

Amyloid Precursor Proteins Inhibit Heme Oxygenase Activity and Augment Neurotoxicity in Alzheimer's Disease

2000 • 182 citations

MR evaluation of age-related increase of brain iron in young adult and older normal males

1997 • 182 citations

Genotypic and phenotypic spectrum of PANK2 mutations in patients with neurodegeneration with brain iron accumulation

2006 • 180 citations

Iron metabolism in Parkinsonian syndromes

2006 • 179 citations

The iron regulatory proteins: targets and modulators of free radical reactions and oxidative damage1,2 1Guest Editor: Mario Comporti 2This article is part of a series of reviews on “Iron and Cellular Redox Status.” The full list of papers may be found on the homepage of the journal.

2002 • 177 citations

Iron and iron management proteins in neurobiology

2001 • 174 citations

Serum levels of the iron binding protein p97 are elevated in Alzheimer′s disease

1996 • 171 citations

Brain iron deposition and the free radical-mitochondrial theory of ageing

2004 • 171 citations

Use of desferrioxamine in the treatment of aceruloplasminemia

1997 • 170 citations

Abnormal localization of iron regulatory protein in Alzheimer's disease

1998 • 170 citations

Mechanisms of Iron Accumulation in Hereditary Hemochromatosis

2002 • 169 citations

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

1993 • 167 citations

Hallervorden‐Spatz disease: Cysteine accumulation and cysteine dioxygenase deficiency in the globus pallidus

1985 • 164 citations

Expression of the ceruloplasmin gene in the human retina and brain: implications for a pathogenic model in aceruloplasminemia

1996 • 163 citations

Metals in our minds: therapeutic implications for neurodegenerative disorders

2004 • 162 citations

Immunohistochemical localization of intraneuronal transferrin receptor immunoreactivity in the adult mouse central nervous system

1996 • 161 citations

Heme, iron, and the mitochondrial decay of ageing

2004 • 158 citations

Intracellular Ferritin Accumulation in Neural and Extraneural Tissue Characterizes a Neurodegenerative Disease Associated with a Mutation in theFerritin Light PolypeptideGene

2004 • 158 citations

Characterization of the iron transporter DMT1 (NRAMP2/DCT1) in red blood cells of normal and anemic mk/mkmice

2001 • 158 citations

Nanoparticle and other metal chelation therapeutics in Alzheimer disease

2005 • 154 citations

Iron and transferrrin uptake by brain and cerebrospinal fluid in the rat

1992 • 152 citations

In Vitro Studies of Ferritin Iron Release and Neurotoxicity

1998 • 152 citations

Pharmacokinetics and brain uptake of lactoferrin in rats

2005 • 149 citations

Ferritin: isolation of aluminum-ferritin complex from brain.

1987 • 147 citations

Hephaestin is a ferroxidase that maintains partial activity in sex-linked anemia mice

2004 • 147 citations

Hereditary Ferritinopathy: A Novel Mutation, Its Cellular Pathology, and Pathogenetic Insights

2005 • 146 citations

Clinical heterogeneity of neurodegeneration with brain iron accumulation (Hallervorden‐Spatz syndrome) and pantothenate kinase‐associated neurodegeneration

2004 • 145 citations

Altered Neuronal Mitochondrial Coenzyme A Synthesis in Neurodegeneration with Brain Iron Accumulation Caused by Abnormal Processing, Stability, and Catalytic Activity of Mutant Pantothenate Kinase 2

2005 • 145 citations

Ceruloplasmin Ferroxidase Activity Stimulates Cellular Iron Uptake by a Trivalent Cation-specific Transport Mechanism

1999 • 143 citations

Ceruloplasmin in neurodegenerative diseases

2005 • 143 citations

Hemochromatosis: Genetics and Pathophysiology

2005 • 142 citations

Existing and emerging mechanisms for transport of iron and manganese to the brain

1999 • 140 citations

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin

1996 • 139 citations

A Mammalian Iron ATPase Induced by Iron

2000 • 138 citations

Aceruloplasminemia

1998 • 137 citations

The history of iron in the brain

1995 • 136 citations

Aceruloplasminemia, an iron metabolic disorder

2003 • 134 citations

A histochemical study of iron‐positive cells in the developing rat brain

1995 • 133 citations

Evolution of duplications in the transferrin family of proteins

2004 • 133 citations

Iron accumulation, iron‐mediated toxicity and altered levels of ferritin and transferrin receptor in cultured astrocytes during incubation with ferric ammonium citrate

2004 • 129 citations

The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis

1994 • 129 citations

An isoform of hPANK2, deficient in pantothenate kinase-associated neurodegeneration, localizes to mitochondria

2003 • 126 citations

Iron Metabolism in Eukaryotes—Mars and Venus at It Again

1996 • 126 citations

Increasing striatal iron content associated with normal aging

1998 • 124 citations

Role of heme oxygenase-1 in the regulation of manganese superoxide dismutase gene expression in oxidatively-challenged astroglia

2000 • 124 citations

Synthesis and localization of plasma proteins in the developing human brain

1988 • 123 citations

Systemic regulation of Hephaestin and Ireg1 revealed in studies of genetic and nutritional iron deficiency

2003 • 123 citations

Iron, neuroinflammation, and Alzheimer's disease

2005 • 122 citations

Does cellular iron dysregulation play a causative role in Parkinson’s disease?

2004 • 122 citations

Chemical evidence for 6-hydroxydopamine to be an endogenous toxic factor in the pathogenesis of Parkinson's disease.

1995 • 121 citations

Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases

1996 • 119 citations

Divalent metal transporter 1

2005 • 117 citations

Neurodegenerative disease and iron storage in the brain

2004 • 117 citations

Unraveling the Hallervorden-Spatz syndrome: pantothenate kinase???associated neurodegeneration is the name . . .

2003 • 117 citations

Modifications of the iron–neuromelanin system in Parkinson's disease

2006 • 117 citations

Brain iron homeostasis.

2002 • 116 citations

Are hereditary hemochromatosis mutations involved in Alzheimer disease?

2000 • 116 citations

Characterization of a Nonsense Mutation in the Ceruloplasmin Gene Resulting in Diabetes and Neurodegenerative Disease

1996 • 116 citations

Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid

1998 • 116 citations

The significance of the mutated divalent metal transporter (DMT1) on iron transport into the Belgrade rat brain

2003 • 116 citations

Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains

1999 • 115 citations

Heme Oxygenase‐1: Transducer of Pathological Brain Iron Sequestration under Oxidative Stress

2004 • 114 citations

Neuromelanin and iron in human locus coeruleus and substantia nigra during aging: consequences for neuronal vulnerability

2006 • 113 citations

The diverse phenotype and genotype of pantothenate kinase-associated neurodegeneration

2005 • 113 citations

Dietary iron induces rapid changes in rat intestinal divalent metal transporter expression

2000 • 113 citations

Copper, Ceruloplasmin, Superoxide Dismutase and Iron Parameters in Parkinson's Disease

1999 • 112 citations

The hemochromatosis gene affects the age of onset of sporadic Alzheimer’s disease

2001 • 112 citations

Over‐expression of heme oxygenase‐1 promotes oxidative mitochondrial damage in rat astroglia

2005 • 110 citations

Hereditary haemochromatosis: a case of iron accumulation in the basal ganglia associated with a parkinsonian syndrome.

1995 • 109 citations

Mitochondrial Localization of Human PANK2 and Hypotheses of Secondary Iron Accumulation in Pantothenate Kinase‐Associated Neurodegeneration

2004 • 109 citations

The role of the transferrin–transferrin-receptor system in drug delivery and targeting

2002 • 106 citations

Novel Chelators for Central Nervous System Disorders That Involve Alterations in the Metabolism of Iron and Other Metal Ions

2004 • 105 citations

Mechanisms of iron uptake by mammalian cells

1995 • 105 citations

HARP syndrome is allelic with pantothenate kinase–associated neurodegeneration

2002 • 104 citations

Brain capillary endothelium and choroid plexus epithelium regulate transport of transferrin-bound and free iron into the rat brain

2004 • 104 citations

Neurodegeneration With Brain Iron Accumulation: From Genes to Pathogenesis

2006 • 102 citations

Alzheimer disease: Evidence for a central pathogenic role of iron-mediated reactive oxygen species

2004 • 102 citations

Mechanisms and regulation of transferrin and iron transport in a model blood–brain barrier system

2003 • 102 citations

Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium

1996 • 99 citations

Iron Deficiency Alters Iron Regulatory Protein and Iron Transport Protein Expression in the Perinatal Rat Brain

2003 • 99 citations

Expression of the iron transporter DMT1 in kidney from normal and anemic mk mice

2002 • 99 citations

Increased manganese uptake by primary astrocyte cultures with altered iron status is mediated primarily by divalent metal transporter

2005 • 98 citations

The Iron Carrier Transferrin Is Upregulated in Retinas from Patients with Age-Related Macular Degeneration

2006 • 97 citations

Increased lipid peroxidation in the brains of aceruloplasminemia patients

2000 • 97 citations

Severity of Neurodegeneration Correlates with Compromise of Iron Metabolism in Mice with Iron Regulatory Protein Deficiencies

2004 • 97 citations

Iron in neurodegenerative disorders

2002 • 97 citations

Recent advances in disorders of iron metabolism: mutations, mechanisms and modifiers

2001 • 97 citations

Dynamic Traffic through the Recycling Compartment Couples the Metal Transporter Nramp2 (DMT1) with the Transferrin Receptor

2003 • 96 citations

The physiopathological significance of ceruloplasmin

2000 • 96 citations

Transferrin receptors in rat central nervous system

1990 • 96 citations

Neuroferritinopathy: Missense mutation in FTL causing early-onset bilateral pallidal involvement

2005 • 95 citations

Disturbance of iron metabolism in Parkinson’s disease — ultrasonography as a biomarker

2006 • 95 citations

Iron regulatory proteins in pathobiology

2000 • 93 citations

Hephaestin—a ferroxidase of cellular iron export

2005 • 93 citations

Neuro-Ophthalmologic and Electroretinographic Findings in Pantothenate Kinase-Associated Neurodegeneration (formerly Hallervorden-Spatz Syndrome)

2005 • 93 citations

Contribution of redox-active iron and copper to oxidative damage in Alzheimer disease

2004 • 92 citations

Reduced ferroxidase activity in the cerebrospinal fluid from patients with Parkinson's disease

1999 • 92 citations

Age-dependent and iron-independent expression of two mRNA isoforms of divalent metal transporter 1 in rat brain

2004 • 91 citations

Association of HFE mutations with neurodegeneration and oxidative stress in Alzheimer's disease and correlation with APOE

2003 • 91 citations

Differential Localization of Divalent Metal Transporter 1 with and without Iron Response Element in Rat PC12 and Sympathetic Neuronal Cells

2000 • 90 citations

Rate of ⁵⁹Fe Uptake into Brain and Cerebrospinal Fluid and the Influence Thereon of Antibodies Against the Transferrin Receptor

1993 • 90 citations

Iron and Brain Disorders

2004 • 88 citations

Iron Transport Across Biologic Membranes

2009 • 88 citations

Hallervorden-Spatz syndrome

2001 • 88 citations

REVIEW ARTICLE Neurodegeneration with brain iron accumulation

2006 • 88 citations

Hallervorden-Spatz disease: clinical and MRI study of 11 cases diagnosed in life

1992 • 87 citations

Correlation of R2 with total iron concentration in the brains of rhesus monkeys

2005 • 87 citations

Mutations in the hemochromatosis gene (HFE), Parkinson's disease and parkinsonism

2003 • 86 citations

Systemic iron metabolism: a review and implications for brain iron metabolism

2001 • 85 citations

Biochemical Properties of Human Pantothenate Kinase 2 Isoforms and Mutations Linked to Pantothenate Kinase-associated Neurodegeneration

2005 • 85 citations

Biochemical Analysis of a Missense Mutation in Aceruloplasminemia

2002 • 84 citations

Mitochondrial Iron Sequestration in Dopamine-Challenged Astroglia: Role of Heme Oxygenase-1 and the Permeability Transition Pore

1999 • 84 citations

The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non‐transferrin‐bound iron uptake

1999 • 84 citations

Post‐transcriptional expression of DMT1 in the heart of rat

2003 • 83 citations

Neuroferritinopathy: a neurodegenerative disorder associated with L-ferritin mutation

2005 • 83 citations

Stromal cell-derived receptor 2 and cytochrome b561 are functional ferric reductases

2003 • 83 citations

Increase of transferrin receptors and iron uptake in regenerating motor neurons

1989 • 82 citations

Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis

2000 • 82 citations

Characterization and Distribution of Ferritin Binding Sites in the Adult Mouse Brain

1999 • 82 citations

Iron Dysregulation and Neurodegeneration: The Molecular Connection

2006 • 81 citations

New insights into the regulation of iron homeostasis

2006 • 81 citations

Distribution of divalent metal transporter-1 in the monkey basal ganglia

2004 • 80 citations

Transferrin gene expression and secretion by rat brain cells in vitro

1990 • 80 citations

The mechanism of Fe2+-initiated lipid peroxidation in liposomes: the dual function of ferrous ions, the roles of the pre-existing lipid peroxides and the lipid peroxyl radical

2000 • 80 citations

Functional relevance of ceruloplasmin mutations in Parkinson's Disease

2005 • 79 citations

Lactoferrin is synthesized by activated microglia in the human substantia nigra and its synthesis by the human microglial CHME cell line is upregulated by tumor necrosis factor α or 1-methyl-4-phenylpyridinium treatment

2001 • 79 citations

The Copper Transport Protein Atox1 Promotes Neuronal Survival

2000 • 78 citations

Fe-saturation and proteolysis of human lactoferrin: effect on brush-border receptor-mediated uptake of Fe and Mn

1989 • 76 citations

Iron and ageing: an introduction to iron regulatory mechanisms

2004 • 76 citations

Estimation of the gene frequency of aceruloplasminemia in Japan

1999 • 75 citations

HFE mutations and Alzheimer's disease

2006 • 73 citations

Neuroferritinopathy: A Window on the Role of Iron in Neurodegeneration

2002 • 73 citations

Rethinking the role of ceruloplasmin in brain iron metabolism

2001 • 72 citations

Serum Melanotransferrin, p97 as a Biochemical Marker of Alzheimer's Disease

2001 • 72 citations

Iron overload and antioxidative role of perivascular astrocytes in aceruloplasminemia

2006 • 71 citations

Receptor-Mediated Transport of Lactoferrin into the Cerebrospinal Fluid via Plasma in Young Calves

2003 • 71 citations

In vivo detection of iron and neuromelanin by transcranial sonography – a new approach for early detection of substantia nigra damage

2006 • 70 citations

Interferon‐γ and lipopolysaccharide regulate the expression of Nramp2 and increase the uptake of iron from low relative molecular mass complexes by macrophages

2000 • 69 citations

The role of the membrane‐bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell

2000 • 69 citations

Glial HO-1 expression, iron deposition and oxidative stress in neurodegenerative diseases

1999 • 69 citations

Domain homologues of dopamine beta-hydroxylase and ferric reductase: roles for iron metabolism in neurodegenerative disorders?

2001 • 68 citations

Hepatic iron overload in aceruloplasminaemia

2000 • 67 citations

Iron accumulation in the striatum predicts aging-related decline in motor function in rhesus monkeys

2006 • 67 citations

Neuroferritinopathy in a French family with late onset dominant dystonia

2003 • 67 citations

Interleukin-1β increases binding of the iron regulatory protein and the synthesis of ferritin by increasing the labile iron pool

2000 • 67 citations

Hepcidin: an important new regulator of iron homeostasis

2006 • 65 citations

Concurrent hereditary haemochromatosis and idiopathic Parkinson's disease: a case report series

2004 • 65 citations

Iron homeostasis in neuronal cells: a role for IREG1.

2005 • 65 citations

Mechanism and Developmental Changes in Iron Transport across the Blood-Brain Barrier

2002 • 64 citations

Pantothenate kinase-associated neurodegeneration (Hallervorden–Spatz syndrome)

2002 • 64 citations

Glial cells contribute more to iron and aluminum accumulation but are more resistant to oxidative stress than neuronal cells

2000 • 63 citations

Neuromelanin induces oxidative stress in mitochondria through release of iron: mechanism behind the inhibition of 26S proteasome

2005 • 63 citations

Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis

2001 • 62 citations

Iron dysregulation and Parkinson's disease

2005 • 62 citations

Site-directed Mutagenesis of the Yeast Multicopper Oxidase Fet3p

1998 • 62 citations

Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys

2003 • 61 citations

Cranial MRI changes may precede symptoms in Hallervorden-Spatz syndrome

2001 • 60 citations

Ferroportin in the Postnatal Rat Brain: Implications for Axonal Transport and Neuronal Export of Iron

2006 • 60 citations

Ran-2, a glial lineage marker, is a GPI-anchored form of ceruloplasmin

1998 • 60 citations

Role of ceruloplasmin and ascorbate in cellular iron release

1999 • 59 citations

Ceruloplasmin, transferrin and apotransferrin facilitate iron release from human liver cells

1997 • 59 citations

Effects of development and iron status on ceruloplasmin expression in rat brain

2005 • 59 citations

A Morphological Study of the Developmentally Regulated Transport of Iron into the Brain

2002 • 59 citations

The Cys282Tyr polymorphism in the HFE gene in Australian Parkinson's disease patients

2002 • 58 citations

Upregulation of DMT1 expression in choroidal epithelia of the blood–CSF barrier following manganese exposure in vitro

2006 • 55 citations

Nitric oxide transcriptionally down‐regulates specific isoforms of divalent metal transporter (DMT1) via NF‐κB

2006 • 54 citations

Development and iron‐dependent expression of hephaestin in different brain regions of rats

2007 • 54 citations

The membrane‐bound transferrin homologue melanotransferrin: roles other than iron transport?

2000 • 53 citations

Lactoferrin is synthesized by mouse brain tissue and its expression is enhanced after MPTP treatment

1999 • 53 citations

Identification of a Novel Route of Iron Transcytosis across the Mammalian Blood‐Brain Barrier

2003 • 53 citations

A light and electron microscopic study of the iron transporter protein DMT-1 in the monkey cerebral neocortex and hippocampus.

2001 • 53 citations

Transferrin receptors on the plasma membrane of cultured rat astrocytes

1999 • 52 citations

Intestinal iron-transport defect in the mouse with sex-linked anemia

1971 • 51 citations

Regulation of the Profile of Iron-Management Proteins in Brain Microvasculature

2003 • 51 citations

Immunohistochemical analysis of transferrin receptor: regional and cellular distribution in the hypotransferrinemic (hpx) mouse brain

1998 • 51 citations

An update on iron metabolism: Summary of the Fifth International Conference on Disorders of Iron Metabolism

1996 • 50 citations

Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease

1999 • 50 citations

[10] In situ methods for detection and localization of markers of oxidative stress: Application in neurodegenerative disorders

1999 • 49 citations

Spectrum of movement disorders in neuroferritinopathy

2004 • 49 citations

Autoimmunity in Paraneoplastic Neurological Syndromes

1999 • 49 citations

Iron crosses the endosomal membrane by a carrier-mediated process

1997 • 48 citations

Haemochromatosis: novel gene discovery and the molecular pathophysiology of iron metabolism

2000 • 48 citations

MR Imaging of Cerebral Cortical Involvement in Aceruloplasminemia

2005 • 47 citations

Role of melanotransferrin in iron metabolism: studies using targeted gene disruption in vivo

2005 • 47 citations

An oxidative stress‐mediated positive‐feedback iron uptake loop in neuronal cells

2002 • 47 citations

CSF abnormalities in patients with aceruloplasminemia

1998 • 47 citations

Stabilization of iron regulatory protein 2, IRP2, by aluminum

1999 • 47 citations

Effect of metabolic inhibitors on uptake of non-transferrin-bound iron by reticulocytes

1991 • 46 citations

Ironing out Parkinson's disease: is therapeutic treatment with iron chelators a real possibility?

2002 • 45 citations

Distribution of Ferroportin1 Protein in Different Regions of Developing Rat Brain

2002 • 44 citations

Increased oxysterols associated with iron accumulation in the brains and visceral organs of acaeruloplasminaemia patients

2001 • 43 citations

Changes in the uptake of transferrin-free and transferrin-bound iron during reticulocyte maturation in vivo and in vitro

1992 • 43 citations

Hereditary haemochromatosis is unlikely to cause movement disorders

2004 • 43 citations

Is neuromelanin changed in Parkinson’s disease? Investigations by magnetic spectroscopies

2006 • 43 citations

Neuroferritinopathy

2006 • 41 citations

Upregulation of iron regulatory proteins and divalent metal transporter-1 isoforms in the rat hippocampus after kainate induced neuronal injury

2005 • 41 citations

Lactoferrin binding by leukemia cell lines

1987 • 40 citations

Expression and localization of different forms of DMT1 in normal and tumor astroglial cells

2004 • 40 citations

The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain

2004 • 39 citations

Hereditary caeruloplasmin deficiency: clinicopathological study of a patient.

1996 • 39 citations

Parallels and contrasts between iron and copper metabolism.

2003 • 39 citations

Transferrin receptor expression in myelin deficient (md)rats

1992 • 39 citations

Brain iron and neurological disorders.

1997 • 38 citations

Increased IRP1 and IRP2 RNA binding activity accompanies a reduction of the labile iron pool in HFE‐expressing cells*

2002 • 38 citations

Dopamine release rather than content in the caudate putamen is associated with behavioral changes in the iron rat model of parkinson’s disease

2003 • 38 citations

Interleukin-1β up-regulates iron efflux in rat C6 glioma cells through modulation of ceruloplasmin and ferroportin-1 synthesis

2004 • 37 citations

Effect of lead on the transport of transferrin-free and transferrin-bound iron into rabbit reticulocytes

1990 • 37 citations

Adult-Onset Neurodegeneration With Brain Iron Accumulation and Cortical α-Synuclein and Tau Pathology

2007 • 37 citations

Ferritinopathy: diagnosis by muscle or nerve biopsy, with a note on other nuclear inclusion body diseases

2005 • 36 citations

Demonstration and Characterization of the Iron Regulatory Protein in Human Brain

1996 • 35 citations

HFE inhibits apical iron uptake by intestinal epithelial (Caco‐2) cells

2001 • 35 citations

Immunohistochemical and Ultrastructural Findings Related to the Blood–Brain Barrier in the Blood Vessels of the Cerebral White Matter in Aged Dogs

2005 • 33 citations

Adult‐onset generalized dystonia due to a mutation in the neuroferritinopathy gene

2004 • 33 citations

Examination of the distribution of the transferrin homologue, melanotransferrin (tumour antigen p97), in mouse and human

2005 • 33 citations

A fungal multicopper oxidase restores iron homeostasis in aceruloplasminemia

2004 • 31 citations

Membrane-inserted conformation of transmembrane domain 4 of divalent-metal transporter

2003 • 30 citations

Transferrin-bound and transferrin free iron uptake by cultured rat astrocytes.

2000 • 29 citations

Aceruloplasminemia with Juvenile-onset Diabetes Mellitus Caused by Exon Skipping in the Ceruloplasmin Gene

2003 • 27 citations

Ceruloplasmin promotes iron uptake rather than release in BT325 cells

2001 • 27 citations

Iron and glutathione at the crossroad of redox metabolism in neurons

2006 • 27 citations

Brain sites of movement disorder: Genetic and environmental agents in neurodevelopmental perturbations

2003 • 27 citations

Role of soluble ceruloplasmin in iron uptake by midbrain and hippocampus neurons

2006 • 26 citations

p97 as a biomarker for alzheimer disease

2002 • 26 citations

Stimulation of the Ferroxidase Activity of Ceruloplasmin during Iron Loading into Ferritin

1997 • 25 citations

Effect of Retinoic Acid on Ferritin H Expression During Brain Development and Neuronal Differentiation

2003 • 25 citations

Effect of altered thyroid hormone status on rat brain ferritin H and ferritin L mRNA during postnatal development

2000 • 24 citations

Effect of lipid peroxidation on transferrin-free iron uptake by rabbit reticulocytes

1996 • 23 citations

A case of aceruloplasminaemia: abnormal serum ceruloplasmin protein without ferroxidase activity.

2002 • 22 citations

The mechanism of Fe2+-initiated lipid peroxidation in liposomes: the dual function of ferrous ions, the roles of the pre-existing lipid peroxides and the lipid peroxyl radical

2000 • 22 citations

Exercise Decreases Cytosolic Aconitase Activity in the Liver, Spleen, and Bone Marrow in Rats

2001 • 21 citations

Calorimetric Studies of Melanotransferrin (p97) and Its Interaction with Iron

2005 • 21 citations

Increased HO-1 Expression and Decreased iNOS Expression in the Hippocampus From Adult Spontaneously Hypertensive Rats

2006 • 20 citations

Late‐Onset neurodegeneration with brain iron accumulation type 1: Expanding the clinical spectrum

2001 • 20 citations

Pumping iron in Parkinson's disease

1996 • 19 citations

Apotransferrin is internalized and distributed in the same way as holotransferrin in K562 cells

2004 • 19 citations

Glucose and Oxygen Hypometabolism in Aceruloplasminemia Brains.

2002 • 19 citations

Neurodegeneration with Brain Iron Accumulation

2014 • 19 citations

Assessing p97 as an Alzheimer's disease serum biomarker

2001 • 18 citations

A novel 3-bp deletion in the PANK2 gene of Dutch patients with pantothenate kinase-associated neurodegeneration: evidence for a founder effect

2005 • 17 citations

Effects of ferroxidase activity and species on ceruloplasmin mediated iron uptake by BT325 cells

2002 • 15 citations

Nitric oxide and changes of iron metabolism in exercise

2002 • 15 citations

Ceruloplasmin expression and its role in iron transport in C6 cells

2007 • 14 citations

Pantothenate kinase-associated neurodegeneration initially presenting as postural tremor alone in a Japanese family with homozygous N245S substitutions in the pantothenate kinase gene

2004 • 14 citations

Regulation of Hfe by stress factors in BV-2 cells

2004 • 13 citations

Increased accumulation of transferrin by motor neurons of the mouse mutant progressive motor neuronopathy (pmn/pmn)

1995 • 11 citations

Transferrin-bound iron uptake by the cultured cerebellar granule cells

1998 • 10 citations

New genes reveal major role for iron in neurodegeneration

2001 • 10 citations

Cerebellar granule cells acquire transferrin-free iron by a carrier-mediated process

1999 • 6 citations