Multiple, diverse senile plaque–associated proteins are ligands of an apolipoprotein e receptor, the α₂‐macroglobulin receptor/low‐density‐lipoprotein receptor—related protein

Alzheimer's disease: Initial report of the purification and characterization of a novel cerebrovascular amyloid protein

1984 • 5,166 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Amyloid β-peptide is produced by cultured cells during normal metabolism

1992 • 1,888 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Isolation and quantification of soluble Alzheimer's β-peptide from biological fluids

1992 • 1,701 citations

Amyloid β Protein Gene: cDNA, mRNA Distribution, and Genetic Linkage Near the Alzheimer Locus

1987 • 1,589 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Production of the Alzheimer Amyloid β Protein by Normal Proteolytic Processing

1992 • 1,438 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Characterization and Chromosomal Localization of a cDNA Encoding Brain Amyloid of Alzheimer's Disease

1987 • 1,316 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

1993 • 1,092 citations

Apolipoprotein E polymorphism and Alzheimer's disease

1993 • 1,076 citations

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

Immunochemical identification of the serine protease inhibitor α1-antichymotrypsin in the brain amyloid deposits of Alzheimer's disease

1988 • 899 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Lipoproteins and their receptors in the central nervous system. Characterization of the lipoproteins in cerebrospinal fluid and identification of apolipoprotein B,E(LDL) receptors in the brain.

1987 • 696 citations

The LDL–receptor–related protein, LRP, is an apolipoprotein E-binding protein

1989 • 680 citations

Astrocytes synthesize apolipoprotein E and metabolize apolipoprotein E-containing lipoproteins

1987 • 666 citations

Sequence identity between the alpha 2-macroglobulin receptor and low density lipoprotein receptor-related protein suggests that this molecule is a multifunctional receptor.

1990 • 666 citations

Low density lipoprotein receptor-related protein mediates uptake of cholesteryl esters derived from apoprotein E-enriched lipoproteins.

1989 • 600 citations

39-kDa protein modulates binding of ligands to low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1991 • 586 citations

Aggregation and secondary structure of synthetic amyloid βA4 peptides of Alzheimer's disease

1991 • 580 citations

Generation of beta-amyloid in the secretory pathway in neuronal and nonneuronal cells.

1993 • 557 citations

Interleukin‐6 and α‐2‐macroglobulin indicate an acute‐phase state in Alzheimer's disease cortices

1991 • 484 citations

Synthetic peptide homologous to beta protein from Alzheimer disease forms amyloid-like fibrils in vitro.

1987 • 475 citations

Low density lipoprotein receptor-related protein and gp330 bind similar ligands, including plasminogen activator-inhibitor complexes and lactoferrin, an inhibitor of chylomicron remnant clearance.

1992 • 466 citations

Purified alpha 2-macroglobulin receptor/LDL receptor-related protein binds urokinase.plasminogen activator inhibitor type-1 complex. Evidence that the alpha 2-macroglobulin receptor mediates cellular degradation of urokinase receptor-bound complexes.

1992 • 464 citations

Immunoglobulins and complement factors in senile plaques

1982 • 427 citations

The presence of heparan sulfate proteoglycans in the neuritic plaques and congophilic angiopathy in Alzheimer's disease.

1988 • 410 citations

Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

1992 • 385 citations

A novel mechanism for controlling the activity of alpha 2-macroglobulin receptor/low density lipoprotein receptor-related protein. Multiple regulatory sites for 39-kDa receptor-associated protein.

1992 • 341 citations

Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth

1988 • 337 citations

Alzheimer's disease : basic mechanisms, diagnosis and therapeutic strategies

1991 • 327 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor is an hepatic receptor for tissue-type plasminogen activator.

1992 • 318 citations

Proteolytic processing of the 600 kd low density lipoprotein receptor-related protein (LRP) occurs in a trans-Golgi compartment.

1990 • 279 citations

Complexes of tissue-type plasminogen activator and its serpin inhibitor plasminogen-activator inhibitor type 1 are internalized by means of the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor.

1992 • 244 citations

The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2-macroglobulin receptor and glycoprotein 330.

1992 • 190 citations

Analysis of ligand recognition by the purified alpha 2-macroglobulin receptor (low density lipoprotein receptor-related protein). Evidence that high affinity of alpha 2-macroglobulin-proteinase complex is achieved by binding to adjacent receptors

1991 • 186 citations

Low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor mediates cellular uptake of pro-urokinase.

1993 • 186 citations

Characterization and immunohistochemical localization of alpha 2-macroglobulin receptor (low-density lipoprotein receptor-related protein) in human brain.

1992 • 177 citations

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

1993 • 167 citations

Kunitz Protease Inhibitor-Containing Amyloid β Protein Precursor Immunoreactivity in Alzheimer's Disease

1992 • 137 citations

Frequency of the apolipoprotein E ε2 allele is diminished in sporadic Alzheimer disease

1994 • 126 citations

Alzheimer's Disease: A Description of the Structural Lesions

1991 • 113 citations

α2-macroglobulin expression in neuritic-type plaques in patients with Alzheimer's disease

1993 • 101 citations

Localization of mRNA for low density lipoprotein receptor and a cholesterol synthetic enzyme in rabbit nervous system by in situ hybridization.

1988 • 81 citations

Immunohistochemical study of α2 Macroglobulin receptor in Alzheimer and control postmortem human brain

1993 • 70 citations

α1-Trypsin Immunoreactivity in Alzheimer Disease

1993 • 28 citations