Expression of indoleamine 2,3-dioxygenase by plasmacytoid dendritic cells in tumor-draining lymph nodes

Tolerogenic Dendritic Cells

2003 • 3,131 citations

Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity.

1993 • 2,828 citations

T cell receptor antagonist peptides induce positive selection

1994 • 2,818 citations

Prevention of Allogeneic Fetal Rejection by Tryptophan Catabolism

1998 • 2,538 citations

Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2,3-dioxygenase

2003 • 2,177 citations

Inhibition of T Cell Proliferation by Macrophage Tryptophan Catabolism

1999 • 1,560 citations

Modulation of tryptophan catabolism by regulatory T cells

2003 • 1,323 citations

Role of Bone Marrow-Derived Cells in Presenting MHC Class I-Restricted Tumor Antigens

1994 • 1,185 citations

CTLA-4–Ig regulates tryptophan catabolism in vivo

2002 • 1,150 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

Tryptophan-derived Catabolites Are Responsible for Inhibition of T and Natural Killer Cell Proliferation Induced by Indoleamine 2,3-Dioxygenase

2002 • 1,060 citations

Potential Regulatory Function of Human Dendritic Cells Expressing Indoleamine 2,3-Dioxygenase

2002 • 1,035 citations

Synergism of Cytotoxic T Lymphocyte–Associated Antigen 4 Blockade and Depletion of Cd25+ Regulatory T Cells in Antitumor Therapy Reveals Alternative Pathways for Suppression of Autoreactive Cytotoxic T Lymphocyte Responses

2001 • 1,033 citations

Relationship between interferon‐γ, indoleamine 2,3‐dioxygenase, and tryptophan catabolism

1991 • 1,018 citations

Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology

2001 • 1,017 citations

Natural selection of tumor variants in the generation of “tumor escape” phenotypes

2002 • 1,014 citations

T cell apoptosis by tryptophan catabolism

2002 • 960 citations

Tumor Regression and Autoimmunity after Reversal of a Functionally Tolerant State of Self-reactive CD8+ T Cells

2003 • 919 citations

Inhibition of Allogeneic T Cell Proliferation by Indoleamine 2,3-Dioxygenase–expressing Dendritic Cells

2002 • 917 citations

Interferon gamma blocks the growth of Toxoplasma gondii in human fibroblasts by inducing the host cells to degrade tryptophan.

1984 • 847 citations

Tolerance, DCs and tryptophan: much ado about IDO

2003 • 752 citations

Indoleamine 2,3-Dioxygenase Production by Human Dendritic Cells Results in the Inhibition of T Cell Proliferation

2000 • 733 citations

A fresh look at tumor immunosurveillance and immunotherapy

2001 • 723 citations

Induction of antigen-specific T cell anergy: An early event in the course of tumor progression

1998 • 710 citations

Clinical significance of defective dendritic cell differentiation in cancer.

2000 • 694 citations

Freshly Isolated Peyer's Patch, but Not Spleen, Dendritic Cells Produce Interleukin 10 and Induce the Differentiation of T Helper Type 2 Cells

1999 • 656 citations

Models of T cell anergy: is there a common molecular mechanism?

1996 • 575 citations

Flt3 Ligand Regulates Dendritic Cell Development from Flt3+ Lymphoid and Myeloid-committed Progenitors to Flt3+ Dendritic Cells In Vivo

2003 • 573 citations

Regulation of B Lymphocyte Responses to Foreign and Self-Antigens by the CD19/CD21 Complex

2000 • 513 citations

Roles of tumour localization, second signals and cross priming in cytotoxic T-cell induction

2001 • 500 citations

Cutting Edge: Induced Indoleamine 2,3 Dioxygenase Expression in Dendritic Cell Subsets Suppresses T Cell Clonal Expansion

2003 • 460 citations

Ligation of B7-1/B7-2 by Human CD4+ T Cells Triggers Indoleamine 2,3-Dioxygenase Activity in Dendritic Cells

2004 • 459 citations

Unopposed Production of Granulocyte-Macrophage Colony-Stimulating Factor by Tumors Inhibits CD8+ T Cell Responses by Dysregulating Antigen-Presenting Cell Maturation

1999 • 406 citations

Mouse Plasmacytoid Cells

2002 • 377 citations

Indoleamine 2,3‐dioxygenase contributes to tumor cell evasion of T cell‐mediated rejection

2002 • 364 citations

Eradication of Established Tumors by CD8+ T Cell Adoptive Immunotherapy

2000 • 349 citations

Cells Expressing Indoleamine 2,3-Dioxygenase Inhibit T Cell Responses

2002 • 344 citations

Reversal of Tumor-induced Dendritic Cell Paralysis by CpG Immunostimulatory Oligonucleotide and Anti–Interleukin 10 Receptor Antibody

2002 • 340 citations

Self Antigens Expressed by Solid Tumors Do Not Efficiently Stimulate Naive or Activated T Cells: Implications for Immunotherapy

1997 • 316 citations

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1998 • 314 citations

Inhibition of Cell Cycle Progression by Rapamycin Induces T Cell Clonal Anergy Even in the Presence of Costimulation

1999 • 288 citations

CTLA-4 Blockade Reverses CD8+ T Cell Tolerance to Tumor by a CD4+ T Cell– and IL-2-Dependent Mechanism

1999 • 287 citations

Reversion of B Cell Commitment upon Loss of Pax5 Expression

2002 • 285 citations

IDO and tolerance to tumors

2003 • 262 citations

Clonal anergy is induced in vitro by T cell receptor occupancy in the absence of proliferation.

1991 • 255 citations

Characterization of a new subpopulation of mouse CD8α+ B220+ dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential

2002 • 254 citations

Functional expression of indoleamine 2,3-dioxygenase by murine CD8α+ dendritic cells

2002 • 251 citations

Subtractive hybridization reveals the expression of immunoglobulinlike transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells

2002 • 243 citations

Cancer-associated immunodeficiency and dendritic cell abnormalities mediated by the prostaglandin EP2 receptor

2003 • 241 citations

Increasing Tumor Antigen Expression Overcomes “Ignorance” to Solid Tumors via Crosspresentation by Bone Marrow-Derived Stromal Cells

2002 • 239 citations

Expression of cytokine/growth factors and their receptors in human melanoma and melanocytes

1994 • 238 citations

Dendritic Cells in Immunity and Tolerance—Do They Display Opposite Functions?

2003 • 237 citations

Effect of indoleamine 2,3-dioxygenase on induction of experimental autoimmune encephalomyelitis

2002 • 228 citations

Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice

2003 • 226 citations

Cross-presentation of tumor antigens by bone marrow–derived antigen-presenting cells is the dominant mechanism in the induction of T-cell tolerance during B-cell lymphoma progression

2001 • 214 citations

A Defect in Tryptophan Catabolism Impairs Tolerance in Nonobese Diabetic Mice

2003 • 213 citations

The Lymphoid Past of Mouse Plasmacytoid Cells and Thymic Dendritic Cells

2003 • 210 citations

Antigenic Cancer Cells Grow Progressively in Immune Hosts without Evidence for T Cell Exhaustion or Systemic Anergy

1997 • 205 citations

Tryptophan Catabolism and Regulation of Adaptive Immunity

2003 • 198 citations

Induction of potent antitumor immunity by in situ targeting of intratumoral DCs

2004 • 183 citations

Mini‐review: Regulation of cytotoxic T lymphocyte responses by dendritic cells: peaceful coexistence of cross‐priming and direct priming?

2003 • 181 citations

Role of IFN-gamma-induced indoleamine 2,3 dioxygenase and inducible nitric oxide synthase in the replication of human cytomegalovirus in retinal pigment epithelial cells.

1999 • 179 citations

Induction of potent antitumor immunity by in situ targeting of intratumoral DCs

2004 • 175 citations

CD40L Blockade Prevents Autoimmune Diabetes by Induction of Bitypic NK/DC Regulatory Cells

2002 • 159 citations

Rejection of H-Y Disparate Skin Grafts by Monospecific CD4+ Th1 and Th2 Cells: No Requirement for CD8+ T Cells or B Cells

1998 • 146 citations

Role of IFN-γ-Induced Indoleamine 2,3 Dioxygenase and Inducible Nitric Oxide Synthase in the Replication of Human Cytomegalovirus in Retinal Pigment Epithelial Cells

1999 • 145 citations

Dendritic Cells Permit Identification of Genes Encoding MHC Class II–Restricted Epitopes of Transplantation Antigens

2000 • 131 citations

Tumor Growth Enhances Cross-Presentation Leading to Limited T Cell Activation without Tolerance

2002 • 129 citations

Extra-lymphatic solid tumor growth is not immunologically ignored and results in early induction of antigen-specific T-cell anergy: dominant role of cross-tolerance to tumor antigens.

2003 • 124 citations

Antiparasitic and antiproliferative effects of indoleamine 2,3-dioxygenase enzyme expression in human fibroblasts

1994 • 118 citations

A Common Pathway for Dendritic Cell and Early B Cell Development

2001 • 117 citations

A Universal Granulocyte-Macrophage Colony-Stimulating Factor-Producing Bystander Cell Line for Use in the Formulation of Autologous Tumor Cell-Based Vaccines

1999 • 116 citations

Pattern of Recruitment of Immunoregulatory Antigen-Presenting Cells in Malignant Melanoma

2003 • 114 citations

Role of Indoleamine-2,3-Dioxygenase in Alpha/Beta and Gamma Interferon-Mediated Antiviral Effects against Herpes Simplex Virus Infections

2004 • 112 citations

IFN-γ Inhibits Presentation of a Tumor/Self Peptide by CD8α− Dendritic Cells Via Potentiation of the CD8α+ Subset

2000 • 101 citations

CD19+ pro-B cells can give rise to dendritic cells in vitro.

1998 • 100 citations

FcεRI Induces the Tryptophan Degradation Pathway Involved in Regulating T Cell Responses

2002 • 98 citations

Cutting Edge: CD19+ Pro-B Cells Can Give Rise to Dendritic Cells In Vitro

1998 • 81 citations

Regulation of tumour immunity by CD25⁺ T cells

2002 • 80 citations

Complementary Role of CD4+ T Cells and Secondary Lymphoid Tissues for Cross-presentation of Tumor Antigen to CD8+ T Cells

2003 • 76 citations

Tumor Progression Despite Efficient Tumor Antigen Cross-Presentation and Effective “Arming” of Tumor Antigen-Specific CTL

2001 • 68 citations

Tumor immunity meets autoimmunity: antigen levels and dendritic cell maturation

2003 • 56 citations

Cytokine Profiles of Sentinel Lymph Nodes Draining the Primary Melanoma

2002 • 53 citations

Effects of different antigenic microenvironments on the course of CD8⁺ T cell responses in vivo

1996 • 17 citations