Kainate-induced genes in the hippocampus: lessons from expression patterns

The Steroid and Thyroid Hormone Receptor Superfamily

1988 • 7,590 citations

The rat nervous system

1985 • 3,774 citations

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

Molecular Diversity of Glutamate Receptors and Implications for Brain Function

1992 • 2,535 citations

Calcium oscillations increase the efficiency and specificity of gene expression

1998 • 1,870 citations

Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy

1985 • 1,730 citations

Physiological and pathophysiological roles of excitatory amino acids during central nervous system development

1990 • 1,427 citations

Expression of a mitogen-inducible cyclooxygenase in brain neurons: Regulation by synaptic activity and glucocorticoids

1993 • 1,222 citations

A Nerve Growth Factor-Induced Gene Encodes a Possible Transcriptional Regulatory Factor

1987 • 1,217 citations

Arc, a growth factor and activity-regulated gene, encodes a novel cytoskeleton-associated protein that is enriched in neuronal dendrites

1995 • 1,181 citations

Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid

1986 • 1,148 citations

Homer: a protein that selectively binds metabotropic glutamate receptors

1997 • 1,058 citations

The Biochemistry of Memory: A New and Specific Hypothesis

1984 • 1,048 citations

Interaction of the p53-Regulated Protein Gadd45 with Proliferating Cell Nuclear Antigen

1994 • 941 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

Tissue-plasminogen activator is induced as an immediate–early gene during seizure, kindling and long-term potentiation

1993 • 841 citations

Altered gene expression in neurons during programmed cell death: identification of c-jun as necessary for neuronal apoptosis.

1994 • 820 citations

Characterization of Multiple Phosphorylation Sites on the AMPA Receptor GluR1 Subunit

1996 • 802 citations

A c-jun dominant negative mutant protects sympathetic neurons against programmed cell death

1995 • 800 citations

Intraventricular kainic acid preferentially destroys hippocampal pyramidal cells

1978 • 745 citations

Widespread patterns of neuronal damage following systemic or intracerebral injections of kainic acid: A histological study

1980 • 700 citations

Molecular cloning and neurotrophic activities of a protein with structural similarities to nerve growth factor: developmental and topographical expression in the brain.

1990 • 700 citations

Kainic acid seizures in the rat

1994 • 693 citations

Kainic acid induced limbic seizures: metabolic, behavioral, electroencephalographic and neuropathological correlates

1981 • 683 citations

Identification of a potent Xenopus mesoderm-inducing factor as a homologue of activin A

1990 • 660 citations

Excitotoxin-induced neuronal degeneration and seizure are mediated by tissue plasminogen activator

1995 • 659 citations

Electrographic, clinical and pathological alterations following systemic administration of kainic acid, bicuculline or pentetrazole: Metabolic mapping using the deoxyglucose method with special reference to the pathology of epilepsy

1981 • 654 citations

Activins are expressed early in Xenopus embryogenesis and can induce axial mesoderm and anterior structures

1990 • 600 citations

Basic fibroblast growth factor prevents death of lesioned cholinergic neurons in vivo

1988 • 599 citations

Quantitative aspects of reactive gliosis: A review

1992 • 548 citations

A gene inducible by serum growth factors encodes a member of the steroid and thyroid hormone receptor superfamily.

1988 • 532 citations

Kainic acid induced seizures: Neurochemical and histopathological changes

1983 • 526 citations

Numerous candidate plasticity-related genes revealed by differential cDNA cloning

1993 • 522 citations

Structure and expression of human B cell stimulatory factor-2 (BSF-2/IL-6) gene.

1987 • 509 citations

Brain-derived neurotrophic factor prevents neuronal death in vivo

1988 • 490 citations

Kainate-induced apoptotic cell death in hippocampal neurons

1994 • 404 citations

Anatomical distribution of the growth-associated protein GAP-43/B-50 in the adult rat brain

1988 • 390 citations

Identification of a new brain-specific transcription factor, NURR1.

1992 • 373 citations

Injections of kainic acid into the amygdaloid complex of the rat: An electrographic, clinical and histological study in relation to the pathology of epilepsy

1980 • 370 citations

An 18-kd heparin-binding protein of developing brain that is distinct from fibroblast growth factors.

1989 • 369 citations

The molecular function of adrenal chromaffin granules: Established facts and unresolved topics

1986 • 358 citations

Cell-derived proteases and protease inhibitors as regulators of neurite outgrowth

1988 • 337 citations

Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus

1990 • 332 citations

Effects of kainic acid on messenger RNA levels of IL-1β, IL-6, TNFα and LIF in the rat brain

1991 • 330 citations

Glutamate receptor agonists increase the expression of Fos, Fra, and AP‐1 DNA binding activity in the mammalian brain

1989 • 330 citations

Lesion-induced increase in nerve growth factor mRNA is mediated by c-fos.

1990 • 314 citations

Heat shock proteins as markers of neural injury

1989 • 304 citations

Narp, a novel member of the pentraxin family, promotes neurite outgrowth and is dynamically regulated by neuronal activity

1996 • 301 citations

Activin is a nerve cell survival molecule

1990 • 298 citations

rheb, a growth factor- and synaptic activity-regulated gene, encodes a novel Ras-related protein.

1994 • 294 citations

vesl, a gene encoding VASP/Ena family related protein, is upregulated during seizure, long‐term potentiation and synaptogenesis¹

1997 • 278 citations

J1/tenascin in substrate-bound and soluble form displays contrary effects on neurite outgrowth.

1991 • 276 citations

Phorbol Ester Enhancement of Neurotransmitter Release from Rat Brain Synaptosomes

1987 • 273 citations

Transient Formation of Superoxide Radicals in Polyunsaturated Fatty Acid‐Induced Brain Swelling

1980 • 267 citations

Degeneration of hippocampal CA3 pyramidal cells induced by intraventricular kainic acid

1980 • 257 citations

Identification and localization of an actin-binding motif that is unique to the epsilon isoform of protein kinase C and participates in the regulation of synaptic function.

1996 • 252 citations

Proto-oncogene transcription factors and epilepsy

1991 • 252 citations

Differential usage of multiple brain-derived neurotrophic factor promoters in the rat brain following neuronal activation.

1993 • 248 citations

Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat

1992 • 242 citations

Identification of a new brain-specific transcription factor, NURR1

1992 • 229 citations

Regional and cellular codistribution of interleukin 1 beta and nerve growth factor mRNA in the adult rat brain: possible relationship to the regulation of nerve growth factor synthesis.

1990 • 221 citations

EGR3, a novel member of the Egr family of genes encoding immediate-early transcription factors.

1991 • 218 citations

Is c-Jun involved in nerve cell death following status epilepticus and hypoxic-ischaemic brain injury?

1993 • 215 citations

Activin can induce the formation of axial structures and is expressed in the hypoblast of the chick

1990 • 213 citations

Tenascin promotes cerebellar granule cell migration and neurite outgrowth by different domains in the fibronectin type III repeats.

1992 • 211 citations

Morphogenetic effect of kainate on adult hippocampal neurons associated with a prolonged expression of brain-derived neurotrophic factor

1995 • 211 citations

Isotypes of alpha-tubulin are differentially regulated during neuronal maturation.

1987 • 207 citations

The early response gene NGFI-C encodes a zinc finger transcriptional activator and is a member of the GCGGGGGCG (GSG) element-binding protein family.

1991 • 201 citations

A different form of long-lasting potentiation revealed in tissue plasminogen activator mutant mice

1996 • 200 citations

Alterations of the GluR-B AMPA receptor subunit flip/flop expression in kainate-induced epilepsy and ischemia

1993 • 196 citations

The differentiation primary response gene MyD118, related to GADD45, encodes for a nuclear protein which interacts with PCNA and p21WAF1/CIP1.

1996 • 176 citations

A homodimer of the β-subunits of inhibin a stimulates the secretion of pituitary follicle stimulating hormone

1986 • 176 citations

TGF-β1 mRNA Increases in Macrophage/Microglial Cells of the Hippocampus in Response to Deafferentation and Kainic Acid-Induced Neurodegeneration

1993 • 174 citations

JUN, FOS, KROX, and CREB transcription factor proteins in the rat cortex: Basal expression and induction by spreading depression and epileptic seizures

1993 • 174 citations

Characterization of multiple adhesive and counteradhesive domains in the extracellular matrix protein cytotactin.

1992 • 173 citations

Influence of janusin and tenascin on growth cone behavior in vitro

1993 • 170 citations

Kainic acid-induced neuronal death is associated with DNA damage and a unique immediate-early gene response in c-fos-lacZ transgenic rats

1995 • 162 citations

Conserved domain structure of beta-neurexins. Unusual cleaved signal sequences in receptor-like neuronal cell-surface proteins.

1994 • 157 citations

Hippocampal plasticity involves extensive gene induction and multiple cellular mechanisms

1998 • 156 citations

Glucocorticoids Exacerbate Kainic Acid–Induced Extracellular Accumulation of Excitatory Amino Acids in the Rat Hippocampus

1992 • 154 citations

Localization of the growth-associated phosphoprotein GAP-43 (B-50, F1) in the human cerebral cortex

1989 • 151 citations

Increased cyclin D1 in vulnerable neurons in the hippocampus after ischaemia and epilepsy: a modulator of in vivo programmed cell death?

1999 • 141 citations

Tissue Inhibitor of Metalloproteinases-1 (TIMP-1) Is Differentially Induced in Neurons and Astrocytes after Seizures: Evidence for Developmental, Immediate Early Gene, and Lesion Response

1997 • 137 citations

DNA fragmentation in rat brain after intraperitoneal administration of kainate

1994 • 136 citations

Immunohistochemical localization of interleukin-1β, interleukin-1 receptor antagonist and interleukin-1β converting enzyme/caspase-1 in the rat brain after peripheral administration of kainic acid

1999 • 135 citations

Kainic acid‐induced limbic seizures

1981 • 126 citations

Spatiotemporal Induction of Immediate Early Genes in the Rat Brain after Limbic Seizures: Effects of NMDA Receptor Antagonist MK‐801

1993 • 125 citations

Specific interactions of Mss4 with members of the Rab GTPase subfamily.

1994 • 117 citations

Protooncogene expression during the cell cycle.

1986 • 116 citations

Apoptosis associated DNA fragmentation in epileptic brain damage

1994 • 114 citations

In situ hybridization study of interleukin-1β mRNA induced by kainic acid in the rat brain

1993 • 114 citations

Glutamate receptors in cortical plasticity: molecular and cellular biology

1997 • 112 citations

Dynamic Changes in the Composition of the AP‐1 Transcription Factor DNA‐binding Activity in Rat Brain Following Kainate‐induced Seizures and Cell Death

1994 • 111 citations

Identification of the interleukin-6/oncostation M response element in the rat tissue inhibitor of metalloproteinases-1 (TIMP-1)Promoter

1995 • 109 citations

Developmental and plasticity-related differential expression of two SNAP-25 isoforms in the rat brain

1996 • 107 citations

Expression of cyclo-oxygenase 2 in rat brain following kainate treatment

1995 • 102 citations

Basic fibroblast growth factor mRNA increases in specific brain regions following convulsive seizures

1992 • 97 citations

Induction of β-A activin expression by synaptic activity and during neocortical development

1995 • 96 citations

Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity

1999 • 95 citations

Dual function of tenascin: simultaneous promotion of neurite growth and inhibition of glial migration

1993 • 90 citations

NMDA receptor blockade prevents kainate induction of protein F1/GAP-43 mRNA in hippocampal granule cells and subsequent mossy fiber sprouting in the rat

1995 • 89 citations

Differential regulation of apoptosis-related genes in resistant and vulnerable subfields of the rat epileptic hippocampus

1999 • 85 citations

Status Epilepticus-Induced Alterations in Metabotropic Glutamate Receptor Expression in Young and Adult Rats

1997 • 81 citations

Increase in activin βA mRNA in rat hippocampus during long‐term potentiation

1996 • 80 citations

Prolonged expression of zinc finger immediate‐early gene mRNAs and decreased protein synthesis following kainic acid induced seizures

1999 • 78 citations

Proto-oncogene c-fos induction in rat hippocampus

1988 • 71 citations

Temporal lobe epilepsy of the rat: differential expression of mRNAs of chromogranin B, secretogranin II, synaptin/synaptophysin and p65 in subfields of the hippocampus

1992 • 68 citations

Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia

1993 • 68 citations

Kainate‐Induced Changes in Opioid Peptide Genes and AP‐1 Protein Expression in the Rat Hippocampus

1993 • 67 citations

Rapid induction by kainic acid of both axonal growth and F1/GAP-43 protein in the adult rat hippocampal granule cells

1996 • 67 citations

Neuronal Excitation-driven and AP-1-dependent Activation of Tissue Inhibitor of Metalloproteinases-1 Gene Expression in Rodent Hippocampus

1999 • 66 citations

Fast and widespread increase of basic fibroblast growth factor messenger RNA and protein in the forebrain after kainate-induced seizures

1993 • 65 citations

Kainic acid induced expression of interleukin-1 receptor antagonist mRNA in the rat brain

1998 • 63 citations

Short- and long-term induction of basic fibroblast growth factor gene expression in rat central nervous system following kainate injection

1994 • 63 citations

Specific transcellular carbocyanine-labelling of rat retinal microglia during injury-induced neuronal degeneration

1991 • 63 citations

A single dose of kainic acid elevates the levels of enkephalins and activator protein-1 transcription factors in the hippocampus for up to 1 year

1997 • 60 citations

Kainic acid activates transient expression of tenascin-C in the adult rat hippocampus

1996 • 59 citations

Two synaptotagmin genes, Syt 1 and Syt 4, are differentially regulated in adult brain and during postnatal development following kainic acid-induced seizures

1996 • 59 citations

Induction of heparin-binding growth-associated molecule expression in reactive astrocytes following hippocampal neuronal injury

1995 • 54 citations

The COOH terminus of synaptotagmin mediates interaction with the neurexins.

1994 • 52 citations

Mossy fiber sprouting in epileptic rats is associated with a transient increased expression of α-tubulin

1993 • 51 citations

Increased expression of cyclin D1 in the adult rat brain following kainic acid treatment

1996 • 51 citations

Complex expression pattern of tenascin during innervation of the posterior limb buds of the developing chicken

1991 • 50 citations

Expression of erythroid differentiation factor (EDF) in Chinese hamster ovary cells

1988 • 49 citations

Increased expression of the mRNA for brain- and skin-type but not heart-type fatty acid binding proteins following kainic acid systemic administration in the hippocampal glia of adult rats

1996 • 48 citations

Elevated Cathepsin D Expression in Kainate-Evoked Rat Brain Neurodegeneration

1995 • 46 citations

PARTICULAR NUCLEAR TRANSCRIPTION FACTORS RESPONSIVE TO SYSTEMIC ADMINISTRATION OF KAINIC ACID IN MURINE BRAIN

1996 • 43 citations

Expression of thymosin β4 messenger RNA in normal and kainate-treated rat forebrain

1999 • 43 citations

Expression of Heat Shock Protein‐70 and Limbic Seizure‐induced Neuronal Death in the Rat Brain

1996 • 41 citations

Protein Kinase C Modulates Calcium Channels in Isolated Presynaptic Nerve Terminals of Rat Hippocampus

1995 • 40 citations

Differential regulation of catalytic and non-catalytictrkB messenger RNAs in the rat hippocampus following seizures induced by systemic administration of kainate

1995 • 40 citations

Co-expression of HSP72 and c-fos in rat brain following kainic acid treatment

1993 • 39 citations

Regional Studies of Changes in Brain Fatty Acids Following Experimental Ischaemia and Reperfusion in the Gerbil

1984 • 39 citations

Seizures induce tenascin-C mRNA expression in neurons

1996 • 39 citations

Mirror Image Motifs Mediate the Interaction of the COOH Terminus of Multiple Synaptotagmins with the Neurexins and Calmodulin

1996 • 36 citations

Kainate-evoked changes in dystrophin messenger RNA levels in the rat hippocampus

1998 • 36 citations

Seizures-evoked activation of transcription factors

1994 • 35 citations

Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat Kv4.2 potassium channel gene

1997 • 35 citations

Kainic acid increases the expression of the prohormone convertases furin and PC1 in the mouse hippocampus

1996 • 33 citations

Plasticity- and neurodegeneration-linked cyclic-AMP responsive element modulator/inducible cyclic-AMP early repressor messenger RNA expression in the rat brain

1998 • 32 citations

Cortistatin and somatostatin mRNAs are differentially regulated in response to kainate

1999 • 32 citations

Long‐Term Expression of Fos‐Related Antigen and Transient Expression of ΔFosB Associated with Seizures in the Rat Hippocampus and Striatum

1997 • 31 citations

Kainate induces the expression of the DNA damage-inducible gene, GADD45, in the rat brain

1997 • 30 citations

Prolonged alteration in E-box binding after a single systemic kainate injection: potential relation to F1/GAP-43 gene expression

1996 • 29 citations

Kainic acid-induced seizure upregulates Na+/myo-inositol cotransporter mRNA in rat brain

1999 • 29 citations

Seizure related changes in the regulation of opioid genes and transcription factors in the dentate gyrus of rat hippocampus

1995 • 29 citations

Selective up-regulation of protein kinase Cϵ in granule cells after kainic acid-induced seizures in rat

1997 • 29 citations

Transient expression of the mitogen-activated protein kinase phosphatase MKP-1 (3CH134/ERP1) in the rat brain after limbic epilepsy

1996 • 27 citations

Molecular target size of NMDA antagonist binding sites

1987 • 27 citations

Tenascin-C in peripheral nerve morphogenesis.

1994 • 27 citations

Regulation of Calcium Channel α1A Subunit Splice Variant mRNAs in Kainate-Induced Temporal Lobe Epilepsy

1999 • 27 citations

Elevated basal AP-1 DNA binding activity in developing rat brain

1993 • 25 citations

Differential Seizure-Induced and Developmental Changes of Neurexin Expression

1999 • 25 citations

Adrenalectomy reduces FGF-1 and FGF-2 gene expression in specific rat brain regions and differently affects their induction by seizures

1995 • 25 citations

Kainate-evoked modulation of gene expression in rat brain.

1997 • 24 citations

Induction of Heme Oxygenase-1 in the Rat Brain by Kainic Acid-Mediated Excitotoxicity: The Dissociation of mRNA and Protein Expression in Hippocampus

1999 • 23 citations

Kainate-evoked secondary gene expression in the rat hippocampus

1995 • 23 citations

Changes in Activating Protein 1 (AP-1) Composition Correspond with the Biphasic Profile of Nerve Growth Factor mRNA Expression in Rat Hippocampus after Hilus Lesion-Induced Seizures

2000 • 22 citations

Expression of enkephalin and dynorphin precursor mRNAs in brain areas of hypo-and hyperthyroid rat: effect of kainic acid injection

1995 • 22 citations

Kainate-evoked modulation of gene expression in rat brain.

1997 • 21 citations

Kainic acid-induced generalized seizures alter the regional hippocampal expression of the rat m1 and m3 muscarinic acetylcholine receptor genes

1997 • 20 citations

Prominent expression of the actin-sequestering peptide Fx gene in the hippocampal region of rat brain

1993 • 19 citations

Effects of pilocarpine- and kainate-induced seizures on thyrotropin-releasing hormone biosynthesis and receptors in the rat brain

1999 • 19 citations

Increased Expression of Cathepsin D in Retrosplenial Cortex of MK-801-Treated Rats

1997 • 17 citations

Expression of the thymosin β10 gene in normal and kainic acid-treated rat forebrain

1999 • 16 citations

Spontaneous and evoked glutamate signalling influences Fos-lacZ expression and pyramidal cell death in hippocampal slice cultures from transgenic rats

1995 • 13 citations

Induction of heat-shock protein-70 messenger RNA and protein following systemic kainate injection in the rat: Evidence of protein axonal transport

1995 • 11 citations

Novel Differentially Expressed Genes Induced by Kainic Acid in Hippocampus: Putative Molecular Effectors of Plasticity and Injury

1997 • 10 citations