Prespliceosomal Assembly on Microinjected Precursor mRNA Takes Place in Nuclear Speckles

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

1997 • 905 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

Exonic splicing enhancers: mechanism of action, diversity and role in human genetic diseases

2000 • 689 citations

THE STRUCTURE AND FUNCTION OF PROTEINS INVOLVED IN MAMMALIAN PRE-mRNA SPLICING

1996 • 687 citations

The superfamily of arginine/serine-rich splicing factors.

1995 • 671 citations

SR proteins and splicing control.

1996 • 668 citations

The dynamics of a pre-mRNA splicing factor in living cells

1997 • 604 citations

Split genes and RNA splicing

1994 • 562 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Interactions between small nuclear ribonucleoprotein particles in formation of spliceosomes

1987 • 530 citations

Stepwise assembly of a pre-mRNA splicing complex requires U-snRNPs and specific intron sequences

1985 • 524 citations

Associations between distinct pre-mRNA splicing components and the cell nucleus.

1991 • 523 citations

The plurifunctional nucleolus

1998 • 515 citations

Subnuclear localization of WT1 in splicing or transcription factor domains is regulated by alternative splicing

1995 • 502 citations

Electrophoretic separation of complexes involved in the splicing of precursors to mRNAs

1986 • 490 citations

Monomethylated cap structures facilitate RNA export from the nucleus

1990 • 411 citations

Identification of functional U1 snRNA-pre-mRNA complexes committed to spliceosome assembly and splicing

1989 • 391 citations

Structure and Function of Major and Minor Small Nuclear Ribonucleoprotein Particles

1988 • 363 citations

The Ultrastructural Visualization of Nucleolar and Extranucleolar RNA Synthesis and Distribution

1980 • 344 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

RNA Polymerase II Targets Pre-mRNA Splicing Factors to Transcription Sites In Vivo

1999 • 322 citations

An ATP-independent complex commits pre-mRNA to the mammalian spliceosome assembly pathway.

1991 • 297 citations

Perichromatin fibrils are in situ forms of nascent transcripts

1994 • 290 citations

Functions of the Abundant U-snRNPs

1988 • 284 citations

Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription

1994 • 277 citations

An ordered pathway of snRNP binding during mammalian pre-mRNA splicing complex assembly.

1987 • 272 citations

Localization of pre-mRNA splicing in mammalian nuclei

1994 • 269 citations

SR proteins promote the first specific recognition of Pre-mRNA and are present together with the U1 small nuclear ribonucleoprotein particle in a general splicing enhancer complex.

1994 • 267 citations

Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains.

1995 • 251 citations

Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing.

1994 • 230 citations

Coupling RNA polymerase II transcription with pre-mRNA processing

1999 • 228 citations

Inefficient processing impairs release of RNA from the site of transcription

1999 • 227 citations

U1 snRNP targets an essential splicing factor, U2AF65, to the 3' splice site by a network of interactions spanning the exon.

1992 • 225 citations

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

1990 • 225 citations

Cell biology of transcription and pre-mRNA splicing: nuclear architecture meets nuclear function

2000 • 218 citations

Protein components specifically associated with prespliceosome and spliceosome complexes.

1992 • 218 citations

Immunoelectron microscopic localization of snRNPs

1984 • 208 citations

Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript Environment

1997 • 205 citations

Processing of Endogenous Pre-mRNAs in Association with SC-35 Domains Is Gene Specific

1999 • 194 citations

Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells

1999 • 190 citations

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors

1994 • 189 citations

Gel electrophoretic isolation of splicing complexes containing U1 small nuclear ribonucleoprotein particles.

1988 • 183 citations

mRNA polyadenylation and its coupling to other RNA processing reactions and to transcription

1999 • 177 citations

Intron-dependent recruitment of pre-mRNA splicing factors to sites of transcription.

1996 • 174 citations

A functional association between the 5' and 3' splice site is established in the earliest prespliceosome complex (E) in mammals.

1993 • 173 citations

Tracking Col1a1 RNA in Osteogenesis Imperfecta

2000 • 164 citations

A CTD function linking transcription to splicing

1997 • 160 citations

Localization of signal recognition particle RNA in the nucleolus of mammalian cells

1998 • 150 citations

Evidence for channeled diffusion of pre-mRNAs during nuclear RNA transport in metazoans.

1993 • 144 citations

Early commitment of yeast pre-mRNA to the spliceosome pathway.

1988 • 143 citations

Targeted snRNP depletion reveals an additional role for mammalian U1 snRNP in spliceosome assembly

1990 • 143 citations

Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription.

1997 • 141 citations

Localization of pre-messenger RNA at discrete nuclear sites.

1991 • 131 citations

Immunodetection of Poly(A) Binding Protein II in the Cell Nucleus

1994 • 126 citations

Purification and visualization of native spliceosomes

1988 • 121 citations

Probing the structure and function of U2 snRNP with antisense oligonucleotides made of 2′-OMe RNA

1989 • 115 citations

Physical Isolation of Nascent RNA Chains Transcribed by RNA Polymerase II: Evidence for Cotranscriptional Splicing

1994 • 114 citations

The spliceosome assembly pathway in mammalian extracts.

1992 • 111 citations

Syndet is a novel SNAP-25 related protein expressed in many tissues

1997 • 110 citations

Regulation of pre-mRNA splicing in metazoa

1997 • 110 citations

Nuclear pre-mRNA Compartmentalization: Trafficking of Released Transcripts to Splicing Factor Reservoirs

2000 • 108 citations

Dynamic localization of RNase MRP RNA in the nucleolus observed by fluorescent RNA cytochemistry in living cells.

1995 • 106 citations

Nuclear domains of the RNA subunit of RNase P

1997 • 103 citations

Functional analysis of mutant Xenopus U2 snRNAs

1989 • 103 citations

Gel Electrophoretic Isolation of Splicing Complexes Containing U1 Small Nuclear Ribonucleoprotein Particles

1988 • 95 citations

Immunocytochemical identification of nuclear structures containing snRNPs in isolated rat liver cells

1984 • 87 citations

Nuclear organization studied with the help of a hypotonic shift: its use permits hydrophilic molecules to enter into living cells

1999 • 78 citations

Early Commitment of Yeast Pre-mRNA to the Spliceosome Pathway

1988 • 75 citations

Non-snRNP protein splicing factors

1993 • 71 citations

Different Small Nuclear Ribonucleoprotein Particles Are Involved in Different Steps of Splicing Complex Formation

1987 • 68 citations

Assembly of Functional U1 and U2 Human-Amphibian Hybrid snRNPs in Xenopus laevis oocytes

1988 • 60 citations

Evidence for the function of an exonic splicing enhancer after the first catalytic step of pre-mRNA splicing

1999 • 59 citations

A supraspliceosome model for large nuclear ribonucleoprotein particles based on mass determinations by scanning transmission electron microscopy 1 1Edited by W. Baumeister

1998 • 53 citations

Mammalian pre-mRNA splicing factors

1997 • 53 citations

Roles of U4 and U6 snRNAs in the assembly of splicing complexes.

1992 • 52 citations

The Spliceosome Assembly Pathway in Mammalian Extracts

1992 • 51 citations

Nuclear ultrastructures associated with the RNA synthesis and processing

1995 • 45 citations

Splicing factors associate with nuclear HCMV-IE transcripts after transcriptional activation of the gene, but dissociate upon transcription inhibition: evidence for a dynamic organization of splicing factors

1997 • 45 citations

A Minimal Spliceosomal Complex A Recognizes the Branch Site and Polypyrimidine Tract

1997 • 44 citations

In vitro splicing of pre-mRNA containing bromouridine

1994 • 38 citations

The reversible action of α-amanitin on nuclear structure and molecular composition

1978 • 38 citations

Involvement of U1 Small Nuclear Ribonucleoproteins (snRNP) in 5′ Splice Site-U1 snRNP Interaction

1996 • 37 citations

A 7-methylguanosine cap commits U3 and U8 small nuclear RNAs to the nucleolar localization pathway

1998 • 33 citations

Small nuclear RNAs and pre-mRNA splicing

1994 • 31 citations

A base-pairing interaction between U2 and U6 small nuclear RNAs occurs in > 150S complexes in HeLa cell extracts: implications for the spliceosome assembly pathway.

1993 • 30 citations

Alterations in the Polypyrimidine Sequence Affect the in vitro Splicing Reactions Catalyzed by HeLa cell-Free Preparations

1989 • 28 citations

Base Pairing at the 5′ Splice Site with U1 Small Nuclear RNA Promotes Splicing of the Upstream Intron but May Be Dispensable for Splicing of the Downstream Intron

1996 • 25 citations

RNA splicing

1998 • 25 citations

Uncoupling two functions of the U1 small nuclear ribonucleoprotein particle during in vitro splicing.

1993 • 23 citations

Movement and localization of RNA in the cell nucleus

1999 • 23 citations

Running rings around RNA

1999 • 21 citations

Two spliceosomes can form simultaneously and independently on synthetic double-intron messenger RNA precursors.

1987 • 20 citations

RNA Polymerase II Localizes at Sites of Human Cytomegalovirus Immediate-early RNA Synthesis and Processing

1999 • 18 citations

Simian virus 40 cRNA is processed into functional mRNA in microinjected monkey cells.

1982 • 14 citations

A downstream splicing enhancer is essential for in vitro pre‐mRNA splicing

1999 • 13 citations

[Intranuclear structures of monkey kidney cells recognised by immunofluorescence and immuno-electron microscopy using anti-ribonucleoprotein antibodies (author's transl)].

1979 • 13 citations

Uncoupling Two Functions of the U1 Small Nuclear Ribonucleoprotein Particle During in Vitro Splicing

1993 • 11 citations

Factors Involved in the Activation of Pre-mRNA Splicing from Downstream Splicing Enhancers

1996 • 11 citations

Structural Organization of the Pre-mRNA Splicing Commitment: A Hypothesis

1996 • 7 citations

Detection of β-Globin mRNA Precursor in Heterogeneous Nuclear Ribonucleoprotein Associated with Ul-RNP by Using Anti-RNP Antibody1

1985 • 3 citations