scid mutation in mice confers hypersensitivity to ionizing radiation and a deficiency in DNA double-strand break repair.

A severe combined immunodeficiency mutation in the mouse

1983 • 2,193 citations

RAG-1 and RAG-2, Adjacent Genes That Synergistically Activate V(D)J Recombination

1990 • 1,450 citations

The V(D)J recombination activating gene, RAG-1

1989 • 1,164 citations

Microcolony Survival Assay for Cells of Mouse Intestinal Mucosa Exposed to Radiation

1970 • 702 citations

The scid mutation in mice causes a general defect in DNA repair

1990 • 525 citations

Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction.

1986 • 465 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

X-ray sensitive mutants of Chinese hamster ovary cells defective in double-strand break rejoining

1984 • 379 citations

The Sensitivity of Cells from Normal Mouse Bone Marrow to Gamma Radiation in Vitro and in Vivo

1962 • 253 citations

Repair of Potentially Lethal Radiation DamageIn VitroandIn Vivo

1973 • 194 citations

Studies on mammalian mutants defective in rejoining double-strand breaks in DNA

1990 • 178 citations

The Repair of Double-Strand DNA Breaks Correlates with Radiosensitivity of L5178Y-S and L5178Y-R Cells

1987 • 177 citations

Radiation-resistant and repair-proficient human tumor cells may be associated with radiotherapy failure in head- and neck-cancer patients.

1986 • 176 citations

Nonhomologous Recombination in Mammalian Cells: Role for Short Sequence Homologies in the Joining Reaction

1986 • 154 citations

Cell cycle-dependent repair of double-strand DNA breaks in a ?-ray-sensitive Chinese hamster cell

1985 • 150 citations

Asymmetric Field Inversion Gel Electrophoresis: A New Method for Detecting DNA Double-Strand Breaks in Mammalian Cells

1990 • 150 citations

The Effect of Divided Doses of 15 MeV Electrons on the Skin Response of Mice

1965 • 147 citations

The mouse mutation severe combined immune deficiency (scid) is on chromosome 16

1989 • 113 citations

‘Wasted’, a new mutant of the mouse with abnormalities characteristic of ataxia telangiectasia

1982 • 97 citations

The scid gene encodes a trans-acting factor that mediates the rejoining event of Ig gene rearrangement.

1988 • 94 citations

Growth of Human Tumors in Immune-Deficient scid Mice and nude Mice

1989 • 79 citations

Human chromosome 5 complements the DNA double-strand break-repair deficiency and gamma-ray sensitivity of the XR-1 hamster variant.

1990 • 54 citations

Nature of the scid Defect: A Defective VDJ Recombinase System

1989 • 54 citations

Evaluation of the mouse mutant “wasted” as an animal model for ataxia telangiectasia

1986 • 22 citations

Effect of DNA-damaging agents on isolated spleen cells and lung fibroblasts from the mouse mutant "wasted," a putative animal model for ataxia-telangiectasia.

1986 • 18 citations

A search for radiosensitive mouse mutants by use of the micronucleus technique

1987 • 14 citations

Studies of V(D)J Recombination with Extrachromosomal Substrates

1988 • 10 citations

The scid Mutation Disrupts Gene Rearrangement at the Rejoining of Coding Strands

1989 • 7 citations