Poly(A)+ RNAs roam the cell nucleus and pass through speckle domains in transcriptionally active and inactive cells

Nuclear speckles: a model for nuclear organelles

2003 • 955 citations

TREX is a conserved complex coupling transcription with messenger RNA export

2002 • 829 citations

Maintenance of Stable Heterochromatin Domains by Dynamic HP1 Binding

2003 • 608 citations

The dynamics of a pre-mRNA splicing factor in living cells

1997 • 604 citations

Polyadenylic Acid Sequences: Role in Conversion of Nuclear RNA into Messenger RNA

1971 • 569 citations

The protein Aly links pre-messenger-RNA splicing to nuclear export in metazoans

2000 • 514 citations

SR Splicing Factors Serve as Adapter Proteins for TAP-Dependent mRNA Export

2003 • 464 citations

The Mex67p-mediated nuclear mRNA export pathway is conserved from yeast to human

1999 • 431 citations

Pre-mRNA splicing and mRNA export linked by direct interactions between UAP56 and Aly

2001 • 385 citations

Splicing is required for rapid and efficient mRNA export in metazoans

1999 • 375 citations

The human dystrophin gene requires 16 hours to be transcribed and is cotranscriptionally spliced

1995 • 361 citations

Characteristics of the polyadenylic acid segment associated with messenger ribonucleic acid in mouse sarcoma 180 ascites cells

1972 • 339 citations

A Three-Dimensional View of Precursor Messenger RNA Metabolism Within the Mammalian Nucleus

1993 • 335 citations

Nuclear export of different classes of RNA is mediated by specific factors

1994 • 323 citations

Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus.

1991 • 300 citations

Perichromatin fibrils are in situ forms of nascent transcripts

1994 • 290 citations

Modulation of Heterochromatin Protein 1 Dynamics in Primary Mammalian Cells

2003 • 289 citations

Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription

1994 • 277 citations

Intranuclear diffusion and hybridization state of oligonucleotides measured by fluorescence correlation spectroscopy in living cells

1998 • 276 citations

In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

1993 • 272 citations

Ultrastructural Analysis of Transcription and Splicing in the Cell Nucleus after Bromo-UTP Microinjection

1999 • 256 citations

Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains.

1995 • 251 citations

In vivo analysis of the stability and transport of nuclear poly(A)+ RNA.

1994 • 233 citations

Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing.

1994 • 230 citations

Inefficient processing impairs release of RNA from the site of transcription

1999 • 227 citations

Messenger RNAs are recruited for nuclear export during transcription

2001 • 220 citations

Lateral mobility in membranes as detected by fluorescence recovery after photobleaching

1982 • 212 citations

Advantages of 2'-O-methyl oligoribonucleotide probes for detecting RNA targets

1998 • 206 citations

The inhibition of DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells

1976 • 204 citations

Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity

1997 • 197 citations

Nuclear RNA export

2003 • 197 citations

Clustering of multiple specific genes and gene-rich R-bands around SC-35 domains

2003 • 196 citations

REF1/Aly and the additional exon junction complex proteins are dispensable for nuclear mRNA export

2002 • 194 citations

Processing of Endogenous Pre-mRNAs in Association with SC-35 Domains Is Gene Specific

1999 • 194 citations

Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells

1999 • 190 citations

Linear 2' O-Methyl RNA probes for the visualization of RNA in living cells

2001 • 176 citations

Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription.

1996 • 174 citations

The protein Mago provides a link between splicing and mRNA localization

2001 • 167 citations

Tracking Col1a1 RNA in Osteogenesis Imperfecta

2000 • 164 citations

Three-Dimensional Visualization of Transcription Sites and Their Association with Splicing Factor–Rich Nuclear Speckles

1999 • 157 citations

Disassembly of interchromatin granule clusters alters the coordination of transcription and pre-mRNA splicing

2002 • 151 citations

Evidence for channeled diffusion of pre-mRNAs during nuclear RNA transport in metazoans.

1993 • 144 citations

Differential interaction of splicing snRNPs with coiled bodies and interchromatin granules during mitosis and assembly of daughter cell nuclei.

1994 • 135 citations

Overexpression of TAP/p15 Heterodimers Bypasses Nuclear Retention and Stimulates Nuclear mRNA Export

2001 • 135 citations

Ultrastructure of the Nucleus in Relation to Transcription and Splicing: Roles of Perichromatin Fibrils and Interchromatin Granules

1996 • 129 citations

Targeting of U2AF65 to Sites of Active Splicing in the Nucleus

1997 • 124 citations

Export of mRNA from microinjected nuclei of Xenopus laevis oocytes.

1992 • 121 citations

The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive

2002 • 120 citations

Physical Isolation of Nascent RNA Chains Transcribed by RNA Polymerase II: Evidence for Cotranscriptional Splicing

1994 • 114 citations

Nuclear pre-mRNA Compartmentalization: Trafficking of Released Transcripts to Splicing Factor Reservoirs

2000 • 108 citations

Intron status and 3′-end formation control cotranscriptional export of mRNA

2002 • 108 citations

Deciphering the cellular pathway for transport of poly(A)-binding protein II

2000 • 95 citations

The Intranuclear Movement of Balbiani Ring Premessenger Ribonucleoprotein Particles

1999 • 83 citations

Identity Elements Used in Export of mRNAs

2002 • 78 citations

Evidence that all SC-35 domains contain mRNAs and that transcripts can be structurally constrained within these domains

2002 • 71 citations

Localisation of splicing snRNPs in mammalian cells

1993 • 67 citations

Electron Tomography Reveals Posttranscriptional Binding of Pre-Mrnps to Specific Fibers in the Nucleoplasm

2000 • 63 citations

Prespliceosomal Assembly on Microinjected Precursor mRNA Takes Place in Nuclear Speckles

2001 • 54 citations

Localization of poly(A)-binding protein 2 (PABP2) in nuclear speckles is independent of import into the nucleus and requires binding to poly(A) RNA

2000 • 53 citations

Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain.

1996 • 47 citations

RNAs radiate from gene to cytoplasm as revealed by fluorescence in situ hybridization

1995 • 45 citations

Splicing factors associate with nuclear HCMV-IE transcripts after transcriptional activation of the gene, but dissociate upon transcription inhibition: evidence for a dynamic organization of splicing factors

1997 • 45 citations

Demonstration of a dynamic, transcription-dependent organization of pre-mRNA splicing factors in polytene nuclei.

1996 • 40 citations

Accumulation of mature mRNA in the nuclear fraction of mammalian cells

1999 • 25 citations

Induction of p21 mRNA Synthesis After Short-wavelength UV Light Visualized in Individual Cells by RNA FISH

2002 • 19 citations

RNA Polymerase II Localizes at Sites of Human Cytomegalovirus Immediate-early RNA Synthesis and Processing

1999 • 18 citations

Kinetics of HCMV immediate early mRNA expression in stably transfected fibroblasts

2002 • 16 citations

Detection of specific messenger RNA by electron microscopic in situ hybridization: implications for nucleocytoplasmic transport.

1995 • 6 citations

An ATP-dependent step is required for the translocation of microinjected precursor mRNA into nuclear speckles.

2002 • 4 citations