RNA Polymerase II Localizes at Sites of Human Cytomegalovirus Immediate-early RNA Synthesis and Processing

The C-terminal domain of RNA polymerase II couples mRNA processing to transcription

1997 • 905 citations

Visualization of focal sites of transcription within human nuclei.

1993 • 656 citations

Control of RNA Polymerase II Elongation Potential by a Novel Carboxyl-terminal Domain Kinase

1996 • 645 citations

Macromolecular Domains within the Cell Nucleus

1993 • 611 citations

The dynamics of a pre-mRNA splicing factor in living cells

1997 • 604 citations

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

1993 • 541 citations

5′-Capping enzymes are targeted to pre-mRNA by binding to the phosphorylated carboxy-terminal domain of RNA polymerase II

1997 • 540 citations

Splice site selection, rate of splicing, and alternative splicing on nascent transcripts.

1988 • 539 citations

Inhibition of RNA synthesis by actinomycin D: Characteristic dose‐response of different RNA species

1970 • 531 citations

Reversible Phosphorylation of the C-terminal Domain of RNA Polymerase II

1996 • 498 citations

mRNA capping enzyme is recruited to the transcription complex by phosphorylation of the RNA polymerase II carboxy-terminal domain

1997 • 467 citations

The C-terminal domain of the largest subunit of RNA polymerase II interacts with a novel set of serine/arginine-rich proteins.

1996 • 351 citations

A Three-Dimensional View of Precursor Messenger RNA Metabolism Within the Mammalian Nucleus

1993 • 335 citations

Transcription-dependent redistribution of the large subunit of RNA polymerase II to discrete nuclear domains.

1995 • 328 citations

A hyperphosphorylated form of the large subunit of RNA polymerase II is associated with splicing complexes and the nuclear matrix.

1996 • 324 citations

Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus.

1991 • 300 citations

Perichromatin fibrils are in situ forms of nascent transcripts

1994 • 290 citations

Splicing of Balbiani ring 1 gene pre-mRNA occurs simultaneously with transcription

1994 • 277 citations

In vivo evidence that transcription and splicing are coordinated by a recruiting mechanism

1993 • 272 citations

Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains.

1995 • 251 citations

Splicing Factors Associate with Hyperphosphorylated RNA Polymerase II in the Absence of Pre-mRNA

1997 • 245 citations

Physical isolation of nascent RNA chains transcribed by RNA polymerase II: evidence for cotranscriptional splicing.

1994 • 230 citations

Inhibition of in Vivo and in Vitro Transcription by Monoclonal Antibodies Prepared against Wheat Germ RNA Polymerase II That React with the Heptapeptide Repeat of Eukaryotic RNA Polymerase II

1989 • 228 citations

Nuclear distribution of transcription factors in relation to sites of transcription and RNA polymerase II

1997 • 217 citations

Human Cytomegalovirus Immediate Early Interaction with Host Nuclear Structures: Definition of an Immediate Transcript Environment

1997 • 205 citations

Dynamic relocation of transcription and splicing factors dependent upon transcriptional activity

1997 • 197 citations

Disruption of pre-mRNA splicing in vivo results in reorganization of splicing factors

1994 • 189 citations

Phosphorylation of RNA polymerase IIA occurs subsequent to interaction with the promoter and before the initiation of transcription.

1990 • 178 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

Locus-specific variation in phosphorylation state of RNA polymerase II in vivo: correlations with gene activity and transcript processing.

1993 • 175 citations

Pre-mRNA Processing and the CTD of RNA Polymerase II: The Tail That Wags the Dog?

1997 • 165 citations

Serine/threonine phosphatase 1 modulates the subnuclear distribution of pre-mRNA splicing factors.

1996 • 160 citations

Distribution of pre-mRNA splicing factors at sites of RNA polymerase II transcription.

1997 • 141 citations

A Functional Interaction between the Carboxy-Terminal Domain of RNA Polymerase II and Pre-mRNA Splicing

1997 • 139 citations

Inhibitors of transcription such as 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole and isoquinoline sulfonamide derivatives (H-8 and H-7) promote dephosphorylation of the carboxyl-terminal domain of RNA polymerase II largest subunit.

1994 • 122 citations

Positive patches and negative noodles: linking RNA processing to transcription?

1993 • 117 citations

Specificity of RNA maturation pathways: RNAs transcribed by RNA polymerase III are not substrates for splicing or polyadenylation.

1987 • 115 citations

The nuclear matrix protein p255 is a highly phosphorylated form of RNA polymerase II largest subunit which associates with spliceosomes

1996 • 90 citations

5′-terminal caps of snRNAs are reactive with antibodies specific for 2,2,7-trimethylguanosine in whole cells and nuclear matrices

1984 • 79 citations

Partial purification and characterization of two distinct protein kinases that differentially phosphorylate the carboxyl-terminal domain of RNA polymerase subunit IIa.

1993 • 75 citations

Compartmentalization of specific pre-mRNA metabolism: an emerging view

1995 • 70 citations

Methodologies for specific intron and exon RNA localization in cultured cells by haptenized and fluorochromized probes

1993 • 68 citations

Dynamics of Transcription and Pre-mRNA Splicing within the Mammalian Cell Nucleus

1993 • 65 citations

Phosphorylation of the RNA polymerase II largest subunit during heat shock and inhibition of transcription in hela cells

1994 • 57 citations

Fluorescence in situ hybridization using horseradish peroxidase-labeled oligodeoxynucleotides and tyramide signal amplification for sensitive DNA and mRNA detection

1998 • 50 citations

The nuclear matrix phosphoprotein p255 associates with splicing complexes as part of the [U4/Y6.U5]tri-snRNP particle

1995 • 46 citations

Establishment of a rat cell line inducible for the expression of human cytomegalovirus immediate-early gene products by protein synthesis inhibition

1986 • 45 citations

RNAs radiate from gene to cytoplasm as revealed by fluorescence in situ hybridization

1995 • 45 citations

Splicing factors associate with nuclear HCMV-IE transcripts after transcriptional activation of the gene, but dissociate upon transcription inhibition: evidence for a dynamic organization of splicing factors

1997 • 45 citations

Colocalization of a high molecular mass phosphoprotein of the nuclear matrix (p255) with spliceosomes

1995 • 40 citations

Demonstration of a dynamic, transcription-dependent organization of pre-mRNA splicing factors in polytene nuclei.

1996 • 40 citations

RNA molecules lighting up under the microscope

1996 • 34 citations

Cell-cycle-dependent gene expression studied by two-colour fluorescent detection of a mRNA and histone mRNA

1995 • 11 citations