Evidence that all SC-35 domains contain mRNAs and that transcripts can be structurally constrained within these domains

High mobility of proteins in the mammalian cell nucleus

2000 • 1,163 citations

An extensive network of coupling among gene expression machines

2002 • 1,137 citations

Evolutionary conservation in the untranslated regions of actin mRNAs: DNA sequence of a human beta-actin cDNA

1984 • 973 citations

TREX is a conserved complex coupling transcription with messenger RNA export

2002 • 829 citations

Visualization of focal sites of transcription within human nuclei.

1993 • 656 citations

Fluorescent labeling of nascent RNA reveals transcription by RNA polymerase II in domains scattered throughout the nucleus

1993 • 541 citations

Highly localized tracks of specific transcripts within interphase nuclei visualized by in situ hybridization

1989 • 434 citations

Evolution of the Functional Human β-Actin Gene and Its Multi-Pseudogene Family: Conservation of Noncoding Regions and Chromosomal Dispersion of Pseudogenes

1985 • 378 citations

Discrete nuclear domains of poly(A) RNA and their relationship to the functional organization of the nucleus.

1991 • 300 citations

Perichromatin fibrils are in situ forms of nascent transcripts

1994 • 290 citations

Nup98 Is a Mobile Nucleoporin with Transcription-dependent Dynamics

2002 • 263 citations

The Role of the Poly(A) Sequence in Mammalian Messenger RN

1981 • 254 citations

Nonrandom gene organization: structural arrangements of specific pre-mRNA transcription and splicing with SC-35 domains.

1995 • 251 citations

In vivo analysis of the stability and transport of nuclear poly(A)+ RNA.

1994 • 233 citations

Animal DNA-dependent RNA polymerases 11. Mechanism of the inhibition of RNA polymerases B by amatoxins

1974 • 225 citations

Evolution of the functional human beta-actin gene and its multi-pseudogene family: conservation of noncoding regions and chromosomal dispersion of pseudogenes.

1985 • 211 citations

The inhibition of DRB (5,6-dichloro-1-β-d-ribofuranosylbenzimidazole) of hnRNA and mRNA production in HeLa cells

1976 • 204 citations

Processing of Endogenous Pre-mRNAs in Association with SC-35 Domains Is Gene Specific

1999 • 194 citations

Movement of nuclear poly(A) RNA throughout the interchromatin space in living cells

1999 • 190 citations

Localization and characterization of newly synthesized nuclear RNA in isolated rat hepatocytes

1976 • 184 citations

The Transcriptional Elongation Inhibitor 5,6-Dichloro-1-β-D-ribofuranosylbenzimidazole Inhibits Transcription Factor IIH-associated Protein Kinase

1995 • 178 citations

Analysis of the COL1A1 and COL1A2 Genes by PCR Amplification and Scanning by Conformation-Sensitive Gel Electrophoresis Identifies Only COL1A1 Mutations in 15 Patients with Osteogenesis Imperfecta Type I: Identification of Common Sequences of Null-Allele Mutations

1998 • 175 citations

Reduced Mobility of the Alternate Splicing Factor (Asf) through the Nucleoplasm and Steady State Speckle Compartments

2000 • 175 citations

Tracking Col1a1 RNA in Osteogenesis Imperfecta

2000 • 164 citations

Three-Dimensional Visualization of Transcription Sites and Their Association with Splicing Factor–Rich Nuclear Speckles

1999 • 157 citations

Intranuclear Distribution of Poly(A) RNA Determined by Electron Microscope in Situ Hybridization

1993 • 154 citations

Evidence for channeled diffusion of pre-mRNAs during nuclear RNA transport in metazoans.

1993 • 144 citations

Preservation of specific RNA distribution within the chromatin-depleted nuclear substructure demonstrated by in situ hybridization coupled with biochemical fractionation.

1991 • 139 citations

Chapter 3 Fluorescent Detection of Nuclear RNA and DNA: Implications for Genome Organization

1991 • 131 citations

Ultrastructure of the Nucleus in Relation to Transcription and Splicing: Roles of Perichromatin Fibrils and Interchromatin Granules

1996 • 129 citations

The intranuclear mobility of messenger RNA binding proteins is ATP dependent and temperature sensitive

2002 • 120 citations

Nuclear pre-mRNA Compartmentalization: Trafficking of Released Transcripts to Splicing Factor Reservoirs

2000 • 108 citations

α-amanitin-resistant D. melanogaster with an altered RNA polymerase II

1979 • 106 citations

The Intranuclear Movement of Balbiani Ring Premessenger Ribonucleoprotein Particles

1999 • 83 citations

A new view of mRNA export: Separating the wheat from the chaff

2001 • 75 citations

Compartmentalization of specific pre-mRNA metabolism: an emerging view

1995 • 70 citations

The path of transcripts from extra-nucleolar synthetic sites to nuclear pores: transcripts in transit are concentrated in discrete structures containing SR proteins

1998 • 65 citations

Probing Functional Organization within the Nucleus: Is Genome Structure Integrated with RNA Metabolism?

1993 • 55 citations

Intranuclear migration of newly synthesized extranucleolar ribonucleoproteins

1978 • 49 citations

Spliced exons of adenovirus late RNAs colocalize with snRNP in a specific nuclear domain.

1996 • 47 citations

RNAs radiate from gene to cytoplasm as revealed by fluorescence in situ hybridization

1995 • 45 citations

Multiple decay rates of heterogeneous nuclear RNA in HeLa cells

1977 • 42 citations

Construction of a full-length cDNA encoding human pro-alpha 2(I) collagen and its expression in pro-alpha 2(I)-deficient W8 rat cells.

1988 • 35 citations

Expression of the cell-binding domain of human fibronectin in E. coli

1987 • 34 citations

Nuclear RNA Accumulations Contain Released Transcripts and Exhibit Specific Distributions with Respect to Sm Antigen Foci

1997 • 25 citations

Actinomycin D and RNA transport

1974 • 20 citations

Induction of p21 mRNA Synthesis After Short-wavelength UV Light Visualized in Individual Cells by RNA FISH

2002 • 19 citations

Inhibition of the intracellular transport of influenza viral RNA by actinomycin D

1995 • 15 citations

An ATP-dependent step is required for the translocation of microinjected precursor mRNA into nuclear speckles.

2002 • 4 citations