The role of the transferrin–transferrin-receptor system in drug delivery and targeting

Drug Delivery and Targeting

2016 • 2,037 citations

Transferrin receptor on endothelium of brain capillaries

1984 • 1,008 citations

Brain drug delivery of small molecules using immunoliposomes

1996 • 640 citations

Tumor regression with regional distribution of the targeted toxin TF-CRM107 in patients with malignant brain tumors

1997 • 526 citations

Coupling of adenovirus to transferrin-polylysine/DNA complexes greatly enhances receptor-mediated gene delivery and expression of transfected genes.

1992 • 483 citations

Delivery of peptides and proteins through the blood–brain barrier

2001 • 450 citations

Adenovirus enhancement of transferrin-polylysine-mediated gene delivery.

1991 • 431 citations

Iron homeostasis: insights from genetics and animal models

2000 • 410 citations

Transferrin as a Metal Ion Mediator

1999 • 367 citations

Drug Delivery and Targeting

2024 • 325 citations

Brain-specific expression of an exogenous gene after i.v. administration

2001 • 271 citations

Noninvasive gene targeting to the brain

2000 • 251 citations

Ti^IV Uptake and Release by Human Serum Transferrin and Recognition of Ti^IV-Transferrin by Cancer Cells: Understanding the Mechanism of Action of the Anticancer Drug Titanocene Dichloride

2000 • 220 citations

Vector-mediated delivery of a polyamide ("peptide") nucleic acid analogue through the blood-brain barrier in vivo.

1995 • 193 citations

Brain iron transport and neurodegeneration

2001 • 191 citations

Transferrin As A Targeting Ligand for Liposomes and Anticancer Drugs

1999 • 183 citations

Ligand-Receptor-Mediated Drug Delivery: An Emerging Paradigm in Cellular Drug Targeting

2001 • 173 citations

Neuroprotection in Transient Focal Brain Ischemia After Delayed Intravenous Administration of Brain-Derived Neurotrophic Factor Conjugated to a Blood-Brain Barrier Drug Targeting System

2001 • 172 citations

Conjugation of brain-derived neurotrophic factor to a blood–brain barrier drug targeting system enables neuroprotection in regional brain ischemia following intravenous injection of the neurotrophin

2001 • 165 citations

Decreased Binding to Proteins and Cells of Polymeric Gene Delivery Vectors Surface Modified with a Multivalent Hydrophilic Polymer and Retargeting through Attachment of Transferrin

2000 • 157 citations

Transport of [125I]transferrin through the rat blood-brain barrier

1995 • 157 citations

Receptor-mediated gene targeting to tissues in vivo following intravenous administration of pegylated immunoliposomes.

2001 • 156 citations

The First Specific TiIV-Protein Complex: Potential Relevance to Anticancer Activity of Titanocenes

1998 • 112 citations

Mechanisms of iron uptake by mammalian cells

1995 • 105 citations

Antisense imaging of gene expression in the brain in vivo

2000 • 91 citations

Endogenous carriers and ligands in non-immunogenic site-specific drug delivery

2000 • 74 citations

Vascular protection by chloroquine during brain tumor therapy with Tf-CRM107.

2000 • 61 citations

Competitive Binding of Bismuth to Transferrin and Albumin in Aqueous Solution and in Blood Plasma

2001 • 56 citations

Interactions of Bismuth with Human Lactoferrin and Recognition of the Bi^III−Lactoferrin Complex by Intestinal Cells

2001 • 50 citations

Transferrin Trojan Horses as a Rational Approach for the Biological Delivery of Therapeutic Peptide Domains

1999 • 26 citations