Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains.

Fluorescence in situ hybridization with human chromosome-specific libraries: detection of trisomy 21 and translocations of chromosome 4.

1988 • 1,334 citations

The human XIST gene: Analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus

1992 • 1,269 citations

Delineation of individual human chromosomes in metaphase and interphase cells by in situ suppression hybridization using recombinant DNA libraries

1988 • 1,171 citations

A new staining procedure for electron microscopical cytology

1969 • 830 citations

Immunological method for mapping genes on Drosophila polytene chromosomes.

1982 • 772 citations

Monoclonal antibodies to nucleic acid-containing cellular constituents: probes for molecular biology and autoimmune disease.

1981 • 725 citations

Factor required for mammalian spliceosome assembly is localized to discrete regions in the nucleus

1990 • 723 citations

Visualization of focal sites of transcription within human nuclei.

1993 • 656 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

Expression of the cardiac ventricular alpha- and beta-myosin heavy chain genes is developmentally and hormonally regulated.

1984 • 609 citations

Gene gating: a hypothesis.

1985 • 599 citations

Sensitive, high-resolution chromatin and chromosome mapping in situ: Presence and orientation of two closely integrated copies of EBV in a lymphoma line

1988 • 550 citations

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

1993 • 541 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Associations between distinct pre-mRNA splicing components and the cell nucleus.

1991 • 523 citations

Role of Chromosome Territories in the Functional Compartmentalization of the Cell Nucleus

1993 • 504 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

The nonchromatin substructures of the nucleus: the ribonucleoprotein (RNP)-containing and RNP-depleted matrices analyzed by sequential fractionation and resinless section electron microscopy.

1986 • 420 citations

Determinants of messenger RNA stability

1987 • 414 citations

The Ultrastructural Visualization of Nucleolar and Extranucleolar RNA Synthesis and Distribution

1980 • 344 citations

A Three-Dimensional View of Precursor Messenger RNA Metabolism Within the Mammalian Nucleus

1993 • 335 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

Immunological and ultrastructural studies of the nuclear coiled body with autoimmune antibodies

1991 • 327 citations

Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus.

1991 • 300 citations

Perichromatin fibrils are in situ forms of nascent transcripts

1994 • 290 citations

Arrangement of chromatin in the nucleus

1980 • 283 citations

In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

1993 • 272 citations

Specific commitment of different pre-mRNAs to splicing by single SR proteins

1993 • 272 citations

Localization of pre-mRNA splicing in mammalian nuclei

1994 • 269 citations

Interphase and Metaphase Resolution of Different Distances Within the Human Dystrophin Gene

1990 • 260 citations

The Role of the Poly(A) Sequence in Mammalian Messenger RN

1981 • 254 citations

Evidence for a nuclear compartment of transcription and splicing located at chromosome domain boundaries

1993 • 241 citations

Nascent pre-mRNA transcripts are associated with nuclear regions enriched in splicing factors.

1991 • 239 citations

In vivo analysis of the stability and transport of nuclear poly(A)+ RNA.

1994 • 233 citations

Localisation of rapidly and slowly labelled nuclear RNA as visualized by high resolution autoradiography

1971 • 233 citations

Mapping of human chromosome Xq28 by two-color fluorescence in situ hybridization of DNA sequences to interphase cell nuclei.

1991 • 226 citations

Higher order nuclear organization: three-dimensional distribution of small nuclear ribonucleoprotein particles.

1990 • 225 citations

Units of transcription and translation: the relationship between heterogeneous nuclear RNA and messenger RNA

1975 • 219 citations

The rat gene encoding neurotensin and neuromedin N. Structure, tissue-specific expression, and evolution of exon sequences.

1988 • 216 citations

Association of nuclear matrix antigens with exon-containing splicing complexes.

1994 • 214 citations

Immunoelectron microscopic localization of snRNPs

1984 • 208 citations

Different central nervous system cell types display distinct and nonrandom arrangements of satellite DNA sequences.

1984 • 191 citations

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors

1994 • 189 citations

High-resolution in situ hybridization using DNA halo preparations

1992 • 171 citations

Human cardiac myosin heavy chain genes and their linkage in the genome

1987 • 166 citations

Expression of a foreign gene in a line of transgenic mice is modulated by a chromosomal position effect.

1990 • 160 citations

Dynamic changes in the higher-level chromatin organization of specific sequences revealed by in situ hybridization to nuclear halos.

1994 • 158 citations

Intranuclear Distribution of Poly(A) RNA Determined by Electron Microscope in Situ Hybridization

1993 • 154 citations

Analysis of chromosome positions in the interphase nucleus of Chinese hamster cells by laser-UV-microirradiation experiments

1982 • 147 citations

Evidence for channeled diffusion of pre-mRNAs during nuclear RNA transport in metazoans.

1993 • 144 citations

Intranuclear localization of snRNP antigens.

1986 • 140 citations

Structure–function relationships in eukaryotic nuclei

1991 • 138 citations

Chapter 3 Fluorescent Detection of Nuclear RNA and DNA: Implications for Genome Organization

1991 • 131 citations

Message and non-message sequences adjacent to poly(A) in steady state heterogeneous nuclear RNA of HeLa cells

1976 • 131 citations

Localization of pre-messenger RNA at discrete nuclear sites.

1991 • 131 citations

Immunodetection of Poly(A) Binding Protein II in the Cell Nucleus

1994 • 126 citations

Molecular cloning and characterization of mutant and wild-type human beta-actin genes.

1984 • 108 citations

DNA and chromatin structure of the human alpha 1 (I) collagen gene.

1984 • 90 citations

Nuclear and Cytoplasmic Messenger-like RNA and Their Relation to the Active Messenger RNA in Polyribosomes of HeLa Cells

1970 • 85 citations

Compartmentalization of specific pre-mRNA metabolism: an emerging view

1995 • 70 citations

Interactions of minute virus of mice and adenovirus with host nucleoli

1989 • 67 citations

Large heterogeneous nuclear ribonucleic acid has three times as many 5' caps as polyadenylic acid segments, and most caps do not enter polyribosomes.

1981 • 63 citations

Nuclear RNA tracks: structural basis for transcription and splicing?

1993 • 57 citations

Probing Functional Organization within the Nucleus: Is Genome Structure Integrated with RNA Metabolism?

1993 • 55 citations

Expression of a Foreign Gene in a Line of Transgenic Mice Is Modulated by a Chromosomal Position Effect

1990 • 54 citations

The human serum albumin gene: structure of a unique locus

1982 • 51 citations

The nucleus-limited Hsr-omega-n transcript is a polyadenylated RNA with a regulated intranuclear turnover.

1994 • 49 citations

Cell Fine Structure: An Atlas of Drawings of Whole-Cell Structure.

1971 • 48 citations

Multiple decay rates of heterogeneous nuclear RNA in HeLa cells

1977 • 42 citations

Drug and metabolite-induced perturbations in nuclear structure and function: a review

1990 • 39 citations

Molecular Cloning and Characterization of Mutant and Wild-Type Human β-Actin Genes

1984 • 36 citations

Detection of Mutations in Human Type I Collagen mRNA in Osteogenesis Imperfecta by Indirect RNase Protection

1989 • 32 citations

Large Heterogeneous Nuclear Ribonucleic Acid Has Three Times as Many 5′ Caps as Polyadenylic Acid Segments, and Most Caps Do Not Enter Polyribosomes

1981 • 21 citations

Isolation and Mapping of Human T-Cell Protein Tyrosine Phosphatase Sequences: Localization of Genes and Pseudogenes Discriminated Using Fluorescence Hybridization with Genomic versus cDNA Probes

1993 • 20 citations

RNA polymerase II transcription and the functional organization of the mammalian cell nucleus

1995 • 16 citations

Reversible disassembly of transcription domains in lymphocyte nuclei during inhibition of RNA synthesis by DRB

1993 • 15 citations

Spatial localization of pre-mRNA transcription and processing within the nucleus

1994 • 8 citations

Transcription by RNA Polymerase II and Nuclear Architecture

1997 • 4 citations