Regulation of Apoptotic Protease Activating Factor-1 Oligomerization and Apoptosis by the WD-40 Repeat Region

Mitochondria and Apoptosis

1998 • 8,909 citations

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

1997 • 7,177 citations

Caspases: Enemies Within

1998 • 6,923 citations

A novel genetic system to detect protein–protein interactions

1989 • 6,022 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Apaf-1, a Human Protein Homologous to C. elegans CED-4, Participates in Cytochrome c–Dependent Activation of Caspase-3

1997 • 3,130 citations

FLICE, A Novel FADD-Homologous ICE/CED-3–like Protease, Is Recruited to the CD95 (Fas/APO-1) Death-Inducing Signaling Complex

1996 • 3,065 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase

1995 • 2,402 citations

Involvement of MACH, a Novel MORT1/FADD-Interacting Protease, in Fas/APO-1- and TNF Receptor–Induced Cell Death

1996 • 2,306 citations

Caspases: Intracellular Signaling by Proteolysis

1997 • 2,114 citations

Studies on the transformation of intact yeast cells by the LiAc/SS‐DNA/PEG procedure

1995 • 2,001 citations

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

1999 • 1,927 citations

Mitochondrial control of apoptosis

1997 • 1,500 citations

Protease activation during apoptosis: Death by a thousand cuts?

1995 • 1,335 citations

Apaf1 Is Required for Mitochondrial Pathways of Apoptosis and Brain Development

1998 • 1,143 citations

Autoactivation of Procaspase-9 by Apaf-1-Mediated Oligomerization

1998 • 1,132 citations

An Induced Proximity Model for Caspase-8 Activation

1998 • 1,030 citations

Apaf1 (CED-4 Homolog) Regulates Programmed Cell Death in Mammalian Development

1998 • 894 citations

Mitochondrial permeability transition is a central coordinating event of apoptosis.

1996 • 857 citations

Pro-caspase-3 Is a Major Physiologic Target of Caspase-8

1998 • 743 citations

In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains.

1996 • 731 citations

RAIDD is a new 'death' adaptor molecule

1997 • 547 citations

Bcl-X _L interacts with Apaf-1 and inhibits Apaf-1-dependent caspase-9 activation

1998 • 534 citations

Caspase-9, Bcl-XL, and Apaf-1 Form a Ternary Complex

1998 • 523 citations

Autoproteolytic Activation of Pro-Caspases by Oligomerization

1998 • 424 citations

Membrane Oligomerization and Cleavage Activates the Caspase-8 (FLICE/MACHα1) Death Signal

1998 • 366 citations

The cytotoxic cell protease granzyme B initiates apoptosis in a cell-free system by proteolytic processing and activation of the ICE/CED-3 family protease, CPP32, via a novel two-step mechanism.

1996 • 279 citations

Essential Role of CED-4 Oligomerization in CED-3 Activation and Apoptosis

1998 • 269 citations

WD-40 Repeat Region Regulates Apaf-1 Self-association and Procaspase-9 Activation

1998 • 252 citations

Boo, a novel negative regulator of cell death, interacts with Apaf-1

1999 • 177 citations

Diva, a Bcl-2 Homologue that Binds Directly to Apaf-1 and Induces BH3-independent Cell Death

1998 • 170 citations

Interleukin-1 beta converting enzyme requires oligomerization for activity of processed forms in vivo.

1995 • 133 citations