The ferritins: molecular properties, iron storage function and cellular regulation

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

Oxygen toxicity, oxygen radicals, transition metals and disease

1984 • 5,301 citations

Nitric oxide as a secretory product of mammalian cells

1992 • 4,437 citations

FERRITIN: STRUCTURE, GENE REGULATION, AND CELLULAR FUNCTION IN ANIMALS, PLANTS, AND MICROORGANISMS

1987 • 1,305 citations

Microbial Iron Compounds

1981 • 1,246 citations

Regulating the fate of mRNA: The control of cellular iron metabolism

1993 • 1,233 citations

Ferritin: a cytoprotective antioxidant strategem of endothelium.

1992 • 1,100 citations

Crystal structure of a bacterial non-haem iron hydroxylase that catalyses the biological oxidation of methane

1993 • 904 citations

Three-dimensional structure of the free radical protein of ribonucleotide reductase

1990 • 833 citations

Solving the structure of human H ferritin by genetically engineering intermolecular crystal contacts

1991 • 748 citations

Iron metabolism in man

1979 • 726 citations

Iron-Responsive Elements: Regulatory RNA Sequences That Control mRNA Levels and Translation

1988 • 707 citations

Iron transport in microbes, plants and animals

1988 • 604 citations

A stem-loop in the 3′ untranslated region mediates iron-dependent regulation of transferrin receptor mRNA stability in the cytoplasm

1988 • 565 citations

Magnetoferritin: in Vitro Synthesis of a Novel Magnetic Protein

1992 • 560 citations

Ferritin: design and formation of an iron-storage molecule

1984 • 559 citations

Biomineralization: chemical and biochemical perspectives

1990 • 553 citations

Identification of the Iron-Responsive Element for the Translational Regulation of Human Ferritin mRNA

1987 • 547 citations

Ferritin and superoxide-dependent lipid peroxidation.

1985 • 532 citations

A specific mRNA binding factor regulates the iron-dependent stability of cytoplasmic transferrin receptor mRNA

1989 • 511 citations

Trace Elements in Human Tissue Part II. Adult Subjects from the United States

1963 • 507 citations

On ferritin heterogeneity. Further evidence for heteropolymers.

1978 • 464 citations

Structure and Function of the Escherichia coli Ribonucleotide Reductase Protein R2

1993 • 462 citations

Oxo‐Bridged Polyiron Centers in Biology and Chemistry

1988 • 460 citations

Nitric oxide as an antioxidant

1991 • 441 citations

Inorganic Biochemistry of Iron Metabolism

2001 • 439 citations

Molecular mechanism of regulation of siderophore-mediated iron assimilation

1987 • 414 citations

Oxidative stress resulting from ultraviolet A irradiation of human skin fibroblasts leads to a heme oxygenase-dependent increase in ferritin

1993 • 394 citations

Translational regulation via iron-responsive elements by the nitric oxide/NO-synthase pathway.

1993 • 393 citations

Iron mobilization from ferritin by superoxide derived from stimulated polymorphonuclear leukocytes. Possible mechanism in inflammation diseases.

1984 • 392 citations

Oxidation-Reduction and the Molecular Mechanism of a Regulatory RNA-Protein Interaction

1989 • 387 citations

Biomineralization : Chemical and Biochemical Perspectives

1989 • 379 citations

Human erythroid 5-aminolevulinate synthase: promoter analysis and identification of an iron-responsive element in the mRNA.

1991 • 374 citations

Iron regulates ferritin mRNA translation through a segment of its 5' untranslated region.

1987 • 365 citations

Binding of a Cytosolic Protein to the Iron-Responsive Element of Human Ferritin Messenger RNA

1988 • 363 citations

Iron transport in microbes, plants, and animals

1987 • 359 citations

Ferritin as a source of iron for oxidative damage

1992 • 359 citations

Ferritin in Serum

1975 • 352 citations

Identification of a novel iron-responsive element in murine and human erythroid delta-aminolevulinic acid synthase mRNA.

1991 • 349 citations

Regulation of ferritin and transferrin receptor mRNAs.

1990 • 339 citations

Iron regulation of transferrin receptor mRNA levels requires iron-responsive elements and a rapid turnover determinant in the 3′ untranslated region of the mRNA.

1989 • 334 citations

Rapid responses to oxidative stress mediated by iron regulatory protein.

1995 • 331 citations

Regulation of Synthesis and Turnover of Ferritin in Rat Liver

1966 • 329 citations

Structure, function, and evolution of ferritins

1992 • 323 citations

Induction of Ferritin Synthesis by Oxidative Stress

1995 • 321 citations

Identification of the ferroxidase centre in ferritin

1989 • 297 citations

The molecular cloning and characterization of murine ferritin heavy chain, a tumor necrosis factor-inducible gene.

1988 • 295 citations

Mutation in the iron responsive element of the L ferritin mRNA in a family with dominant hyperferritinaemia and cataract

1995 • 294 citations

Nitric oxide mediates iron release from ferritin

1990 • 290 citations

Iron regulatory protein prevents binding of the 43S translation pre-initiation complex to ferritin and eALAS mRNAs.

1994 • 273 citations

Evidence of H- and L-chains have co-operative roles in the iron-uptake mechanism of human ferritin

1992 • 270 citations

Translational control during the acute phase response. Ferritin synthesis in response to interleukin-1.

1990 • 264 citations

Siderophore mediated absorption of iron

2007 • 263 citations

Iron regulates cytoplasmic levels of a novel iron-responsive element-binding protein without aconitase activity.

1994 • 262 citations

A cis-acting element is necessary and sufficient for translational regulation of human ferritin expression in response to iron.

1987 • 250 citations

Long term results of venesection therapy in idiopathic haemochromatosis.

1976 • 247 citations

The formation of ferritin from apoferritin. Kinetics and mechanism of iron uptake

1972 • 244 citations

Hereditary ceruloplasmin deficiency with hemosiderosis: A clinicopathological study of a japanese family

1995 • 242 citations

Classical and Quantum Magnetic Phenomena in Natural and Artificial Ferritin Proteins

1995 • 240 citations

Structural and functional relationships of human ferritin H and L chains deduced from cDNA clones.

1985 • 239 citations

Noncoding 3′ sequences of the transferrin receptor gene are required for mRNA regulation by iron.

1987 • 220 citations

Induction of ferritin subunit synthesis by iron is regulated at both the transcriptional and translational levels.

1988 • 214 citations

Methodology of siderophores

2007 • 212 citations

Engineering of protein bound iron‐sulfur clusters

1989 • 211 citations

Translational control of 5-aminolevulinate synthase mRNA by iron-responsive elements in erythroid cells.

1993 • 210 citations

Structure of a unique twofold symmetric haem-binding site

1994 • 209 citations

Iron regulatory elements (IREs): a family of mRNA non-coding sequences

1994 • 207 citations

Ferric Oxyhydroxide Core of Ferritin

1967 • 202 citations

Molecular basis for the recently described hereditary hyperferritinemia- cataract syndrome: a mutation in the iron-responsive element of ferritin L-subunit gene (the "Verona mutation") [see comments]

1995 • 200 citations

Identification of leukemia-associated inhibitory activity as acidic isoferritins. A regulatory role for acidic isoferritins in the production of granulocytes and macrophages.

1981 • 194 citations

Role for NF-κB in the Regulation of Ferritin H by Tumor Necrosis Factor-α

1995 • 188 citations

Resonance Raman Evidence for an Fe-O-Fe Center in Stearoyl-ACP Desaturase. Primary Sequence Identity with Other Diiron-Oxo Proteins

1994 • 184 citations

Homology between IRE-BP, a regulatory RNA-binding protein, aconitase, and isopropylmalate isomerase

1991 • 183 citations

The structure of aconitase

1989 • 183 citations

The release of iron from horse spleen ferritin by reduced flavins

1974 • 182 citations

Manipulations of cellular iron metabolism for modulating normal and malignant cell proliferation: achievements and prospects

1990 • 181 citations

Mutational analysis of the [4Fe-4S]-cluster converting iron regulatory factor from its RNA-binding form to cytoplasmic aconitase.

1994 • 176 citations

The Role of the L-Chain in Ferritin Iron Incorporation

1994 • 175 citations

Azotobacter cytochrome b557.5 is a bacterioferritin

1979 • 175 citations

Ultrastructure of ferritin and apoferritin: A review

1993 • 171 citations

Reductive mobilisation of ferritin iron

1985 • 170 citations

Characterization of a second RNA-binding protein in rodents with specificity for iron-responsive elements.

1993 • 169 citations

Evidence for conservation of ferritin sequences among plants and animals and for a transit peptide in soybean.

1990 • 168 citations

Iron induces ferritin synthesis in maize plantlets

1992 • 168 citations

Inhibition of superoxide and ferritin-dependent lipid peroxidation by ceruloplasmin

1989 • 164 citations

Regulation of Interaction of the Iron-Responsive Element Binding Protein with Iron-Responsive RNA Elements

1989 • 164 citations

Iron storage in Saccharomyces cerevisiae

1988 • 163 citations

Production and characterization of recombinant heteropolymers of human ferritin H and L chains

1993 • 162 citations

Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactorof E. coli Ribonucleotide Reductase. 3. Kinetics of the Limiting Fe2+ Reaction by Optical, EPR, and Moessbauer Spectroscopies

1994 • 160 citations

Free manganese(II) and iron(II) cations can act as intracellular cell controls

1982 • 159 citations

Structure and composition of ferritin cores isolated from human spleen, limpet (Patella vulgata) hemolymph and bacterial (Pseudomonas aeruginosa) cells

1986 • 158 citations

Differences in the regulation of messenger RNA for housekeeping and specialized-cell ferritin. A comparison of three distinct ferritin complementary DNAs, the corresponding subunits, and identification of the first processed in amphibia.

1987 • 156 citations

Modulation of iron metabolism in monocyte cell line U937 by inflammatory cytokines: changes in transferrin uptake, iron handling and ferritin mRNA

1993 • 153 citations

Optimal sequence and structure of iron-responsive elements. Selection of RNA stem-loops with high affinity for iron regulatory factor

1994 • 153 citations

Influence of site-directed modifications on the formation of iron cores in ferritin

1991 • 152 citations

A Mixed-Valent Polyiron Oxo Complex that Models the Biomineralization of the Ferritin Core

1993 • 150 citations

Mössbauer spectroscopic investigation of structure-function relations in ferritins

1991 • 150 citations

Translational repression by a complex between the iron-responsive element of ferritin mRNA and its specific cytoplasmic binding protein is position-dependent in vivo.

1990 • 147 citations

FERRITIN

1943 • 141 citations

The Trapping of Iron Hydroxide Units by the Ligand “heidi”: Two New Hydroxo(oxo)iron Clusters Containing 19 and 17 Iron Atoms

1992 • 140 citations

Position Is the Critical Determinant for Function of Iron-Responsive Elements as Translational Regulators

1992 • 138 citations

Purification of a Specific Repressor of Ferritin mRNA Translation from Rabbit Liver

1989 • 138 citations

Evidence that a salt bridge in the light chain contributes to the physical stability difference between heavy and light human ferritins.

1992 • 137 citations

The composition and the structure of bacterioferritin of Escherichia coli

1981 • 136 citations

Interleukin 1 induces ferritin heavy chain in human muscle cells

1990 • 135 citations

Interactions between isolated hepatocytes and kupffer cells in iron metabolism: A possible role for ferritin as an iron carrier protein

1988 • 134 citations

Translational regulation by mRNA/protein interactions in eukaryotic cells: Ferritin and beyond

1993 • 134 citations

Iron-Dependent Regulation of Ferritin and Transferrin Receptor Expression by the Iron-Responsive Element Binding Protein

1992 • 132 citations

Release of iron from ferritin by xanthine oxidase. Role of the superoxide radical

1987 • 132 citations

Structure of gene and pseudogenes of human apoferritin H

1986 • 132 citations

Defining the roles of the threefold channels in iron uptake, iron oxidation and iron-core formation in ferritin: a study aided by site-directed mutagenesis

1993 • 131 citations

Adaptive responses of rat tissue isoferritins to iron administration. Changes in subunit synthesis, isoferritin abundance, and capacity for iron storage.

1981 • 131 citations

The Role of Endocytosis in Transferrin Uptake by Reticulocytes and Bone Marrow Cells

1977 • 128 citations

Incorporation and release of inorganic phosphate in horse spleen ferritin

1978 • 128 citations

Substitution of manganese for iron in ribonucleotide reductase from Escherichia coli. Spectroscopic and crystallographic characterization.

1992 • 128 citations

Expression and structural and functional properties of human ferritin L-chain from Escherichia coli

1989 • 127 citations

Amino acid sequence of horse spleen apoferritin

1981 • 127 citations

High Resolution Crystal Structures of Amphibian Red-Cell L Ferritin: Potential Roles for Structural Plasticity and Solvation in Function

1995 • 127 citations

Evidence that the specificity of iron incorporation into homopolymers of human ferritin L- and H-chains is conferred by the nucleation and ferroxidase centres

1996 • 126 citations

Binding to cellular receptors results in increased iron release from transferrin at mildly acidic pH

1991 • 125 citations

Low-Mr iron isolated from guinea pig reticulocytes as AMP-Fe and ATP-Fe complexes

1989 • 125 citations

The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution

1990 • 125 citations

Reconstituted and native iron-cores of bacterioferritin and ferritin

1987 • 124 citations

Regulation of iron metabolism in HepG2 cells: A possible role for cytokines in the hepatic deposition of iron

1993 • 123 citations

Iron oxidation chemistry in ferritin. Increasing Fe/O2 stoichiometry during core formation.

1991 • 123 citations

Ferrous iron transport mutants inEscherichia coliK12

1987 • 122 citations

Mössbauer spectroscopic studies of the cores of human, limpet and bacterial ferritins

1986 • 121 citations

Uptake of iron from transferrin by isolated rat hepatocytes. A redox-mediated plasma membrane process?

1988 • 121 citations

Coordmation of cellular iron metabolism by post-transcriptional gene regulation

1992 • 121 citations

Mechanism of Assembly of the Tyrosyl Radical-Diiron(III) Cofactor of E. coli Ribonucleotide Reductase. 2. Kinetics of The Excess Fe2+ Reaction by Optical, EPR, and Moessbauer Spectroscopies

1994 • 120 citations

Multiple mechanisms of iron-induced ferritin synthesis in HeLa cells

1985 • 119 citations

Derepression of Ferritin Mmessenger RNA Translation by Hemin in Vitro

1990 • 118 citations

Identification of the EPR-Active Iron-Nitrosyl Complexes in Mammalian Ferritins

1994 • 117 citations

Iron and aluminium in relation to brain ferritin in normal individuals and Alzheimer's-disease and chronic renal-dialysis patients

1992 • 117 citations

Release of iron from ferritin by cardiotoxic anthracycline antibiotics

1986 • 115 citations

On the limited ability of superoxide to release iron from ferritin

1990 • 114 citations

A linkage between hereditary hyperferritinaemia not related to iron overload and autosomal dominant congenital cataract

1995 • 114 citations

Probing Structure-Function Relations In Ferritin And Bacterioferritin

1991 • 114 citations

Structural requirements of iron-responsive elements for binding of the protein involved in both transferrin receptor and ferritin mRNA post-transcriptional regulation

1990 • 114 citations

The catalytic activity of horse spleen apoferritin. Preliminary kinetic studies and the effect of chemical modification

1973 • 113 citations

Isolation and Characterization of Iron‐Binding Proteins from Rat Intestinal Mucosa

1976 • 113 citations

Determinants of the interaction between the iron-responsive element-binding protein and its binding site in rat L-ferritin mRNA.

1990 • 112 citations

Iron binding by horse spleen apoferritin. A vanadyl(IV) EPR spin probe study.

1982 • 111 citations

Cloning, sequencing, and mapping of the bacterioferritin gene (bfr) of Escherichia coli K-12

1989 • 110 citations

Metal ion homeostasis: Molecular biology and chemistry

1988 • 110 citations

Detection and isolation of a hepatic membrane receptor for ferritin.

1983 • 109 citations

Tumor necrosis factor-alpha and interleukin 1-alpha regulate transferrin receptor in human diploid fibroblasts. Relationship to the induction of ferritin heavy chain.

1991 • 108 citations

Inorganic biochemistry of iron metabolism

1992 • 108 citations

Iron incorporation into apoferritin. The role of apoferritin as a ferroxidase.

1986 • 107 citations

Ferritin Synthesis in Inflammation: II. MECHANISM OF INCREASED FERRITIN SYNTHESIS

1981 • 107 citations

Characterization of Serum Ferritin in Iron Overload: Possible Identity to Natural Apoferritin

1977 • 106 citations

Iron Up-modulates the Expression of Transferrin Receptors during Monocyte-Macrophage Maturation

1989 • 105 citations

Cloning of the gene coding for human L apoferritin

1986 • 104 citations

Translational control of ferritin synthesis by iron in embryonic reticulocytes of the bullfrog.

1982 • 104 citations

Modification of a free Fe-S cluster cysteine residue in the active iron-responsive element-binding protein prevents RNA binding.

1993 • 103 citations

Iron environment in ferritin with large amounts of phosphate, from Azotobacter vinelandii and horse spleen, analyzed using extended x-ray absorption fine structure (EXAFS)

1990 • 102 citations

Assignment of human ferritin genes to chromosomes 11 and 19q13.3→19qter

1985 • 100 citations

Mössbauer spectroscopy of Escherichia coli and its iron-storage protein

1980 • 99 citations

Transcriptional regulation of ferritin H and L subunits in adult erythroid and liver cells from the mouse

1989 • 99 citations

Amino-acid sequence and predicted three-dimensional structure of pea seed (Pisum sativum) ferritin

1992 • 97 citations

Metal ion complexes of apoferritin. Evidence for initial binding in the hydrophilic channels.

1986 • 97 citations

Ferroxidase kinetics of human liver apoferritin, recombinant H-chain apoferritin, and site-directed mutants

1993 • 97 citations

Mechanism of the Transition from Plant Ferritin to Phytosiderin

1989 • 97 citations

Immunochemical characterization of human liver and heart ferritins with monoclonal antibodies

1986 • 97 citations

Iron assimilation storage in prokaryotes

1992 • 96 citations

Redox properties and Moessbauer spectroscopy of Azotobacter vinelandii bacterioferritin

1986 • 96 citations

Direct observation of the iron binding sites in a ferritin

1994 • 95 citations

Characterization and evolution of the expressed rat ferritin light subunit gene and its pseudogene family. Conservation of sequences within noncoding regions of ferritin genes.

1987 • 95 citations

Abscisic acid is involved in the iron-induced synthesis of maize ferritin.

1993 • 95 citations

Ferritin and hemosiderin in pathological tissues

1992 • 95 citations

Overexpression of the ferritin H subunit in cultured erythroid cells changes the intracellular iron distribution

1996 • 95 citations

Regulation of interaction of the iron-responsive element binding protein with iron-responsive RNA elements.

1989 • 94 citations

Iron regulatory factor expressed from recombinant baculovirus: conversion between the RNA-binding apoprotein and Fe-S cluster containing aconitase

1993 • 93 citations

Induction of ferritin synthesis in maize leaves by an iron‐mediated oxidative stress

1995 • 93 citations

Bis-methionine axial ligation of haem in bacterioferritin from Pseudomonas aeruginosa

1990 • 92 citations

An iron-sulfur cluster plays a novel regulatory role in the iron-responsive element binding protein

1992 • 89 citations

Ferroxidase kinetics of horse spleen apoferritin.

1992 • 89 citations

Site-directed Replacement of the Coaxial Heme Ligands of Bacterioferritin Generates Heme-free Variants

1995 • 89 citations

Iron detoxifying activity of ferritin

1990 • 88 citations

Receptor-modulated iron release from transferrin: differential effects on N- and C-terminal sites

1991 • 88 citations

Paracrystalline inclusions of a novel ferritin containing nonheme iron, produced by the human gastric pathogen Helicobacter pylori: evidence for a third class of ferritins

1993 • 87 citations

Iron release and uptake by plant ferritin: effects of pH, reduction and chelation

1993 • 87 citations

Dioxygen is the source of the mu-oxo bridge in iron ribonucleotide reductase.

1994 • 87 citations

Iron (II) oxidation and early intermediates of iron-core formation in recombinant human H-chain ferritin

1993 • 87 citations

Structure and expression of the chicken ferritin H-subunit gene.

1987 • 85 citations

A high yield affinity purification method for specific RNA-binding proteins: isolation of the iron regulatory factor from human placenta

1990 • 85 citations

Moessbauer spectroscopic study of the initial stages of iron-core formation in horse spleen apoferritin: evidence for both isolated iron(III) atoms and oxo-bridged iron(III) dimers as early intermediates

1989 • 84 citations

Kinetic and structural characterization of an intermediate in the biomineralization of bacterioferritin

1993 • 84 citations

Mechanism of catalysis of Fe(II) oxidation by ferritin H chains

1992 • 84 citations

Iron(II) Oxidation by H Chain Ferritin: Evidence from Site-Directed Mutagenesis That a Transient Blue Species Is Formed at the Dinuclear Iron Center

1995 • 83 citations

Mutagenesis of the iron-regulatory element further defines a role for RNA secondary structure in the regulation of ferritin and transferrin receptor expression.

1992 • 83 citations

Identification of the ferroxidase centre of Escherichia coli bacterioferritin

1995 • 82 citations

Formation of an Fe(III)-Tyrosinate Complex During Biomineralization of H-Subunit Ferritin

1993 • 81 citations

Overproduction, purification and characterization of the Escherichia coli ferritin

1993 • 81 citations

Ferritin: Iron incorporation and iron release

1970 • 81 citations

Structure and Differential Expression of two Maize Ferritin Genes in Response to Iron and Abscisic Acid

1995 • 80 citations

Formation of iron(III)-tyrosinate is the fastest reaction observed in ferritin

1993 • 79 citations

The iron-responsive element binding protein. Purification, cloning, and regulation in rat liver.

1992 • 78 citations

Position is the critical determinant for function of iron-responsive elements as translational regulators.

1992 • 77 citations

In vivo and in vitro modulation of the mRNA‐binding activity of iron‐regulatory factor

1992 • 77 citations

Ferritin and ceruloplasmin in oxidative damage: review and recent findings

1993 • 76 citations

Differential turnover of rat liver isoferritins.

1980 • 76 citations

Transcriptional Regulation of Ferritin Messenger Ribonucleic Acid Levels by Insulin in Cultured Rat Glioma Cells

1991 • 76 citations

cDNA cloning and deduced amino acid sequence of two ferritins: soma ferritin and yolk ferritin, from the snail Lymnaea stagnalis L.

1994 • 75 citations

Isolation of a human hepatic ferritin receptor

1988 • 75 citations

Iron regulates the activity of the iron-responsive element binding protein without changing its rate of synthesis or degradation.

1992 • 75 citations

Cellular pharmacology of deferrioxamine B and derivatives in cultured rat hepatocytes in relation to iron mobilization

1985 • 74 citations

Tyrosyl free radical formation in the small subunit of mouse ribonucleotide reductase.

1990 • 73 citations

Rapid mobilization of ferritin iron by ascorbate in the presence of oxygen

1980 • 73 citations

The formation of ferritin from apoferritin. Catalytic action of apoferritin

1973 • 73 citations

Tumor cell heme uptake induces ferritin synthesis resulting in altered oxidant sensitivity: possible role in chemotherapy efficacy.

1993 • 72 citations

Biochemistry of Nonheme Iron

1981 • 71 citations

Recombinant H‐chain ferritins: Effects of changes in the 3‐fold channels

1989 • 71 citations

Iron regulatory factor — the conductor of cellular iron regulation

1993 • 70 citations

Specific binding sites for H-ferritin on human lymphocytes: modulation during cellular proliferation and potential implication in cell growth control

1991 • 69 citations

Iron deposition in apoferritin. Evidence for the formation of a mixed valence binuclear iron complex.

1985 • 69 citations

Expression of active iron regulatory factor from a full length human cDNA byin vitrotranscription/translation

1992 • 69 citations

FERRITIN

1943 • 69 citations

Differential regulation of two related RNA-binding proteins, iron regulatory protein (IRP) and IRPB.

1995 • 69 citations

The anion requirement for iron release from transferrin is preserved in the receptor-transferrin complex

1993 • 68 citations

The induction and distribution of an insect ferritin — A new function for the endoplasmic reticulum

1984 • 68 citations

Spectroscopic studies on the binding of Iron, Terbium, and Zinc by Apoferritin

1984 • 68 citations

Biochemical studies on the isolation and characterization of human spleen haemosiderin

1984 • 68 citations

Human serum ferritin G-peptide is recognized by anti-L ferritin subunit antibodies and concanavalin-A

1987 • 68 citations

Multiple red cell ferritin mRNAs, which code for an abundant protein in the embryonic cell type, analyzed by cDNA sequence and by primer extension of the 5'-untranslated regions.

1986 • 68 citations

Structure of the 5' untranslated regulatory region of ferritin mRNA studied in solution

1990 • 67 citations

Studies of iron overload. Rat liver siderosome ferritin.

1984 • 67 citations

A new synthetic approach to the ferritin core uncovers the soluble iron(III) oxo-hydroxo aggregate [Fe11O6(OH)6(O2CPh)15]

1986 • 66 citations

Immunohistochemical evidence for a lack of ferritin in duodenal absorptive epithelial cells in idiopathic hemochromatosis

1989 • 66 citations

Structural distinction between ferritin and iron-dextran (imferon). An electron diffraction comparison.

1981 • 66 citations

The genetics of haemochromatosis

1988 • 66 citations

Ferritin in Human Liver Cells of Homozygous Beta‐Thalassaemia: Ultrastructural Observations

1977 • 66 citations

Release of iron from diferric transferrin in the presence of rat liver plasma membranes: No evidence of a plasma membrane diferric transferrin reductase

1990 • 66 citations

Functional roles of the ferritin receptors of human liver, hepatoma, lymphoid and erythroid cells

1992 • 66 citations

The Influence of the Base-paired Flanking region on Structure and Function of the Ferritin mRNA Iron Regulatory Element

1993 • 66 citations

Self-assembly of apoferritin from horse spleen after reversible chemical modification with 2,3-dimethylmaleic anhydride

1988 • 65 citations

Effect of nitric oxide on expression of transferrin receptor and ferritin and on cellular iron metabolism in K562 human erythroleukemia cells

1995 • 65 citations

Overproduction, purification and characterization of the bacterioferritin of Escherichia coli and a C‐terminally extended variant

1993 • 65 citations

The structure of aPhaseolus vulgaris cDNA encoding the iron storage protein ferritin

1991 • 64 citations

Bacterioferritins and ferritins are distantly related in evolution Conservation of ferroxidase‐centre residues

1991 • 64 citations

A note on the composition and properties of ferritin iron cores

1987 • 64 citations

Ferritins of Schistosoma mansoni: sequence comparison and expression in female and male worms

1992 • 63 citations

Identification and characterization of a receptor for tissue ferritin on activated rat lipocytes.

1994 • 62 citations

FERRITIN IN THE FUNGUS PHYCOMYCES

1971 • 62 citations

The superoxide-dependent transfer of iron from ferritin to transferrin and lactoferrin

1988 • 61 citations

Characteristics and expression of binding sites specific for ferritin H- chain on human cell lines

1988 • 61 citations

Mössbauer spectroscopy, electron microscopy and electron diffraction studies of the iron cores in various human and animal haemosiderins

1988 • 60 citations

Iron Induction of Ferritin Synthesis in Soybean Cell Suspensions

1989 • 59 citations

Progress in Iron Research

1994 • 58 citations

Ferritin as an iron-storage protein: mechanisms of iron uptake

1986 • 58 citations

The IRE (iron regulatory element) family: structures which regulate mRNA translation or stability.

1993 • 57 citations

The formation of delta‐Aminolevulinate a precursor of chlorophyll, in barley and the role of iron

1982 • 57 citations

Reductive release of ferritin iron: A kinetic assay

1988 • 57 citations

Structural specificity of haemosiderin iron cores in iron‐overload diseases

1988 • 57 citations

On the mechanism of horse spleen apoferritin assembly: a sedimentation velocity and circular dichroism study

1987 • 57 citations

Cloning of a functional cDNA for the rabbit ferritin mRNA repressor protein. Demonstration of a tissue-specific pattern of expression.

1992 • 56 citations

Purification, characterization and function of bacterioferritin from the cyanobacterium Synechocystis P.C.C. 6803

1992 • 56 citations

FER-1, an Enhancer of the Ferritin H Gene and a Target of E1A-Mediated Transcriptional Repression

1995 • 56 citations

Suppressor Cytokines and Regulation of Myelopoiesis; Biology and Possible Clinical Uses

1992 • 56 citations

Identification of the iron entry channels in apoferritin. Chemical modification and spectroscopic studies

1989 • 56 citations

Structure and Differential Expression of two Maize Ferritin Genes in Response to Iron and Abscisic Acid

1995 • 56 citations

Role of phosphate in initial iron deposition in apoferritin

1991 • 55 citations

Receptor-induced switch in site-site cooperativity during iron release by transferrin

1992 • 55 citations

The Ferritin Genes: Their Response to Iron Status

2009 • 54 citations

Modulation of Ferritin Η-Chain Expression in Friend Erythroleukemia Cells: Transcriptional and Translational Regulation by Hemin

1992 • 54 citations

The structural relationship between ferritin protein and its mineral core

1969 • 53 citations

Iron(2+) and phosphate interactions in bacterial ferritin from Azotobacter vinelandii

1992 • 52 citations

Cloning and sequencing of an Escherichia coli K12 gene which encodes a polypeptide having similarity to the human ferritin H subunit

1991 • 52 citations

Translational enhancement of H-ferritin mRNA by interleukin-1β acts through 5′ leader sequences distinct from the iron responsive element

1994 • 52 citations

Enhanced Degradation of the Ferritin Repressor Protein During Induction of Ferritin Messenger RNA Translation

1992 • 52 citations

Suppressive effects in vivo of purified recombinant human H-subunit (acidic) ferritin on murine myelopoiesis

1989 • 51 citations

The mobilization of ferritin iron by liver cytosol. A comparison of xanthine and NADH as reducing substrates

1989 • 51 citations

Stabilization of iron in a ferrous form by ferritin. A study using dispersive and conventional x-ray absorption spectroscopy.

1987 • 50 citations

Pathways in the binding and uptake of ferritin by hepatocytes

1989 • 50 citations

Redox reactions of apo mammalian ferritin

1992 • 50 citations

A novel mechanism for ferritin iron oxidation and deposition

1978 • 49 citations

Haem and non-haem iron sites in Escherichia coli bacterioferritin: spectroscopic and model building studies

1993 • 46 citations

Nitric oxide and the post-transcriptional control of cellular iron traffic

1994 • 46 citations

Crystallization and structural analysis of bullfrog red cell L‐subunit ferritins

1994 • 46 citations

Large amount of (Apo)ferritin in the pancreatic insulin cell and its stimulation by glucose

1994 • 45 citations

Photoreduction and incorporation of iron into ferritins

1990 • 45 citations

Increased expression of cytokeratin and ferritin-H genes in tumorigenic clones of the SW 613-S human colon carcinoma cell line

1992 • 44 citations

Studies on haemosiderin and ferritin from iron-loaded rat liver

1988 • 44 citations

The role of superoxide anion radical in the reduction of ferritin iron by xanthine oxidase.

1974 • 43 citations

Mycobacterium paratuberculosis antigen D: characterization and evidence that it is a bacterioferritin

1991 • 43 citations

Iron(+2) binding to apo and holo mammalian ferritin

1989 • 43 citations

The inhibition of the iron responsive element RNA-protein interaction by heme does not mimic in vivo iron regulation.

1990 • 42 citations

Hypoxia Specifically and Reversibly Induces the Synthesis of Ferritin in Oligodendrocytes and Human Oligodendrogliomas

1994 • 42 citations

Regulation of hepatic transferrin, transferrin receptor and ferritin genes in human siderosis

1991 • 42 citations

Iron release from haemosiderin and ferritin by therapeutic and physiological chelators

1989 • 41 citations

Increased ferritin gene expression is both promoted by cAMP and a marker of growth arrest in rabbit vascular smooth muscle cells.

1991 • 40 citations

Differential regulation of ferritin H and L subunit mRNA during inflammation and long‐term iron overload

1993 • 40 citations

Iron binding to horse spleen apoferritin: a vanadyl ENDOR spin probe study

1991 • 40 citations

Regulation of ferritin and transferrin receptor expression by iron in human hepatocyte cultures

1993 • 40 citations

Siderosomal ferritin. The missing link between ferritin and haemosiderin?

1987 • 40 citations

Tyrosyl radical formation during the oxidative deposition of iron in human apoferritin

1995 • 40 citations

Permeation of small molecules into the cavity of ferritin as revealed by proton nuclear magnetic resonance relaxation

1995 • 39 citations

The binding of ferric iron by ferritin

1979 • 39 citations

Polyiron(III) Oxyhydroxide Clusters: The Role of Iron(III) Hydrolysis and Mineralization in Nature

1994 • 39 citations

Characterization of the binding of ferritin to the rat liver ferritin receptor

1985 • 39 citations

Release of iron from ferritin molecules and their iron-cores by 3-hydroxypyridinone chelators in vitro

1989 • 39 citations

Characterization of the ligand environment of vanadyl complexes of apoferritin by multifrequency electron spin-echo envelope modulation

1991 • 39 citations

Construction of a ferroxidase center in human ferritin L-chain.

1994 • 38 citations

Removal of ferritin‐bound iron by <scp>DL</scp>‐dihydrolipoate and DL‐dihydrolipoamide

1986 • 38 citations

Differences in subunit composition and iron content of isoferritins.

1975 • 37 citations

Properties and role of ferritin in the hemolymph of the chiton Clavarizona hirtosa

1986 • 37 citations

Protein coats of ferritin can sequester large amounts of ferrous iron

1989 • 37 citations

Biomineralization of iron: Moessbauer spectroscopy and electron microscopy of ferritin cores from the chiton Acanthopleura hirtosa and the limpet Patella laticostata

1990 • 36 citations

Iron incorporation into ferritins: evidence for the transfer of monomeric Fe(III) between ferritin molecules and for the formation of an unusual mineral in the ferritin of Escherichia coli

1994 • 36 citations

Cloning and sequencing of the bacterioferritin gene of Brucella melitensis 16M strain

1995 • 36 citations

Promoter for the human ferritin heavy chain-encoding gene (FERH): structural and functional characterization

1992 • 35 citations

Microsomal reduction of low-molecular-weight Fe3+ chelates and ferritin: Enhancement by adriamycin, paraquat, menadione, and anthraquinone 2-sulfonate and inhibition by oxygen

1988 • 35 citations

Iron K-edge absorption spectroscopic investigations of the cores of ferritin and haemosiderins

1991 • 34 citations

Further Characterisation of Forms of Haemosiderin in Iron‐Overloaded Tissues

1994 • 34 citations

Binding of Fe2+ by mammalian ferritin

1987 • 34 citations

A possible role for the conserved trimer interface of ferritin in iron incorporation

1992 • 33 citations

Role of phosphate in iron(2+) binding to horse spleen holoferritin

1993 • 32 citations

Characterization of a ferritin isolated from the midgut epithelial cells of a homopteran insect, Philaenus spumarius L.

1988 • 32 citations

Stoichiometry of iron oxidation by apoferritin

1978 • 32 citations

The Regulation of Iron Release from the Perfused Rat Liver

1980 • 32 citations

Hereditary haemochromatosis

1989 • 32 citations

Initial iron oxidation in horse spleen apoferritin. Characterization of a mixed-valence iron(II)-iron(III) complex.

1991 • 32 citations

In vitro loading of apoferritin

1992 • 30 citations

Uptake of ferritin and iron bound to ferritin by rat hepatocytes: modulation by apotransferrin, iron chelators and chloroquine

1989 • 30 citations

Functional Genes Found for Three Different Plant Ferritin Subunits in the Legume, Vigna unguiculata

1993 • 30 citations

Direct observation of bis-sulfur ligation to the heme of bacterioferritin

1993 • 30 citations

Iron metabolism in Rhodobacter capsulatus

1994 • 30 citations

Iron entry route in horse spleen apoferritin

1991 • 29 citations

Metallothionein-II and Ferritin H mRNA Levels Are Increased in Arsenite-Exposed HeLa Cells

1994 • 29 citations

Variable stoichiometry of Fe(II)‐oxidation in ferritin

1978 • 29 citations

Modulation of ferritin H-chain expression in Friend erythroleukemia cells: transcriptional and translational regulation by hemin.

1992 • 29 citations

Differential effects of iron and inflammation on ferritin synthesis on free and membrane-bound polyribosomes of rat liver

1992 • 29 citations

An EPR investigation of non‐haem iron sites in Escherichia coli bacterioferritin and their interaction with phosphate

1993 • 29 citations

Nitrobacter winogradskyi cytochrome b-559: a nonhaem iron-containing cytochrome related to bacterioferritin

1989 • 27 citations

Rapid Kinetics of the EPR-Active Species Formed during Initial Iron Uptake in Horse Spleen Apoferritin

1994 • 27 citations

Haem binding to horse spleen ferritin and its effect on the rate of iron release

1992 • 27 citations

The synthesis and turnover of ferritin in rat L-6 cells. Rates and response to iron, actinomycin D, and desferrioxamine.

1984 • 27 citations

Specificity of the induction of ferritin synthesis by hemin

1990 • 27 citations

The Uptake of Ferric Iron by Rat Liver Ferritin in Vivo and in Vitro

1976 • 26 citations

Characteristics of the interaction of the ferritin repressor protein with the iron-responsive element

1991 • 25 citations

Complete sequence of the gene encoding the bacterioferritin subunit of Mycobacterium avium subspecies silvaticum

1994 • 25 citations

ISH Regulation of ferritin H chain messenger RNA levels in the rat thyroids

1988 • 25 citations

A comparison of an undecairon(III) complex with the ferritin iron core

1989 • 25 citations

Interaction of acidic isoferritins with human promyelocytic HL60 cells

1988 • 25 citations

Fate of oxygen during ferritin iron incorporation

1983 • 25 citations

Transcriptional regulation of the human H ferritin-encoding gene (FERH) in G418-treated cells: role of the B-box-binding factor

1994 • 25 citations

Haem binding to ferritin and possible mechanisms of physiological iron uptake and release by ferritin

1992 • 25 citations

Oxidant specificity in ferritin formation

1979 • 25 citations

Mechanisms of regulation of ferritin synthesis in rat liver during experimental inflammation

1988 • 25 citations

Human ferritin light chain gene sequences mapped to several sorted chromosomes

1985 • 24 citations

A new type of prosome‐like particle, composed of small cytoplasmic RNA and multimers of a 21‐kDa protein, inhibits protein synthesis in vitro

1987 • 24 citations

Nucleotide sequence of cDNA encoding rabbit ferritin L chain

1988 • 24 citations

Thyrotropin stimulates transcription from the ferritin heavy chain promoter

1989 • 23 citations

Ferritin excretion and iron balance in humans

1995 • 23 citations

Isolation of a ferritin fromBacteroides fragilis

1992 • 23 citations

Iron and Neoplasia: Ferritin and Hemosiderin in Tumor Cells

1989 • 22 citations

A new form of ferritin heterogeneity explained. Isolation and identification of a nineteen-amino-acid-residue fragment from siderosomal ferritin of rat liver

1987 • 22 citations

Murine ferritin heavy chain: isolation and characterization of a functional gene

1990 • 22 citations

Specific binding of placental acidic isoferritin to cells of the T‐cell line HD‐MAR

1990 • 21 citations

Chemical and structural characterisation of iron cores of haemosiderins isolated from different sources

1992 • 21 citations

H- and L-rich ferritins suppress antibody production, but not proliferation, of human B lymphocytes in vitro

1994 • 21 citations

Characteristics of ferritins in human milk secretions: Similarities to serum and tissue isoferritins

1986 • 21 citations

Biochemical studies of the iron cores and polypeptide shells of haemosiderin isolated from patients with primary or secondary haemochromatosis

1989 • 21 citations

Sequence of a cDNA encoding the ferritin h-chain from an 11-week-old human fetal brain

1993 • 21 citations

Quantitative analysis of immunogold labelling for ferritin in liver from control and iron-overloaded rats

1988 • 19 citations

Thyrotropin and Adenosine 3′, 5′- Monophosphate Stimulate the Activity of the Ferritin-H Promoter

1990 • 19 citations

Purification and characterization of a cell growth factor from a human leukemia cell line: immunological identity with ferritin.

1994 • 19 citations

Isoferritins in rat Kupffer cells, hepatocytes, and extrahepatic macrophages. Biosynthesis in cell suspensions and cultures in response to iron.

1981 • 19 citations

Iron-induced changes in rat liver isoferritins

1984 • 19 citations

Role of protein synthesis in the accumulation of ferritin mRNA during exposure of cells to iron

1990 • 18 citations

Alloxan- and glutathione-dependent ferritin iron release and lipid peroxidation

1989 • 18 citations

A negative cis-acting G-fer element participates in the regulation of expression of the human H-ferritin-encoding gene (FERH)

1994 • 17 citations

The location of exon boundaries in the multimeric iron-storage protein ferritin

1991 • 17 citations

Activation of globin gene expression by cDNAs from induced K562 cells. Evidence for involvement of ferritin in globin gene expression.

1991 • 17 citations

Mouse ferritin H multigene family is polymorphic and contains a single multiallelic functional gene located on chromosome 19

1991 • 17 citations

Molecular Cloning and Expression of Ferritin mRNA in Heavy Metal-PoisonedXenopus laevisCells

1991 • 17 citations

Isolation and characterization of ferritin from the liver of the rainbow trout (Salmo gairdneri R.)

1991 • 16 citations

Electron transfer between horse ferritin and ferrihaemoproteins

1991 • 15 citations

Properties of ferritin from the earthworm Octolasium complanatum

1984 • 15 citations

Correlation between levels of ferritin and the iron-containing component of ribonucleotide reductase in hydroxyurea-sensitive, -resistant, and -revertant cell lines

1991 • 15 citations

Xenopus liver ferritin H subunit: cDNA sequence and mRNA production in the liver following estrogen treatment

1991 • 14 citations

The ferritin content of human red blood cells during the replacement of embryonic cells by fetal cells

1981 • 14 citations

Nucleotide sequence of the mouse ferritin H chain gene

1989 • 14 citations

Characterization of an insect ferritin subunit synthesized in a cell-free system

1990 • 14 citations

Lability of iron at the dinuclear centres of ferritin studied by competition with four chelators

1996 • 14 citations

Binding and suppressive activity of human recombinant ferritins on erythroid cells

1992 • 14 citations

Further characterization of the redox and spectroscopic properties of azotobacter vinelandii ferritin

1993 • 14 citations

Ferritin mRNAs on rat liver membrane-bound polysomes synthesize ferritin that does not translocate across membranes

1992 • 13 citations

Progress in iron research

1995 • 13 citations

Ferritin does not accumulate iron oxidized by caeruloplasmin

1995 • 12 citations

Purification of a cell growth factor from a human lung cancer cell line: Its relationship with ferritin

1994 • 11 citations

Nitric oxide does not promote iron release from ferritin

1996 • 10 citations

Stimulation of growth of neuroblastoma cells by ferritin in vitro.

1992 • 10 citations

Expression in Escherichia coli of a secreted invertebrate ferritin

1994 • 10 citations

Characterization of a ferritin isolated from the midgut epithelial cells of a homopteran insect, Philaenus spumarius L.

1988 • 9 citations

Mouse ferritin H sequences map to chromosomes 3, 6, and 19

1991 • 9 citations

The Cellular U-Particle, Whose Synthesis Is Induced by Mengovirus Infection, Is Homologous to Apoferritin

1994 • 8 citations

Spectroscopic identification of the haem axial ligands of haemoferritin and location of possible haem-binding sites in ferritin by molecular modelling

1992 • 8 citations

Regulation of Ferritin Synthesis in Macrophages by Oxygen and Sulfhydryl-Reactive Agent

1994 • 8 citations

Secretagogue action on membrane voltage of colonic cancer cell line HT-29

1988 • 7 citations

The protein of M_r 21 000 constituting the prosome‐like particle of duck erythroblasts is homologous to apoferritin

1992 • 7 citations

Induction of Ferritin Synthesis in vitro: Problems of Specificity Inherent in the Use of Iron Compounds

1990 • 5 citations

First-order phase transition in protein dynamics of ferritin

1987 • 5 citations

Cytokine mediation of the suppressive effect of ferritin on colony-stimulating factor-1-dependent monocytopoiesis.

1993 • 5 citations

Polymorphism in a ferritin H gene from chromosome 6p

1991 • 5 citations

Detection and quantitation of the novel ferritin heavy chain message in human tissues.

1994 • 4 citations

Structure and Function of Major and Minor Small Nuclear Ribonucleoprotein Particles.Max L. Birnstiel

1989 • 2 citations

A Mössbauer spectroscopic study of the forms of storage iron in the larval and adult stages of the lamprey,Geotria australis

1992 • 2 citations

Ferritin stimulation of a monokine inhibitor of lipopolysaccharide-augmented myelopoiesis is ferroxidase dependent

1994 • 1 citations