Iron, neuroinflammation, and Alzheimer's disease

Plasma Homocysteine as a Risk Factor for Dementia and Alzheimer's Disease

2002 • 3,174 citations

Cloning and characterization of a mammalian proton-coupled metal-ion transporter

1997 • 3,130 citations

Statins and the risk of dementia

2000 • 1,741 citations

The Curry Spice Curcumin Reduces Oxidative Damage and Amyloid Pathology in an Alzheimer Transgenic Mouse

2001 • 1,482 citations

Treatment with a Copper-Zinc Chelator Markedly and Rapidly Inhibits β-Amyloid Accumulation in Alzheimer's Disease Transgenic Mice

2001 • 1,418 citations

Decreased Prevalence of Alzheimer Disease Associated With 3-Hydroxy-3-Methyglutaryl Coenzyme A Reductase Inhibitors

2000 • 1,415 citations

The Aβ Peptide of Alzheimer's Disease Directly Produces Hydrogen Peroxide through Metal Ion Reduction

1999 • 1,070 citations

Metal-Protein Attenuation With Iodochlorhydroxyquin (Clioquinol) Targeting Aβ Amyloid Deposition and Toxicity in Alzheimer Disease

2003 • 963 citations

Dietary fat intake and the risk of incident dementia in the Rotterdam study

1997 • 873 citations

A Role for 4‐Hydroxynonenal, an Aldehydic Product of Lipid Peroxidation, in Disruption of Ion Homeostasis and Neuronal Death Induced by Amyloid β‐Peptide

1997 • 779 citations

Intramuscular desferrioxamine in patients with Alzheimer's disease

1991 • 723 citations

I<scp>RON</scp> R<scp>EGULATORY</scp> P<scp>ROTEINS AND THE</scp> M<scp>OLECULAR</scp> C<scp>ONTROL OF</scp> M<scp>AMMALIAN</scp> I<scp>RON</scp> M<scp>ETABOLISM</scp>

2000 • 657 citations

Metal-induced oxidative stress and signal transduction

2004 • 650 citations

An Iron-responsive Element Type II in the 5′-Untranslated Region of the Alzheimer's Amyloid Precursor Protein Transcript

2002 • 530 citations

Curcumin interaction with copper and iron suggests one possible mechanism of action in Alzheimer's disease animal models

2004 • 457 citations

Metal Binding Modes of Alzheimer's Amyloid β-Peptide in Insoluble Aggregates and Soluble Complexes

2000 • 449 citations

Redox‐Active Metals, Oxidative Stress, and Alzheimer's Disease Pathology

2004 • 408 citations

Ceruloplasmin Regulates Iron Levels in the CNS and Prevents Free Radical Injury

2002 • 362 citations

Expression of heme oxygenase‐1 in the senescent and alzheimer‐diseased brain

1995 • 352 citations

Multifunctional Activities of Green Tea Catechins in Neuroprotection

2005 • 338 citations

Iron misregulation in the brain: a primary cause of neurodegenerative disorders

2003 • 334 citations

Mild hypercholesterolemia is an early risk factor for the development of Alzheimer amyloid pathology

2003 • 309 citations

Ribosomal RNA in Alzheimer Disease Is Oxidized by Bound Redox-active Iron

2005 • 286 citations

Iron‐Melanin Interaction and Lipid Peroxidation: Implications for Parkinson's Disease

1991 • 285 citations

Iron deposits in multiple sclerosis and Alzheimer's disease brains

1997 • 262 citations

Cholesterol and Alzheimer’s disease

2001 • 258 citations

Neuroprotection by a novel brain permeable iron chelator, VK-28, against 6-hydroxydopamine lession in rats

2003 • 241 citations

In Vivo Evaluation of Brain Iron in Alzheimer Disease Using Magnetic Resonance Imaging

2000 • 227 citations

Suggested mechanisms for the production of 4-hydroxy-2-nonenal from the autoxidation of polyunsaturated fatty acids

1990 • 225 citations

High transcytosis of melanotransferrin (P97) across the blood–brain barrier

2002 • 209 citations

Oxidative Stress and Redox‐Active Iron in Alzheimer's Disease

2004 • 202 citations

Histidine-13 Is a Crucial Residue in the Zinc Ion-Induced Aggregation of the Aβ Peptide of Alzheimer's Disease

1999 • 195 citations

Brain Ferritin Iron as a Risk Factor for Age at Onset in Neurodegenerative Diseases

2004 • 187 citations

Receptor-mediated endocytosis of transferrin at the blood-brain barrier

1993 • 187 citations

MR evaluation of age-related increase of brain iron in young adult and older normal males

1997 • 182 citations

Oxidation of Cholesterol by Amyloid Precursor Protein and β-Amyloid Peptide

2005 • 181 citations

Iron and iron management proteins in neurobiology

2001 • 174 citations

Serum levels of the iron binding protein p97 are elevated in Alzheimer′s disease

1996 • 171 citations

Methionine residue 35 is important in amyloid β-peptide-associated free radical oxidative stress

1999 • 171 citations

Degeneration of nigrostriatal dopaminergic neurons increases iron within the substantia nigra: a histochemical and neurochemical study

1994 • 154 citations

Methionine residue 35 is critical for the oxidative stress and neurotoxic properties of Alzheimer’s amyloid β-peptide 1–42

2002 • 149 citations

Iron: A Pathological Mediator of Alzheimer Disease?

2002 • 147 citations

Cytosolic phospholipase A2 is induced in reactive glia following different forms of neurodegeneration

1999 • 145 citations

Preliminary studies of a novel bifunctional metal chelator targeting Alzheimer's amyloidogenesis

2004 • 140 citations

Role of iron in NF-kappa B activation and cytokine gene expression by rat hepatic macrophages

1997 • 140 citations

4-Hydroxynonenal, a Product of Lipid Peroxidation, Damages Cholinergic Neurons and Impairs Visuospatial Memory in Rats

1998 • 133 citations

Aceruloplasminemia, an inherited disorder of iron metabolism.

2003 • 133 citations

Iron accumulation in the substantia nigra of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced hemiparkinsonian monkeys

1994 • 133 citations

The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis

1994 • 129 citations

Cellular distribution of iron in the brain of the Belgrade rat

1999 • 128 citations

Coordmation of cellular iron metabolism by post-transcriptional gene regulation

1992 • 121 citations

Iron and aluminium in relation to brain ferritin in normal individuals and Alzheimer's-disease and chronic renal-dialysis patients

1992 • 117 citations

Are hereditary hemochromatosis mutations involved in Alzheimer disease?

2000 • 116 citations

Differential Effects of Apolipoprotein E Isoforms on Metal-Induced Aggregation of Aβ Using Physiological Concentrations

1999 • 109 citations

Novel Chelators for Central Nervous System Disorders That Involve Alterations in the Metabolism of Iron and Other Metal Ions

2004 • 105 citations

A novel iron uptake mechanism mediated by GPI-anchored human p97.

1995 • 100 citations

Mechanisms by which metals promote events connected to neurodegenerative diseases

2001 • 98 citations

Increased lipid peroxidation in the brains of aceruloplasminemia patients

2000 • 97 citations

Ceruloplasmin levels in the human superior temporal gyrus in aging and Alzheimer's disease

1993 • 95 citations

Long‐term Induction of Haem Oxygenase‐1 (HSP‐32) in Astrocytes and Microglia Following Transient Focal Brain Ischaemia in the Rat

1996 • 88 citations

Distribution of divalent metal transporter-1 in the monkey basal ganglia

2004 • 80 citations

Selective response of various brain cell types during neurodegeneration induced by mild impairment of oxidative metabolism

2004 • 78 citations

Endogenous ferritin protects cells with iron-laden lysosomes against oxidative stress

1998 • 73 citations

Abnormal Iron Deposition Associated With Lipid Peroxidation in Transgenic Mice Expressing Interleukin-6 in the Brain

1998 • 72 citations

Clinical analysis of longstanding subacute myelo-optico-neuropathy: sequelae of clioquinol at 32 years after its ban

2003 • 68 citations

Non-haem iron histochemistry of the normal and Alzheimer's disease hippocampus.

1994 • 63 citations

Dopaminergic cell death precedes iron elevation in MPTP-injected monkeys

2003 • 61 citations

The Amyloid Paradox: Amyloid‐β‐Metal Complexes can be Neurotoxic and Neuroprotective

2004 • 59 citations

Plasmalogens, Docosahexaenoic Acid and Neurological Disorders

2003 • 57 citations

The role of iron in the basal ganglion.

1990 • 55 citations

Differential regulation of H- and L-ferritin messenger RNA subunits, ferritin protein and iron following focal cerebral ischemia–reperfusion

2000 • 53 citations

Increase in Cholesterol and Cholesterol Oxidation Products, and Role of Cholesterol Oxidation Products in Kainate‐induced Neuronal Injury

2003 • 48 citations

Elevated Ferritin Production, Iron Containment, and Oxidant Resistance in Hemin-Treated Leukemia Cells

1997 • 47 citations

Time-dependent changes in iron levels and associated neuronal loss within the substantia nigra following lesions within the neostriatum/globus pallidus complex

1995 • 46 citations

A Nuclear Microscopic Study of Elemental Changes in the Rat Hippocampus After Kainate‐Induced Neuronal Injury

1999 • 43 citations

MPTP selectively induces haem oxygenase‐1 expression in striatal astrocytes

2000 • 42 citations

[Increased DMT1 expression and iron content in MPTP-treated C57BL/6 mice].

2003 • 40 citations

Nuclear microscope analysis in Alzheimer's and Parkinson's disease: A review.

1996 • 34 citations

Effects of Transferrin Genetic Phenotypes on Total Iron-Binding Capacity

1986 • 34 citations

Effects of quinacrine on endothelial cell morphology and transcription factor–DNA interactions

2000 • 22 citations

Nutritional Iron Deprivation Attenuates Kainate‐Induced Neurotoxicity in Rats: Implications for Involvement of Iron in Neurodegeneration

2004 • 20 citations

Increased iron staining in the cerebral cortex of cholesterol fed rabbits

2004 • 16 citations

Time-course and localization of transferrin receptor expression in the substantia nigra of 6-hydroxydopamine-induced parkinsonian rats

1999 • 15 citations

Quinacrine attenuates increases in divalent metal transporter-1 and iron levels in the rat hippocampus, after kainate-induced neuronal injury

2003 • 12 citations