Consequences of knocking out BMP signaling in the mouse

Manipulating the mouse embryo: A laboratory manual

1986 • 4,548 citations

Regulation of skeletal muscle mass in mice by a new TGF-p superfamily member

1997 • 3,802 citations

Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4

1998 • 3,360 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Mechanism of activation of the TGF-β receptor

1994 • 2,298 citations

Manipulating the mouse embryo: A laboratory manual

1986 • 2,165 citations

Bone morphogenetic proteins: multifunctional regulators of vertebrate development.

1996 • 1,959 citations

Bone morphogenetic protein-4 is required for mesoderm formation and patterning in the mouse.

1995 • 1,782 citations

Growth differentiation factor-9 is required during early ovarian folliculogenesis

1996 • 1,618 citations

The Spemann Organizer Signal noggin Binds and Inactivates Bone Morphogenetic Protein 4

1996 • 1,604 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

TGFβ2 knockout mice have multiple developmental defects that are non-overlapping with other TGFβ knockout phenotypes

1997 • 1,404 citations

Dorsoventral Patterning in Xenopus: Inhibition of Ventral Signals by Direct Binding of Chordin to BMP-4

1996 • 1,126 citations

A requirement for bone morphogenetic protein-7 during development of the mammalian kidney and eye.

1995 • 1,118 citations

BMP-7 is an inducer of nephrogenesis, and is also required for eye development and skeletal patterning.

1995 • 1,021 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Mice deficient for BMP2 are nonviable and have defects in amnion/chorion and cardiac development

1996 • 959 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Transforming growth factor–β3 is required for secondary palate fusion

1995 • 895 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

α-lnhibin is a tumour-suppressor gene with gonadal specificity in mice

1992 • 887 citations

Limb alterations in brachypodism mice due to mutations in a new member of the TGFβ-superfamily

1994 • 855 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Activin receptor-like kinase 1 modulates transforming growth factor-β1 signaling in the regulation of angiogenesis

2000 • 823 citations

Bmpr encodes a type I bone morphogenetic protein receptor that is essential for gastrulation during mouse embryogenesis.

1995 • 784 citations

Induction of epidermis and inhibition of neural fate by Bmp-4

1995 • 782 citations

A primary requirement for nodal in the formation and maintenance of the primitive streak in the mouse

1994 • 769 citations

Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity

1994 • 759 citations

Synergistic Roles of Bone Morphogenetic Protein 15 and Growth Differentiation Factor 9 in Ovarian Function

2001 • 757 citations

Axis Development and Early Asymmetry in Mammals

1999 • 740 citations

MADR2 Is a Substrate of the TGFβ Receptor and Its Phosphorylation Is Required for Nuclear Accumulation and Signaling

1996 • 740 citations

Regulation of neural induction by the Chd and Bmp-4 antagonistic patterning signals in Xenopus

1995 • 731 citations

MADR1, a MAD-Related Protein That Functions in BMP2 Signaling Pathways

1996 • 710 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Genetic characterization and cloning of mothers against dpp, a gene required for decapentaplegic function in Drosophila melanogaster.

1995 • 672 citations

Müllerian-inhibiting substance function during mammalian sexual development

1994 • 661 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

TGF-β/Smad3 Signals Repress Chondrocyte Hypertrophic Differentiation and Are Required for Maintaining Articular Cartilage

2001 • 614 citations

Nodal is a novel TGF-β-like gene expressed in the mouse node during gastrulation

1993 • 606 citations

Intestinal Tumorigenesis in Compound Mutant Mice of both Dpc4(Smad4) and Apc Genes

1998 • 603 citations

Human Type II Receptor for Bone Morphogenic Proteins (BMPs): Extension of the Two-Kinase Receptor Model to the BMPs

1995 • 602 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

Different phenotypes for mice deficient in either activins or activin receptor type II

1995 • 598 citations

Functional analysis of activins during mammalian development

1995 • 579 citations

Relationship between asymmetric nodal expression and the direction of embryonic turning

1996 • 547 citations

Highly Prolific Booroola Sheep Have a Mutation in the Intracellular Kinase Domain of Bone Morphogenetic Protein IB Receptor (ALK-6) That Is Expressed in Both Oocytes and Granulosa Cells1

2001 • 542 citations

lefty-1 Is Required for Left-Right Determination as a Regulator of lefty-2 and nodal

1998 • 539 citations

Nodal signalling in the epiblast patterns the early mouse embryo

2001 • 532 citations

Caenorhabditis elegans genes sma-2, sma-3, and sma-4 define a conserved family of transforming growth factor beta pathway components.

1996 • 528 citations

Solubilized and insolubilized bone morphogenetic protein.

1979 • 495 citations

The tumor suppressor gene Smad4/Dpc4 is required for gastrulation and later for anterior development of the mouse embryo

1998 • 494 citations

A role for Smad6 in development and homeostasis of the cardiovascular system

2000 • 488 citations

Inhibition of activin receptor signaling promotes neuralization in Xenopus

1994 • 484 citations

The mouse short ear skeletal morphogenesis locus is associated with defects in a bone morphogenetic member of the TGFβ superfamily

1992 • 483 citations

The Bone Morphogenetic Protein 15 Gene Is X-Linked and Expressed in Oocytes

1998 • 480 citations

Specific Activation of Smad1 Signaling Pathways by the BMP7 Type I Receptor, ALK2

1998 • 472 citations

Smad2 Signaling in Extraembryonic Tissues Determines Anterior-Posterior Polarity of the Early Mouse Embryo

1998 • 469 citations

Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor 11

1999 • 453 citations

A truncated bone morphogenetic protein receptor affects dorsal-ventral patterning in the early Xenopus embryo.

1994 • 449 citations

Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo

1998 • 448 citations

Overlapping expression domains of bone morphogenetic protein family members potentially account for limited tissue defects inBMP7 deficient embryos

1997 • 448 citations

Oocyte-specific expression of growth/differentiation factor-9.

1995 • 447 citations

Smad5 knockout mice die at mid-gestation due to multiple embryonic and extraembryonic defects

1999 • 436 citations

BMP4 is essential for lens induction in the mouse embryo

1998 • 435 citations

Xenopus Mad Proteins Transduce Distinct Subsets of Signals for the TGFβ Superfamily

1996 • 432 citations

Bone morphogenetic protein-3 is a negative regulator of bone density

2001 • 420 citations

Induction of visceral and cardiac mesoderm by ectodermal Dpp in the early Drosophila embryo

1995 • 419 citations

BMP Type II Receptor Is Required for Gastrulation and Early Development of Mouse Embryos

2000 • 413 citations

Requirement of Bmp8b for the Generation of Primordial Germ Cells in the Mouse

2000 • 412 citations

Bone morphogenetic protein 4 regulates the budding site and elongation of the mouse ureter

2000 • 407 citations

Zebrafish genetics and vertebrate heart formation

2001 • 403 citations

Patterning Mechanisms Controlling Vertebrate Limb Development

2001 • 403 citations

Activin/inhibin beta B subunit gene disruption leads to defects in eyelid development and female reproduction.

1994 • 395 citations

Angiogenesis defects and mesenchymal apoptosis in mice lacking SMAD5

1999 • 394 citations

Cooperation of Endoderm-Derived BMP2 and Extraembryonic Ectoderm-Derived BMP4 in Primordial Germ Cell Generation in the Mouse

2001 • 391 citations

The type I BMP receptor BMPRIB is required for chondrogenesis in the mouse limb

2000 • 391 citations

Joint patterning defects caused by single and double mutations in members of the bone morphogenetic protein (BMP) family

1996 • 387 citations

The signaling pathway mediated by the type IIB activin receptor controls axial patterning and lateral asymmetry in the mouse.

1997 • 387 citations

nodal expression in the primitive endoderm is required for specification of the anterior axis during mouse gastrulation

1997 • 384 citations

Mouse embryos lacking Smad1 signals display defects in extra-embryonic tissues and germ cell formation

2001 • 383 citations

The dorsalizing and neural inducing gene follistatin is an antagonist of BMP-4

1997 • 382 citations

Nodal Signals to Smads through Cripto-Dependent and Cripto-Independent Mechanisms

2001 • 377 citations

Mouse Lefty2 and Zebrafish Antivin Are Feedback Inhibitors of Nodal Signaling during Vertebrate Gastrulation

1999 • 372 citations

The tumor suppressor SMAD4/DPC4 is essential for epiblast proliferation and mesoderm induction in mice

1998 • 368 citations

Mice lackingBmp6 function

1998 • 363 citations

Genetic analysis of the Müllerian-inhibiting substance signal transduction pathway in mammalian sexual differentiation.

1996 • 354 citations

Early embryonic lethality in Bmp5;Bmp7 double mutant mice suggests functional redundancy within the 60A subgroup

1999 • 343 citations

Wnt signaling in Xenopus embryos inhibits Bmp4 expression and activates neural development

1999 • 338 citations

Neuronal patterning by BMPs: a requirement for GDF7 in the generation of a discrete class of commissural interneurons in the mouse spinal cord

1998 • 333 citations

BMP signaling plays a role in visceral endoderm differentiation and cavitation in the early mouse embryo

1999 • 330 citations

Distinct spatial and temporal expression patterns of two type I receptors for bone morphogenetic proteins during mouse embryogenesis.

1995 • 326 citations

Genetic dissection ofnodalfunction in patterning the mouse embryo

2001 • 320 citations

An absolute requirement for both the type II and type I receptors, punt and thick veins, for Dpp signaling in vivo

1995 • 312 citations

The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate development

2001 • 306 citations

Genetic screens to identify elements of the decapentaplegic signaling pathway in Drosophila.

1995 • 306 citations

Induction of primordial germ cells from murine epiblasts by synergistic action of BMP4 and BMP8B signaling pathways

2001 • 304 citations

Failure of egg cylinder elongation and mesoderm induction in mouse embryos lacking the tumor suppressor smad2

1998 • 295 citations

Endocardial cushion and myocardial defects after cardiac myocyte-specific conditional deletion of the bone morphogenetic protein receptor ALK3

2002 • 282 citations

Haploinsufficient Phenotypes inBmp4Heterozygous Null Mice and Modification by Mutations inGli3andAlx4

1997 • 282 citations

Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic

1994 • 275 citations

The gene encoding bone morphogenetic protein 8B is required for the initiation and maintenance of spermatogenesis in the mouse.

1996 • 274 citations

Oocyte-specific expression of growth/differentiation factor-9

1995 • 273 citations

BMP7 Acts in Murine Lens Placode Development

1999 • 272 citations

Conditional inactivation of the TGF‐β type II receptor using Cre:Lox

2002 • 265 citations

Generation ofBmpr/Alk3conditional knockout mice

2002 • 253 citations

The type I serine/threonine kinase receptor ActRIA (ALK2) is required for gastrulation of the mouse embryo

1999 • 252 citations

Signaling via hetero-oligomeric complexes of type I and type II serine/threonine kinase receptors

1996 • 250 citations

BMP5 and the Molecular, Skeletal, and Soft-Tissue Alterations in short ear Mice

1994 • 247 citations

RETRACTED: Deficient Smad7 expression: A putative molecular defect in scleroderma

2002 • 247 citations

Two closely‐related left‐right asymmetrically expressed genes, lefty‐1 and lefty‐2: their distinct expression domains, chromosomal linkage and direct neuralizing activity in Xenopus embryos

1997 • 245 citations

The Xenopus Dorsalizing Factor noggin Ventralizes Drosophila Embryos by Preventing DPP from Activating Its Receptor

1996 • 242 citations

BMPR-IA signaling is required for the formation of the apical ectodermal ridge and dorsal-ventral patterning of the limb

2001 • 242 citations

Haploid loss of the tumor suppressor Smad4/Dpc4 initiates gastric polyposis and cancer in mice

2000 • 241 citations

dally, a Drosophila glypican, controls cellular responses to the TGF-β-related morphogen, Dpp

1997 • 241 citations

BMPs negatively regulate structure and function of the limb apical ectodermal ridge

1999 • 232 citations

BMP7 Null Mutation in Mice: Developmental Defects in Skeleton, Kidney, and Eye

1997 • 230 citations

Generation of Smad4/Dpc4 conditional knockout mice

2002 • 228 citations

Combinatorial signaling through BMP receptor IB and GDF5: shaping of the distal mouse limb and the genetics of distal limb diversity

2000 • 223 citations

The type I activin receptor ActRIB is required for egg cylinder organization and gastrulation in the mouse

1998 • 221 citations

Smad1 Recognition and Activation by the ALK1 Group of Transforming Growth Factor-β Family Receptors

1999 • 219 citations

Bmp6 and Bmp7 Are Required for Cushion Formation and Septation in the Developing Mouse Heart

2001 • 217 citations

Regulation of left-right patterning in mice by growth/differentiation factor-1

2000 • 216 citations

The type I BMP receptor BmprIB is essential for female reproductive function

2001 • 206 citations

Smad5 is required for mouse primordial germ cell development

2001 • 205 citations

BMP2 is required for early heart development during a distinct time period

2000 • 204 citations

The Type II Activin Receptors Are Essential for Egg Cylinder Growth, Gastrulation, and Rostral Head Development in Mice

1999 • 192 citations

Cloning of a Novel Type II Serine/Threonine Kinase Receptor through Interaction with the Type I Transforming Growth Factor-β Receptor

1995 • 189 citations

Targeted Mutagenesis of Smad1 Reveals an Essential Role in Chorioallantoic Fusion

2001 • 181 citations

Formation of the definitive endoderm in mouse is a Smad2-dependent process

2000 • 180 citations

Glypican-3 Modulates BMP- and FGF-Mediated Effects during Renal Branching Morphogenesis

2001 • 179 citations

glypican-3 Controls Cellular Responses to Bmp4 in Limb Patterning and Skeletal Development

2000 • 174 citations

Bone morphogenetic protein 8A plays a role in the maintenance of spermatogenesis and the integrity of the epididymis

1998 • 173 citations

Multiple Roles for Activin-Like Kinase-2 Signaling during Mouse Embryogenesis

1999 • 173 citations

A Novel BMP Expressed in Developing Mouse Limb, Spinal Cord, and Tail Bud Is a Potent Mesoderm Inducer inXenopusEmbryos

1999 • 166 citations

Bone morphogenetic protein 4 in the extraembryonic mesoderm is required for allantois development and the localization and survival of primordial germ cells in the mouse

2001 • 162 citations

Intracellular signalling: The Mad way to do it

1996 • 162 citations

Competition between noggin and bone morphogenetic protein 4 activities may regulate dorsalization during Xenopus development.

1995 • 161 citations

Complementation between kinase-defective and activation-defective TGF-beta receptors reveals a novel form of receptor cooperativity essential for signaling.

1996 • 158 citations

Postgastrulation Smad2- deficient embryos show defects in embryo turning and anterior morphogenesis

1999 • 157 citations

Smad5 Is Essential for Left–Right Asymmetry in Mice

2000 • 151 citations

BMP-2 and OP-1 exert direct and opposite effects on renal branching morphogenesis

1997 • 138 citations

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

2000 • 132 citations

Diffusion of Nodal Signaling Activity in the Absence of the Feedback Inhibitor Lefty2

2001 • 130 citations

A Dominant Negative Bone Morphogenetic Protein 4 Receptor Causes Neuralization in Xenopus Ectoderm

1995 • 127 citations

Revelations of ovarian follicle biology from gene knockout mice

2000 • 126 citations

BMP3: To Be or Not To Be a BMP

2001 • 120 citations

Skeletal abnormalities in doubly heterozygousBmp4 andBmp7 mice

1998 • 120 citations

Evidence that mouse Bmp8a (Op2) and Bmp8b are duplicated genes that play a role in spermatogenesis and placental development

1996 • 118 citations

Nodal Signaling Uses Activin and Transforming Growth Factor-β Receptor-regulated Smads

2001 • 114 citations

BMP-4 inhibits neural differentiation of murine embryonic stem cells

1999 • 111 citations

Expression of inhibin beta A and beta B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium.

1992 • 109 citations

Generation of the floxed allele of the SIP1 (Smad‐interacting protein 1) gene for Cre‐mediated conditional knockout in the mouse

2002 • 105 citations

Nodal Regulates Trophoblast Differentiation and Placental Development

2001 • 90 citations

Mutation in Bmp7 Exacerbates the Phenotype of Bmp8a Mutants in Spermatogenesis and Epididymis

2001 • 87 citations

Mechanism of the pleiotropic effects of the short‐ear mutant gene in the mouse

1968 • 70 citations

The BMP Family Member Gdf7 Is Required for Seminal Vesicle Growth, Branching Morphogenesis, and Cytodifferentiation

2001 • 65 citations

Localization of activin receptor (ActR-IIB2) mRNA in the rat seminiferous epithelium.

1993 • 61 citations

Conditional knockout of the Smad1 gene

2002 • 47 citations

mRNAs for activin receptors II and IIB are expressed in mouse oocytes and in the epiblast of pregastrula and gastrula stage mouse embryos

1995 • 46 citations

Generation of a loxP flanked bmp4loxPlacZ allele marked by conditional lacZ expression

2002 • 43 citations

Expression of inhibin beta A and beta B, follistatin and activin-A receptor messenger ribonucleic acids in the rat seminiferous epithelium

1992 • 41 citations

A morphogeneric matrix for differentiation of bone tissue

1970 • 40 citations

Generation of a loxP flanked bmp4^loxP‐lacZ allele marked by conditional lacZ expression

2002 • 36 citations

Evidence that Mothers-against-dpp-related 1 (Madr1) plays a role in the initiation and maintenance of spermatogenesis in the mouse

1997 • 34 citations

The Battle of the Sexes: Opposing Pathways in Sex Determination

2002 • 28 citations

Localization of activin receptor (ActR-IIB2) mRNA in the rat seminiferous epithelium

1993 • 25 citations

Reversible extinction of the morphogen in bone matrix by reduction and oxidation of disulfide bonds

1975 • 24 citations

A bone morphogenetic polypeptide

1975 • 21 citations