Attenuation of Transient Focal Cerebral Ischemic Injury in Transgenic Mice Expressing a Mutant ICE Inhibitory Protein

Apoptosis in the Pathogenesis and Treatment of Disease

1995 • 6,610 citations

Identification and inhibition of the ICE/CED-3 protease necessary for mammalian apoptosis

1995 • 4,003 citations

Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.

1986 • 2,584 citations

Mechanisms and Genes of Cellular Suicide

1995 • 2,514 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Mechanisms and Functions of Cell Death

1991 • 2,061 citations

A Semiautomated Method for Measuring Brain Infarct Volume

1990 • 1,610 citations

Effects of Cerebral Ischemia in Mice Deficient in Neuronal Nitric Oxide Synthase

1994 • 1,578 citations

Programmed Cell Death and the Control of Cell Survival: Lessons from the Nervous System

1993 • 1,470 citations

Structure and mechanism of interleukin-lβ converting enzyme

1994 • 842 citations

Inhibition of interleukin 1β converting enzyme family proteases reduces ischemic and excitotoxic neuronal damage

1997 • 835 citations

Polymorphonuclear leukocytes and monocytes/macrophages in the pathogenesis of cerebral ischemia and stroke.

1992 • 617 citations

Interleukin-1 as a Pathogenetic Mediator of Ischemic Brain Damage in Rats

1995 • 572 citations

Crystal structure of the cysteine protease interleukin-1β-converting enzyme: A (p20/p10)2 homodimer

1994 • 567 citations

The role of proteases during apoptosis

1996 • 558 citations

Interleukin-1 receptor antagonist inhibits ischaemic and excitotoxic neuronal damage in the rat

1992 • 547 citations

The Caenorhabditis elegans genes ced-3 and ced-4 act cell autonomously to cause programmed cell death

1990 • 533 citations

Evidence of apoptotic cell death after experimental traumatic brain injury in the rat.

1995 • 517 citations

Reduced Brain Edema and Infarction Volume in Mice Lacking the Neuronal Isoform of Nitric Oxide Synthase after Transient MCA Occlusion

1996 • 422 citations

ICE-like proteases in apoptosis

1995 • 353 citations

Microscale autoradiographic method for the qualitative and quantitative analysis of apoptotic DNA fragmentation

1993 • 348 citations

Expression of a Dominant Negative Mutant of Interleukin-1β Converting Enzyme in Transgenic Mice Prevents Neuronal Cell Death Induced by Trophic Factor Withdrawal and Ischemic Brain Injury

1997 • 345 citations

Apoptosis and Necrosis after Reversible Focal Ischemia: An in Situ DNA Fragmentation Analysis

1996 • 339 citations

Interleukin-1 beta mRNA expression in ischemic rat cortex.

1993 • 335 citations

The biological properties of interleukin-1.

1994 • 320 citations

Induction of DNA Fragmentation After 10 to 120 Minutes of Focal Cerebral Ischemia in Rats

1995 • 276 citations

Early increases in TNF-α, IL-6 and IL-1β levels following transient cerebral ischemia in gerbil brain

1996 • 262 citations

An ICE inhibitor, z-VAD-DCB attenuates ischaemic brain damage in the rat

1996 • 207 citations

DNA damage consistent with apoptosis in transient focal ischaemic neocortex

1994 • 198 citations

Functional role of interleukin 1 beta (IL-1 beta) in IL-1 beta-converting enzyme-mediated apoptosis.

1996 • 185 citations

Neuronal Apoptosis: Current Understanding of Molecular Mechanisms and Potential Role in Ischemic Brain Injury

1995 • 168 citations

In situ detection of DNA fragmentation after focal cerebral ischemia in mice

1995 • 137 citations

Purification of an Interleukin-1β Converting Enzyme-related Cysteine Protease That Cleaves Sterol Regulatory Element-binding Proteins between the Leucine Zipper and Transmembrane Domains

1995 • 135 citations