Interaction of DNA-dependent protein kinase with DNA and with Ku: biochemical and atomic-force microscopy studies

Atomic Force Microscope

1986 • 14,074 citations

Accurate transcription initiation by RNA polymerase II in a soluble extract from isolated mammalian nuclei

1983 • 11,902 citations

The DNA-dependent protein kinase: Requirement for DNA ends and association with Ku antigen

1993 • 1,219 citations

The DNA-dependent protein kinase

1999 • 896 citations

Requirement for Ku80 in growth and immunoglobulin V(D)J recombination

1996 • 657 citations

Fractured polymer/silica fiber surface studied by tapping mode atomic force microscopy

1993 • 610 citations

Mechanism of interaction between Ku protein and DNA.

1986 • 485 citations

Human DNA-Activated Protein Kinase Phosphorylates Serines 15 and 37 in the Amino-Terminal Transactivation Domain of Human p53

1992 • 473 citations

Impairment of V(D)J Recombination in Double-Strand Break Repair Mutants

1993 • 457 citations

The defect in murine severe combined immune deficiency: Joining of signal sequences but not coding segments in V(D)J recombination

1988 • 441 citations

Ku86-Deficient Mice Exhibit Severe Combined Immunodeficiency and Defective Processing of V(D)J Recombination Intermediates

1996 • 430 citations

DNA binding to mica correlates with cationic radius: assay by atomic force microscopy

1996 • 356 citations

DNA double-strand break repair and V(D)J recombination: involvement of DNA-PK

1995 • 344 citations

DNA-dependent protein kinase activity is absent in xrs-6 cells: implications for site-specific recombination and DNA double-strand break repair.

1995 • 342 citations

Reconstruction of STM and AFM images distorted by finite-size tips

1991 • 325 citations

The scid defect affects the final step of the immunoglobulin VDJ recombinase mechanism

1988 • 306 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

A DNA-activated protein kinase from HeLa cell nuclei.

1990 • 285 citations

HeLa nuclear protein recognizing DNA termini and translocating on DNA forming a regular DNA-multimeric protein complex

1989 • 273 citations

EBP-80, a transcription factor closely resembling the human autoantigen Ku, recognizes single- to double-strand transitions in DNA

1993 • 247 citations

Visualizing Protein-Nucleic Acid Interactions on a Large Scale with the Scanning Force Microscope

1996 • 230 citations

V(D)J recombination in mammalian cell mutants defective in DNA double-strand break repair.

1993 • 193 citations

The nuclear serine/threonine protein kinase DNA-PK.

1992 • 192 citations

Purification and characterization of a template-associated protein kinase that phosphorylates RNA polymerase II

1993 • 184 citations

Photocrosslinking of 5-Iodouracil-Substituted RNA and DNA to Proteins

1993 • 177 citations

Molecular and Biochemical Characterization of xrs Mutants Defective in Ku80

1997 • 174 citations

DNA-dependent protein kinase (Ku protein-p350 complex) assembles on double-stranded DNA.

1994 • 168 citations

The DNA-activated protein kinase is required for the phosphorylation of replication protein A during simian virus 40 DNA replication.

1994 • 163 citations

Purification and characterization of proximal sequence element-binding protein 1, a transcription activating protein related to Ku and TREF that binds the proximal sequence element of the human U1 promoter.

1990 • 141 citations

Recent advances in atomic force microscopy of DNA

1993 • 139 citations

Tying loose ends: roles of Ku and DNA-dependent protein kinase in the repair of double-strand breaks

1997 • 136 citations

Characterization of coding ends in thymocytes of scid mice: Implications for the mechanism of V(D)J recombination

1995 • 113 citations

Protein-Protein and Protein-DNA Interaction Regions within the DNA End-Binding Protein Ku70-Ku86

1996 • 112 citations

The DNA-Activated Protein Kinase — DNA-PK

1996 • 111 citations

Phosphorylation of the p34 subunit of human single-stranded-DNA-binding protein in cyclin A-activated G1 extracts is catalyzed by cdk-cyclin A complex and DNA-dependent protein kinase.

1994 • 110 citations

A DNA-Activated Protein Kinase from HeLa Cell Nuclei

1990 • 109 citations

Biological Atomic Force Microscopy: From Microns to Nanometers and Beyond

1995 • 90 citations

Purification and characterization of the double-stranded DNA-activated protein kinase, DNA-PK, from human placenta

1996 • 81 citations

Purification of an 86-70 kDa nuclear DNA-associated protein complex

1985 • 80 citations

On the mechanisms of ku protein binding to DNA

1992 • 80 citations

Production and characterization of recombinant human Ku antigen

1994 • 69 citations

V(D)J Recombination in Mammalian Cell Mutants Defective in DNA Double-Strand Break Repair

1993 • 54 citations

Crosslinking of an iodo-uridine-RNA hairpin to a single site on the human U1A N-terminal RNA binding domain.

1995 • 48 citations

Mapping of epitopes on the 86 kDa subunit of the Ku autoantigen

1990 • 32 citations

Toward True Surface Recovery: Studying Distortions in Scanning Probe Microscopy Image Data

1996 • 28 citations

Molecular Analysis of DNA Rearrangements in the Immune System

1996 • 27 citations

Antigenic determinants of the 70-kDa subunit of the Ku autoantigen

1992 • 13 citations

Non-linear epitopes of the large subunit of Ku autoantigen recognized by monoclonal and autoantibodies

1992 • 4 citations