Mechanism of Mitogen-activated Protein Kinase Phosphatase-3 Activation by ERK2

Mitogen-Activated Protein Kinase: Conservation of a Three-Kinase Module From Yeast to Human

1999 • 2,692 citations

Mechanism of protein stabilization by glycerol: preferential hydration in glycerol-water mixtures

1981 • 1,170 citations

MKP-1 (3CH134), an immediate early gene product, is a dual specificity phosphatase that dephosphorylates MAP kinase in vivo

1993 • 1,169 citations

Identification of the regulatory phosphorylation sites in pp42/mitogen-activated protein kinase (MAP kinase).

1991 • 1,041 citations

Activation Mechanism of the MAP Kinase ERK2 by Dual Phosphorylation

1997 • 724 citations

Structural Basis for Phosphotyrosine Peptide Recognition by Protein Tyrosine Phosphatase 1B

1995 • 575 citations

Multiple components in an epidermal growth factor-stimulated protein kinase cascade

1991 • 502 citations

Catalytic Activation of the Phosphatase MKP-3 by ERK2 Mitogen-Activated Protein Kinase

1998 • 496 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

Thermodynamic and kinetic examination of protein stabilization by glycerol

1981 • 473 citations

Differential regulation of the MAP, SAP and RK/p38 kinases by Pyst1, a novel cytosolic dual-specificity phosphatase.

1996 • 414 citations

Crystal structure of Yersinia protein tyrosine phosphatase at 2.5 Å and the complex with tungstate

1994 • 392 citations

The Dual Specificity Phosphatases M3/6 and MKP-3 Are Highly Selective for Inactivation of Distinct Mitogen-activated Protein Kinases

1996 • 385 citations

Inactivation of p42 MAP kinase by protein phosphatase 2A and a protein tyrosine phosphatase, but not CL100, in various cell lines

1995 • 363 citations

MKP-3, a Novel Cytosolic Protein-tyrosine Phosphatase That Exemplifies a New Class of Mitogen-activated Protein Kinase Phosphatase

1996 • 350 citations

Crystal Structure of the Dual Specificity Protein Phosphatase VHR

1996 • 340 citations

PTP-SL and STEP protein tyrosine phosphatases regulate the activation of the extracellular signal-regulated kinases ERK1 and ERK2 by association through a kinase interaction motif

1998 • 313 citations

Crystal Structure of the Catalytic Domain of the Human Cell Cycle Control Phosphatase, Cdc25A

1998 • 282 citations

Visualization of intermediate and transition-state structures in protein-tyrosine phosphatase catalysis.

1996 • 271 citations

Protein-Tyrosine Phosphatases: Biological Function, Structural Characteristics, and Mechanism of Catalysis

1998 • 261 citations

Dissecting the catalytic mechanism of protein-tyrosinephosphatases.

1994 • 255 citations

Visualization of the Cysteinyl-phosphate Intermediate of a Protein-tyrosine Phosphatase by X-ray Crystallography

1998 • 233 citations

Molecular Cloning and Characterization of a Novel Dual Specificity Phosphatase, MKP-5

1999 • 216 citations

Crystal Structure of Bovine Low Molecular Weight Phosphotyrosyl Phosphatase Complexed with the Transition State Analog Vanadate^,

1997 • 199 citations

Dephosphorylation and inactivation of the mitogen-activated protein kinase by a mitogen-induced Thr/Tyr protein phosphatase

1993 • 170 citations

The Cys(X)5Arg Catalytic Motif in Phosphoester Hydrolysis

1994 • 159 citations

The Mitogen-activated Protein Kinase Phosphatase-3 N-terminal Noncatalytic Region Is Responsible for Tight Substrate Binding and Enzymatic Specificity

1998 • 158 citations

Protein phosphatases and the regulation of MAP kinase activity

1998 • 151 citations

Crystal structure of the MAPK phosphatase Pyst1 catalytic domain and implications for regulated activation.

1999 • 145 citations

Nature of the transition state of the protein-tyrosine phosphatase-catalyzed reaction

1995 • 134 citations

Low-Affinity Binding Determined by Titration Calorimetry Using a High-Affinity Coupling Ligand: A Thermodynamic Study of Ligand Binding to Protein Tyrosine Phosphatase 1B

1998 • 126 citations

Pre-steady-state and steady-state kinetic analysis of the low molecular weight phosphotyrosyl protein phosphatase from bovine heart

1991 • 120 citations

A Novel Cytoplasmic Dual Specificity Protein Tyrosine Phosphatase Implicated in Muscle and Neuronal Differentiation

1996 • 117 citations

The Catalytic Role of Aspartic Acid-92 in the Human Dual-Specific Protein-Tyrosine-Phosphatase Vaccinia H1-Related

1995 • 112 citations

A ligand-induced conformational change in theyersiniaprotein tyrosine phosphatase

1995 • 112 citations

Walden-Inversion-Enforced Transition-State Stabilization in a Protein Tyrosine Phosphatase

1998 • 99 citations

The Purification and Characterization of a Human Dual-specific Protein Tyrosine Phosphatase

1995 • 94 citations

Nature of the rate-determining steps of the reaction catalyzed by the Yersinia protein-tyrosine phosphatase.

1994 • 94 citations

Kinetic and Mechanistic Characterization of a Mammalian Protein-tyrosine Phosphatase, PTP1

1995 • 89 citations

Kinetic Analysis of the Catalytic Domain of Human Cdc25B

1996 • 86 citations

Probing the Function of Asp128 in the Low Molecular Weight Protein-Tyrosine Phosphatase-Catalyzed Reaction. A Pre-Steady-State and Steady-State Kinetic Investigation

1996 • 70 citations

Impaired Transition State Complementarity in the Hydrolysis of O-Arylphosphorothioates by Protein-Tyrosine Phosphatases

1999 • 60 citations

Transition-State Structures for the Native Dual-Specific Phosphatase VHR and D92N and S131A Mutants. Contributions to the Driving Force for Catalysis

1996 • 60 citations

Altering the Nucleophile Specificity of a Protein-tyrosine Phosphatase-catalyzed Reaction

1998 • 59 citations

Rapid Loop Dynamics of Yersinia Protein Tyrosine Phosphatases

1997 • 58 citations

Probing the function of the conserved tryptophan in the flexible loop of the Yersinia protein‐tyrosine phosphatase

1999 • 57 citations

Transition state and rate-limiting step of the reaction catalyzed by the human dual-specificity phosphatase, VHR

1995 • 33 citations

VHR and PTP1 Protein Phosphatases Exhibit Remarkably Different Active Site Specificities toward Low Molecular Weight Nonpeptidic Substrates

1996 • 33 citations

Purification and Kinetic Characterization of the Mitogen-activated Protein Kinase Phosphatase rVH6

1996 • 30 citations

Mechanistic Studies on Full Length and the Catalytic Domain of the Tandem SH2 Domain-Containing Protein Tyrosine Phosphatase: Analysis of Phosphoenzyme Levels and V_max Stimulatory Effects of Glycerol and of a Phosphotyrosyl Peptide Ligand

1997 • 15 citations