The transferrin homologue, melanotransferrin (p97), is rapidly catabolized by the liver of the rat and does not effectively donate iron to the brain

Surface location and high affinity for calcium of a 500-kd liver membrane protein closely related to the LDL-receptor suggest a physiological role as lipoprotein receptor.

1988 • 947 citations

The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells

1997 • 697 citations

Receptor-mediated endocytosis of transferrin in developmentally totipotent mouse teratocarcinoma stem cells.

1981 • 497 citations

Transferrin, biochemistry, physiology and clinical significance

1981 • 310 citations

Human melanoma-associated antigen p97 is structurally and functionally related to transferrin

1982 • 288 citations

Identification of a cell surface protein, p97, in human melanomas and certain other neoplasms.

1980 • 259 citations

Quantitative analysis of melanoma-associated antigen p97 in normal and neoplastic tissues.

1981 • 250 citations

Primary structure of the human melanoma-associated antigen p97 (melanotransferrin) deduced from the mRNA sequence.

1986 • 232 citations

The kinetics of transferrin endocytosis and iron uptake from transferrin in rabbit reticulocytes.

1983 • 222 citations

High transcytosis of melanotransferrin (P97) across the blood–brain barrier

2002 • 209 citations

Structural characterization of human melanoma-associated antigen p97 with monoclonal antibodies.

1981 • 203 citations

The uptake of iron and transferrin by the human malignant melanoma cell

1990 • 178 citations

Serum levels of the iron binding protein p97 are elevated in Alzheimer′s disease

1996 • 171 citations

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin

1996 • 139 citations

Two mechanisms of iron uptake from transferrin by melanoma cells. The effect of desferrioxamine and ferric ammonium citrate.

1992 • 121 citations

Transport and expression in human melanomas of a transferrin-like glycosylphosphatidylinositol-anchored protein.

1994 • 104 citations

A novel iron uptake mechanism mediated by GPI-anchored human p97.

1995 • 100 citations

Human melanotransferrin (p97) has only one functional iron‐binding site

1992 • 92 citations

Two saturable mechanisms of iron uptake from transferrin in human melanoma cells: The effect of transferrin concentration, chelators, and metabolic probes on transferrin and iron uptake

1994 • 86 citations

Assignment of the gene for human melanoma-associated antigen p97 to chromosome 3

1983 • 79 citations

The uptake of inorganic iron complexes by human melanoma cells

1991 • 74 citations

Glycosyl phosphatidylinositol membrane anchoring of melanotransferrin (p97): apical compartmentalization in intestinal epithelial cells

1993 • 74 citations

Analysis of normal neoplastic human tissues for the tumor‐associated protein p97

1981 • 73 citations

Regulation of plasminogen activation: a role for melanotransferrin (p97) in cell migration

2003 • 72 citations

Serum Melanotransferrin, p97 as a Biochemical Marker of Alzheimer's Disease

2001 • 72 citations

Factors Affecting the Synthesis of Transferrin by Rat Tissue Slices

1969 • 70 citations

The role of the membrane‐bound tumour antigen, melanotransferrin (p97), in iron uptake by the human malignant melanoma cell

2000 • 69 citations

Intravesicular pH and iron uptake by immature erythroid cells

1984 • 63 citations

The mechanisms of iron uptake by fetal rat hepatocytes in culture

1986 • 59 citations

Subcellular localization of the low density lipoprotein receptor-related protein (α2-macroglobulin receptor) in human brain

1995 • 53 citations

The membrane‐bound transferrin homologue melanotransferrin: roles other than iron transport?

2000 • 53 citations

The human melanoma associated protein melanotransferrin promotes endothelial cell migration and angiogenesis in vivo

2002 • 53 citations

The release of iron and transferrin from the human melanoma cell

1991 • 53 citations

Identification of a Novel Route of Iron Transcytosis across the Mammalian Blood‐Brain Barrier

2003 • 53 citations

TRANSFERRIN AND IRON UPTAKE BY THE LIVER IN THE RAT

1974 • 47 citations

The soluble form of the membrane‐bound transferrin homologue, melanotransferrin, inefficiently donates iron to cells via nonspecific internalization and degradation of the protein

2002 • 42 citations

In situ localization of melanotransferrin (melanoma‐associated antigen P97) in human liver. A light‐ and electronmicroscopic immunohistochemical study

1989 • 42 citations

Crayfish antennae as tactile organs: their mobility and the responses of their proprioceptors to displacement

1985 • 39 citations

Transferrin and albumin distribution and turnover in the rat

1966 • 34 citations

Expression of melanotransferrin isoforms in human serum: relevance to Alzheimer's disease

2003 • 30 citations

Internal iron exchange in the rat

1967 • 29 citations

Transferrin-receptor interaction and iron uptake by reticulocytes of vertebrate animals ? a comparative study

1987 • 29 citations

Overestimate of 125I-protein uptake from the adult mouse gut.

1982 • 24 citations

Role of transferrin in iron uptake by the brain: a comparative study

1991 • 23 citations

Comparative aspects of transferrin-reticulocyte interactions: Membrane receptors and iron uptake

1982 • 19 citations

Specificity of hepatic iron uptake from plasma transferrin in the rat

1991 • 12 citations

Vectorization of proteins across the blood–brain barrier: high transcytosis of melanotransferrin (P97)

2003 • 4 citations

Deletion of the GPI pre-anchor sequence in Mtf as a mechanism for generating the soluble form of the protein

1999 • 3 citations

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