Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene

1997 • 1,178 citations

Natural resistance to infection with intracellular parasites: Isolation of a candidate for Bcg

1993 • 1,107 citations

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

1998 • 946 citations

Purification and characterization of (Na+ + K+)-ATPase III. Purification from the outer medulla of mammalian kidney after selective removal of membrane components by sodium dodecylsulphate

1974 • 936 citations

Variations in theNRAMP1Gene and Susceptibility to Tuberculosis in West Africans

1998 • 736 citations

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1997 • 697 citations

Identification, developmental regulation, and response to heat shock of two antigenically related forms of a major nuclear envelope protein in Drosophila embryos: application of an improved method for affinity purification of antibodies using polypeptides immobilized on nitrocellulose blots

1984 • 668 citations

The Ity/Lsh/Bcg locus: natural resistance to infection with intracellular parasites is abrogated by disruption of the Nramp1 gene.

1995 • 603 citations

Natural Resistance to Infection with Intracellular Pathogens: The Nramp1 Protein Is Recruited to the Membrane of the Phagosome

1997 • 438 citations

Nramp2 is mutated in the anemic Belgrade (b) rat : evidence of a role for Nramp2 in endosomal iron transport

1998 • 410 citations

Nramp defines a family of membrane proteins.

1995 • 355 citations

A yeast manganese transporter related to the macrophage protein involved in conferring resistance to mycobacteria.

1996 • 330 citations

The Human Nramp2 Gene: Characterization of the Gene Structure, Alternative Splicing, Promoter Region and Polymorphisms

1998 • 314 citations

The Iron Transport Protein NRAMP2 Is an Integral Membrane Glycoprotein That Colocalizes with Transferrin in Recycling Endosomes

1999 • 303 citations

Identification and characterization of a second mouse Nramp gene

1995 • 289 citations

Susceptibility to Leprosy Is Linked to the HumanNRAMP1Gene

1998 • 266 citations

Regulation of Iron Metabolism in Eukaryotes

1997 • 248 citations

Natural resistance to intracellular infections: Nramp1 encodes a membrane phosphoglycoprotein absent in macrophages from susceptible (Nramp1 D169) mouse strains.

1996 • 235 citations

Iron absorption.

1973 • 230 citations

The G185R Mutation Disrupts Function of the Iron Transporter Nramp2

1998 • 215 citations

Host Resistance to Intracellular Infection: Mutation of Natural Resistance-associated Macrophage Protein 1 (Nramp1) Impairs Phagosomal Acidification

1998 • 206 citations

Managed care for viruses

1997 • 203 citations

Molecular mechanisms of iron uptake in eukaryotes

1996 • 184 citations

Changes in Cu,Zn-Superoxide Dismutase, Cytochrome c Oxidase, Glutathione Peroxidase and Glutathione Transferase Activities in Copper-Deficient Mice and Rats

1991 • 177 citations

Active transport of iron by intestine: features of the two-step mechanism

1962 • 161 citations

Natural resistance to infection with intracellular parasites: molecular genetics identifies Nramp1 as the Bcg/Ity/Lsh locus

1995 • 158 citations

The Nramp1 Protein and Its Role in Resistance to Infection and Macrophage Function

1999 • 157 citations

Effects of Positive Iron Status at a Cellular Level

2009 • 149 citations

Infection Genomics:Nramp1as a Major Determinant of Natural Resistance to Intracellular Infections

1998 • 144 citations

Reduction of Fe(III) is required for uptake of nonheme iron by Caco-2 cells.

1995 • 132 citations

Resistance to intracellular infections: comparative genomic analysis of Nramp

1996 • 128 citations

Investigation of a role for reduction in ferric iron uptake by mouse duodenum

1992 • 124 citations

Functional Complementation of the Yeast Divalent Cation Transporter Family SMF by NRAMP2, a Member of the Mammalian Natural Resistance-associated Macrophage Protein Family

1997 • 116 citations

Cloning and characterization of a second human NRAMP gene on chromosome 12q13

1995 • 114 citations

Cell-specific and inducible Nramp1 gene expression in mouse macrophages in vitro and in vivo

1997 • 104 citations

Characterization of cell lines showing growth control isolated from both the wild type and a leucyl‐tRNA synthetase mutant of chinese hamster ovary cells

1979 • 100 citations

Membrane Topology of P-Glycoprotein As Determined by Epitope Insertion: Transmembrane Organization of the N-Terminal Domain of mdr3

1995 • 86 citations

Iron uptake by human upper small intestine microvillous membrane vesicles. Indication for a facilitated transport mechanism mediated by a membrane iron-binding protein.

1990 • 86 citations

Expression of the human NRAMP1 gene in professional primary phagocytes: studies in blood cells and in HL-60 promyelocytic leukemia

1997 • 85 citations

Iron transport across brush-border membranes from normal and iron-deficient mouse upper small intestine.

1984 • 82 citations

Defect of Intestinal Mucosal Iron Uptake in Mice with Hereditary Microcytic Anemia

1972 • 79 citations

The expression of mouse biliary glycoprotein, a carcinoembryonic antigen-related gene, is down-regulated in malignant mouse tissues.

1993 • 77 citations

Optimal ratios of biliary glycoprotein isoforms required for inhibition of colonic tumor cell growth.

1997 • 75 citations

Regional specificity of iron uptake by small intestinal brush-border membranes from normal and iron-deficient mice

1985 • 73 citations

Recently Identified Molecular Aspects of Intestinal Iron Absorption

1998 • 70 citations

Function of integrin in duodenal mucosal uptake of iron

1993 • 70 citations

The effect of Escherichia coli STa enterotoxin and other secretagogues on mucosal surface pH of rat small intestine in vivo

1988 • 69 citations

Iron uptake by rat duodenal microvillous membrane vesicles: evidence for a carrier mediated transport system

1987 • 63 citations

Small intestinal regulation of iron absorption in the rat.

1987 • 61 citations

Expression of the Bgp gene and characterization of mouse colon biliary glycoprotein isoforms

1993 • 61 citations

Defective iron uptake by the duodenum of Belgrade rats fed diets of different iron contents

1996 • 61 citations

The iron responsive element (IRE) family of mRNA regulators. Regulation of iron transport and uptake compared in animals, plants, and microorganisms.

1998 • 60 citations

Role of redox systems on Fe3+ uptake by transformed human intestinal epithelial (Caco-2) cells

1994 • 60 citations

Characterization and Genetic Studies of Microcytic Anemia in House Mouse

1970 • 57 citations

Iron regulatory proteins 1 and 2

1996 • 56 citations

Diminished iron acquisition by cells and tissues of Belgrade laboratory rats

1992 • 53 citations

THE CONTROL OF IRON ABSORPTION

1968 • 52 citations

Iron supplementation moderates but does not cure the Belgrade anemia.

1997 • 48 citations

Activation of NMDA receptors is necessary for the induction of associative long‐term potentiation in area CA1 of the rat hippocampal slice

1997 • 48 citations

Metabolism of copper 67 by the copper-deficient rat

1971 • 48 citations

Genetic defects of iron transport.

1976 • 45 citations

Adaptive Response of Iron Absorption to Anemia, Increased Erythropoiesis, Iron Deficiency, and Iron Loading in β2-Microglobulin Knockout Mice

1998 • 45 citations

Absorption of Iron

1970 • 43 citations

Molecular genetics and control of iron metabolism in hemochromatosis.

1998 • 36 citations

Characterization ofmsim,a Murine Homologue of theDrosophila simTranscription Factor

1996 • 36 citations

Mechanisms involved in increased iron uptake across rat duodenal brush‐border membrane during hypoxia.

1997 • 32 citations

Mapping the Gene for Sex-Linked Anemia: An Inherited Defect of Intestinal Iron Absorption in the Mouse

1998 • 31 citations

Biliary glycoprotein 1 expression during embryogenesis: Correlation with events of epithelial differentiation, mesenchymal-epithelial interactions, absorption, and myogenesis

1996 • 30 citations

Effects of dietary iron loading with carbonyl iron and of iron depletion on intestinal growth, morphology, and expression of transferrin receptor in the rat

1996 • 28 citations

Structure and Function of Ires, the Noncoding mRNA Sequences Regulating Synthesis of Ferritin, Transferrin Receptor and (Erythroid) 5-Aminolevulinate Synthase

1994 • 21 citations

The valency state of absorbed iron appearing in the portal blood and ceruloplasmin substitution

1990 • 20 citations

Biochemistry of nonheme iron in man. II. Absorption of iron.

1989 • 19 citations

Fe2+ uptake by mouse intestinal mucosa in vivo and by isolated intestinal brush-border membrane vesicles

1986 • 19 citations

Uptake of circulating iron by the duodenum of normal mice and mice with altered iron stores, including sex-linked anemia: high resolution radioautographic study.

1976 • 19 citations

Characterization of isolated duodenal epithelial cells along a cryptvillus axis in rats fed diets with different iron content

1997 • 14 citations

The kinetics of iron uptake by isolated intestinal cells from normal mice and mice with sex-linked anemia

1982 • 14 citations

A model of intestinal iron absorption and plasma iron kinetics: Optimal parameter estimates for normal dogs

1984 • 12 citations

Hemochromatosis-Related Mutation Detection

1998 • 12 citations

Indication for a Facilitated Transport Mechanism Mediated by a Membrane Iron-binding Protein

1990 • 9 citations

Characteristics of Iron Binding to Solubilized Brush Border Membrane of the Rat Intestine.

1995 • 8 citations