Role of erythropoietin in the brain

Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients

2017 • 4,665 citations

Cellular and developmental control of O₂ homeostasis by hypoxia-inducible factor 1α

1998 • 2,392 citations

Endothelial Cells Stimulate Self-Renewal and Expand Neurogenesis of Neural Stem Cells

2004 • 1,498 citations

Erythropoietin crosses the blood–brain barrier to protect against experimental brain injury

2000 • 1,409 citations

Erythropoietin Therapy for Acute Stroke Is Both Safe and Beneficial

2002 • 1,038 citations

Generation of committed erythroid BFU-E and CFU-E progenitors does not require erythropoietin or the erythropoietin receptor

1995 • 1,027 citations

In vivo evidence that erythropoietin protects neurons from ischemic damage

1998 • 931 citations

Erythropoietin-mediated neuroprotection involves cross-talk between Jak2 and NF-κB signalling cascades

2001 • 930 citations

Erythropoietin is a potent physiologic stimulus for endothelial progenitor cell mobilization

2003 • 839 citations

Derivatives of Erythropoietin That Are Tissue Protective But Not Erythropoietic

2004 • 785 citations

Treatment of Stroke With Erythropoietin Enhances Neurogenesis and Angiogenesis and Improves Neurological Function in Rats

2004 • 756 citations

Enhanced Proliferation, Survival, and Dopaminergic Differentiation of CNS Precursors in Lowered Oxygen

2000 • 720 citations

A Potential Role for Erythropoietin in Focal Permanent Cerebral Ischemia in Mice

1999 • 716 citations

Erythropoietin receptor is expressed in rat hippocampal and cerebral cortical neurons, and erythropoietin prevents in vitro glutamate-induced neuronal death

1996 • 658 citations

Erythropoietin Regulates theIn VitroandIn VivoProduction of Neuronal Progenitors by Mammalian Forebrain Neural Stem Cells

2001 • 649 citations

Erythropoietin mediates tissue protection through an erythropoietin and common β-subunit heteroreceptor

2004 • 631 citations

Targeted disruption of the GATA3 gene causes severe abnormalities in the nervous system and in fetal liver haematopoiesis

1995 • 619 citations

Crystallographic Evidence for Preformed Dimers of Erythropoietin Receptor Before Ligand Activation

1999 • 597 citations

Erythropoietin receptor mRNA expression in human endothelial cells.

1994 • 584 citations

Erythropoietin has a mitogenic and positive chemotactic effect on endothelial cells.

1990 • 574 citations

Erythropoietin Gene Expression in Human, Monkey and Murine Brain

1996 • 562 citations

Human Erythropoietin Induces a Pro-Angiogenic Phenotype in Cultured Endothelial Cells and Stimulates Neovascularization In Vivo

1999 • 526 citations

HIF-1-induced erythropoietin in the hypoxic retina protects against light-induced retinal degeneration

2002 • 522 citations

Erythropoietin Selectively Attenuates Cytokine Production and Inflammation in Cerebral Ischemia by Targeting Neuronal Apoptosis

2003 • 512 citations

Emerging biological roles for erythropoietin in the nervous system

2005 • 508 citations

Erythropoietin regulates endothelial progenitor cells

2003 • 503 citations

Localization of specific erythropoietin binding sites in defined areas of the mouse brain.

1995 • 481 citations

Erythropoietin prevents motor neuron apoptosis and neurologic disability in experimental spinal cord ischemic injury

2002 • 479 citations

A novel site of erythropoietin production. Oxygen-dependent production in cultured rat astrocytes.

1994 • 476 citations

Erythropoietin is a paracrine mediator of ischemic tolerance in the brain: evidence from an in vitro model.

2002 • 455 citations

Differential effects of an erythropoietin receptor gene disruption on primitive and definitive erythropoiesis.

1996 • 439 citations

Asialoerythropoietin is a nonerythropoietic cytokine with broad neuroprotective activity in vivo

2003 • 430 citations

A Critical Role of Erythropoietin Receptor in Neurogenesis and Post-Stroke Recovery

2006 • 398 citations

Differentiating the functional role of hypoxia‐inducible factor (HIF)‐1α and HIF‐2α (EPAS‐1) by the use of RNA interference: erythropoietin is a HIF‐2α target gene in Hep3B and Kelly cells

2004 • 390 citations

Recombinant human erythropoietin counteracts secondary injury and markedly enhances neurological recovery from experimental spinal cord trauma

2002 • 389 citations

Erythropoietin Is a Novel Vascular Protectant Through Activation of Akt1 and Mitochondrial Modulation of Cysteine Proteases

2002 • 385 citations

Erythropoietin Is a Paracrine Mediator of Ischemic Tolerance in the Brain: Evidence from anIn VitroModel

2002 • 380 citations

Erythropoietin receptor signalling is required for normal brain development

2002 • 360 citations

Erythropoietin and Erythropoietin Receptor in the Developing Human Central Nervous System

1998 • 358 citations

Normobaric Hypoxia Induces Tolerance to Focal Permanent Cerebral Ischemia in Association with an Increased Expression of Hypoxia-Inducible Factor-1 and its Target Genes, Erythropoietin and VEGF, in the Adult Mouse Brain

2002 • 351 citations

Erythropoietin and erythropoietin receptor in human ischemic/hypoxic brain

2001 • 350 citations

Survival of recombinant erythropoietin in the circulation: the role of carbohydrates

1989 • 339 citations

Survival of recombinant erythropoietin in the circulation: the role of carbohydrates

1989 • 334 citations

Erythropoietin and Erythropoietin Receptors in Human CNS Neurons, Astrocytes, Microglia, and Oligodendrocytes Grown in Culture

2001 • 307 citations

Erythropoietin Prevents Place Navigation Disability and Cortical Infarction in Rats with Permanent Occlusion of the Middle Cerebral Artery

1998 • 304 citations

Matrix Metalloproteinase 2 (MMP2) and MMP9 Secreted by Erythropoietin-Activated Endothelial Cells Promote Neural Progenitor Cell Migration

2006 • 304 citations

Erythropoietin and the hypoxic brain

2004 • 297 citations

Hypoxia-Induced Stroke Tolerance in the Mouse Is Mediated by Erythropoietin

2003 • 290 citations

Erythropoietin and hypoxia stimulate erythropoietin receptor and nitric oxide production by endothelial cells

2004 • 276 citations

Erythropoietin Induces Activation of Stat5 through Association with Specific Tyrosines on the Receptor That Are Not Required for a Mitogenic Response

1996 • 272 citations

Erythropoietin Stimulates Proliferation and Interferes with Differentiation of Myoblasts

2000 • 265 citations

Estrogen-dependent Production of Erythropoietin in Uterus and Its Implication in Uterine Angiogenesis

1998 • 263 citations

Nitric oxide prevents cardiovascular disease and determines survival in polyglobulic mice overexpressing erythropoietin

2000 • 262 citations

Erythropoietin fosters both intrinsic and extrinsic neuronal protection through modulation of microglia, Akt1, Bad, and caspase‐mediated pathways

2003 • 243 citations

Brain Capillary Endothelial Cells Express two forms of Erythropoietin Receptor mRNA

1996 • 241 citations

Erythropoietin is neuroprotective, improves functional recovery, and reduces neuronal apoptosis and inflammation in a rodent model of experimental closed head injury

2005 • 237 citations

Erythropoietin protects against brain ischemic injury by inhibition of nitric oxide formation

2000 • 237 citations

The Transcriptional Activator Hypoxia Inducible Factor 2 (HIF-2/EPAS-1) Regulates the Oxygen-Dependent Expression of Erythropoietin in Cortical Astrocytes

2006 • 230 citations

Brain‐derived erythropoietin protects from focal cerebral ischemia by dual activation of ERK‐1/‐2 and Akt pathways

2005 • 217 citations

Erythropoietin-Mobilized Endothelial Progenitors Enhance Reendothelialization via Akt-Endothelial Nitric Oxide Synthase Activation and Prevent Neointimal Hyperplasia

2006 • 212 citations

Erythropoietin: a candidate compound for neuroprotection in schizophrenia

2003 • 207 citations

Erythroid-specific expression of the erythropoietin receptor rescued its null mutant mice from lethality

2002 • 206 citations

The role of erythropoietin in regulating angiogenesis

2004 • 200 citations

Important Role of Endogenous Erythropoietin System in Recruitment of Endothelial Progenitor Cells in Hypoxia-Induced Pulmonary Hypertension in Mice

2006 • 198 citations

Effects of erythropoietin on glial cell development; oligodendrocyte maturation and astrocyte proliferation

2002 • 197 citations

Erythropoietin: a Model System for Studying Oxygen-Dependent Gene Regulation

1998 • 191 citations

Erythropoietin stimulates phosphorylation and activation of GATA-1 via the PI3-kinase/AKT signaling pathway

2005 • 189 citations

Erythropoietin in the central nervous system, and its use to prevent hypoxic‐ischemic brain damage

2002 • 166 citations

Erythropoietin protects the in vitro blood–brain barrier against VEGF‐induced permeability

2003 • 165 citations

Detection of erythropoietin in human liquor: Intrinsic erythropoietin production in the brain

1997 • 161 citations

The Brain Erythropoietin System and its Potential for Therapeutic Exploitation in Brain Disease

2006 • 161 citations

Erythropoietin protects primary hippocampal neurons increasing the expression of brain‐derived neurotrophic factor

2005 • 156 citations

Increased Cerebral Infarct Volumes in Polyglobulic Mice Overexpressing Erythropoietin

2001 • 156 citations

Regulated Human Erythropoietin Receptor Expression in Mouse Brain

1997 • 151 citations

Erythropoietin as an angiogenic factor

2003 • 151 citations

Tissue-specific regulation of erythropoietin production in the murine kidney, brain, and uterus

2000 • 144 citations

Production and processing of erythropoietin receptor transcripts in brain

2000 • 144 citations

Beneficial and ominous aspects of the pleiotropic action of erythropoietin

2004 • 142 citations

Passage of erythropoietic agents across the blood–brain barrier: a comparison of human and murine erythropoietin and the analog darbepoetin alfa

2004 • 141 citations

Erythropoietin regulates hypoxic ventilation in mice by interacting with brainstem and carotid bodies

2005 • 136 citations

Erythropoietin exerts neuroprotection in 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated C57/BL mice via increasing nitric oxide production

2001 • 132 citations

Survival of hippocampal neurons in culture upon hypoxia

2000 • 129 citations

Erythropoietin Concentrations in Cerebrospinal Fluid of Nonhuman Primates and Fetal Sheep following High-Dose Recombinant Erythropoietin

2003 • 128 citations

The β Chain of the Interleukin-3 Receptor Functionally Associates With the Erythropoietin Receptor

1997 • 126 citations

Erythropoietin in the Cerebrospinal Fluid of Neonates Who Sustained CNS Injury

1999 • 125 citations

Constitutive Overexpression of Human Erythropoietin Protects the Mouse Retina against Induced But Not Inherited Retinal Degeneration

2004 • 120 citations

Mechanisms of Erythropoietin-induced Brain Protection in Neonatal Hypoxia-Ischemia Rat Model

2004 • 112 citations

The nonerythropoietic asialoerythropoietin protects against neonatal hypoxia‐ischemia as potently as erythropoietin

2004 • 112 citations

A single subcutaneous bolus of erythropoietin normalizes cerebral blood flow autoregulation after subarachnoid haemorrhage in rats

2002 • 111 citations

Erythropoietin Depresses Nitric Oxide Synthase Expression by Human Endothelial Cells

1999 • 108 citations

The pharmacokinetics of erythropoietin in the cerebrospinal fluid after intravenous administration of recombinant human erythropoietin

2005 • 106 citations

Erythropoietin treatment improves neurological functional recovery in EAE mice

2005 • 104 citations

Antiapoptotic Effects of Erythropoietin in Differentiated Neuroblastoma SH-SY5Y Cells Require Activation of Both the STAT5 and AKT Signaling Pathways

2006 • 104 citations

Beneficial effect of erythropoietin on experimental allergic encephalomyelitis

2004 • 101 citations

New agents that stimulate erythropoiesis

2006 • 100 citations

The oviduct produces erythropoietin in an estrogen- and oxygen-dependent manner

2000 • 95 citations

Physicochemical and biological characterization of asialoerythropoietin

1990 • 93 citations

Effects of Erythropoietin on Brain Function

2005 • 91 citations

Expression patterns of erythropoietin and its receptor in the developing midbrain

2004 • 89 citations

Role of nitric oxide resistance in erythropoietin-induced hypertension in rats with chronic renal failure

1996 • 89 citations

Exposure of endothelial cells to recombinant human erythropoietin induces nitric oxide synthase activity

2000 • 87 citations

Amelioration of spinal cord compressive injury by pharmacological preconditioning with erythropoietin and a nonerythropoietic erythropoietin derivative

2006 • 87 citations

Erythropoietin-mediated preservation of the white matter in rat spinal cord injury

2006 • 86 citations

Erythropoietin decreases cytotoxicity and nitric oxide formation induced by inflammatory stimuli in rat oligodendrocytes

2006 • 82 citations

The human erythropoietin receptor gene rescues erythropoiesis and developmental defects in the erythropoietin receptor null mouse

2001 • 80 citations

Erythropoietin‐induced excessive erythrocytosis activates the tissue endothelin system in mice

2002 • 73 citations

Regulation of transcription of the human erythropoietin receptor gene by proteins binding to GATA–1 and Sp1 motifs

1995 • 67 citations

Reassessment of interactions between hematopoietic receptors using common beta-chain and interleukin-3–specific receptor beta-chain–null cells: no evidence of functional interactions with receptors for erythropoietin, granulocyte colony-stimulating factor, or stem cell factor

2000 • 66 citations

Ischemic preconditioning is mediated by erythropoietin through PI-3 kinase signaling in an animal model of transient ischemic attack

2005 • 62 citations

Erythropoietin prevents the increase in blood–brain barrier permeability during pentylentetrazol induced seizures

2005 • 60 citations

Erythropoietin Induces Tyrosine Phosphorylation of the β Chain of the GM-CSF Receptor

1995 • 56 citations

Transient forebrain ischemia increases the blood-brain barrier permeability for albumin in stroke-prone spontaneously hypertensive rats.

2002 • 54 citations

Neurogenin 1 Mediates Erythropoietin Enhanced Differentiation of Adult Neural Progenitor Cells

2005 • 52 citations

Erythropoietin Administration In Vivo Increases Vascular Nitric Oxide Synthase Expression

2003 • 46 citations

Preventive Effect of Erythropoietin on Spinal Cord Cell Apoptosis Following Acute Traumatic Injury in Rats

2006 • 45 citations

In vivo stimulatory effect of erythropoietin on endothelial nitric oxide synthase in cerebral arteries

2006 • 42 citations

Polycythemia Impairs Vasodilator Response to Acetylcholine in Patients with Chronic Hypoxemic Lung Disease

1998 • 37 citations

Permanent focal cerebral ischemia activates erythropoietin receptor in the neonatal rat brain

2003 • 37 citations

Erythropoietin in the cerebrospinal fluid of patients with aneurysmal subarachnoid haemorrhage originates from the brain

2003 • 31 citations

Chronic excessive erythrocytosis induces endothelial activation and damage in mouse brain

2005 • 21 citations

Quantitation of the mRNA levels of Epo and EpoR in various tissues in the ovine fetus

2002 • 19 citations

Receptor binding of asialoerythropoietin

1992 • 12 citations