A caspase inhibitor blocks ischaemia‐induced delayed neuronal death in the gerbil

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Delayed neuronal death in the gerbil hippocampus following ischemia

1982 • 2,856 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

CPP32, a novel human apoptotic protein with homology to Caenorhabditis elegans cell death protein Ced-3 and mammalian interleukin-1 beta-converting enzyme.

1994 • 1,239 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Delayed neuronal death in the CA1 pyramidal cell layer of the gerbil hippocampus following transient ischemia is apoptosis

1995 • 834 citations

Apopain/CPP32 cleaves proteins that are essential for cellular repair: a fundamental principle of apoptotic death.

1996 • 621 citations

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995 • 572 citations

Delayed and prolonged post-ischemic hypothermia is neuroprotective in the gerbil

1994 • 418 citations

Role of Ced-3/ICE-family proteases in staurosporine-induced programmed cell death.

1996 • 371 citations

Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons

1997 • 280 citations

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

1996 • 262 citations

Mechanisms of Calpain Proteolysis Following Traumatic Brain Injury: Implications for Pathology and Therapy: A Review and Update

1997 • 206 citations

Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis.

1996 • 185 citations

Involvement of CPP32/Yama(-like) proteases in Fas-mediated apoptosis.

1996 • 165 citations

Aspartate-Based Inhibitor of Interleukin-1β-Converting Enzyme Prevents Antitumor Agent-Induced Apoptosis in Human Myeloid Leukemia U937 Cells

1995 • 151 citations

Evidence of Nuclear DNA Fragmentation Following Hypoxia‐Ischemia in the Infant Rat Brain, and Transient Forebrain Ischemia in the Adult Gerbil

1994 • 150 citations

Increased Expression of IL-1β Converting Enzyme in Hippocampus after Ischemia: Selective Localization in Microglia

1996 • 149 citations

Internucleosomal DNA Cleavage Involved in Ischemia-Induced Neuronal Death

1993 • 139 citations

Ceramide induces apoptosis via CPP32 activation

1996 • 133 citations

Structural and functional analysis of poly(ADP ribose) polymerase: an immunological study

1988 • 121 citations

Interleukin-6 prevents ischemia-induced learning disability and neuronal and synaptic loss in gerbils

1996 • 113 citations

Cytokines and Fever

1995 • 100 citations

Biochemical changes associated with selective neuronal death following short-term cerebral ischaemia

1995 • 94 citations

Involvement of interleukin-1 and lipocortin-1 in ischaemic brain damage.

1993 • 90 citations

Ciliary neurotrophic factor prevents ischemia-induced learning disability and neuronal loss in gerbils

1995 • 59 citations

Superoxide dismutase, catalase, and U78517F attenuate neuronal damage in gerbils with repeated brief ischemic insults

1994 • 49 citations

Protective effect of basic fibroblast growth factor-heparin and neurotoxic effect of platelet factor 4 on ischemic neuronal loss and learning disability in gerbils

1995 • 46 citations

Apoptosis: Breaking the ICE

1994 • 46 citations

IL-1 beta convertase (ICE) does not play a requisite role in apoptosis induced in T lymphoblasts by Fas-dependent or Fas-independent CTL effector mechanisms.

1997 • 42 citations

Role of oxidative damage and IL-1β-converting enzyme-like proteases in Fas-based cytotoxicity exerted by effector T cells

1996 • 24 citations

Behavioral and histological changes after repeated brief cerebral ischemia by carotid artery occlusion in gerbils

1993 • 23 citations