Inhibition of indoleamine 2,3-dioxygenase, an immunoregulatory target of the cancer suppression gene Bin1, potentiates cancer chemotherapy

The Hallmarks of Cancer

2000 • 27,569 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

BAR Domains as Sensors of Membrane Curvature: The Amphiphysin BAR Structure

2003 • 1,660 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Cytokines in cancer pathogenesis and cancer therapy

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Current protocols in immunology

1992 • 1,464 citations

Colorectal carcinoma antigens detected by hybridoma antibodies

1979 • 1,342 citations

Escape of Human Solid Tumors from T–Cell Recognition: Molecular Mechanisms and Functional Significance

1999 • 1,168 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Tolerance, DCs and tryptophan: much ado about IDO

2003 • 752 citations

APPL Proteins Link Rab5 to Nuclear Signal Transduction via an Endosomal Compartment

2004 • 536 citations

Inhibition of farnesyltransferase induces regression of mammary and salivary carcinomas in ras transgenic mice

1995 • 533 citations

Cyclophosphamide, doxorubicin, and paclitaxel enhance the antitumor immune response of granulocyte/macrophage-colony stimulating factor-secreting whole-cell vaccines in HER-2/neu tolerized mice.

2001 • 454 citations

Synergy between chemotherapy and immunotherapy in the treatment of established murine solid tumors.

2003 • 401 citations

Indoleamine 2,3‐dioxygenase contributes to tumor cell evasion of T cell‐mediated rejection

2002 • 364 citations

BIN1 is a novel MYC–interacting protein with features of a tumour suppressor

1996 • 358 citations

SOME VIRUS ISOLATIONS FROM COMMON COLDS

1960 • 334 citations

CtBP/BARS induces fission of Golgi membranes by acylating lysophosphatidic acid

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N-myc amplification causes down-modulation of MHC class I antigen expression in neuroblastoma

1986 • 297 citations

c-myc down-regulates class I HLA expression in human melanomas.

1988 • 248 citations

The amphiphysin family of proteins and their role in endocytosis at the synapse

1998 • 246 citations

A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor

1999 • 182 citations

Mechanism for elimination of a tumor suppressor: Aberrant splicing of a brain-specific exon causes loss of function of Bin1 in melanoma

1999 • 181 citations

The metabolism of tryptophan. 2. The metabolism of tryptophan in patients suffering from cancer of the bladder

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Gene expression profiling of low-grade diffuse astrocytomas by cDNA arrays.

2000 • 172 citations

Cytoplasmic transport of Stat3 by receptor-mediated endocytosis

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Macrophages as accessory cells for class I MHC-restricted immune responses.

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Targeted Disruption of the Murine Bin1/Amphiphysin II Gene Does Not Disable Endocytosis but Results in Embryonic Cardiomyopathy with Aberrant Myofibril Formation

2003 • 119 citations

Bin1 functionally interacts with Myc and inhibits cell proliferation via multiple mechanisms

1999 • 116 citations

A Role for the Putative Tumor Suppressor Bin1 in Muscle Cell Differentiation

1998 • 116 citations

The c-Myc-interacting adaptor protein Bin1 activates a caspase-independent cell death program

2000 • 101 citations

Nucleocytoplasmic Shuttling of Endocytic Proteins

2001 • 97 citations

Loss of heterozygosity and tumor suppressor activity ofBin1 in prostate carcinoma

2000 • 91 citations

Losses of the tumor suppressor BIN1 in breast carcinoma are frequent and reflect deficits in programmed cell death capacity

2000 • 86 citations

Expression and Purification of Recombinant Human Indoleamine 2,3-Dioxygenase

2000 • 85 citations

DrosophilaAmphiphysin is implicated in protein localization and membrane morphogenesis but not in synaptic vesicle endocytosis

2001 • 79 citations

Sorting nexin 4 and amphiphysin 2, a new partnership between endocytosis and intracellular trafficking

2003 • 75 citations

TRYPTOPHAN METABOLISM IN CARCINOMA OF THE BREAST

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Bin1 mediates apoptosis by c-Myc in transformed primary cells.

2001 • 72 citations

Analysis of Transcription Factors Regulating Induction of Indoleamine 2,3-Dioxygenase by IFN-gamma

2000 • 62 citations

Expression of a MYCN-interacting isoform of the tumor suppressor BIN1 is reduced in neuroblastomas with unfavorable biological features.

2003 • 58 citations

Enhancement of tumor radioresponse by docetaxel: Involvement of immune system

2001 • 53 citations

In Vivo Depletion of <scp>CD</scp>4‐ and <scp>CD</scp>8‐Specific <scp>T</scp> Cells

1992 • 51 citations

Immunohistochemical analysis of Bin1/Amphiphysin II in human tissues: Diverse sites of nuclear expression and losses in prostate cancer

2002 • 46 citations

The putative tumor suppressor BIN1 is a short-lived nuclear phosphoprotein, the localization of which is altered in malignant cells.

1997 • 44 citations

Mammary glands reconstituted with Neu/ErbB2 transformed HC11 cells provide a novel orthotopic tumor model for testing anti-cancer agents

2001 • 43 citations

Effect of elevated levels of ornithine decarboxylase on cell cycle progression in skin.

1999 • 36 citations

The metabolism of tryptophan

1928 • 30 citations

hob1+, the fission yeast homolog of Bin1, is dispensable for endocytosis or actin organization, but required for the response to starvation or genotoxic stress

2003 • 28 citations

Targeted deletion of the suppressor gene bin1/amphiphysin2 accentuates the neoplastic character of transformed mouse fibroblasts

2004 • 23 citations

Transformation-selective apoptotic program triggered by farnesyltransferase inhibitors requires Bin1

2003 • 19 citations

Suppression of in vitro growth of virulent and avirulent herpes simplex viruses by cell-mediated immune mechanisms, antibody, and interferon

1978 • 17 citations