Indoleamine 2,3-Dioxygenase in Immune Suppression and Cancer

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

2002 • 5,109 citations

N<scp>aturally</scp>A<scp>rising</scp>CD4⁺R<scp>egulatory</scp>T C<scp>ells for</scp>I<scp>mmunologic</scp>S<scp>elf</scp>-T<scp>olerance and</scp>N<scp>egative</scp>C<scp>ontrol of</scp>I<scp>mmune</scp>R<scp>esponses</scp>

2003 • 3,323 citations

The Immunobiology of Cancer Immunosurveillance and Immunoediting

2004 • 2,788 citations

IFNγ and lymphocytes prevent primary tumour development and shape tumour immunogenicity

2001 • 2,658 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Ido expression by dendritic cells: tolerance and tryptophan catabolism

2004 • 2,235 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

B7/CD28 Costimulation Is Essential for the Homeostasis of the CD4+CD25+ Immunoregulatory T Cells that Control Autoimmune Diabetes

2000 • 2,090 citations

Immunosuppressive networks in the tumour environment and their therapeutic relevance

2005 • 1,990 citations

Smoldering and polarized inflammation in the initiation and promotion of malignant disease

2005 • 1,730 citations

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

2003 • 1,660 citations

The B7–CD28 superfamily

2002 • 1,646 citations

Regulatory T cells mediate maternal tolerance to the fetus

2004 • 1,568 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Regulatory T cells in transplantation tolerance

2003 • 1,323 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

GCN2 Kinase in T Cells Mediates Proliferative Arrest and Anergy Induction in Response to Indoleamine 2,3-Dioxygenase

2005 • 1,156 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

2005 • 1,021 citations

Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

2004 • 834 citations

Characterization of Dendritic Cells that Induce Tolerance and T Regulatory 1 Cell Differentiation In Vivo

2003 • 811 citations

Tolerance, DCs and tryptophan: much ado about IDO

2003 • 752 citations

Tumor cells convert immature myeloid dendritic cells into TGF-β–secreting cells inducing CD4+CD25+ regulatory T cell proliferation

2005 • 716 citations

Tryptophan catabolism and T-cell tolerance: immunosuppression by starvation?

1999 • 650 citations

APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment

2004 • 536 citations

Abnormal T-Cell Reactivity against Paternal Antigens in Spontaneous Abortion

2005 • 533 citations

The CD8α+ Dendritic Cell Is Responsible for Inducing Peripheral Self-Tolerance to Tissue-associated Antigens

2002 • 468 citations

Reduction of Myeloid-Derived Suppressor Cells and Induction of M1 Macrophages Facilitate the Rejection of Established Metastatic Disease

2005 • 462 citations

Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion

2003 • 460 citations

Prevention of T cell–driven complement activation and inflammation by tryptophan catabolism during pregnancy

2001 • 425 citations

Treatment of Autoimmune Neuroinflammation with a Synthetic Tryptophan Metabolite

2005 • 406 citations

Crystal structure of human indoleamine 2,3-dioxygenase: Catalytic mechanism of O ₂ incorporation by a heme-containing dioxygenase

2006 • 406 citations

Naturally-occurring CD4+CD25+ immunoregulatory T cells: central players in the arena of peripheral tolerance

2004 • 399 citations

A two-step induction of indoleamine 2,3 dioxygenase (IDO) activity during dendritic-cell maturation

2005 • 390 citations

Botanicals in cancer chemoprevention.

2002 • 385 citations

Indoleamine 2,3-Dioxygenase Serves as a Marker of Poor Prognosis in Gene Expression Profiles of Serous Ovarian Cancer Cells

2005 • 384 citations

Indoleamine 2,3‐dioxygenase contributes to tumor cell evasion of T cell‐mediated rejection

2002 • 364 citations

Indoleamine 2,3-dioxygenase. Purification and some properties

1978 • 362 citations

BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

1996 • 358 citations

Interleukin-13–regulated M2 Macrophages in Combination with Myeloid Suppressor Cells Block Immune Surveillance against Metastasis

2005 • 309 citations

CD28 induces immunostimulatory signals in dendritic cells via CD80 and CD86

2004 • 296 citations

Specific subsets of murine dendritic cells acquire potent T cell regulatory functions following CTLA4-mediated induction of indoleamine 2,3 dioxygenase

2004 • 290 citations

Cutting Edge: CpG Oligonucleotides Induce Splenic CD19+ Dendritic Cells to Acquire Potent Indoleamine 2,3-Dioxygenase-Dependent T Cell Regulatory Functions via IFN Type 1 Signaling

2005 • 289 citations

1-methyl-dl-tryptophan, β-(3-benzofuranyl)-dl-alanine (the oxygen analog of tryptophan), and β-[3-benzo(b)thienyl]-dl-alanine (the sulfur analog of tryptophan) are competitive inhibitors for indoleamine 2,3-dioxygenase

1991 • 279 citations

Indoleamine 2,3-dioxygenase expression is restricted to fetal trophoblast giant cells during murine gestation and is maternal genome specific

2004 • 279 citations

Conversion of CD4+ CD25− cells into CD4+ CD25+ regulatory T cells in vivo requires B7 costimulation, but not the thymus

2005 • 271 citations

Functional expression of indoleamine 2,3-dioxygenase by murine CD8α+ dendritic cells

2002 • 251 citations

Amphiphysin II (SH3P9; BIN1), a Member of the Amphiphysin/Rvs Family, Is Concentrated in the Cortical Cytomatrix of Axon Initial Segments and Nodes of Ranvier in Brain and around T Tubules in Skeletal Muscle

1997 • 243 citations

Induction of indoleamine 2,3-dioxygenase: a mechanism of the antitumor activity of interferon gamma.

1988 • 241 citations

A subclass of dendritic cells regulates the response of naive CD8 T cells by limiting their IL-2 production.

1996 • 238 citations

Dendritic Cells in Immunity and Tolerance—Do They Display Opposite Functions?

2003 • 237 citations

Cloning of ligand targets: Systematic isolation of SH3 domain-containing proteins

1996 • 224 citations

Cancer chemopreventive activity of brassinin, a phytoalexin from cabbage

1995 • 220 citations

Murine Plasmacytoid Dendritic Cells Initiate the Immunosuppressive Pathway of Tryptophan Catabolism in Response to CD200 Receptor Engagement

2004 • 218 citations

Interferon enhances tryptophan metabolism by inducing pulmonary indoleamine 2,3-dioxygenase: its possible occurrence in cancer patients.

1986 • 191 citations

Regulatory T cells in transplantation

2002 • 189 citations

Mechanism for elimination of a tumor suppressor: Aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma

1999 • 181 citations

A minor population of splenic dendritic cells expressing CD19 mediates IDO-dependent T cell suppression via type I IFN signaling following B7 ligation

2005 • 178 citations

The inhibitory function of B7 costimulators in T cell responses to foreign and self-antigens

2003 • 177 citations

[26] Indoleamine 2,3-dioxygenase

1987 • 176 citations

Identification and Characterization of a Nerve Terminal-enriched Amphiphysin Isoform

1997 • 176 citations

Structure−Activity Study of Brassinin Derivatives as Indoleamine 2,3-Dioxygenase Inhibitors

2005 • 171 citations

Systemic application of CpG‐rich DNA suppresses adaptive T cell immunity via induction of IDO

2005 • 170 citations

CD40L Blockade Prevents Autoimmune Diabetes by Induction of Bitypic NK/DC Regulatory Cells

2002 • 159 citations

Eosinophil Granulocytes Account for Indoleamine 2,3-Dioxygenase-Mediated Immune Escape in Human Non Small Cell Lung Cancer

2005 • 156 citations

Indoleamine 2,3 dioxygenase and regulation of T cell immunity

2005 • 149 citations

<scp>l</scp>-Tryptophan-<scp>l</scp>-Kynurenine Pathway Metabolism Accelerated byToxoplasmagondiiInfection Is Abolished in Gamma Interferon-Gene-Deficient Mice: Cross-Regulation between Inducible Nitric Oxide Synthase and Indoleamine-2,3-Dioxygenase

2002 • 146 citations

Akt/PKB Signaling in Cancer: A Function in Cell Motility and Invasion

2006 • 146 citations

Structural Analysis of the Human BIN1 Gene

1997 • 133 citations

CTLA-4–Ig Activates Forkhead Transcription Factors and Protects Dendritic Cells from Oxidative Stress in Nonobese Diabetic Mice

2004 • 126 citations

Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms

1999 • 116 citations

Indoleamine 2,3-dioxygenase in cancer: targeting pathological immune tolerance with small-molecule inhibitors

2005 • 115 citations

Pattern of Recruitment of Immunoregulatory Antigen-Presenting Cells in Malignant Melanoma

2003 • 114 citations

Functional Plasticity of Dendritic Cell Subsets as Mediated by CD40 Versus B7 Activation

2003 • 108 citations

The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program

2000 • 101 citations

IFN-γ Inhibits Presentation of a Tumor/Self Peptide by CD8α− Dendritic Cells Via Potentiation of the CD8α+ Subset

2000 • 101 citations

Indoleamine 2, 3-dioxygenase (IDO) is essential for dendritic cell activation and chemotactic responsiveness to chemokines

2005 • 98 citations

Cutting Edge: Silencing Suppressor of Cytokine Signaling 3 Expression in Dendritic Cells Turns CD28-Ig from Immune Adjuvant to Suppressant

2005 • 91 citations

Loss of heterozygosity and tumor suppressor activity ofBin1 in prostate carcinoma

2000 • 91 citations

The immunoregulatory role of IDO-producing human dendritic cells revisited

2006 • 89 citations

Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity

2000 • 86 citations

Modulation of cellular tryptophan metabolism in human fibroblasts by transforming growth factor-β: Selective inhibition of indoleamine 2,3-dioxygenase and tryptophanyl-tRNA synthetase gene expression

1998 • 85 citations

Ligand and cytokine dependence of the immunosuppressive pathway of tryptophan catabolism in plasmacytoid dendritic cells

2005 • 76 citations

TRYPTOPHAN METABOLISM IN CARCINOMA OF THE BREAST

1967 • 73 citations

Bin1 mediates apoptosis by c-Myc in transformed primary cells.

2001 • 72 citations

Nitration and Inactivation of IDO by Peroxynitrite

2006 • 65 citations

IL-12 acts selectively on CD8 alpha- dendritic cells to enhance presentation of a tumor peptide in vivo.

1999 • 63 citations

cDNA Cloning of a Novel Amphiphysin Isoform and Tissue-Specific Expression of Its Multiple Splice Variants

1997 • 63 citations

Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features.

2003 • 58 citations

Inhibitors of human indoleamine 2,3‐dioxygenase identified with a target‐based screen in yeast

2006 • 56 citations

The amphiphysin-like protein 1 (ALP1) interacts functionally with the cABL tyrosine kinase and may play a role in cytoskeletal regulation

1997 • 56 citations

Gene structure of human indoleamine 2,3-dioxygenase

1992 • 51 citations

Induction of apoptosis and differentiation in neuroblastoma and astrocytoma cells by the overexpression of Bin1, a novel myc interacting protein

1999 • 47 citations

Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: Diverse sites of nuclear expression and losses in prostate cancer

2002 • 46 citations

Inhibition of interferon-mediated induction of indoleamine 2,3-dioxygenase in mouse lung by inhibitors of prostaglandin biosynthesis.

1981 • 42 citations

Enhanced tryptophan catabolism in the absence of the molecular adapter DAP12

2005 • 40 citations

Tryptophan availability selectively limits NO-synthase induction in macrophages

2003 • 35 citations

Regulation of prostaglandin synthesis and cell adhesion by a tryptophan catabolizing enzyme

2001 • 33 citations

Tumor-Infiltrating Dendritic Cell Subsets of Progressive or Regressive Tumors Induce Suppressive or Protective Immune Responses

2005 • 32 citations

Localization of indoleamine 2,3-dioxygenase gene (INDO) to chromosome 8p12→p11 by fluorescent in situ hybridization

1993 • 26 citations

Targeted deletion of the suppressor gene bin1/amphiphysin2 accentuates the neoplastic character of transformed mouse fibroblasts

2004 • 23 citations