A Targeted DNA-PKcs-Null Mutation Reveals DNA-PK-Independent Functions for KU in V(D)J Recombination

Somatic generation of antibody diversity

1983 • 3,275 citations

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

The DNA-dependent protein kinase

1999 • 896 citations

DNA-dependent protein kinase catalytic subunit: A relative of phosphatidylinositol 3-kinase and the ataxia telangiectasia gene product

1995 • 742 citations

Cell Cycle and Genetic Requirements of Two Pathways of Nonhomologous End-Joining Repair of Double-Strand Breaks in Saccharomyces cerevisiae

1996 • 733 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Ku80: product of the XRCC5 gene and its role in DNA repair and V(D)J recombination

1994 • 637 citations

Homology-directed repair is a major double-strand break repair pathway in mammalian cells

1998 • 628 citations

Involvement of Brca2 in DNA Repair

1998 • 624 citations

Absence of p350 Subunit of DNA-Activated Protein Kinase from a Radiosensitive Human Cell Line

1995 • 530 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

1991 • 509 citations

Saccharomyces cerevisiae Ku70 potentiates illegitimate DNA double-strand break repair and serves as a barrier to error-prone DNA repair pathways.

1996 • 492 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

The XRCC4 gene encodes a novel protein involved in DNA double-strand break repair and V(D)J recombination

1995 • 449 citations

V(D)J recombination: Broken DNA molecules with covalently sealed (hairpin) coding ends in scid mouse thymocytes

1992 • 449 citations

Growth Retardation and Leaky SCID Phenotype of Ku70-Deficient Mice

1997 • 445 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Yeast Ku as a Regulator of Chromosomal DNA End Structure

1998 • 432 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

DNA-dependent protein kinase is one of a subset of autoantigens specifically cleaved early during apoptosis.

1995 • 422 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

Ku70-deficient embryonic stem cells have increased ionizing radiosensitivity, defective DNA end-binding activity, and inability to support V(D)J recombination

1997 • 396 citations

DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis.

1996 • 351 citations

Restoration of X-ray Resistance and V(D)J Recombination in Mutant Cells by Ku cDNA

1994 • 351 citations

Identification of a nonsense mutation in the carboxyl-terminal region of DNA-dependent protein kinase catalytic subunit in the scid mouse.

1996 • 349 citations

Evidence of functional lymphocytes in some (leaky) scid mice.

1988 • 347 citations

Silencing factors participate in DNA repair and recombination in Saccharomyces cerevisiae

1997 • 330 citations

Targeted Disruption of the Catalytic Subunit of the DNA-PK Gene in Mice Confers Severe Combined Immunodeficiency and Radiosensitivity

1998 • 323 citations

Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

1997 • 315 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

A link between double-strand break-related repair and V(D)J recombination: the scid mutation.

1991 • 295 citations

Ku protein stimulates DNA end joining by mammalian DNA ligases: a direct role for Ku in repair of DNA double-strand breaks

1998 • 292 citations

Loss of the catalytic subunit of the DNA-dependent protein kinase in DNA double-strand-break-repair mutant mammalian cells.

1995 • 286 citations

A DNA-activated protein kinase from HeLa cell nuclei.

1990 • 285 citations

Human DNA-activated protein kinase phosphorylates serines 15 and 37 in the amino-terminal transactivation domain of human p53.

1992 • 255 citations

DNA-dependent protein kinase: DNA binding and activation in the absence of Ku

1998 • 238 citations

Assembly of a 12/23 Paired Signal Complex: A Critical Control Point in V(D)J Recombination

1998 • 233 citations

Human DNA helicase II: a novel DNA unwinding enzyme identified as the Ku autoantigen.

1994 • 225 citations

What to do at an end: DNA double-strand-break repair

1995 • 195 citations

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.

1993 • 193 citations

Biochemical and Genetic Defects in the DNA-Dependent Protein Kinase in Murine scid Lymphocytes

1996 • 185 citations

DNA-dependent protein kinase

1997 • 181 citations

DNA-PK: at the cross-roads of biochemistry and genetics

1997 • 169 citations

A kinase-negative mutation of DNA-PK(CS) in equine SCID results in defective coding and signal joint formation.

1997 • 165 citations

Characterization of broken DNA molecules associated with V(D)J recombination.

1993 • 163 citations

Equine severe combined immunodeficiency: a defect in V(D)J recombination and DNA-dependent protein kinase activity.

1995 • 156 citations

Double-strand break repair by Ku70 requires heterodimerization with Ku80 and DNA binding functions

1997 • 147 citations

DNA-PKcs: a T-cell tumour suppressor encoded at the mouse scid locus

1997 • 144 citations

Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks

1997 • 136 citations

Mouse model for the lysosomal disorder galactosialidosis and correction of the phenotype with overexpressing erythroid precursor cells.

1995 • 133 citations

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

1995 • 113 citations

A DNA repair defect in Chinese hamster ovary cells affects V(D)J recombination similarly to the murine scid mutation.

1994 • 100 citations

Binding of Ku and c-Abl at the Kinase Homology Region of DNA-dependent Protein Kinase Catalytic Subunit

1997 • 99 citations

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement.

1988 • 94 citations

XR-C1, a new CHO cell mutant which is defective in DNA-PKcs, is impaired in both V(D)J coding and signal joint formation

1998 • 58 citations

Murine Cell Line SX9 Bearing a Mutation in the dna-pkcsGene Exhibits Aberrant V(D)J Recombination Not Only in the Coding Joint but Also in the Signal Joint

1998 • 47 citations

V(D)J recombination gets a break

1992 • 42 citations

Characterization of Two DNA Double-stranded Break Repair-deficient Cell Lines That Express Inactive DNA-dependent Protein Kinase Catalytic Subunits

1997 • 40 citations

Activities Involved in V(D)J Recombination

1992 • 29 citations

Intact G 2 -Phase Checkpoint in Cells of a Human Cell Line Lacking DNA-Dependent Protein Kinase Activity

1997 • 26 citations

The MurineDNA-PKcsGene Consists of 86 Exons Dispersed in More Than 250 kb

1997 • 16 citations