Brain iron uptake and homeostatic mechanisms: an overview.

ALTERATIONS IN THE LEVELS OF IRON, FERRITIN AND OTHER TRACE METALS IN PARKINSON'S DISEASE AND OTHER NEURODEGENERATIVE DISEASES AFFECTING THE BASAL GANGLIA

1991 • 1,012 citations

Transferrin receptor on endothelium of brain capillaries

1984 • 1,008 citations

Dramatic Aggregation of Alzheimer Aβ by Cu(II) Is Induced by Conditions Representing Physiological Acidosis

1998 • 988 citations

Aconitase and mitochondrial iron–sulphur protein deficiency in Friedreich ataxia

1997 • 975 citations

Nramp 2 is mutated in the anemic Belgrade ( b ) rat: Evidence of a role for Nramp2 in endosomal iron transport

1998 • 946 citations

A novel pantothenate kinase gene (PANK2) is defective in Hallervorden-Spatz syndrome

2001 • 738 citations

Increased iron (III) and total iron content in post mortem substantia nigra of parkinsonian brain

1988 • 738 citations

Abnormalities in CSF concentrations of ferritin and transferrin in restless legs syndrome

2000 • 598 citations

Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux

1999 • 572 citations

MRI measurement of brain iron in patients with restless legs syndrome

2001 • 557 citations

Mutation in the gene encoding ferritin light polypeptide causes dominant adult-onset basal ganglia disease

2001 • 533 citations

Receptor‐mediated transcytosis of transferrin across the blood‐brain barrier

1987 • 523 citations

Entry of peroxidase into neurons of the central and peripheral nervous systems from extracerebral and cerebral blood

1976 • 510 citations

The regional distribution and cellular localization of iron in the rat brain

1984 • 487 citations

The A53T alpha-synuclein mutation increases iron-dependent aggregation and toxicity.

2000 • 483 citations

Aluminum, Iron, and Zinc Ions Promote Aggregation of Physiological Concentrations of β‐Amyloid Peptide

1993 • 461 citations

Cellular distribution of transferrin, ferritin, and iron in normal and aged human brains

1990 • 457 citations

A histochemical study of iron, transferrin, and ferritin in Alzheimer's diseased brains

1992 • 450 citations

Cellular and Subcellular Localization of the Nramp2 Iron Transporter in the Intestinal Brush Border and Regulation by Dietary Iron

1999 • 445 citations

Nramp2 is mutated in the anemic Belgrade (b) rat : evidence of a role for Nramp2 in endosomal iron transport

1998 • 410 citations

Human Blood—Brain Barrier Insulin Receptor

1985 • 386 citations

Regional distribution of iron and iron‐regulatory proteins in the brain in aging and Alzheimer's disease

1992 • 367 citations

Receptor-mediated Transcytosis of Lactoferrin through the Blood-Brain Barrier

1999 • 365 citations

Human blood-brain barrier transferrin receptor

1987 • 347 citations

A Novel Glycosylphosphatidylinositol-anchored Form of Ceruloplasmin Is Expressed by Mammalian Astrocytes

1997 • 318 citations

Blood-Brain Barrier Penetration and in Vivo Activity of an NGF Conjugate

1993 • 316 citations

Distribution of divalent metal transporter 1 and metal transport protein 1 in the normal and Belgrade rat

2001 • 287 citations

Mechanism of increased iron absorption in murine model of hereditary hemochromatosis: Increased duodenal expression of the iron transporter DMT1

1999 • 278 citations

Transport of Iron in the Blood‐Brain‐Cerebrospinal Fluid System

1997 • 272 citations

Sialic acid-deficient serum and cerebrospinal fluid transferrin in a newly recognized genetic syndrome

1984 • 268 citations

Aceruloplasminemia: an inherited neurodegenerative disease with impairment of iron homeostasis

1998 • 249 citations

Regional Brain Iron, Ferritin and Transferrin Concentrations during Iron Deficiency and Iron Repletion in Developing Rats

1997 • 239 citations

Ferritin, transferrin, and iron in selected regions of the adult and aged rat brain

1993 • 237 citations

Studies on Parkinson's Disease Including X-Ray Fluorescent Spectroscopy of Formalin Fixed Brain Tissue

1968 • 227 citations

Huntingtin: an iron-regulated protein essential for normal nuclear and perinuclear organelles

2000 • 226 citations

Hereditary hypotransferrinemia with hemosiderosis, a murine disorder resembling human atransferrinemia.

1987 • 225 citations

Aluminum access to the brain: a role for transferrin and its receptor.

1990 • 223 citations

Developmental changes in transferrin and iron uptake by the brain in the rat

1990 • 219 citations

Increased iron in the dentate nucleus of patients with Friedreich's ataxia

1999 • 218 citations

Expression of lactoferrin receptors is increased in the mesencephalon of patients with Parkinson disease.

1995 • 209 citations

Cellular management of iron in the brain

1995 • 202 citations

Hallervorden-Spatz Syndrome and Brain Iron Metabolism

1991 • 197 citations

Transport of human recombinant brain-derived neurotrophic factor (BDNF) through the rat blood-brain barrier in vivo using vector-mediated peptide drug delivery.

1994 • 194 citations

Iron Deficiency: The Global Perspective

1994 • 188 citations

Receptor-mediated endocytosis of transferrin at the blood-brain barrier

1993 • 187 citations

Increased Basal Ganglia Iron Levels in Huntington Disease

1999 • 183 citations

MR evaluation of age-related increase of brain iron in young adult and older normal males

1997 • 182 citations

Iron, Transferrin, and Ferritin in the Rat Brain During Development and Aging

1994 • 179 citations

Iron and iron management proteins in neurobiology

2001 • 174 citations

Variations in Dietary Iron Alter Brain Iron Metabolism in Developing Rats

2000 • 168 citations

Reactive microglia specifically associated with amyloid plaques in Alzheimer's disease brain tissue express melanotransferrin

1996 • 139 citations

Studies of the ultrastructure and permeability of the blood-brain barrier in the developing corpus callosum in postnatal rat brain using electron dense tracers.

1994 • 130 citations

Cellular distribution of iron in the brain of the Belgrade rat

1999 • 128 citations

Iron in the Brain: An Important Contributor in Normal and Diseased States

2000 • 127 citations

Cellular distribution of the iron-binding protein lactotransferrin in the mesencephalon of Parkinson's disease cases

1996 • 119 citations

Development of transferrin‐positive oligodendrocytes in the rat central nervous system

1987 • 119 citations

Immunohistochemical evidence for an intracellular localization of plasma proteins in human foetal choroid plexus and brain

1979 • 118 citations

Non‐transferrin‐bound iron is present in serum of hereditary haemochromatosis heterozygotes

2000 • 116 citations

Evidence for low molecular weight, non-transferrin-bound iron in rat brain and cerebrospinal fluid

1998 • 116 citations

Are hereditary hemochromatosis mutations involved in Alzheimer disease?

2000 • 116 citations

Distribution of transferrin and ferritin binding in normal and multiple sclerotic human brains

1999 • 115 citations

The brain-type glucose transporter mRNA is specifically expressed at the blood-brain barrier

1990 • 114 citations

The hemochromatosis gene affects the age of onset of sporadic Alzheimer’s disease

2001 • 112 citations

Cognitive deficits in iron-deficient and iron-deficient anemic children

1986 • 109 citations

Gray matter T2 hypointensity is related to plaques and atrophy in the brains of multiple sclerosis patients

2001 • 109 citations

A splicing defect in the mouse transferrin gene leads to congenital atransferrinemia

1989 • 107 citations

Characterization and Distribution of Transferrin Receptors in the Rat Brain

1990 • 103 citations

Coincident expression and distribution of melanotransferrin and transferrin receptor in human brain capillary endothelium

1996 • 99 citations

Kupffer cell staining by an HFE‐specific monoclonal antibody: implications for hereditary haemochromatosis

1998 • 91 citations

Rate of ⁵⁹Fe Uptake into Brain and Cerebrospinal Fluid and the Influence Thereon of Antibodies Against the Transferrin Receptor

1993 • 90 citations

Studies of the slow bidirectional transport of iron and transferrin across the blood-brain barrier

1988 • 90 citations

Ferritin, transferrin and iron concentrations in the cerebrospinal fluid of multiple sclerosis patients

1999 • 87 citations

Transferrin receptors of rat and human brain and cerebral microvessels and their status in Alzheimer's disease

1992 • 87 citations

A THALASSEMIA‐LIKE DISORDER IN BELGRADE LABORATORY RATS*

1969 • 84 citations

Characterization and Distribution of Ferritin Binding Sites in the Adult Mouse Brain

1999 • 82 citations

The Development of the Blood-Brain Barrier

1968 • 82 citations

Oligodendrocyte progenitor cells internalize ferritin via clathrin-dependent receptor mediated endocytosis

2000 • 82 citations

Is hemochromatosis a risk factor for Alzheimer's disease?

2001 • 81 citations

Brain iron-deficiency causes reduced learning capacity in rats

1986 • 81 citations

Learning achievement and behavior at school of anemic and non-anemic infants

1985 • 80 citations

Expression of Transferrin mRNA in the CNS of Normal and Jimpy Mice

1991 • 78 citations

Developmental patterns of gene expression of secreted proteins in brain and choroid plexus

1989 • 77 citations

Regional Variation in the Levels of Transferrin in the CNS of Normal and Myelin‐Deficient Rats

1987 • 77 citations

The basal ganglia in haemochromatosis

2000 • 76 citations

Serum Melanotransferrin, p97 as a Biochemical Marker of Alzheimer's Disease

2001 • 72 citations

Transferrin is required for normal distribution of 59Fe and 54Mn in mouse brain

1999 • 70 citations

Intestinal iron uptake determined by divalent metal transporter is enhanced in HFE-deficient mice with hemochromatosis

2001 • 62 citations

Kinetics and distribution of [59Fe–125I]transferrin injected into the ventricular system of the rat

1998 • 62 citations

Cellular distribution of iron, transferrin, and ferritin in the hypotransferrinemic (Hp) mouse brain

1995 • 59 citations

Iron deposits in the central nervous system of SJL mice with experimental allergic encephalomyelitis

1998 • 54 citations

The clinical relevance of ferritin concentration in the cerebrospinal fluid.

1981 • 54 citations

Diminished iron acquisition by cells and tissues of Belgrade laboratory rats

1992 • 53 citations

Studies of the mechanism of iron transport across the blood-brain barrier

1992 • 52 citations

Melanotransferrin is produced by senile plaque-associated reactive microglia in Alzheimer's disease

1999 • 50 citations

Cerebrospinal fluid ferritin in brain necrosis: evidence for local synthesis

1993 • 50 citations

Defective iron uptake and globin synthesis by erythroid cells in the anemia of the Belgrade laboratory rat

1978 • 49 citations

Changes in glial cell markers in recent and old demyelinated lesions in central pontine myelinolysis

1990 • 48 citations

Iron Regulation in the Developing Rat Brain: Effect of In Utero Ethanol Exposure

1995 • 48 citations

Proteins in Cerebrospinal Fluid and Plasma of Fetal Pigs during Development

1982 • 43 citations

Comparative immunocytochemistry of Pelizaeus-Merzbacher disease, the jimpy mouse, and the myelin-deficient rat

1988 • 42 citations

Comparison of proteins in CSF of lateral and IVth ventricles during early development of fetal sheep

1983 • 36 citations

HFE inhibits apical iron uptake by intestinal epithelial (Caco‐2) cells

2001 • 35 citations

Microscopic R2* mapping of reduced brain iron in the Belgrade rat

2002 • 30 citations

Model for transport in the central nervous system

1977 • 30 citations

Developmental profile of non-heme iron distribution in the rat brain during ontogenesis

1995 • 29 citations

Regional Congruence and Divergence of Glucose Transporters (GLUT1) and Capillaries in Rat Brains

1995 • 28 citations

High frequency of the H63D mutation of the hemochromatosis gene (HFE) in malignant gliomas

2001 • 26 citations

Cerebrospinal Fluid Ferritin Levels in Screening for Meningism

1986 • 23 citations

Cerebrospinal fluid ferritin in human disease.

1986 • 18 citations

A 39-Year-Old Man with Chronic Hepatitis, Elevated Serum Ferritin Values, and a Family History of Hemochromatosis

1993 • 15 citations

White matter disorders.

1991 • 11 citations

Iron Deficiency in two Adolescents with Conduct, Dysthymic and Movement Disorders

1994 • 11 citations

Citrate and alpha-ketoglutarate in cerebrospinal fluid and blood

1971 • 11 citations

Brain Transfer Coefficients for ⁶⁷Ga: Comparison to ⁵⁵Fe and Effect of Calcium Deficiency

1992 • 7 citations

Ferritin concentration in cerebrospinal fluid

2009 • 6 citations

Randomness and creativity

2001 • 5 citations

A case of neuroferritinopathy

2001 • 1 citations

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