Astrocytes Induce Hemeoxygenase-1 Expression in Microglia: A Feasible Mechanism for Preventing Excessive Brain Inflammation

An Nrf2/Small Maf Heterodimer Mediates the Induction of Phase II Detoxifying Enzyme Genes through Antioxidant Response Elements

1997 • 3,743 citations

Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain

1999 • 3,344 citations

Release of reactive nitrogen intermediates and reactive oxygen intermediates from mouse peritoneal macrophages. Comparison of activating cytokines and evidence for independent production.

1988 • 2,865 citations

Neuroglial activation and neuroinflammation in the brain of patients with autism

2004 • 1,932 citations

Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications

1988 • 1,699 citations

Activation of microglial cells by β-amyloid protein and interferon-γ

1995 • 1,298 citations

Characterization of ameboid microglia isolated from developing mammalian brain

1986 • 1,287 citations

iNOS-mediated nitric oxide production and its regulation

2004 • 1,257 citations

MICROGLIA AS MEDIATORS OF INFLAMMATORY AND DEGENERATIVE DISEASES

1999 • 977 citations

Evidence for an immune response in major depression: A review and hypothesis

1995 • 954 citations

Neuronal activity triggers calcium waves in hippocampal astrocyte networks

1992 • 818 citations

Heme oxygenase: A novel target for the modulation of inflammatory response

1996 • 784 citations

Decline in transcriptional activity of Nrf2 causes age-related loss of glutathione synthesis, which is reversible with lipoic acid

2004 • 739 citations

NADPH Oxidase Mediates Lipopolysaccharide-induced Neurotoxicity and Proinflammatory Gene Expression in Activated Microglia

2004 • 562 citations

Overexpression of Heme Oxygenase‐1 Is Neuroprotective in a Model of Permanent Middle Cerebral Artery Occlusion in Transgenic Mice

1999 • 418 citations

Mechanism of Heme Oxygenase-1 Gene Activation by Cadmium in MCF-7 Mammary Epithelial Cells

2000 • 406 citations

Heme Oxygenase-1 Modulates Early Inflammatory Responses

2004 • 406 citations

Proinflammatory and regulatory cytokine production associated with innate and adaptive immune responses in children with autism spectrum disorders and developmental regression

2001 • 381 citations

Carbon monoxide‐releasing molecules (CO‐RMs) attenuate the inflammatory response elicited by lipopolysaccharide in RAW264.7 murine macrophages

2005 • 375 citations

Interaction between astrocytes and adult subventricular zone precursors stimulates neurogenesis

1999 • 358 citations

Overexpression of heme oxygenase-1 in human pulmonary epithelial cells results in cell growth arrest and increased resistance to hyperoxia.

1996 • 348 citations

The role of glial cells in Parkinsonʼs disease

2001 • 322 citations

Transcriptional Regulation of the Heme Oxygenase-1 Gene Via the Stress Response Element Pathway

2003 • 309 citations

IL-12 production by central nervous system microglia is inhibited by astrocytes.

1997 • 263 citations

Identification of a Second Region Upstream of the Mouse Heme Oxygenase-1 Gene That Functions as a Basal Level and Inducer-dependent Transcription Enhancer

1995 • 219 citations

Heme protein-induced chronic renal inflammation: Suppressive effect of induced heme oxygenase-1

2001 • 216 citations

Mitogen-activated protein kinases activated by lipopolysaccharide and β-amyloid in cultured rat microglia

1998 • 213 citations

Bilirubin inhibits iNOS expression and NO production in response to endotoxin in rats

2004 • 210 citations

Transplants of purified astrocytes promote behavioral recovery after frontal cortex ablation

1986 • 208 citations

Astrocytes prevent neuronal death induced by reactive oxygen and nitrogen species

1999 • 204 citations

Heme activates the heme oxygenase-1 gene in renal epithelial cells by stabilizing Nrf2

2003 • 166 citations

Thrombin Induces NO Release from Cultured Rat Microglia via Protein Kinase C, Mitogen-activated Protein Kinase, and NF-κB

2000 • 155 citations

Carbon monoxide attenuates aeroallergen-induced inflammation in mice

2001 • 147 citations

Long-term expression of heme oxygenase-1 (HO-1, HSP-32) following focal cerebral infarctions and traumatic brain injury in humans

2000 • 135 citations

Heme Oxygenase-mediated Resistance to Oxygen Toxicity in Hamster Fibroblasts

1997 • 135 citations

Bilirubin as a potent antioxidant suppresses experimental autoimmune encephalomyelitis: implications for the role of oxidative stress in the development of multiple sclerosis

2003 • 134 citations

Multiple elements within the 5' distal enhancer of the mouse heme oxygenase-1 gene mediate induction by heavy metals.

1994 • 130 citations

Astrocyte Protection of Neurons

2003 • 126 citations

Inhibition of endotoxin-induced nitric oxide synthase production in microglial cells by the presence of astroglial cells: A role for transforming growth factor ?

1997 • 124 citations

Oxidation of heme c derivatives by purified heme oxygenase. Evidence for the presence of one molecular species of heme oxygenase in the rat liver.

1982 • 105 citations

Gangliosides activate microglia via protein kinase C and NADPH oxidase

2004 • 103 citations

Modulation of Macrophage Phenotype by Soluble Product(s) Released from Neutrophils

2005 • 100 citations

Cultured rat striatal and cortical astrocytes protect mesencephalic dopaminergic neurons against hydrogen peroxide toxicity independent of their effect on neuronal development

1995 • 95 citations

Long‐term Induction of Haem Oxygenase‐1 (HSP‐32) in Astrocytes and Microglia Following Transient Focal Brain Ischaemia in the Rat

1996 • 88 citations

Transforming Growth Factor-β Mediates Astrocyte-Specific Regulation of Brain Endothelial Anticoagulant Factors

1999 • 87 citations

The active role of astrocytes in synaptic transmission

1999 • 86 citations

Smad7-dependent Regulation of Heme Oxygenase-1 by Transforming Growth Factor-β in Human Renal Epithelial Cells

2000 • 85 citations

Opposite regulation of prostaglandin E2 synthesis by transforming growth factor-β1 and interleukin 10 in activated microglial cultures

1998 • 71 citations

Correlation of the biologic responses of C3H/HEJ mice to endotoxin with the chemical and structural properties of the lipopolysaccharides from Pseudomonas aeruginosa and Escherichia coli.

1981 • 67 citations

Plasminogen-induced IL-1β and TNF-α production in microglia is regulated by reactive oxygen species

2003 • 65 citations

Inhalation of carbon monoxide prevents liver injury and inflammation following hind limb ischemia/reperfusion

2004 • 55 citations

Neuregulin induces GABA_A receptor β₂ subunit expression in cultured rat cerebellar granule neurons by activating multiple signaling pathways

2004 • 50 citations

Gradual inhibition of inducible nitric oxide synthase but not of interleukin-1β production in rat microglial cells of endotoxin-treated mixed glial cell cultures

1996 • 46 citations

Survival and Differentiation of Dopaminergic Mesencephalic Neurons Are Promoted by Dopamine-Mediated Induction of FGF-2 in Striatal Astroglial Cells

2000 • 44 citations

Astrocyte-mediated trophic support of developing serotonin neurons: effects of ethanol, buspirone, and S100B

2001 • 43 citations

Control of cellular iron homeostasis by iron‐responsive elements in vivo

1994 • 42 citations

Hemin Induces Heme Oxygenase-1 in Spinal Cord Vasculature and Attenuates Barrier Disruption and Neutrophil Infiltration in the Injured Murine Spinal Cord

2004 • 40 citations

Wortmannin enhances lipopolysaccharide-induced inducible nitric oxide synthase expression in microglia in the presence of astrocytes in rats

2003 • 37 citations

Glial soluble factors regulate the activity and expression of the neuronal glutamate transporter EAAC1: implication of cholesterol

2004 • 32 citations

Astrocytes Regulate N-Methyl-d-aspartate Receptor Subunit Composition Increasing Neuronal Sensitivity to Excitotoxicity

2001 • 32 citations

Identification of protein kinase C isoforms involved in interferon-gamma-induced expression of inducible nitric oxide synthase in murine BV2 microglia

2001 • 27 citations

Release of plasminogen activator inhibitor-1 from human astrocytes is regulated by intracellular ceramide

2000 • 20 citations